miRNA-Targeted Therapies in the Most Prevalent Pediatric Solid Tumors

miRNA-Targeted Therapies in the Most Prevalent Pediatric Solid Tumors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/978-3-319-05134-5_14

P2093author name stringJosep Roma
Soledad Gallego
José Sánchez de Toledo
Miguel F. Segura
Ana Almazán-Moga
P2860cites workIdentification of microRNAs as potential prognostic markers in ependymomaQ21135016
Use of preclinical models to improve treatment of retinoblastomaQ21144714
Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumoursQ24298221
Germline mutations in DIS3L2 cause the Perlman syndrome of overgrowth and Wilms tumor susceptibilityQ24304444
miR-17~92 cooperates with RB pathway mutations to promote retinoblastomaQ24606181
Molecular subgroups of medulloblastoma: the current consensusQ24615271
Mutation and cancer: statistical study of retinoblastomaQ24618185
The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1Q24629399
The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursorsQ24629817
MicroRNA-1/206 targets c-Met and inhibits rhabdomyosarcoma developmentQ24648202
The miR-17~92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastomaQ24657463
Inhibition of neuroblastoma tumor growth by targeted delivery of microRNA-34a using anti-disialoganglioside GD2 coated nanoparticlesQ27301841
MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastomaQ27320938
MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastomaQ27350129
EWS-FLI1 fusion transcript structure is an independent determinant of prognosis in Ewing's sarcomaQ27851507
MicroRNA expression profiles classify human cancersQ28032481
Dickkopf-3 is regulated by the MYCN-induced miR-17-92 cluster in neuroblastomaQ28117269
Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapyQ28235397
Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumpingQ28236877
Expression of miR-124 inhibits growth of medulloblastoma cellsQ28279686
Genomic and protein expression profiling identifies CDK6 as novel independent prognostic marker in medulloblastomaQ28284093
Multicenter Independent Assessment of Outcomes in Chronic Myeloid Leukemia Patients Treated With ImatinibQ29999611
Molecular biology and therapeutics in musculoskeletal oncologyQ30426953
Transcription mapping in a medulloblastoma breakpoint interval and Smith-Magenis syndrome candidate region: identification of 53 transcriptional units and new candidate genesQ30640817
Changes in incidence and survival of Ewing sarcoma patients over the past 3 decades: Surveillance Epidemiology and End Results data.Q31157886
The National Cancer Data Base report on patterns of childhood cancers in the United StatesQ32172794
Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological featuresQ33366431
Widespread dysregulation of MiRNAs by MYCN amplification and chromosomal imbalances in neuroblastoma: association of miRNA expression with survivalQ33516231
MicroRNA 128a increases intracellular ROS level by targeting Bmi-1 and inhibits medulloblastoma cancer cell growth by promoting senescenceQ33614641
ATM is down-regulated by N-Myc-regulated microRNA-421.Q33667539
MicroRNA-34a is a potent tumor suppressor molecule in vivo in neuroblastomaQ33803485
Loss of heterozygosity for the short arm of chromosome 1 in human neuroblastomas: correlation with N-myc amplificationQ33858202
miR-338-3p suppresses neuroblastoma proliferation, invasion and migration through targeting PREX2aQ39076744
miR-335 suppresses migration and invasion by targeting ROCK1 in osteosarcoma cellsQ39105277
MicroRNA-340 suppresses osteosarcoma tumor growth and metastasis by directly targeting ROCK1.Q39122905
Epirubicin-mediated expression of miR-302b is involved in osteosarcoma apoptosis and cell cycle regulationQ39127244
MicroRNA-133a, downregulated in osteosarcoma, suppresses proliferation and promotes apoptosis by targeting Bcl-xL and Mcl-1.Q39140942
TGF-β1 suppression of microRNA-450b-5p expression: a novel mechanism for blocking myogenic differentiation of rhabdomyosarcomaQ39153280
MiR-365b-3p, down-regulated in retinoblastoma, regulates cell cycle progression and apoptosis of human retinoblastoma cells by targeting PAX6.Q39154132
