Rapid recruitment of macrophages in interleukin-12-mediated tumour regression

scientific article published on 01 September 1998

Rapid recruitment of macrophages in interleukin-12-mediated tumour regression is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1046/J.1365-2567.1998.00579.X
P698PubMed publication ID9767471

P50authorSang-Jun HaQ37368920
Seong-Beom LeeQ60310510
P2093author name stringH S Shin
C M Kim
Y C Sung
P2860cites workPurification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cellsQ24295111
Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cellsQ24338274
Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factorQ24338518
Tight control of gene expression in mammalian cells by tetracycline-responsive promotersQ24564850
High-efficiency transformation of mammalian cells by plasmid DNAQ27860469
Transcriptional activation by tetracyclines in mammalian cellsQ28303934
Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and PentostamQ28368077
Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophagesQ29618421
Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunityQ29619700
Influence of interleukin 12 on p53 peptide vaccination against established Meth A sarcomaQ34577679
Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytesQ36356764
Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinomaQ37247348
Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic miceQ37303897
Gene gun-mediated skin transfection with interleukin 12 gene results in regression of established primary and metastatic murine tumorsQ37513598
Antitumor effects of interleukin-12 (IL-12): applications for the immunotherapy and gene therapy of cancer.Q40508210
Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytesQ40651348
Interleukin-12 and its role in the generation of TH1 cellsQ40712406
Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector.Q41335213
Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo.Q41503342
Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cellsQ41564337
Antitumor and antimetastatic activity of interleukin 12 against murine tumorsQ41906195
IL-12 induces IFN-gamma expression and secretion in mouse peritoneal macrophages.Q42445043
Contrasting in vitro lymphocyte chemotactic activity of the hydroxyl enantiomers of 12-hydroxy-5,8,10,14-eicosatetraenoic acidQ42848458
Eradication of murine bladder carcinoma by intratumor injection of a bicistronic adenoviral vector carrying cDNAs for the IL-12 heterodimer and its inhibition by the IL-12 p40 subunit homodimerQ45148456
Antitumor efficacy of adenocarcinoma cells engineered to produce interleukin 12 (IL-12) or other cytokines compared with exogenous IL-12.Q52042067
Cytotoxic NK1.1 Ag+ alpha beta T cells with intermediate TCR induced in the liver of mice by IL-12.Q54173684
Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor)Q67695881
Interleukin-4 is chemotactic for mouse macrophagesQ68052203
Systemic administration of rIL-12 induces complete tumor regression and protective immunity: response is correlated with a striking reversal of suppressed IFN-gamma production by anti-tumor T cellsQ70801399
Cytokine and chemokine expression in tumors of mice receiving systemic therapy with IL-12Q70844146
Liver NK1.1+ CD4+ alpha beta T cells activated by IL-12 as a major effector in inhibition of experimental tumor metastasisQ71049413
Injection of complementary DNA encoding interleukin-12 inhibits tumor establishment at a distant site in a murine renal carcinoma modelQ71400886
IL-12-engineered dendritic cells serve as effective tumor vaccine adjuvants in vivoQ71871168
Cancer immunotherapy of established tumors with IL-12. Effective delivery by genetically engineered fibroblastsQ71961070
Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cellsQ72191659
Recombinant IL-12 administration induces tumor regression in association with IFN-gamma productionQ72686394
Interleukin-12 is chemotactic for natural killer cells and stimulates their interaction with vascular endotheliumQ72698910
IL-12 induces T helper 1-directed antitumor responseQ73271308
Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumorsQ73889862
P433issue1
P921main subjectinterleukinsQ194908
P304page(s)156-163
P577publication date1998-09-01
P1433published inImmunologyQ15754984
P1476titleRapid recruitment of macrophages in interleukin-12-mediated tumour regression
P478volume95

Reverse relations

cites work (P2860)
Q40410230Administration route- and immune cell activation-dependent tumor eradication by IL12 electrotransfer
Q44078795Biodegradable polymer-based interleukin-12 gene delivery: role of induced cytokines, tumor infiltrating cells and nitric oxide in anti-tumor activity
Q24806391Efficient delivery of small interfering RNA for inhibition of IL-12p40 expression in vivo
Q52013629Engineering N-glycosylation mutations in IL-12 enhances sustained cytotoxic T lymphocyte responses for DNA immunization.
Q45419597IL-12 deficiency transiently improves viral clearance during the late phase of respiratory tract infection with influenza A virus in mice
Q47854639Immunohistochemical expression of interleukin-4, -6, -8, and -12 in inflammatory cells in surrounding invasive front of oral squamous cell carcinoma
Q33713444Interleukin-37 mediates the antitumor activity in hepatocellular carcinoma: role for CD57+ NK cells
Q82542686Mice overexpressing p40 in lungs have reduced leucocyte influx and slightly impaired resistance during tuberculosis
Q45422073Sustained E2 antibody response correlates with reduced peak viremia after hepatitis C virus infection in the chimpanzee

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