Nrf2/ARE Pathway Modulation by Dietary Energy Regulation in Neurological Disorders

Nrf2/ARE Pathway Modulation by Dietary Energy Regulation in Neurological Disorders is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FPHAR.2019.00033
P932PMC publication ID6369171
P698PubMed publication ID30778297

P2093author name stringCristoforo Scavone
Andrea Rodrigues Vasconcelos
Carolina Demarchi Munhoz
Nilton Barreto Dos Santos
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Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive elementQ24529933
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The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stressQ24648021
Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemiaQ24650258
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Ageing as a risk factor for diseaseQ26853545
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Role of neuroinflammation in neurodegenerative diseases (Review)Q28080292
Peripheral levels of glutathione and protein oxidation as markers in the development of Alzheimer's disease from Mild Cognitive ImpairmentQ46735667
Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1.Q46898118
Luteolin protects rat PC12 and C6 cells against MPP+ induced toxicity via an ERK dependent Keap1-Nrf2-ARE pathway.Q46914467
Differential effects of the Nrf2 activators tBHQ and CDDO-Im on the early events of T cell activationQ47385636
Caloric restriction ameliorates acrolein-induced neurotoxicity in ratsQ47707158
Quercetin ameliorates learning and memory via the Nrf2-ARE signaling pathway in d-galactose-induced neurotoxicity in miceQ47951622
Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's diseaseQ48169104
Alzheimer's disease and type 2 diabetes-related alterations in brain mitochondria, autophagy and synaptic markersQ48184714
Keap1 is localized in neuronal and glial cytoplasmic inclusions in various neurodegenerative diseasesQ48252631
Protective effect of puerarin against beta-amyloid-induced oxidative stress in neuronal cultures from rat hippocampus: involvement of the GSK-3β/Nrf2 signaling pathwayQ48326514
Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus).Q48331169
Thymol improves high-fat diet-induced cognitive deficits in mice via ameliorating brain insulin resistance and upregulating NRF2/HO-1 pathwayQ48470200
Knockdown of Nrf2 inhibits angiogenesis by down-regulating VEGF expression through PI3K/Akt signaling pathway in cerebral microvascular endothelial cells under hypoxic conditionsQ48522321
Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responsesQ48562222
PPARγ agonist improves neuronal insulin receptor function in hippocampus and brain mitochondria function in rats with insulin resistance induced by long term high-fat dietsQ48801682
Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination.Q48819558
Immunocytochemical characterization of the expression of inducible and constitutive isoforms of nitric oxide synthase in demyelinating multiple sclerosis lesionsQ48822577
High-fat diet exacerbates MPTP-induced dopaminergic degeneration in miceQ48860838
Trends in stroke hospitalizations and associated risk factors among children and young adults, 1995-2008.Q48913040
Elevated myeloperoxidase activity in white matter in multiple sclerosis.Q48954285
A dynamic view of the blood-brain barrier in active multiple sclerosis lesionsQ49118418
Antioxidant and pro-angiogenic effects of corilagin in rat cerebral ischemia via Nrf2 activationQ49569556
Linagliptin potentiates the effect of l-dopa on the behavioural, biochemical and immunohistochemical changes in experimentally-induced Parkinsonism: Role of toll-like receptor 4, TGF-β1, NF-κB and glucagon-like peptide 1.Q50151859
Hippocampal Mutant APP and Amyloid Beta Induced Cognitive Decline, Dendritic Spine Loss, Defective Autophagy, Mitophagy and Mitochondrial Abnormalities in a Mouse Model of Alzheimer's Disease.Q50161371
The effects of obesity on the cerebral vasculatureQ50187880
Surgical stress resistance induced by single amino acid deprivation requires Gcn2 in miceQ36503034
Childhood obesity and risk of pediatric multiple sclerosis and clinically isolated syndrome.Q36659702
NRF2 and the Phase II Response in Acute Stress Resistance Induced by Dietary RestrictionQ36678635
Body mass index and magnetic resonance markers of brain integrity in adultsQ36889018
Early effects of high-fat diet on neurovascular function and focal ischemic brain injuryQ36923873
Innate immunity, insulin resistance and type 2 diabetes.Q37033028
Multiple sclerosis patients have a distinct gut microbiota compared to healthy controlsQ37040077
Alterations of the human gut microbiome in multiple sclerosis.Q37060934
Chronic calorie restriction attenuates experimental autoimmune encephalomyelitisQ37089838
Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's DiseaseQ37091371
Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration.Q37096592
Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyteQ37115302
Modeling the heterogeneity of multiple sclerosis in animalsQ37119854
Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humansQ37194226
The Nrf2/ARE pathway as a potential therapeutic target in neurodegenerative diseaseQ37248671
Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production.Q37273149
Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic optionsQ37299615
Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolideQ37364482
Glutathione dysregulation and the etiology and progression of human diseases.Q37372896
Interplay between VEGF and Nrf2 regulates angiogenesis due to intracranial venous hypertensionQ37425072
Biomarkers of oxidative and nitrosative damage in Alzheimer's disease and mild cognitive impairmentQ37450188
Heterogeneity of microglial activation in the innate immune response in the brainQ37572598
Diet-induced obesity causes cerebral vessel remodeling and increases the damage caused by ischemic strokeQ37648333
Psychological Symptoms in Obesity and Related FactorsQ37703662
Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52.Q37708598
Targeting the Nrf2-Keap1 antioxidant defence pathway for neurovascular protection in stroke.Q37885608
Lipid peroxidation and neurodegenerative disease.Q37904195
Oxidative stress and β-amyloid protein in Alzheimer's diseaseQ37928994
Dietary factors and low-grade inflammation in relation to overweight and obesityQ37963508
Environmental factors in multiple sclerosisQ38167388
Mitochondrial dysfunction contributes to neurodegeneration in multiple sclerosisQ38173920
Increased oxidative stress in obesity: implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancerQ38181162
Mechanisms of white matter damage in multiple sclerosisQ38182524
Antioxidative defense mechanisms controlled by Nrf2: state-of-the-art and clinical perspectives in neurodegenerative diseasesQ38244092
NF-E2-related factor-2 mediates neuroprotection against mitochondrial complex I inhibitors and increased concentrations of intracellular calcium in primary cortical neuronsQ38352906
Long-term effects of a very low-carbohydrate diet and a low-fat diet on mood and cognitive functionQ38377765
Hydrogen sulfide ameliorates learning memory impairment in APP/PS1 transgenic mice: A novel mechanism mediated by the activation of Nrf2.Q50474369
Pharmacological targeting of the transcription factor Nrf2 at the basal ganglia provides disease modifying therapy for experimental parkinsonism.Q50547983
Preventing stroke: saving lives around the world.Q50796686
Redox Proteomics Analysis of Brains from Subjects with Amnestic Mild Cognitive Impairment Compared to Brains from Subjects with Preclinical Alzheimer's Disease: Insights into Memory Loss in MCIQ51034709
Sodium butyrate activates NRF2 to ameliorate diabetic nephropathy possibly via inhibition of HDAC.Q51352249
Preoperative fasting protects mice against hepatic ischemia/reperfusion injury: mechanisms and effects on liver regeneration.Q51372775
Protective effect of fasting upon cerebral hypoxic-ischemic injury.Q51623638
A Long Journey into Aging, Brain Aging, and Alzheimer's Disease Following the Oxidative Stress Tracks.Q51760887
Decreased plasma antioxidants in patients with Alzheimer's disease.Q51920410
Induction of quinone reductase NQO1 by resveratrol in human K562 cells involves the antioxidant response element ARE and is accompanied by nuclear translocation of transcription factor Nrf2.Q52573261
Type 2 diabetes and the risk of Parkinson's disease.Q53016612
Obesity is associated with reduced white matter integrity in otherwise healthy adults.Q53161853
Brain ischemic preconditioning protects against ischemic injury and preserves the blood-brain barrier via oxidative signaling and Nrf2 activation.Q54108837
Lifestyle and Environmental Factors in Multiple Sclerosis.Q54218943
The transcription factor Nrf2 as a new therapeutic target in Parkinson's diseaseQ58436305
Body mass index and the risk of Parkinson diseaseQ59542870
In vivo imaging of early signs of dopaminergic neuronal death in an animal model of Parkinson's diseaseQ64976816
Dietary lipids and antioxidants in Parkinson's disease: a population-based, case-control studyQ70928225
Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brainsQ71659583
Nutritional factors and multiple sclerosis in Gorski Kotar, CroatiaQ72684508
Quinone reductase (NQO1), a sensitive redox indicator, is increased in Alzheimer's diseaseQ73541748
Neurons overexpressing heme oxygenase-1 resist oxidative stress-mediated cell deathQ73897074
Reactive oxygen species enhance the migration of monocytes across the blood-brain barrier in vitroQ74299346
Peroxide-scavenging deficit underlies oligodendrocyte susceptibility to oxidative stressQ74363334
Differential expressions of antioxidant status in aging rats: the role of transcriptional factor Nrf2 and MAPK signaling pathwayQ79931510
Elevated activity and microglial expression of myeloperoxidase in demyelinated cerebral cortex in multiple sclerosisQ80089503
Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetinQ80225202
Upregulation of thioredoxin system via Nrf2-antioxidant responsive element pathway in adaptive-retinal neuroprotection in vivo and in vitroQ80356068
