Application of Prostate Cancer Models for Preclinical Study: Advantages and Limitations of Cell Lines, Patient-Derived Xenografts, and Three-Dimensional Culture of Patient-Derived Cells

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Application of Prostate Cancer Models for Preclinical Study: Advantages and Limitations of Cell Lines, Patient-Derived Xenografts, and Three-Dimensional Culture of Patient-Derived Cells is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3390/CELLS8010074
P932PMC publication ID6357050
P698PubMed publication ID30669516

P50authorTakeshi NamekawaQ91163671
P2093author name stringSatoshi Inoue
Kazuhiro Ikeda
Kuniko Horie-Inoue
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Niclosamide and Bicalutamide Combination Treatment Overcomes Enzalutamide- and Bicalutamide-Resistant Prostate CancerQ46095028
Antiandrogen bicalutamide promotes tumor growth in a novel androgen-dependent prostate cancer xenograft model derived from a bicalutamide-treated patientQ46788362
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Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF SignalingQ47670505
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Therapeutic Targeting of the CBP/p300 Bromodomain Blocks the Growth of Castration-Resistant Prostate CancerQ47938119
The 22Rv1 prostate cancer cell line carries mixed genetic ancestry: Implications for prostate cancer health disparities research using pre-clinical models.Q48187480
Intraductal carcinoma of the prostate can evade androgen deprivation, with emergence of castrate-tolerant cellsQ48244745
Heterotransplantation of a human prostatic adenocarcinoma cell line in nude mice.Q48253273
Treatment with docetaxel in combination with Aneustat leads to potent inhibition of metastasis in a patient-derived xenograft model of advanced prostate cancerQ49578235
Clusterin knockdown using the antisense oligonucleotide OGX-011 re-sensitizes docetaxel-refractory prostate cancer PC-3 cells to chemotherapyQ40003248
Human urologic cancer cell linesQ40119643
The establishment of two paclitaxel-resistant prostate cancer cell lines and the mechanisms of paclitaxel resistance with two cell linesQ40144292
Establishment and characterization of androgen-independent human prostate cancer cell lines, LN-REC4 and LNCaP-SF, from LNCaP.Q40146469
The BALB/c-specific polymorphic SIRPA enhances its affinity for human CD47, inhibiting phagocytosis against human cells to promote xenogeneic engraftmentQ40152977
Establishment and characterization of a primary androgen-responsive African-American prostate cancer cell line, E006AA.Q40551887
Characterization of a novel androgen receptor mutation in a relapsed CWR22 prostate cancer xenograft and cell lineQ40689267
TSU-Pr1 and JCA-1 cells are derivatives of T24 bladder carcinoma cells and are not of prostatic origin.Q40783686
PEAZ-1: a new human prostate neoplastic epithelial cell lineQ40795415
Widely used prostate carcinoma cell lines share common originsQ40812502
Two mutations identified in the androgen receptor of the new human prostate cancer cell line MDA PCa 2a.Q40916927
A new human prostate carcinoma cell line, 22Rv1.Q40933318
Characterization of a novel androgen-sensitive, prostate-specific antigen-producing prostatic carcinoma xenograft: LuCaP 23.Q40936806
Defining a Population of Stem-like Human Prostate Cancer Cells That Can Generate and Propagate Castration-Resistant Prostate Cancer.Q41009634
The role of epithelial-mesenchymal transition drivers ZEB1 and ZEB2 in mediating docetaxel-resistant prostate cancer.Q41127809
Differential expression of uPA in an aggressive (DU 145) and a nonaggressive (1013L) human prostate cancer xenograftQ41378102
Expression of mRNA for epidermal growth factor, transforming growth factor-alpha and their receptor in human prostate tissue and cell linesQ41526936
p53 oncogene mutations in three human prostate cancer cell linesQ41586000
Human primary prostate tumor cell line, ALVA‐31: A new model for studying the hormonal regulation of prostate tumor cell growthQ41587993
Establishment and Characterization of a Human Primary Prostatic Adenocarcinoma Cell Line (ND-1)Q41597850