MicroRNA-376c inhibits cell proliferation and invasion in osteosarcoma by targeting to transforming growth factor-alphaQ39158217
MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastomaQ39158975
MicroRNA-24 inhibits osteosarcoma cell proliferation both in vitro and in vivo by targeting LPAATβ.Q39167853
miR-16 inhibits cell proliferation by targeting IGF1R and the Raf1-MEK1/2-ERK1/2 pathway in osteosarcomaQ39178990
MiR-137 functions as a tumor suppressor in neuroblastoma by downregulating KDM1A.Q39196320
MiR-383 is downregulated in medulloblastoma and targets peroxiredoxin 3 (PRDX3).Q39228870
Heat shock protein 90B1 plays an oncogenic role and is a target of microRNA-223 in human osteosarcomaQ39233292
Differentially expressed miRNAs in retinoblastomaQ39252603
miR-15a and miR-16-1 downregulate CCND1 and induce apoptosis and cell cycle arrest in osteosarcomaQ39291006
miR-183 inhibits the metastasis of osteosarcoma via downregulation of the expression of Ezrin in F5M2 cellsQ39291031
MicroRNA-204 increases sensitivity of neuroblastoma cells to cisplatin and is associated with a favourable clinical outcomeQ39297570
A TARBP2-dependent miRNA expression profile underlies cancer stem cell properties and provides candidate therapeutic reagents in Ewing sarcomaQ39331421
microRNA-9 targets matrix metalloproteinase 14 to inhibit invasion, metastasis, and angiogenesis of neuroblastoma cellsQ39352460
Pleiotropic effects of miR-183~96~182 converge to regulate cell survival, proliferation and migration in medulloblastomaQ39382947
Downregulation of microRNAs miR-1, -206 and -29 stabilizes PAX3 and CCND2 expression in rhabdomyosarcomaQ39397196
miR-125b suppresses the proliferation and migration of osteosarcoma cells through down-regulation of STAT3.Q39441445
miR-34a predicts survival of Ewing's sarcoma patients and directly influences cell chemo-sensitivity and malignancyQ39465507
MicroRNA-21 suppression impedes medulloblastoma cell migrationQ39503647
MicroRNA-199a-3p is downregulated in human osteosarcoma and regulates cell proliferation and migrationQ39526077
MYCN-regulated miRNA-92 inhibits secretion of the tumor suppressor DICKKOPF-3 (DKK3) in neuroblastomaQ39542401
The miR-17-92 microRNA cluster regulates multiple components of the TGF-β pathway in neuroblastomaQ39621978
Oncogenic role of miR-483-3p at the IGF2/483 locusQ39715206
EWS-FLI-1 modulates miRNA145 and SOX2 expression to initiate mesenchymal stem cell reprogramming toward Ewing sarcoma cancer stem cellsQ39716224
MYCN/c-MYC-induced microRNAs repress coding gene networks associated with poor outcome in MYCN/c-MYC-activated tumors.Q39769505
Functional elucidation of MiR-34 in osteosarcoma cells and primary tumor samplesQ39820788
miR-124 is frequently down-regulated in medulloblastoma and is a negative regulator of SLC16A1.Q39854644
Regulation of cyclin dependent kinase 6 by microRNA 124 in medulloblastomaQ39964030
The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomasQ40497319
Notch1 and notch2 have opposite effects on embryonal brain tumor growthQ40497328
miR-125b develops chemoresistance in Ewing sarcoma/primitive neuroectodermal tumorQ41051759
Transactivation of Igf2 in a mouse model of Beckwith-Wiedemann syndrome.Q41066237
microRNA-195 suppresses osteosarcoma cell invasion and migration in vitro by targeting FASN.Q41113931
Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cellsQ42009448
MicroRNA profiling in human medulloblastoma.Q43415716
NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcomaQ43896876
Differential profiles of microRNAs in retinoblastoma cell lines of different proliferation and adherence patternsQ44624930
Gender affects survival for medulloblastoma only in older children and adults: a study from the Surveillance Epidemiology and End Results RegistryQ45240545
MicroRNA-145 targets vascular endothelial growth factor and inhibits invasion and metastasis of osteosarcoma cellsQ45878313
Embryonal cancers in Europe.Q45906383
Differential microRNA-34a expression and tumor suppressor function in retinoblastoma cells.Q46011331
Biallelic DICER1 mutations occur in Wilms tumours.Q46977021
Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formationQ47302451
miR-218 is downregulated and directly targets SH3GL1 in childhood medulloblastomaQ47719797
Stat3 inhibits WTX expression through up-regulation of microRNA-370 in Wilms tumor.Q50485086
Does expression of different EWS chimeric transcripts define clinically distinct risk groups of Ewing tumor patients?Q50752435
LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression.Q50781580
MicroRNA-182 promotes leptomeningeal spread of non-sonic hedgehog-medulloblastoma.Q53201641
Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR.Q53210793
The Biology of Ewing sarcoma.Q53575285
Effect of curcumin on miRNA expression in human Y79 retinoblastoma cells.Q54314330
Pax6 regulates proliferation and apoptosis of human retinoblastoma cells.Q54396510
A proteomic approach of pediatric astrocytomas: MiRNAs and network insight.Q55461473
High incidence of DNA mutations and gene amplifications of theALKgene in advanced sporadic neuroblastoma tumoursQ61696748
Incidence of second neoplasms in patients with bilateral retinoblastomaQ68005406
Infrequency of ras, p53, WT1, or RB gene alterations in Wilms tumorsQ72636441
Novel genomic imbalances in embryonal rhabdomyosarcoma revealed by comparative genomic hybridization and fluorescence in situ hybridization: an intergroup rhabdomyosarcoma studyQ73553819
Down-regulation of miR-183 promotes migration and invasion of osteosarcoma by targeting EzrinQ83961794
MicroRNA-21 is involved in osteosarcoma cell invasion and migrationQ84245716
MicroRNA cloning and sequencing in osteosarcoma cell lines: differential role of miR-93Q85017897
Micro-RNA-21 regulates the sensitivity to cisplatin in human neuroblastoma cellsQ85236809
First microRNA mimic enters clinicQ87067042
Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children's Cancer GroupQ33876841
microRNA signature and expression of Dicer and Drosha can predict prognosis and delineate risk groups in neuroblastomaQ33893064
Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cellsQ33895297
Let-7a is a direct EWS-FLI-1 target implicated in Ewing's sarcoma developmentQ33997274
Wilms tumor genetics: mutations in WT1, WTX, and CTNNB1 account for only about one-third of tumorsQ34010180
Wilms tumor geneticsQ34067724
Accurate prediction of neuroblastoma outcome based on miRNA expression profilesQ34115726
Survey of MicroRNA expression in pediatric brain tumorsQ34154964
MicroRNA involvement in the pathogenesis of neuroblastoma: potential for microRNA mediated therapeuticsQ34155009
MicroRNA-542-5p as a novel tumor suppressor in neuroblastomaQ34163789
Distinctive microRNA signature of medulloblastomas associated with the WNT signaling pathwayQ34167348
A genome-wide search for promoters that respond to increased MYCN reveals both new oncogenic and tumor suppressor microRNAs associated with aggressive neuroblastomaQ34178892
Tumour-suppressor microRNAs let-7 and mir-101 target the proto-oncogene MYCN and inhibit cell proliferation in MYCN-amplified neuroblastomaQ34191041
miR-335 and miR-363 regulation of neuroblastoma tumorigenesis and metastasisQ34194661
MicroRNA-34a inhibits the proliferation and metastasis of osteosarcoma cells both in vitro and in vivoQ34211970
EWS/FLI1 regulates EYA3 in Ewing sarcoma via modulation of miRNA-708, resulting in increased cell survival and chemoresistance.Q34283431
Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcomaQ34334974
miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma.Q34482630
Diagnosis and current management of retinoblastomaQ34570404
MicroRNA-221 induces cell survival and cisplatin resistance through PI3K/Akt pathway in human osteosarcomaQ34570975
Growth-promoting role of the miR-106a~363 cluster in Ewing sarcomaQ34702270
miR-34a confers chemosensitivity through modulation of MAGE-A and p53 in medulloblastomaQ34722558
A clinical overview of WT1 gene mutationsQ34738955
High-dose rapid and standard induction chemotherapy for patients aged over 1 year with stage 4 neuroblastoma: a randomised trialQ34756587
Identification of miRNAs associated with tumorigenesis of retinoblastoma by miRNA microarray analysisQ34838128