Effects of age and dietary restriction on liver glutathione transferase activities in Lobund-Wistar ratsQ80577972
Oxidative stress and Parkinson's diseaseQ82029447
Short-term consumption of a high-fat diet impairs whole-body efficiency and cognitive function in sedentary menQ82601818
Dietary ellagic acid improves oxidant-induced endothelial dysfunction and atherosclerosis: role of Nrf2 activationQ87392048
Prion-like propagation of α-synuclein in the gut-brain axisQ89078394
Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging PhenotypeQ89113379
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesisQ28242612
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elementsQ28244853
Spare respiratory capacity, oxidative stress and excitotoxicityQ28264586
A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosisQ28270998
Cognitive impairment in multiple sclerosisQ28300777
Expression of inducible nitric oxide synthase and nitrotyrosine in multiple sclerosis lesionsQ28366501
Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disordersQ28384232
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative diseaseQ28394732
Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcriptionQ28395088
NRF2-regulation in brain health and disease: implication of cerebral inflammationQ28397785
Modulation of glutathione and thioredoxin systems by calorie restriction during the aging processQ28564586
N-acetylcysteine reduces lipopolysaccharide-sensitized hypoxic-ischemic brain injuryQ28580718
Energy intake and exercise as determinants of brain health and vulnerability to injury and diseaseQ28710367
Lesion genesis in a subset of patients with multiple sclerosis: a role for innate immunity?Q29042454
Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant responseQ29347088
Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disordersQ29615839
Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjectsQ29617231
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's diseaseQ29617286
Mechanisms underlying inflammation in neurodegenerationQ29617977
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activationQ29618051
Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke AssociationQ29620546
Midlife adiposity and the future risk of Parkinson's diseaseQ30310111
The absence of the pro-antioxidant transcription factor Nrf2 exacerbates experimental autoimmune encephalomyelitisQ30495467
High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signalingQ30496730
NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitisQ30519470
Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer's diseaseQ30544139
Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's diseaseQ30846057
Glutathione levels modulate domoic acid induced apoptosis in mouse cerebellar granule cellsQ33297470
High-fat diet-induced memory impairment in triple-transgenic Alzheimer's disease (3xTgAD) mice is independent of changes in amyloid and tau pathologyQ33624475
Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth.Q33652512
Cognitive impairment following high fat diet consumption is associated with brain inflammation.Q33665160
Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitisQ33708751
Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiationQ33854794
Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetesQ33859600
Leptin increase in multiple sclerosis associates with reduced number of CD4(+)CD25+ regulatory T cellsQ33935880
Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke associationQ33967781
Metabolic dysfunctions in multiple sclerosis: implications as to causation, early detection, and treatment, a case control studyQ35756786
Nrf2 signaling in coordinated activation of antioxidant gene expressionQ35757034
Cell type-specific Nrf2 expression in multiple sclerosis lesions.Q35856138
Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive declineQ35858095
Role of reactive oxygen species in modulation of Nrf2 following ischemic reperfusion injuryQ35966406
Neuroprotection provided by dietary restriction in rats is further enhanced by reducing glucocortocoids.Q36028337
Multiple sclerosis and nutritionQ36054785
Nrf2-mediated protection against 6-hydroxydopamineQ36114124
Short-term dietary restriction and fasting precondition against ischemia reperfusion injury in miceQ36141448
Nrf2 Signaling and the Slowed Aging Phenotype: Evidence from Long-Lived ModelsQ36260040
Dietary energy intake modifies brainstem autonomic dysfunction caused by mutant α-synucleinQ36400251
Calorie restriction mimetics: an emerging research fieldQ36454381
Expression of Nrf2 in neurodegenerative diseasesQ36477584
Nrf2 mediates cancer protection but not prolongevity induced by caloric restrictionQ36497217
High body mass index before age 20 is associated with increased risk for multiple sclerosis in both men and womenQ43865774
Adult nutrient intake as a risk factor for Parkinson's diseaseQ44487546
Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's diseaseQ44807369