Evidence for clonal outgrowth of androgen-independent prostate cancer cells from androgen-dependent tumors through a two-step processQ41695916
Establishment of new human prostatic cancer cell line (JCA-1).Q41729073
Differential Cytokeratin Expression in Normal, Hyperplastic and Malignant Epithelial Cells From Human ProstateQ41757486
Switch from antagonist to agonist of the androgen receptor bicalutamide is associated with prostate tumour progression in a new model systemQ41827081
SRRM4 Expression and the Loss of REST Activity May Promote the Emergence of the Neuroendocrine Phenotype in Castration-Resistant Prostate CancerQ42188512
LuCaP Prostate Cancer Patient-Derived Xenografts Reflect the Molecular Heterogeneity of Advanced Disease an--d Serve as Models for Evaluating Cancer Therapeutics.Q42315779
Development and characterization of efficient xenograft models for benign and malignant human prostate tissueQ42473593
Human prostatic adenocarcinoma: Some characteristics of a serially transplantable line in nude mice (PC 82)Q42801825
BM18: A novel androgen-dependent human prostate cancer xenograft model derived from a bone metastasisQ42802002
Isolation and characterization of PC-3 human prostatic tumor sublines which preferentially metastasize to select organs in S.C.I.D. miceQ42808290
Phenotypic and cytogenetic characterization of a cell line derived from primary prostatic carcinomaQ42815558
Expression of HLA-like structures on a permanent human tumor line PC-93.Q42823457
MiR-34a attenuates paclitaxel-resistance of hormone-refractory prostate cancer PC3 cells through direct and indirect mechanismsQ42945633
Genome sequencing of normal cells reveals developmental lineages and mutational processesQ42997512
Modeling Development and Disease with OrganoidsQ24657457
Downregulation of cytokeratin 18 is associated with paclitaxel‑resistance and tumor aggressiveness in prostate cancer.Q27853342
Organoid development in cancer genome discoveryQ28083032
Androgen-independent growth in LNCaP cell lines and steroid uridine diphosphate-glucuronosyltransferase expressionQ28185109
NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cellsQ28207942
The murine autoimmune diabetes model: NOD and related strainsQ28211565
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal nicheQ28239639
A severe combined immunodeficiency mutation in the mouseQ28274531
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cellsQ28277030
Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: implications for gene therapyQ28298655
Chemoresistance in Prostate Cancer Cells Is Regulated by miRNAs and Hedgehog PathwayQ28480873
BRAF mutation predicts sensitivity to MEK inhibitionQ29614281
Increased survival with enzalutamide in prostate cancer after chemotherapyQ29617511
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trialQ29620155
The role of vascular endothelial growth factor in the tissue specific in vivo growth of prostate cancer cells.Q30307781
Androgen-repressed phenotype in human prostate cancerQ30454285
Androgen receptor-negative human prostate cancer cells induce osteogenesis in mice through FGF9-mediated mechanismsQ30482634
AR intragenic deletions linked to androgen receptor splice variant expression and activity in models of prostate cancer progressionQ30513836
Androgen receptor splice variants determine taxane sensitivity in prostate cancerQ30577613
Expression of the inhibitors of apoptosis proteins in cisplatin-resistant prostate cancer cells.Q33222813
TACC2 Is an Androgen-Responsive Cell Cycle Regulator Promoting Androgen-Mediated and Castration-Resistant Growth of Prostate CancerQ33636574
Reconstituted basement membrane (matrigel) and laminin can enhance the tumorigenicity and the drug resistance of small cell lung cancer cell linesQ33767962
Widespread intraspecies cross-contamination of human tumor cell lines arising at source.Q33875830
Hydrogel-based 3D model of patient-derived prostate xenograft tumors suitable for drug screeningQ33894635
VCaP, a cell-based model system of human prostate cancerQ33943752
Use of nude mouse xenograft models in prostate cancer researchQ33947227
Establishment and characterization of a highly tumorigenic African American prostate cancer cell line, E006AA-hT.Q33970160
