Review of Biomarkers in Ocular Matrices: Challenges and Opportunities

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Review of Biomarkers in Ocular Matrices: Challenges and Opportunities is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/S11095-019-2569-8
P932PMC publication ID6344398
P698PubMed publication ID30673862

P50authorMitalee TamhaneQ91182728
P2093author name stringVeena Viswanath
Grigor Abelian
Sara Cabrera-Ghayouri
P2860cites workHistamine H1 and H4 receptor expression on the ocular surface of patients with chronic allergic conjunctival diseases.Q50740021
The analysis of human conjunctival epithelium proteome in ocular surface diseases using impression cytology and 2D-DIGE.Q51089122
Relationships between vitreous levels of soluble receptor for advanced glycation end products (sRAGE) and renal function in patients with diabetic retinopathy.Q51335095
Detection of IFN-γ+IL-17+ cells in salivary glands of patients with Sjögren's syndrome and Mikulicz's disease: Potential role of Th17•Th1 in the pathogenesis of autoimmune diseases.Q51354997
Correlation of goblet cell density and mucosal epithelial membrane mucin expression with rose bengal staining in patients with ocular irritation.Q51549282
In Vivo Scanning Laser Confocal Microscopy of Conjunctival Goblet Cells in Medically-controlled Glaucoma.Q51748290
Protein composition of human aqueous humor: SDS-PAGE analysis of surgical and post-mortem samples.Q51758042
Aqueous humor protein dysregulation in primary angle-closure glaucoma.Q52656791
Vitreous levels of proteins implicated in angiogenesis are modulated in patients with retinal or choroidal neovascularization.Q52887319
Randomized Controlled Crossover Trial Comparing the Impact of Sham or Intranasal Tear Neurostimulation on Conjunctival Goblet Cell Degranulation.Q52889830
Tear proteomic analysis of patients with type 2 diabetes and dry eye syndrome by two-dimensional nano-liquid chromatography coupled with tandem mass spectrometry.Q53099214
Expression of Lipid Peroxidation Markers in the Tear Film and Ocular Surface of Patients with Non-Sjogren Syndrome: Potential Biomarkers for Dry Eye Disease.Q53177612
Differential cell proliferation, apoptosis, and immune response in healthy and evaporative-type dry eye conjunctival epithelia.Q53255424
A Simple Spontaneous Vitreal Reflux Collecting Procedure During Intravitreal Injection: Set-Up and Validation Studies.Q53310348
Interleukin-6 and tumor necrosis factor-alpha levels in tears of patients with dry eye syndrome.Q53572321
Transforming growth factor-beta 2 levels in aqueous humor of glaucomatous eyes.Q53891879
Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndromeQ21133793
Disease-related quantitation of TGF-beta3 in human aqueous humorQ24301921
iTRAQ quantitative proteomics in the analysis of tears in dry eye patientsQ24624997
Tear fluid biomarkers in ocular and systemic disease: potential use for predictive, preventive and personalised medicineQ26740411
Biomarkers and surrogate endpoints: preferred definitions and conceptual frameworkQ28203935
PEDF: a pigment epithelium-derived factor with potent neuronal differentiative activityQ28241023
Mass spectrometry-based proteomic analyses in contact lens-related dry eyeQ28259300
Autotaxin-lysophosphatidic acid axis is a novel molecular target for lowering intraocular pressureQ28482420
Proteomic Analysis of Vitreous Humor in Retinal Vein OcclusionQ28552292
Vitreous and serum levels of vascular endothelial growth factor and platelet-derived growth factor and their correlation in patients with non-proliferative diabetic retinopathy and clinically significant macula oedema.Q30874452
SELDI-TOF-MS ProteinChip array profiling of tears from patients with dry eye.Q31149662
Chronic kidney disease in US adults with type 2 diabetes: an updated national estimate of prevalence based on Kidney Disease: Improving Global Outcomes (KDIGO) stagingQ31170436
Flow cytometric analysis of inflammatory markers in KCS: 6-month treatment with topical cyclosporin A.Q31775977
Identification and localization of major soluble vitreous proteins in human ocular tissueQ33200770
Analysis of Th17-associated cytokines in tears of patients with dry eye syndromeQ33595169
