Multistate design of influenza antibodies improves affinity and breadth against seasonal viruses

article published in the Proceedings of the National Academy of Sciences of the United States of America

Multistate design of influenza antibodies improves affinity and breadth against seasonal viruses is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1073/PNAS.1806004116
P932PMC publication ID6358683
P698PubMed publication ID30642961

P50authorAlexander M SevyQ87806812
Iuliia M GilchukQ95647761
Jens MeilerQ29315318
James E. Crowe, Jr.Q37366747
Nicholas C WuQ39722696
P2093author name stringIan A Wilson
Kevin L Schey
Erica H Parrish
Marcus B M Nagel
Dina Yousif
Sebastian Burger
P2860cites workComputational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site.Q40163658
In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificityQ40201534
AbDesign: An algorithm for combinatorial backbone design guided by natural conformations and sequences.Q41451876
Key mutations stabilize antigen-binding conformation during affinity maturation of a broadly neutralizing influenza antibody lineageQ41669208
Automated design of specificity in molecular recognitionQ46103643
Contribution of variable domains to the stability of humanized IgG1 monoclonal antibodies.Q52581515
RosettaAntibodyDesign (RAbD): A general framework for computational antibody design.Q52716245
Repertoire Analysis of Antibody CDR-H3 Loops Suggests Affinity Maturation Does Not Typically Result in Rigidification.Q55316178
A highly conserved neutralizing epitope on group 2 influenza A virusesQ24630467
Computational Design of Proteins Targeting the Conserved Stem Region of Influenza HemagglutininQ27667831
Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutininQ27671619
Cross-neutralization of influenza A viruses mediated by a single antibody loopQ27673206
Receptor mimicry by antibody F045–092 facilitates universal binding to the H3 subtype of influenza virusQ27683156
Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interfaceQ27688974
Stereochemical quality of protein structure coordinatesQ27860874
Multi-constraint computational design suggests that native sequences of germline antibody H3 loops are nearly optimal for conformational flexibilityQ28914723
A broadly neutralizing human monoclonal antibody that recognizes a conserved, novel epitope on the globular head of the influenza H1N1 virus hemagglutininQ30406095
Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadthQ30657338
Tradeoff between stability and multispecificity in the design of promiscuous proteinsQ33521300
Human germline antibody gene segments encode polyspecific antibodiesQ34699688
Design of protein-interaction specificity gives selective bZIP-binding peptides.Q34975999
Design of Protein Multi-specificity Using an Independent Sequence Search Reduces the Barrier to Low Energy SequencesQ35683261
Protocols for Molecular Modeling with Rosetta3 and RosettaScriptsQ37223553
Influenza Research Database: An integrated bioinformatics resource for influenza virus research.Q37556959
Variable influenza vaccine effectiveness by subtype: a systematic review and meta-analysis of test-negative design studiesQ38803189
The Rosetta All-Atom Energy Function for Macromolecular Modeling and Design.Q38826829
Improving the accuracy of protein stability predictions with multistate design using a variety of backbone ensemblesQ39323801
A Perspective on the Structural and Functional Constraints for Immune Evasion: Insights from Influenza VirusQ39397313
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivs 4.0 InternationalQ24082749
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)1597-1602
P577publication date2019-01-14
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleMultistate design of influenza antibodies improves affinity and breadth against seasonal viruses
P478volume116

Reverse relations

cites work (P2860)
Q92921968A Sample-Sparing Multiplexed ADCP Assay
Q66680160Connecting the sequence dots: shedding light on the genesis of antibodies reported to be designed in silico
Q96127488Macromolecular modeling and design in Rosetta: recent methods and frameworks
Q89594271Multi-state design of flexible proteins predicts sequences optimal for conformational change

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