Modulation of androgen receptor signaling in hormonal therapy-resistant prostate cancer cell linesQ33988757
Targeting poly(ADP-ribose) polymerase and the c-Myb-regulated DNA damage response pathway in castration-resistant prostate cancerQ34055827
HeLa cells 50 years on: the good, the bad and the uglyQ34127748
Establishment and characterization of a human prostatic carcinoma cell line (PC-3)Q34210915
Evidence for Feedback Regulation Following Cholesterol Lowering Therapy in a Prostate Cancer Xenograft ModelQ38728309
Androgen-induced Long Noncoding RNA (lncRNA) SOCS2-AS1 Promotes Cell Growth and Inhibits Apoptosis in Prostate Cancer CellsQ38762346
Skp2 is associated with paclitaxel resistance in prostate cancer cellsQ38771323
Metabolic heterogeneity signature of primary treatment-naïve prostate cancerQ38810786
Establishment and Characterization of an In Vitro Model of Ovarian Cancer Stem-like Cells with an Enhanced Proliferative Capacity.Q38811667
TET2 repression by androgen hormone regulates global hydroxymethylation status and prostate cancer progressionQ38832692
Development and exploitation of a novel mutant androgen receptor modelling strategy to identify new targets for advanced prostate cancer therapyQ38844202
The Upregulation of PI3K/Akt and MAP Kinase Pathways is Associated with Resistance of Microtubule-Targeting Drugs in Prostate CancerQ38914271
Organoid culture systems for prostate epithelial and cancer tissue.Q39035547
High fidelity patient-derived xenografts for accelerating prostate cancer discovery and drug developmentQ39041750
Characterization of an Abiraterone Ultraresponsive Phenotype in Castration-Resistant Prostate Cancer Patient-Derived XenograftsQ39085996
CCR1/CCL5 interaction promotes invasion of taxane-resistant PC3 prostate cancer cells by increasing secretion of MMPs 2/9 and by activating ERK and Rac signalingQ39122038
Androgen-responsive long noncoding RNA CTBP1-AS promotes prostate cancerQ39156237
A novel antiandrogen, Compound 30, suppresses castration-resistant and MDV3100-resistant prostate cancer growth in vitro and in vivo.Q39181056
Acquisition of paclitaxel resistance is associated with a more aggressive and invasive phenotype in prostate cancerQ39236264
The Master Neural Transcription Factor BRN2 Is an Androgen Receptor-Suppressed Driver of Neuroendocrine Differentiation in Prostate Cancer.Q39246346
ETS1 promotes chemoresistance and invasion of paclitaxel-resistant, hormone-refractory PC3 prostate cancer cells by up-regulating MDR1 and MMP9 expressionQ39420862
Identification of docetaxel resistance genes in castration-resistant prostate cancerQ39452736
Resistance to paclitaxel increases the sensitivity to other microenvironmental stresses in prostate cancer cellsQ39564344
Intragenic Rearrangement and Altered RNA Splicing of the Androgen Receptor in a Cell-Based Model of Prostate Cancer ProgressionQ39605639
MiR-148a attenuates paclitaxel resistance of hormone-refractory, drug-resistant prostate cancer PC3 cells by regulating MSK1 expressionQ39712751
Identification of EP4 as a potential target for the treatment of castration-resistant prostate cancer using a novel xenograft modelQ39741537
Androgen-responsive and -unresponsive prostate cancer cell lines respond differently to stimuli inducing neuroendocrine differentiationQ39749979
CTEN/tensin 4 expression induces sensitivity to paclitaxel in prostate cancerQ39804729
Isolation of a human prostate carcinoma cell line (DU 145)Q34255312
Molecular characterization of human prostate carcinoma cell linesQ34266176
LNCaP model of human prostatic carcinoma.Q34271140
Androgen-independent cancer progression and bone metastasis in the LNCaP model of human prostate cancerQ34340156
Derivation of androgen-independent human LNCaP prostatic cancer cell sublines: role of bone stromal cellsQ34340236
Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cellsQ34416761
Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID miceQ34420980
The Promise of Patient-Derived Xenografts: The Best Laid Plans of Mice and MenQ34443008
Organoid models of human and mouse ductal pancreatic cancerQ34456438
Organoid cultures derived from patients with advanced prostate cancerQ34545103