Proteome alterations in primary open angle glaucoma aqueous humor.Q33643384
Profiles of extracellular miRNAs in the aqueous humor of glaucoma patients assessed with a microarray systemQ33671943
Association of preoperative vitreous IL-8 and VEGF levels with visual acuity after vitrectomy in proliferative diabetic retinopathyQ33745645
Goblet Cells Contribute to Ocular Surface Immune Tolerance-Implications for Dry Eye Disease.Q33755012
The Growing Need for Validated Biomarkers and Endpoints for Dry Eye Clinical ResearchQ33756582
Regulation of intercellular adhesion molecule-1 (CD54) gene expressionQ33805930
Tear cathepsin S as a candidate biomarker for Sjögren's syndromeQ33831656
Association between high tear epidermal growth factor levels and corneal subepithelial fibrosis in dry eye conditionsQ33845310
HLA-DR expression as a biomarker of inflammation for multicenter clinical trials of ocular surface diseaseQ33861286
Tear cytokine and chemokine analysis and clinical correlations in evaporative-type dry eye diseaseQ33869200
Lacrimal gland-derived IL-22 regulates IL-17-mediated ocular mucosal inflammationQ33870377
Effects of azithromycin on gene expression profiles of proinflammatory and anti-inflammatory mediators in the eyelid margin and conjunctiva of patients with meibomian gland diseaseQ33870384
Structural macromolecules and supramolecular organisation of the vitreous gel.Q33882468
Myocilin levels in primary open-angle glaucoma and pseudoexfoliation glaucoma human aqueous humorQ33938138
Proteomics analysis of human tears from aqueous-deficient and evaporative dry eye patientsQ37110777
Interleukin-1β and tumour necrosis factor-α levels in conjunctiva of diabetic patients with symptomatic moderate dry eye: case-control studyQ37177382
Molecular pathology of pseudoexfoliation syndrome/glaucoma--new insights from LOXL1 gene associationsQ37276376
Impression cytology: recent advances and applications in dry eye disease.Q37453774
Dataset of tear film cytokine levels in dry eye disease (DED) patients with and without HIV infectionQ37472797
Biomarkers in clinical drug developmentQ37523221
In vivo confocal microscopy of the ocular surface: from bench to bedsideQ37649719
The Human Eye Proteome Project: perspectives on an emerging proteomeQ37689580
Tissue resident memory T cells in the human conjunctiva and immune signatures in human dry eye diseaseQ37721598
Proteomics in ocular fluidsQ37817122
The role of TGF-β in the pathogenesis of primary open-angle glaucoma.Q37958629
Tear analysis in ocular surface diseasesQ38021534
A brief history of anti-VEGF for the treatment of ocular angiogenesisQ38022991
Molecular and cellular biomarkers in dry eye disease and ocular allergy.Q38034859
Tears as a source of biomarkers for ocular and systemic diseasesQ38123623
Allergy and allergic mediators in tearsQ38124638
Tear fluid biomarker profiling: a review of multiplex bead analysisQ38151225
Vitreous biomarkers in diabetic retinopathy: a systematic review and meta-analysisQ38196079
Mucins: a biologically relevant glycan barrier in mucosal protectionQ38211343
Nitric oxide (NO): an emerging target for the treatment of glaucomaQ38240119
Unraveling the molecular repertoire of tears as a source of biomarkers: beyond ocular diseases.Q38285522
Identification of Potential Biomarkers for Rhegmatogenous Retinal Detachment Associated with Choroidal Detachment by Vitreous iTRAQ-Based Proteomic ProfilingQ38439291
Proteomics of human aqueous humor.Q38463674
Altered Mucin and Glycoprotein Expression in Dry Eye DiseaseQ38565387
Neuroinflammation in Glaucoma and Optic Nerve DamageQ38574387
Angiogenic and Inflammatory Vitreous Biomarkers Associated With Increasing Levels of Retinal IschemiaQ38602347
TFOS DEWS II Tear Film Report.Q38652990
Unconventional aqueous humor outflow: A reviewQ38724447
Goblet cells of the conjunctiva: A review of recent findingsQ38811416
Immunological impression cytology of the conjunctival epithelium in patients with thyroid orbitopathy-related dry eye.Q38814602
The Role of Cathepsin D in the Pathogenesis of Human Neurodegenerative Disorders.Q38817664
Human tear proteomics and peptidomics in ophthalmology: Toward the translation of proteomic biomarkers into clinical practice.Q38835672