Calorie restriction attenuates age-related alterations in the plasma membrane antioxidant system in rat liverQ44809057
Reperfusion-induced oxidative/nitrative injury to neurovascular unit after focal cerebral ischemiaQ44836875
Rapamycin confers preconditioning-like protection against ischemia-reperfusion injury in isolated mouse heart and cardiomyocytesQ44920860
Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's diseaseQ45223637
Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patientsQ45263090
Enhanced susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in high-fat diet-induced obesityQ45275310
Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agentsQ46079650
Impaired regulation of electron transport chain subunit genes by nuclear respiratory factor 2 in multiple sclerosisQ46136205
Caloric restriction attenuates Abeta-deposition in Alzheimer transgenic modelsQ46142687
Keap1/Nrf2 system regulates neuronal survival as revealed through study of keap1 gene-knockout miceQ46148942
Contributions of the sympathetic nervous system, glutathione, body mass and gender to blood pressure increase with normal aging: influence of heredityQ46266846
Nrf2/ARE pathway inhibits ROS-induced NLRP3 inflammasome activation in BV2 cells after cerebral ischemia reperfusionQ46299719
Effect of high-fat diet on cognitive impairment in triple-transgenic mice model of Alzheimer's diseaseQ46312868
Nuclear factor erythroid 2-related factor 2 protects against beta amyloid.Q46427142
Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cellsQ46481176
Dietary restriction affects striatal glutamate in the MPTP-induced mouse model of nigrostriatal degenerationQ46500605
Bromocriptine activates NQO1 via Nrf2-PI3K/Akt signaling: novel cytoprotective mechanism against oxidative damageQ46612826
Increased nuclear factor-erythroid 2 p45-related factor 2 activity protects SH-SY5Y cells against oxidative damageQ46643988
Modulation of astrocytic metabolic phenotype by proinflammatory cytokinesQ46668726
Prevalence of overweight and obesity among adults with diagnosed diabetes--United States, 1988-1994 and 1999-2002.Q33983165
Preventing increased blood pressure in the obese Zucker rat improves severity of strokeQ33994844
Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged ratsQ34001695
Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's diseaseQ34002503
Interaction between adolescent obesity and HLA risk genes in the etiology of multiple sclerosisQ34039789
NRF2, cancer and calorie restrictionQ34148599
Neurodegeneration in an animal model of Parkinson's disease is exacerbated by a high-fat dietQ34212422
Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's diseaseQ34229644
Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophilic [correction of electrophillic] phase II inducersQ34270759
NRF2 and cancer: the good, the bad and the importance of context.Q34289003
Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acidQ34301299
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cellsQ34331407
Nrf2 affects the efficiency of mitochondrial fatty acid oxidation.Q34398472
Leptin: the tale of an obesity geneQ34402454
Glutathione in human plasma: decline in association with aging, age-related macular degeneration, and diabetesQ34468049
Elevated 4-hydroxyhexenal in Alzheimer's disease (AD) progressionQ34512386
Obesity, abdominal obesity and Alzheimer diseaseQ34548468
Lipoic acid affects cellular migration into the central nervous system and stabilizes blood-brain barrier integrityQ34554148
Caloric restriction and intermittent fasting: two potential diets for successful brain agingQ34569825
Prolonged fasting increases glutathione biosynthesis in postweaned northern elephant sealsQ34712306
Diabetes and risk of Parkinson's diseaseQ34718429
Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemiaQ34784446
Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapyQ34993085
Diabetes and the risk of developing Parkinson's disease in Denmark.Q35043736
Increased Alzheimer's disease-like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagyQ35044490
Elevated BMI is associated with decreased blood flow in the prefrontal cortex using SPECT imaging in healthy adultsQ35073637
Oxidative stress disrupts oligodendrocyte maturationQ35111405
Age-associated vascular oxidative stress, Nrf2 dysfunction, and NF-{kappa}B activation in the nonhuman primate Macaca mulatta.Q35142935
Resveratrol encapsulated in novel fusogenic liposomes activates Nrf2 and attenuates oxidative stress in cerebromicrovascular endothelial cells from aged ratsQ35152861
Insulin resistance impairs nigrostriatal dopamine functionQ35202338
Commensal microbiota regulates T cell fate decision in the gut.Q35332058
EPIDEMIOLOGIC STUDY OF MULTIPLE SCLEROSIS IN ISRAEL. I. AN OVERALL REVIEW OF METHODS AND FINDINGS.Q35519054
Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during agingQ35544420
The effect of caloric restriction and glycemic load on measures of oxidative stress and antioxidants in humans: results from the CALERIE Trial of Human Caloric RestrictionQ35587913