Establishment and characterization of a pair of non-malignant and malignant tumor derived cell lines from an African American prostate cancer patientQ35094512
Secretome analysis of an osteogenic prostate tumor identifies complex signaling networks mediating cross-talk of cancer and stromal cells within the tumor microenvironmentQ35148340
Characterisation and manipulation of docetaxel resistant prostate cancer cell linesQ35462077
A neuroendocrine/small cell prostate carcinoma xenograft-LuCaP 49Q35747677
Development of seven new human prostate tumor xenograft models and their histopathological characterization.Q35782119
Cell lines used in prostate cancer research: a compendium of old and new lines--part 1.Q36005681
Cell lines used in prostate cancer research: a compendium of old and new lines--part 2.Q36005687
Detection by DNA fingerprinting of somatic changes during the establishment of a new prostate cell lineQ36079989
PC3 is a cell line characteristic of prostatic small cell carcinoma.Q36185201
Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profilingQ36288956
The human PC346 xenograft and cell line panel: a model system for prostate cancer progressionQ36368670
PVT1 Exon 9: A Potential Biomarker of Aggressive Prostate Cancer?Q36512823
Differentially methylated genes and androgen receptor re-expression in small cell prostate carcinomas.Q36862668
BAY 1024767 blocks androgen receptor mutants found in castration-resistant prostate cancer patientsQ36905832
Humanized mice for immune system investigation: progress, promise and challengesQ37111994
Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistanceQ37145531
Human xenograft models as useful tools to assess the potential of novel therapeutics in prostate cancerQ37352625
Neuroendocrine prostate cancer xenografts with large-cell and small-cell features derived from a single patient's tumor: morphological, immunohistochemical, and gene expression profilesQ37444366
Modeling a Lethal Prostate Cancer Variant with Small-Cell Carcinoma FeaturesQ37582049
Ex vivo culture of human prostate tissue and drug developmentQ38113460
Cancer cell lines for drug discovery and developmentQ38203358
Neuroendocrine Prostate Cancer (NEPC) progressing from conventional prostatic adenocarcinoma: factors associated with time to development of NEPC and survival from NEPC diagnosis-a systematic review and pooled analysisQ38250049
Human Prostate Cancer in a Clinically Relevant Xenograft Mouse Model: Identification of β(1,6)-Branched Oligosaccharides as a Marker of Tumor ProgressionQ38328491
Moving Towards Precision Urologic Oncology: Targeting Enzalutamide-resistant Prostate Cancer and Mutated Forms of the Androgen Receptor Using the Novel Inhibitor Darolutamide (ODM-201).Q38603259
Establishment of primary patient-derived xenografts of palliative TURP specimens to study castrate-resistant prostate cancer.Q50577685
Inhibition of ERG Activity in Patient-derived Prostate Cancer Xenografts by YK-4-279.Q50912583
Combination Treatment with Orlistat-Containing Nanoparticles and Taxanes Is Synergistic and Enhances Microtubule Stability in Taxane-Resistant Prostate Cancer CellsQ50944315
Up-Regulation of Follistatin-Like 1 By the Androgen Receptor and Melanoma Antigen-A11 in Prostate CancerQ51263170
Brief report: a bioassay to identify primary human prostate cancer repopulating cellsQ51864082
Patient-derived Hormone-naive Prostate Cancer Xenograft Models Reveal Growth Factor Receptor Bound Protein 10 as an Androgen Receptor-repressed Gene Driving the Development of Castration-resistant Prostate CancerQ52653620
Establishment of a Patient-Derived Tumor Xenograft Model and Application for Precision Cancer MedicineQ52680757
Heterochromatin protein 1α mediates development and aggressiveness of neuroendocrine prostate cancer.Q52682476
Radium-223 Inhibits Osseous Prostate Cancer Growth by Dual Targeting of Cancer Cells and Bone Microenvironment in Mouse ModelsQ52778839
Metastatic behavior of human tumor cell lines grown in the nude mouse.Q52826702
LuCaP 35: A new model of prostate cancer progression to androgen independenceQ52832790
