Lenvatinib for the treatment of unresectable hepatocellular carcinoma: evidence to date

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Lenvatinib for the treatment of unresectable hepatocellular carcinoma: evidence to date is …
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scholarly articleQ13442814

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P356DOI10.2147/JHC.S168953
P932PMC publication ID6362912
P698PubMed publication ID30775342

P50authorTiziana PressianiQ91670431
Nicola PersoneniQ38524333
Lorenza RimassaQ38524354
P2093author name stringTiziana Pressiani
Nicola Personeni
Lorenza Rimassa
P2860cites workSorafenib in advanced hepatocellular carcinomaQ27861075
New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)Q28131668
Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trialQ29547903
Sunitinib versus sorafenib in advanced hepatocellular cancer: results of a randomized phase III trialQ33410643
Ramucirumab versus placebo as second-line treatment in patients with advanced hepatocellular carcinoma following first-line therapy with sorafenib (REACH): a randomised, double-blind, multicentre, phase 3 trialQ33423800
PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activationQ33569771
Lenvatinib, an angiogenesis inhibitor targeting VEGFR/FGFR, shows broad antitumor activity in human tumor xenograft models associated with microvessel density and pericyte coverageQ34144848
Effect of everolimus on survival in advanced hepatocellular carcinoma after failure of sorafenib: the EVOLVE-1 randomized clinical trialQ34663499
SEARCH: a phase III, randomized, double-blind, placebo-controlled trial of sorafenib plus erlotinib in patients with advanced hepatocellular carcinoma.Q50454368
ADI-PEG 20 Plus Best Supportive Care versus Placebo Plus Best Supportive Care in Patients with Advanced Hepatocellular Carcinoma.Q52586036
SIRveNIB: Selective Internal Radiation Therapy Versus Sorafenib in Asia-Pacific Patients With Hepatocellular Carcinoma.Q52677129
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Cabozantinib in Patients with Advanced and Progressing Hepatocellular CarcinomaQ56373211
Tivantinib for second-line treatment of MET-high, advanced hepatocellular carcinoma (METIV-HCC): a final analysis of a phase 3, randomised, placebo-controlled studyQ56384328
Hepatocellular carcinomaQ58020832
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Lenvatinib May Drastically Change the Treatment Landscape of Hepatocellular CarcinomaQ88379404
Pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib (KEYNOTE-224): a non-randomised, open-label phase 2 trialQ89012806
Ramucirumab after sorafenib in patients with advanced hepatocellular carcinoma and increased α-fetoprotein concentrations (REACH-2): a randomised, double-blind, placebo-controlled, phase 3 trialQ91147767
Linifanib versus Sorafenib in patients with advanced hepatocellular carcinoma: results of a randomized phase III trialQ34786090
CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immunotherapy in sorafenib-treated hepatocellular carcinoma in miceQ35528287
Intratumoral myeloid cells regulate responsiveness and resistance to antiangiogenic therapy.Q35627827
Modified RECIST (mRECIST) assessment for hepatocellular carcinomaQ37696396
Phase 2 study of lenvatinib in patients with advanced hepatocellular carcinomaQ37710134
Modulation of immunity by antiangiogenic molecules in cancerQ38074154
Dose Finding of Lenvatinib in Subjects With Advanced Hepatocellular Carcinoma Based on Population Pharmacokinetic and Exposure-Response AnalysesQ38754388
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Simultaneous blockade of programmed death 1 and vascular endothelial growth factor receptor 2 (VEGFR2) induces synergistic anti-tumour effect in vivoQ39163764
VEGFA-VEGFR pathway blockade inhibits tumor-induced regulatory T-cell proliferation in colorectal cancerQ39252038
A vascular endothelial growth factor receptor-2 inhibitor enhances antitumor immunity through an immune-based mechanismQ40112546
Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trialQ40231174
Safety and Pharmacokinetics of Lenvatinib in Patients with Advanced Hepatocellular CarcinomaQ41187204
Brivanib versus sorafenib as first-line therapy in patients with unresectable, advanced hepatocellular carcinoma: results from the randomized phase III BRISK-FL studyQ43691230
Brivanib in patients with advanced hepatocellular carcinoma who were intolerant to sorafenib or for whom sorafenib failed: results from the randomized phase III BRISK-PS study.Q45980006
Efficacy and safety of selective internal radiotherapy with yttrium-90 resin microspheres compared with sorafenib in locally advanced and inoperable hepatocellular carcinoma (SARAH): an open-label randomised controlled phase 3 trialQ47376936
Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trialQ50046367
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjecthepatocellular carcinomaQ1148337
immunotherapyQ1427096
lenvatinibQ6523413
P304page(s)31-39
P577publication date2019-01-31
P1433published inJournal of hepatocellular carcinomaQ27727369
P1476titleLenvatinib for the treatment of unresectable hepatocellular carcinoma: evidence to date
P478volume6