Analysis of antifungal resistance genes in Candida albicans and Candida glabrata using next generation sequencing

scientific article published in PLoS ONE

Analysis of antifungal resistance genes in Candida albicans and Candida glabrata using next generation sequencing is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PONE.0210397
P932PMC publication ID6328131
P698PubMed publication ID30629653

P50authorIris ZellerQ83379126
Birgit WillingerQ89285388
Kathrin SpettelQ89689851
P2093author name stringPeter-Michael Rath
Athanasios Makristathis
Joerg Steinmann
Marion Nehr
Wolfgang Barousch
Michaela Lackner
Brigitte Selitsch
P2860cites workA rapid method for isolation of genomic DNA from food-borne fungal pathogens.Q54016201
Multiple amino acid substitutions in lanosterol 14alpha-demethylase contribute to azole resistance in Candida albicans.Q54073912
The mutation T315A in Candida albicans sterol 14alpha-demethylase causes reduced enzyme activity and fluconazole resistance through reduced affinityQ73084701
Investigation of mutations in Erg11 gene of fluconazole resistant Candida albicans isolates from Turkish hospitalsQ84517255
Mutations in the fks1 gene in Candida albicans, C. tropicalis, and C. krusei correlate with elevated caspofungin MICs uncovered in AM3 medium using the method of the European Committee on Antibiotic Susceptibility TestingQ36870777
Functional analysis of cis- and trans-acting elements of the Candida albicans CDR2 promoter with a novel promoter reporter system.Q37301949
Variation in susceptibility of bloodstream isolates of Candida glabrata to fluconazole according to patient age and geographic location in the United States in 2001 to 2007.Q37374850
Echinocandin resistance and population structure of invasive Candida glabrata isolates from two university hospitals in Germany and AustriaQ38916677
Persistent Candida albicans colonization and molecular mechanisms of azole resistance in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) patients.Q39279261
Novel point mutations in the ERG11 gene in clinical isolates of azole resistant Candida speciesQ39388869
Amino acid substitutions in the Candida albicans sterol Δ5,6-desaturase (Erg3p) confer azole resistance: characterization of two novel mutants with impaired virulenceQ39606039
A naturally occurring proline-to-alanine amino acid change in Fks1p in Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis accounts for reduced echinocandin susceptibilityQ39686624
Results from the ARTEMIS DISK Global Antifungal Surveillance Study, 1997 to 2007: a 10.5-year analysis of susceptibilities of Candida Species to fluconazole and voriconazole as determined by CLSI standardized disk diffusion.Q39899742
Loss of C-5 Sterol Desaturase Activity Results in Increased Resistance to Azole and Echinocandin Antifungals in a Clinical Isolate of Candida parapsilosis.Q40166236
ERG11 mutations and expression of resistance genes in fluconazole-resistant Candida albicans isolatesQ40562539
Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistanceQ40738359
Fks1 and Fks2 are functionally redundant but differentially regulated in Candida glabrata: implications for echinocandin resistanceQ41184732
Next-generation sequencing offers new insights into the resistance of Candida spp. to echinocandins and azoles.Q41199783
Infectious Disease. How to bolster the antifungal pipelineQ41378447
Candida albicans and Candida glabrata clinical isolates exhibiting reduced echinocandin susceptibilityQ41957394
Caspofungin dose escalation for invasive candidiasis due to resistant Candida albicans.Q41990022
FKS Mutations and Elevated Echinocandin MIC Values among Candida glabrata Isolates from U.S. Population-Based SurveillanceQ42250085
Assessing resistance to the echinocandin antifungal drug caspofungin in Candida albicans by profiling mutations in FKS1Q42408700
Effect of Candida glabrata FKS1 and FKS2 mutations on echinocandin sensitivity and kinetics of 1,3-beta-D-glucan synthase: implication for the existing susceptibility breakpointQ42545839
Contribution of clinically derived mutations in ERG11 to azole resistance in Candida albicansQ43102358
Use of anidulafungin as a surrogate marker to predict susceptibility and resistance to caspofungin among 4,290 clinical isolates of Candida by using CLSI methods and interpretive criteriaQ43125888
Cloning, sequencing, expression and allelic sequence diversity of ERG3 (C-5 sterol desaturase gene) in Candida albicansQ47940968
A tale of three next generation sequencing platforms: comparison of Ion Torrent, Pacific Biosciences and Illumina MiSeq sequencersQ21266698
Epidemiology and risk factors for invasive candidiasisQ27024911
Gain of function mutations in CgPDR1 of Candida glabrata not only mediate antifungal resistance but also enhance virulenceQ27318203
Fast gapped-read alignment with Bowtie 2Q27860699
Guidelines for investigating causality of sequence variants in human diseaseQ28655218
Trimmomatic: a flexible trimmer for Illumina sequence dataQ29547278
Primer3--new capabilities and interfacesQ29614816
The Candida Genome Database (CGD): incorporation of Assembly 22, systematic identifiers and visualization of high throughput sequencing dataQ31136511
Rapid detection of ERG11 gene mutations in clinical Candida albicans isolates with reduced susceptibility to fluconazole by rolling circle amplification and DNA sequencingQ33493582
TAC1, transcriptional activator of CDR genes, is a new transcription factor involved in the regulation of Candida albicans ABC transporters CDR1 and CDR2.Q33559776
Mechanisms of azole resistance in clinical isolates of Candida glabrata collected during a hospital survey of antifungal resistanceQ33805788
Contribution of CgPDR1-regulated genes in enhanced virulence of azole-resistant Candida glabrataQ33847058
Breakthrough invasive Candida glabrata in patients on micafungin: a novel FKS gene conversion correlated with sequential elevation of MIC.Q33900103
VarScan: variant detection in massively parallel sequencing of individual and pooled samplesQ34018143
Microarray and molecular analyses of the azole resistance mechanism in Candida glabrata oropharyngeal isolatesQ34045265
Candida glabrata PDR1, a transcriptional regulator of a pleiotropic drug resistance network, mediates azole resistance in clinical isolates and petite mutantsQ34510712
A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicansQ34588684
New Fks hot spot for acquired echinocandin resistance in Saccharomyces cerevisiae and its contribution to intrinsic resistance of Scedosporium speciesQ35139501
Quick Detection of FKS1 Mutations Responsible for Clinical Echinocandin Resistance in Candida albicansQ35757564
Topological and mutational analysis of Saccharomyces cerevisiae Fks1Q36156130
Increasing echinocandin resistance in Candida glabrata: clinical failure correlates with presence of FKS mutations and elevated minimum inhibitory concentrationsQ36856930
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesmassive parallel sequencingQ6784807
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectCandida glabrataQ139137
Candida albicansQ310443
P304page(s)e0210397
P577publication date2019-01-10
P1433published inPLOS OneQ564954
P1476titleAnalysis of antifungal resistance genes in Candida albicans and Candida glabrata using next generation sequencing
P478volume14

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cites work (P2860)
Q92257617Curative Treatment of Candidiasis by the Live Biotherapeutic Microorganism Lactobacillus rhamnosus Lcr35® in the Invertebrate Model Caenorhabditis elegans: First Mechanistic Insights
Q96685779Mechanisms of action of antimicrobial peptides ToAP2 and NDBP-5.7 against Candida albicans planktonic and biofilm cells