Emerging therapeutics for ocular surface diseaseQ38943854
The Intriguing Role of Neuropeptides at the Ocular SurfaceQ39007110
Presence or absence of ocular surface inflammation directs clinical and therapeutic management of dry eye.Q39030112
Effects of Punctal Occlusion on Clinical Signs and Symptoms and on Tear Cytokine Levels in Patients with Dry Eye.Q39177989
Circulating biomarkers in glaucoma, age-related macular degeneration, and diabetic retinopathyQ39260919
Association of NT-proANP Level in Plasma and Humor Aqueous with Primary Open-Angle GlaucomaQ39306083
Regulation of elastin promoter by lysyl oxidase and growth factors: cross control of lysyl oxidase on TGF-beta1 effectsQ40152221
Level of Vascular Endothelial Growth Factor in the Vitreous Fluid of Proliferative Diabetic Retinopathy Patients and Prognosis after VitrectomyQ40506185
Role of transforming growth factor-beta1 and its latent form binding protein in pseudoexfoliation syndromeQ40660004
The role of conjunctival epithelial cells in chronic ocular allergic diseaseQ40829833
Clinical Usefulness of Monitoring Expression Levels of CCL24 (Eotaxin-2) mRNA on the Ocular Surface in Patients with Vernal Keratoconjunctivitis and Atopic KeratoconjunctivitisQ41266829
Surrogate endpoints in clinical trials: definition and operational criteriaQ41310696
Basic physiology of the drainage of aqueous humorQ41348458
Interaction of IFN-γ with cholinergic agonists to modulate rat and human goblet cell function.Q41386825
Metabolomic analysis of human vitreous humor differentiates ocular inflammatory disease.Q41437955
Nitric oxide in the eye: multifaceted roles and diverse outcomesQ41572716
Safety and Feasibility of Quantitative Multiplexed Cytokine Analysis From Office-Based Vitreous Aspiration.Q41891788
Transforming growth factor-beta levels in human aqueous humor of glaucomatous, diabetic and uveitic eyesQ41911194
Changes of lacrimal gland and tear inflammatory cytokines in thyroid-associated ophthalmopathyQ42461690
Expression of CCR5 and its ligands CCL3, -4, and -5 in the tear film and ocular surface of patients with dry eye diseaseQ42496546
Elevated glucose attenuates agonist- and flow-stimulated endothelial nitric oxide synthase activity in microvascular retinal endothelial cellsQ42509735
Elevated levels of multiple biomarkers of Alzheimer's disease in the aqueous humor of eyes with open-angle glaucomaQ42609277
Transforming growth factor beta 2 levels in the aqueous humor in different types of glaucoma and the relation to filtering bleb developmentQ42652061
Correlation of pseudoexfoliative material and optic nerve damage in pseudoexfoliation syndromeQ42667961
Multiplex immunoassay analysis of biomarkers in clinically accessible quantities of human aqueous humor.Q43202385
Assessment of Neurotrophins and Inflammatory Mediators in Vitreous of Patients With Diabetic Retinopathy.Q43244563
Pro- and anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye diseaseQ43723395
Aqueous humor in primary open-angle glaucoma contains an increased level of CD44S.Q43843361
Significant variation of the elevated nitric oxide levels in aqueous humor from patients with different types of glaucomaQ44211222
Structural differences in the structure of the ciliary muscles in eyes of primates. A histochemical and morphological studyQ44248979
Influence of a controlled environment simulating an in-flight airplane cabin on dry eye disease.Q44536720
Oxidative stress markers in aqueous humor of glaucoma patientsQ44710317
Ocular mucin gene expression levels as biomarkers for the diagnosis of dry eye syndrome.Q44757521
Biomarkers in Ocular Chronic Graft Versus Host Disease: Tear Cytokine- and Chemokine-Based Predictive Model.Q44820020
Immunomodulatory effect of the topical ophthalmic Janus kinase inhibitor tofacitinib (CP-690,550) in patients with dry eye diseaseQ45229126
Hyperosmolar stress upregulates HLA-DR expression in human conjunctival epithelium in dry eye patients and in vitro modelsQ45269167
Correlation between Interleukin-6 and Thrombin-Antithrombin III Complex Levels in Retinal DiseasesQ45869007
[The expression of vascular endothelial growth factor of vitreous in patients with proliferative diabetic retinopathy].Q45941002