Induction of the stem-like cell regulator CD44 by Rho kinase inhibition contributes to the maintenance of colon cancer-initiating cellsQ53143685
TabBO: a model reflecting common molecular features of androgen-independent prostate cancerQ53914758
Targeted chemotherapy with cytotoxic bombesin analogue AN-215 inhibits growth of experimental human prostate cancers.Q54655043
Patient derived organoids to model rare prostate cancer phenotypes.Q55367999
Establishment and characterization of two cabazitaxel-resistant prostate cancer cell lines.Q55379433
A novel selenonucleoside suppresses tumor growth by targeting Skp2 degradation in paclitaxel-resistant prostate cancerQ57186003
Stromal Gene Expression is Predictive for Metastatic Primary Prostate CancerQ58432602
Neuroendocrine differentiation of prostate cancer leads to PSMA suppressionQ58591395
Analysis of cabazitaxel-resistant mechanism in human castration-resistant prostate cancerQ58798456
Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's EpitheliumQ63406947
Patient-derived Models of Abiraterone- and Enzalutamide-resistant Prostate Cancer Reveal Sensitivity to Ribosome-directed TherapyQ64821204
Chromosome identity of human prostate cancer cell lines, PC-3 and PPC-1.Q64950773
Biochemical markers of cultured human prostatic epitheliumQ67343482
Wild-type p53 suppresses growth of human prostate cancer cells containing mutant p53 allelesQ67946434
Identification by C-banding of two human prostate tumour cell lines, 1013L and DU 145Q69651417
The LNCaP cell line--a new model for studies on human prostatic carcinomaQ71222674
Prostatic adenocarcinoma PC EW, a new human tumor line transplantable in nude miceQ71404712
‘Nude’, a new hairless gene with pleiotropic effects in the mouseQ72951103
Rapid ("warm") autopsy study for procurement of metastatic prostate cancerQ73605064
Karyotypic similarity identified by multiplex-FISH relates four prostate adenocarcinoma cell lines: PC-3, PPC-1, ALVA-31, and ALVA-41Q74123190
Establishment and characterization of osseous prostate cancer models: intra-tibial injection of human prostate cancer cellsQ78052193
The effect of osteoprotegerin administration on the intra-tibial growth of the osteoblastic LuCaP 23.1 prostate cancer xenograftQ81323685
CD44 expression is a feature of prostatic small cell carcinoma and distinguishes it from its mimickersQ82208584
Paclitaxel- and lapatinib-loaded lipopolymer micelles overcome multidrug resistance in prostate cancerQ86952613
Aberrant presentation of HPA-reactive carbohydrates implies Selectin-independent metastasis formation in human prostate cancerQ87290450
Movember GAP1 PDX project: An international collection of serially transplantable prostate cancer patient-derived xenograft (PDX) modelsQ90730820
TMEM45B is a novel predictive biomarker for prostate cancer progression and metastasisQ91695777
Patient-derived, three-dimensional spheroid cultures provide a versatile translational model for the study of organ-confined prostate cancerQ93361861
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectprostate cancerQ181257
patientQ181600
spheroidQ208395
organoidQ11293125
cell lineQ21014462
prostate neoplasmQ56014511
xenograftQ64148587
xenograft model antitumor assayQ73347741
P304page(s)74
P577publication date2019-01-20
P1433published inCellsQ27724621
P1476titleApplication of Prostate Cancer Models for Preclinical Study: Advantages and Limitations of Cell Lines, Patient-Derived Xenografts, and Three-Dimensional Culture of Patient-Derived Cells
P478volume8

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cites work (P2860)
Q92316366Cellular and Molecular Mechanisms Underlying Prostate Cancer Development: Therapeutic Implications
Q90694324Development of Prostate Cancer Organoid Culture Models in Basic Medicine and Translational Research
Q96304940Diagnostic value of microRNA panel in endometrial cancer: A systematic review
Q92093077Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model
Q94465892Human Organ-Specific 3D Cancer Models Produced by the Stromal Self-Assembly Method of Tissue Engineering for the Study of Solid Tumors
Q101564383Patient-derived tumour models for personalized therapeutics in urological cancers

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