Loss of heterozygosity at 2q37 in sporadic Wilms' tumor: putative role for miR-562.Q35005638
Ewing's sarcoma: diagnostic, prognostic, and therapeutic implications of molecular abnormalitiesQ35057457
MicroRNA-143 regulates human osteosarcoma metastasis by regulating matrix metalloprotease-13 expressionQ35086698
Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon geneQ35095712
miR-20a encoded by the miR-17-92 cluster increases the metastatic potential of osteosarcoma cells by regulating Fas expression.Q35783986
MiR-27b targets PPARγ to inhibit growth, tumor progression and the inflammatory response in neuroblastoma cellsQ35791401
MiRNA-335 suppresses neuroblastoma cell invasiveness by direct targeting of multiple genes from the non-canonical TGF-β signalling pathwayQ35907425
The micro-RNA 199b-5p regulatory circuit involves Hes1, CD15, and epigenetic modifications in medulloblastoma.Q35914487
International variations in the incidence of childhood renal tumours.Q35982229
Prognostic factors in metastatic rhabdomyosarcomas: results of a pooled analysis from United States and European cooperative groups.Q36022696
Modulation of neuroblastoma disease pathogenesis by an extensive network of epigenetically regulated microRNAsQ36335774
Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.Q36374350
A statin-regulated microRNA represses human c-Myc expression and function.Q36379501
MicroRNA profiling in pediatric pilocytic astrocytoma reveals biologically relevant targets, including PBX3, NFIB, and METAP2.Q36500392
MicroRNA 218 acts as a tumor suppressor by targeting multiple cancer phenotype-associated genes in medulloblastomaQ36543801
Molecular pathogenesis of Ewing sarcoma: new therapeutic and transcriptional targetsQ36562726
The E2F3-Oncomir-1 axis is activated in Wilms' tumorQ36742470
MicroRNA-34a inhibits human osteosarcoma proliferation by downregulating ether à go-go 1 expressionQ36746921
MicroRNA-497 increases apoptosis in MYCN amplified neuroblastoma cells by targeting the key cell cycle regulator WEE1Q36766761
Human chromosome 11 contains two different growth suppressor genes for embryonal rhabdomyosarcomaQ36858083
Medulloblastoma: from molecular pathology to therapyQ37087083
Management of Wilms tumor: current standard of careQ37287143
Osteosarcoma: Conventional treatment vs. gene therapy.Q37355546
Silencing of the miR-17~92 cluster family inhibits medulloblastoma progressionQ37378211
New therapeutic targets for the treatment of high-risk neuroblastomaQ37412535
Subtype-specific FBXW7 mutation and MYCN copy number gain in Wilms' tumor.Q37437735
Pediatric brain tumors: current treatment strategies and future therapeutic approachesQ37533670
Childhood medulloblastoma: current status of biology and treatmentQ37713662
Pathology, genetics and cytogenetics of Wilms' tumourQ37868410
Nephrogenic rests, nephroblastomatosis, and the pathogenesis of Wilms' tumorQ37874427
Multidisciplinary management of childhood brain tumors: a review of outcomes, recent advances, and challengesQ37909392
Medulloblastomas: update on a heterogeneous diseaseQ37926454
Ewing sarcoma treatmentQ37937915
Ewing sarcoma: biology-based therapeutic perspectivesQ37981253
Pediatric neuro-oncology: current status and future directions.Q38035070
Prospects and challenges for the development of new therapies for Ewing sarcomaQ38053823
Models and discovery strategies for new therapies of retinoblastomaQ38083299
microRNAs as pharmacological targets in cancer.Q38093917
MiR-30a-5p connects EWS-FLI1 and CD99, two major therapeutic targets in Ewing tumorQ38321646
A novel oncogenic mechanism in Ewing sarcoma involving IGF pathway targeting by EWS/Fli1-regulated microRNAsQ38334606
Hsa-mir-145 is the top EWS-FLI1-repressed microRNA involved in a positive feedback loop in Ewing's sarcomaQ38338166
MicroRNA miR-183 functions as an oncogene by targeting the transcription factor EGR1 and promoting tumor cell migrationQ38338974
P304page(s)239-263
P577publication date2014-01-01
P1476titlemiRNA-Targeted Therapies in the Most Prevalent Pediatric Solid Tumors

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