A prospective study of in-office diagnostic vitreous sampling in patients with vitreoretinal pathologyQ46047800
Dry eye exacerbation in patients exposed to desiccating stress under controlled environmental conditions.Q46080871
Gene Expression-Based Predictive Models of Graft Versus Host Disease-Associated Dry Eye.Q46136286
Biochemical abnormalities in vitreous of humans with proliferative diabetic retinopathyQ46171948
Components of the fibrinolytic system in the vitreous body in patients with vitreoretinal disordersQ46306576
Analysis of the correlations of mucins, inflammatory markers, and clinical tests in dry eye.Q46716997
Evaluations of tear protein markers in dry eye disease: repeatability of measurement and correlation with diseaseQ46831270
Adaptation of impression cytology to enable conjunctival surface cell transcriptome analysisQ46834579
Proteomics of vitreous in neovascular age-related macular degenerationQ46870123
Upregulation of ICAM-1 expression in the conjunctiva of patients with chronic graft-versus-host diseaseQ46958984
Tear proteome analysis in ocular surface diseases using label-free LC-MS/MS and multiplexed-microarray biomarker validationQ47112214
Link between neurodegeneration and trabecular meshwork injury in glaucomatous patientsQ47144462
A novel and less invasive technique to assess cytokine profile of vitreous in patients of diabetic macular oedemaQ47230436
Natural Immunity and Ocular InflammationQ47308738
Biomarkers of ocular surface disease using impression cytologyQ47357127
Matrix Metalloproteinase 9 Testing in Dry Eye Disease Using a Commercially Available Point-of-Care ImmunoassayQ47374338
RNA Collection From Human Conjunctival Epithelial Cells Obtained With a New Device for Impression CytologyQ47397638
Vitreous Fibronectin and Fibrinogen Expression Increased in Eyes With Proliferative Diabetic Retinopathy After Intravitreal Anti-VEGF TherapyQ47424741
Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucomaQ34005664
Human tear lipocalinQ34073693
Aqueous humor dynamics: a reviewQ34162577
Abnormal protein profiles in tears with dry eye syndromeQ34218114
New proteins as vascular biomarkers in primary open angle glaucomatous aqueous humor.Q34278577
Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disordersQ34292807
Vitreous and plasma VEGF levels as predictive factors in the progression of proliferative diabetic retinopathy after vitrectomyQ34352379
Establishing PAX6 as a biomarker to detect early loss of ocular phenotype in human patients with Sjögren's syndromeQ34473772
Tear proteome and protein network analyses reveal a novel pentamarker panel for tear film characterization in dry eye and meibomian gland dysfunctionQ34497227
Alterations in the tear proteome of dry eye patients--a matter of the clinical phenotypeQ34593416
Significance of mucin on the ocular surfaceQ34627790
Proteome analysis of human aqueous humorQ34735417
Effects of prostaglandins on the aqueous humor outflow pathwaysQ34805026
Alterations of the ocular surface epithelial MUC16 and goblet cell MUC5AC in patients with atopic keratoconjunctivitisQ34824549
A method to extract cytokines and matrix metalloproteinases from Schirmer strips and analyze using LuminexQ34912766
Tumor necrosis factor-alpha (TNF-α) levels in aqueous humor of primary open angle glaucomaQ34987608
Anatomy and pathology of the vitreo-retinal interface.Q35188973
The chemical morphology of the vitreousQ35188978
Proliferative and inflammatory factors in the vitreous of patients with proliferative diabetic retinopathy.Q35189187
Prospective, multicenter, clinical evaluation of point-of-care matrix metalloproteinase-9 test for confirming dry eye diseaseQ35197785
Brain natriuretic peptide: identification of a second natriuretic peptide in human aqueous humourQ35305923
Surrogate endpoints: a basis for a rational approachQ35488355
Alteration of galectin-3 in tears of patients with dry eye diseaseQ35589468
Human preocular mucins reflect changes in surface physiologyQ35591816
Nitric oxide proxies and ocular perfusion pressure in primary open angle glaucomaQ35592096
Role of mucins in the function of the corneal and conjunctival epitheliaQ35624244
Aqueous humor TGF-β2 levels in patients with open-angle glaucoma: A meta-analysis.Q35651380