The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expressionQ35688212
Dietary factors in Parkinson's disease: the role of food groups and specific foodsQ38547790
Dietary habits and multiple sclerosis. A retrospective study in Ferrara, Italy.Q38571971
Nrf2-ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases.Q38652602
Effects of aging and caloric restriction on hepatic drug metabolizing enzymes in the Fischer 344 rat. I: The cytochrome P-450 dependent monooxygenase systemQ38653297
Inhibition of beta-amyloid-induced neurotoxicity by pinocembrin through Nrf2/HO-1 pathway in SH-SY5Y cellsQ38751200
miR-302 Attenuates Amyloid-β-Induced Neurotoxicity through Activation of Akt SignalingQ38793126
Involvement of the Nrf2/HO-1 signaling pathway in sulfuretin-induced protection against amyloid beta25-35 neurotoxicityQ38851186
Targeting Oxidative Stress in Central Nervous System DisordersQ38918789
Role of metabolism in neurodegenerative disorders.Q38923156
Gut Permeability and Microbiota in Parkinson's Disease: Role of Depression, Tryptophan Catabolites, Oxidative and Nitrosative Stress and Melatonergic Pathways.Q38948781
Role of 4-hydroxy-2-nonenal (HNE) in the pathogenesis of alzheimer disease and other selected age-related neurodegenerative disordersQ38993058
Preventive and protective roles of dietary Nrf2 activators against central nervous system diseasesQ39064638
Alzheimer's Disease and NQO1: Is there a Link?Q39121718
How Immune-inflammatory processes link CNS and psychiatric disorders: Classification and Treatment ImplicationsQ39162785
Obesity-Induced Neuroinflammation: Beyond the HypothalamusQ39187555
The impact of obesity on neurodegenerative diseasesQ39352727
Dysfunctional Nrf2-Keap1 redox signaling in skeletal muscle of the sedentary old.Q39667690
Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: modulation by the Nrf2/Trx axis.Q39732353
Redox proteomics identification of 4-hydroxynonenal-modified brain proteins in Alzheimer's disease: Role of lipid peroxidation in Alzheimer's disease pathogenesisQ39756716
Pathophysiology of inflammation and tissue injury in multiple sclerosis: what are the targets for therapyQ39846435
The coffee diterpene kahweol induces heme oxygenase-1 via the PI3K and p38/Nrf2 pathway to protect human dopaminergic neurons from 6-hydroxydopamine-derived oxidative stressQ39966495
Central administration of tert-butylhydroquinone attenuates hypertension via regulating Nrf2 signaling in the hypothalamic paraventricular nucleus of hypertensive ratsQ40070041
Apomorphine protects against 6-hydroxydopamine-induced neuronal cell death through activation of the Nrf2-ARE pathwayQ40262558
Novel cytoprotective mechanism of anti-parkinsonian drug deprenyl: PI3K and Nrf2-derived induction of antioxidative proteinsQ40344247
Alzheimer's disease: a central role for amyloidQ40701623
Oxidative toxicity in diabetes and Alzheimer's disease: mechanisms behind ROS/ RNS generation.Q41714460
Nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) modulates dendritic cell immune function through regulation of p38 MAPK-cAMP-responsive element binding protein/activating transcription factor 1 signaling.Q41852354
Role of Nrf2 Signaling in the Regulation of Vascular BK Channel β1 Subunit Expression and BK Channel Function in High-Fat Diet-Induced Diabetic Mice.Q41972825
The Nrf2/ARE Pathway: A Promising Target to Counteract Mitochondrial Dysfunction in Parkinson's DiseaseQ42010967
Food restriction induces long-lasting recovery of spatial memory deficits following global ischemia in delayed matching and non-matching-to-sample radial arm maze tasksQ42439656
Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: protection against reactive oxygen and nitrogen species-induced cell injuryQ42478374
A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo.Q42486098
Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson's diseaseQ42628290
Resveratrol preconditioning induces cellular stress proteins and is mediated via NMDA and estrogen receptorsQ43205410
Changes of some oxidative stress markers in the serum of patients with mild cognitive impairment and Alzheimer's diseaseQ43242111
Obesity predisposes to Th17 biasQ43296795
Effect of age on the expression of antioxidant enzymes in male Fischer F344 ratsQ43538377
Risk factors in multiple sclerosis: a population-based case-control study in Hautes-Pyrénées, FranceQ43567155
Multiple sclerosis--a global disorder and still poorly managedQ43734952
High glycemic index carbohydrate diet alters the diurnal rhythm of leptin but not insulin concentrationsQ43822537
Effects of leptin resistance on acute fuel metabolism after a high carbohydrate load in lean and overweight young men.Q43842267
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectNRF2 [nucleoplasm]Q50270454
Parkinson’s DiseaseQ39074077
P304page(s)33
P577publication date2019-01-01
P1433published inFrontiers in PharmacologyQ2681208
P1476titleNrf2/ARE Pathway Modulation by Dietary Energy Regulation in Neurological Disorders
P478volume10

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