The effect of ketorolac on posterior thoracolumbar spinal fusions: a prospective double-blinded randomised placebo-controlled trial protocol

scientific article published on 21 January 2019

The effect of ketorolac on posterior thoracolumbar spinal fusions: a prospective double-blinded randomised placebo-controlled trial protocol is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1136/BMJOPEN-2018-025855
P932PMC publication ID6347897
P698PubMed publication ID30670528

P50authorChad ClausQ87613255
P2093author name stringBoyd Richards
Michael Lawless
Prashant Kelkar
Doris Tong
Evan Lytle
Teck M Soo
Amarpal Dosanjh
Clifford Houseman
Dejan Slavnic
Diana Sigler
Dominick Lago
Matthew Bahoura
Peter Bono
P2860cites workRecombinant human bone morphogenetic protein-2 overcomes the inhibitory effect of ketorolac, a nonsteroidal anti-inflammatory drug (NSAID), on posterolateral lumbar intertransverse process spine fusionQ73185913
Adding posterior lumbar interbody fusion to pedicle screw fixation and posterolateral fusion after decompression in spondylolytic spondylolisthesisQ73277397
Ketorolac as an adjunct to patient-controlled morphine in postoperative spine surgery patientsQ73510616
Dose-response of ketorolac as an adjunct to patient-controlled analgesia morphine in patients after spinal fusion surgeryQ74772948
[Risk factors affecting fusion in the treatment of lumbar spine instability]Q83917854
Evaluation of carriers of bone morphogenetic protein for spinal fusionQ93951902
The effects of ketorolac injected via patient controlled analgesia postoperatively on spinal fusionQ28174517
Nonsteroidal anti-inflammatory drugs and bone metabolism in spinal fusion surgery: a pharmacological quandaryQ30306452
Use of ketorolac tromethamine in children undergoing scoliosis surgery. an analysis of complicationsQ35572959
Postoperative ketorolac does not predispose to pseudoarthrosis following posterior spinal fusion and instrumentation for adolescent idiopathic scoliosisQ37151835
Ketorolac and spinal fusion: does the perioperative use of ketorolac really inhibit spinal fusion?Q37242422
Dose-dependent inhibition of diclofenac sodium on posterior lumbar interbody fusion ratesQ37268433
High-dose ketorolac affects adult spinal fusion: a meta-analysis of the effect of perioperative nonsteroidal anti-inflammatory drugs on spinal fusionQ37758195
Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 4: radiographic assessment of fusion statusQ38224853
Impact of smoking on complication and pseudarthrosis rates after single- and 2-level posterolateral fusion of the lumbar spineQ38233122
Lumbar pseudarthrosis: a review of current diagnosis and treatment.Q38596199
Indomethacin and aspirin: effect of nonsteroidal anti-inflammatory agents on the rate of fracture repair in the rat.Q39367480
Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 selective non-steroidal anti-inflammatory drugsQ39394038
Intravenous administration of propacetamol reduces morphine consumption after spinal fusion surgeryQ39418435
Ketorolac trometamol for postoperative analgesia after orthopaedic surgeryQ39501294
Ketorolac Administered in the Recovery Room for Acute Pain Management Does Not Affect Healing Rates of Femoral and Tibial FracturesQ40777584
The effect of postoperative nonsteroidal anti-inflammatory drug administration on spinal fusionQ41751980
Addressing the Opioid Epidemic in the United States: Lessons From the Department of Veterans AffairsQ42044121
Osteogenic protein-1 overcomes the inhibitory effect of nicotine on posterolateral lumbar fusionQ43688848
Cyclo-oxygenase 2 function is essential for bone fracture healingQ44020462
The role of anterior lumbar fusion for internal disc disruptionQ44028471
The effect of cyclooxygenase-2 inhibitors on spinal fusion.Q44178057
Fracture healing in rats inhibited by locally administered indomethacinQ44703474
Effect of COX-2-specific inhibition on fracture-healing in the rat femurQ44719383
Effects of ketorolac on bone repair: A radiographic study in modeled demineralized bone matrix grafted rabbitsQ46291632
High dose nonsteroidal anti-inflammatory drugs compromise spinal fusionQ46472803
A comparison between the effects of acetaminophen and celecoxib on bone fracture healing in ratsQ46825229
The effect of ketoprophen on lumbar spinal fusion healing in a rabbit model. Laboratory investigationQ46854571
Time-dependent inhibitory effects of indomethacin on spinal fusion.Q47996815
The Initiation of Chronic Opioids: A Survey of Chronic Pain PatientsQ48020479
Declaration of Helsinki, 2008: implications for stakeholders in researchQ49160916
The Effect of Ketorolac on Thoracolumbar Posterolateral Fusion: A Systematic Review and Meta-AnalysisQ49920371
Does ketorolac tromethamine, a new analgesic, decrease postoperative recovery time, narcotic requirements, nausea and/or vomiting, and unscheduled hospital admissions: a retrospective analysis.Q51677040
Dose and time-dependent effects of cyclooxygenase-2 inhibition on fracture-healing.Q51764139
Effect of ibuprofen on heterotopic ossification after hip replacementQ58077349
Interobserver and Intraobserver Agreement of Radiograph Interpretation With and Without Pedicle Screw ImplantsQ60439799
Selective and Nonselective Cyclooxygenase-2 Inhibitors and Experimental Fracture-HealingQ60607900
Correlation of Radiologic Assessment of Lumbar Spine Fusions with Surgical ExplorationQ67928581
The rate of pseudarthrosis (surgical nonunion) in patients who are smokers and patients who are nonsmokers: a comparison studyQ69766472
The effects of nonsteroidal anti-inflammatory drugs on posterior spinal fusions in the ratQ71695479
Antiinflammatory drug effects on bone repair and remodeling in rabbitsQ71974755
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectplaceboQ269829
opioidQ427523
spinal fusionQ770609
placebo-controlled trialQ108853737
P304page(s)e025855
P577publication date2019-01-21
P1433published inBMJ OpenQ17003470
P1476titleThe effect of ketorolac on posterior thoracolumbar spinal fusions: a prospective double-blinded randomised placebo-controlled trial protocol
P478volume9

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