Expression of CXCL9, -10, -11, and CXCR3 in the tear film and ocular surface of patients with dry eye syndromeQ35674608
Effects of Dry Eye Therapies on Environmentally Induced Ocular Surface DiseaseQ35732401
Variability of Tear Osmolarity in Patients With Dry Eye.Q35738567
Distribution of mucins at the ocular surfaceQ35755130
Functional dichotomy: glutathione and vitamin E in homeostasis relevant to primary open-angle glaucomaQ35795259
Modulation of HLA-DR in dry eye patients following 30 days of treatment with a lubricant eyedrop solutionQ35799409
Induction of resistance to endothelin-1's biochemical actions by elevated glucose levels in retinal pericytesQ54256762
Correlations between tear cytokines, chemokines, and soluble receptors and clinical severity of dry eye disease.Q54301170
Vascular endothelial growth factor and its soluble receptors-1 and -2 in iris neovascularization and neovascular glaucoma.Q54343860
Analysis of inflammatory cytokines in the tears of dry eye patients.Q54467014
Tear MMP-9 levels as a marker of ocular surface inflammation in conjunctivochalasis.Q54568510
Multiple cytokines in human tear specimens in seasonal and chronic allergic eye disease and in conjunctival fibroblast cultures.Q54596780
Chemokine receptor CCR5 expression in conjunctival epithelium of patients with dry eye syndrome.Q54602794
Proinflammatory Markers, Chemokines, and Enkephalin in Patients Suffering from Dry Eye Disease.Q54943596
Vitreous levels of placental growth factor correlate with activity of proliferative diabetic retinopathy and are not influenced by bevacizumab treatment.Q55007680
Quantitative proteomics analysis of vitreous body from type 2 diabetic patients with proliferative diabetic retinopathy.Q55512926
Differential profiling of lacrimal cytokines in patients suffering from thyroid-associated orbitopathy.Q55717336
Association of tear proteins with Meibomian gland disease and dry eye symptomsQ56775803
Identification of Tear Fluid Biomarkers in Dry Eye Syndrome Using iTRAQ Quantitative ProteomicsQ56775850
Homocysteine levels in aqueous humor and plasma of patients with primary open-angle glaucomaQ57780594
Conjunctival Epithelium Expression of HLA-DR in Dry Eye PatientsQ58205031
Inflammatory Markers in the Tears of Patients with Ocular Surface DiseaseQ58979336
Alterations of Tear Neuromediators in Dry Eye DiseaseQ61196350
Metabolomics Analysis of Human Vitreous in Diabetic Retinopathy and Rhegmatogenous Retinal DetachmentQ61782611
Effects of Sequential Artificial Tear and Cyclosporine Emulsion Therapy on Conjunctival Goblet Cell Density and Transforming Growth Factor-β2 ProductionQ61851319
Cytokine and chemokine levels in tears from healthy subjectsQ62075176
Intra- and inter-day variation of cytokines and chemokines in tears of healthy subjectsQ62116714
Conjunctival Mucin mRNA Expression in Contact Lens WearQ62116743
Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjögren's Syndrome patientsQ62398516
Efficacy of polyethylene glycol-propylene glycol-based lubricant eye drops in reducing squamous metaplasia in patients with dry eye disease.Q64882895
Aqueous humor dynamics in monkeys (Macaca irus and Cercopithecus ethiops)Q67236446
Endothelial leucocyte adhesion molecule-1 (ELAM-1) expression in cutaneous inflammationQ67684445
Protein levels in nonstimulated and stimulated tears of normal human subjectsQ68818873
Tear protein composition and the effects of stimulusQ72058967
Sjögren's syndrome: cytokine and Epstein-Barr viral gene expression within the conjunctival epitheliumQ72120476
Rapid assay of lactoferrin in keratoconjunctivitis siccaQ72504994
Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjögren's syndrome keratoconjunctivitis siccaQ72993423
Tear levels of interferon-gamma, interleukin (IL) -2, IL-4 and IL-5 in patients with vernal keratoconjunctivitis, atopic keratoconjunctivitis and allergic conjunctivitisQ73293753
Flow cytometry in impression cytology specimens. A new method for evaluation of conjunctival inflammationQ73434690
Brush technique in ocular surface cytologyQ73590440
TNF-alpha and IL-4 synergistically increase vascular cell adhesion molecule-1 expression in cultured vascular smooth muscle cellsQ73900323
Interleukin-6 levels in the conjunctival epithelium of patients with dry eye disease treated with cyclosporine ophthalmic emulsionQ74120740
Hepatocyte growth factor is increased in the aqueous humor of glaucomatous eyesQ74151203
Effects of ascorbic acid on levels of fibronectin, laminin and collagen type 1 in bovine trabecular meshwork in organ cultureQ74382421
Aqueous humor dynamics in the aging human eyeQ77370299
The pathology of dry eye: the interaction between the ocular surface and lacrimal glandsQ77575256
Alteration of mucin in human conjunctival epithelia in dry eyeQ77695600
Goblet cell numbers and epithelial proliferation in the conjunctiva of patients with dry eye syndrome treated with cyclosporineQ77729873
Decreased levels of the goblet cell mucin MUC5AC in tears of patients with Sjögren syndromeQ77846439
Decreased nitric oxide production in primary open-angle glaucomaQ77889861
Evaluation of point-of-care test for elevated tear matrix metalloproteinase 9 in post-LASIK dry eyes.Q35872889
Human conjunctival goblet cells express the membrane associated mucin MUC16: Localization to mucin granulesQ35885777
Biomarkers and surrogate endpoints in glaucoma clinical trialsQ35912696
Growth factors in the anterior segment: role in tissue maintenance, wound healing and ocular pathologyQ35925826
Activation of a tissue-specific stress response in the aqueous outflow pathway of the eye defines the glaucoma disease phenotypeQ35935203
MicroRNA signatures in vitreous humour and plasma of patients with exudative AMD.Q35970512
MicroRNA Profiling in Aqueous Humor of Individual Human Eyes by Next-Generation Sequencing.Q35985547
Biomarkers and surrogate markers: an FDA perspectiveQ36045270
Inflammatory Cytokine-Mediated Regulation of Thrombospondin-1 and CD36 in Conjunctival CellsQ36074078
Comparing Optic Nerve Head Rim Width, Rim Area, and Peripapillary Retinal Nerve Fiber Layer Thickness to Axon Count in Experimental GlaucomaQ36074874
Oxidative and Anti-Oxidative Stress Markers in Chronic Glaucoma: A Systematic Review and Meta-AnalysisQ36209773
An Overview of the Fovista and Rinucumab Trials and the Fate of Anti-PDGF MedicationsQ36279711
Analysis of Th17-associated cytokines and clinical correlations in patients with dry eye diseaseQ36335761
Aqueous Tear Deficiency Increases Conjunctival Interferon-γ (IFN-γ) Expression and Goblet Cell LossQ36345503
The role of oxidative stress in glaucomaQ36368431
Investigation of the human tear film proteome using multiple proteomic approachesQ36499336
Molecular biomarkers in glaucomaQ36530573
Tear cytokine profiles in dysfunctional tear syndrome.Q36637791
Production and activity of matrix metalloproteinase-9 on the ocular surface increase in dysfunctional tear syndromeQ36676823
Comparison of low-abundance biomarker levels in capillary-collected nonstimulated tears and washout tears of aqueous-deficient and normal patientsQ36890904
Two Patients with Dry Eye Disease Followed Up Using an Expression Assay of Ocular Surface MucinQ36906345
Diagnostic performance of a tear protein panel in early dry eyeQ36908864
Interferon-γ-Induced Unfolded Protein Response in Conjunctival Goblet Cells as a Cause of Mucin Deficiency in Sjögren SyndromeQ36990222
Introduction to metabolomics and its applications in ophthalmology.Q37000717
Conjunctival HLA-DR and CD8 expression detected by impression cytology in ocular graft versus host diseaseQ37027349
A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host DiseaseQ37038747
Autoimmunity in dry eye is due to resistance of Th17 to Treg suppressionQ37071969
Increased malondialdehyde concentration and reduced total antioxidant capacity in aqueous humor and blood samples from patients with glaucomaQ37091567
Calcium-binding S100 protein expression in pterygiumQ37097531
Multiple cytokine analysis in human tears: an optimized procedure for cytometric bead-based assayQ47594873
Inflammatory cytokines in normal human tearsQ47847615
Concentration of acute phase factors in vitreous fluid in diabetic macular edemaQ48014506
Effects of topical cyclosporine a plus artificial tears versus artificial tears treatment on conjunctival goblet cell density in dysfunctional tear syndromeQ48244820
Blood circulation and fluid dynamics in the eyeQ48452183
Quantification of MUC5AC protein in human tears.Q48520717
Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy.Q49485089
Corneal Nerve Morphology, Sensitivity, and Tear Neuropeptides in Contact Lens Wear.Q50212552
Autotaxin-Lysophosphatidic Acid Pathway in Intraocular Pressure Regulation and Glaucoma Subtypes.Q50215305
Correlation of Tear Film Osmolarity and 2 Different MMP-9 Tests With Common Dry Eye Tests in a Cohort of Non-Dry Eye Patients.Q50279252
Performance of tear osmolarity compared to previous diagnostic tests for dry eye diseases.Q50548182
Evaluation of vitreous levels of advanced glycation end products and angiogenic factors as biomarkers for severity of diabetic retinopathy.Q50674112
Concentration of haemodynamic and inflammatory related cytokines in diabetic retinopathyQ79138206
Proteomic analysis of human vitreous fluid by fluorescence-based difference gel electrophoresis (DIGE): a new strategy for identifying potential candidates in the pathogenesis of proliferative diabetic retinopathyQ80020556
Evidence for vasculoprotective effects of ETB receptors in resistance artery remodeling in diabetesQ80725517
Aqueous humor myocilin protein levels in normal, genetic carriers, and glaucoma BeaglesQ81150259
Distribution of conjunctival HLA-DR expression and the pathogenesis of damage in early dry eyesQ81357274
Inflammatory cytokine profiles in the tears of thyroid-associated ophthalmopathyQ82717721
Tear osmolarity in the diagnosis and management of dry eye diseaseQ83395082
Histamine H4 receptors in normal conjunctiva and in vernal keratoconjunctivitisQ84043469
Evaluation of tear osmolarity in non-Sjögren and Sjögren syndrome dry eye patients with the TearLab systemQ84117967
Tumor necrosis factor-alpha concentrations in the aqueous humor of patients with glaucomaQ84528889
Proinflammatory cytokine profiling of tears from dry eye patients by means of antibody microarraysQ84579952
Immune response in the conjunctival epithelium of patients with dry eyeQ84589672
Limitations of an ocular surface inflammatory biomarker in impression cytology specimensQ84739059
Baseline profiles of ocular surface and tear dynamics after allogeneic hematopoietic stem cell transplantation in patients with or without chronic GVHD-related dry eyeQ84866842
Differential Profiling of T-Cell Cytokines as Measured by Protein Microarray Across Dry Eye SubgroupsQ87050411
Serum and Vitreous Pentraxin 3 Concentrations in Patients with Diabetic RetinopathyQ87210219
Alteration of tear mucin 5AC in office workers using visual display terminals: The Osaka StudyQ88027597
Evaluation of oxidative stress markers in aqueous humor of primary open angle glaucoma and primary angle closure glaucoma patientsQ88044433
Efficacy and safety of 0.1% ciclosporin A cationic emulsion in dry eye disease: a pooled analysis of two double-masked, randomised, vehicle-controlled phase III clinical studiesQ88073084
Variability of Tear Osmolarity Measurements With a Point-of-Care System in Healthy Subjects-Systematic ReviewQ88276926
Severity, therapeutic, and activity tear biomarkers in dry eye disease: An analysis from a phase III clinical trialQ88716938
Proteomic Analysis of Aqueous Humor from Primary Open Angle Glaucoma Patients on Drug Treatment Revealed Altered Complement Activation CascadeQ89100912
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectconjunctivaQ273554
biomarkerQ864574
eye diseaseQ3041498
pharmaceutical scienceQ7180763
molecular medicineQ3523816
biotechnologyQ7108
VitreousQ57047809
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)40
P577publication date2019-01-23
P1433published inPharmaceutical ResearchQ7180737
P1476titleReview of Biomarkers in Ocular Matrices: Challenges and Opportunities
P478volume36

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cites work (P2860)
Q98611558Dry eye in rheumatoid arthritis patients under TNF-inhibitors: conjunctival goblet cell as an early ocular biomarker
Q92994541Endophthalmitis Management: Stain-Culture, Empirical Treatment, and Beyond
Q98288337Inflammatory and angiogenic biomarkers in diabetic retinopathy
Q92759529Proteome alterations in aqueous humour of primary open angle glaucoma patients
Q92372126Tear Metabolomics in Dry Eye Disease: A Review

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