26 S Proteasome-mediated Production of an Authentic Major Histocompatibility Class I-restricted Epitope from an Intact Protein Substrate (scientific article published on 30 July 1999)

Targeting of HIV-1 antigens for rapid intracellular degradation enhances cytotoxic T lymphocyte (CTL) recognition and the induction of de novo CTL responses in vivo after immunization

Q24670153

A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3.

Q27936509

Interferon-gamma can stimulate post-proteasomal trimming of the N terminus of an antigenic peptide by inducing leucine aminopeptidase

Q28115538

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

Q28248180

In vivo assembly of the proteasomal complexes, implications for antigen processing

Q28285019

ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin

Q34310551

Defective presentation to class I-restricted cytotoxic T lymphocytes in vaccinia-infected cells is overcome by enhanced degradation of antigen.

Q36355512

Potential immunocompetence of proteolytic fragments produced by proteasomes before evolution of the vertebrate immune system

Q36380352

A role for the proteasome regulator PA28alpha in antigen presentation

Q38357921

Purification by affinity chromatography and preliminary characterization of ornithine decarboxylase from simian virus 40-transformed 3T3 mouse fibroblasts

Q40121557

Low-Molecular-Weight Enzyme Inhibitors of Microbial Origin

Q40132226

Generation, translocation, and presentation of MHC class I-restricted peptides

Q40422033

Rapid and regulated degradation of ornithine decarboxylase

Q40598219

Genes encoded in the major histocompatibility complex affecting the generation of peptides for TAP transport

Q41371575

Efficiency of MHC class I antigen processing: a quantitative analysis

Q41446613

Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination

Q41589996

Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation

Q41594408

Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein

Q41665138

Empty MHC class I molecules come out in the cold

Q41725383

The high molecular weight multicatalytic proteinase, macropain, exists in a latent form in human erythrocytes

Q42203334

The MHC class I ligand-generating system: roles of immunoproteasomes and the interferon-gamma-inducible proteasome activator PA28.

Q47700046

MHC-linked LMP gene products specifically alter peptidase activities of the proteasome

Q59088266

Coordinated dual cleavages induced by the proteasome regulator PA28 lead to dominant MHC ligands

Q71254579

Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules

Q71684049

Localization, quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody

Q73479961

Production of a specific major histocompatibility complex class I-restricted epitope by ubiquitin-dependent degradation of modified ovalbumin in lymphocyte lysate

Q73596131

Relative functions of the alpha and beta subunits of the proteasome activator, PA28

Q73824858

Double-cleavage production of the CTL epitope by proteasomes and PA28: role of the flanking region

Q74449437

The sizes of peptides generated from protein by mammalian 26 and 20 S proteasomes. Implications for understanding the degradative mechanism and antigen presentation

Q77911981

P433

issue

P407

language of work or name

English

Q1860

P304

page(s)

21963-21972

P577

publication date

1999-07-01

P1433

published in

Journal of Biological Chemistry

Q867727

P1476

title

26 S proteasome-mediated production of an authentic major histocompatibility class I-restricted epitope from an intact protein substrate

P478

volume

274

Reverse relations

cites work (P2860)

Q24535312	26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide
Q44323611	An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope.
Q47605422	Association of growth factors, HIF-1 and NF-κB expression with proteasomes in endometrial cancer.
Q35944320	Changes in the Proteasome Pool during Malignant Transformation of Mouse Liver Cells
Q33859470	Compartmentalized MHC class I antigen processing enhances immunosurveillance by circumventing the law of mass action.
Q34129301	Cut and trim: generating MHC class I peptide ligands
Q36375899	Efficient generation of a hepatitis B virus cytotoxic T lymphocyte epitope requires the structural features of immunoproteasomes
Q85793510	Expression of vascular endothelial growth factor and transcription factors HIF-1, NF-kB expression in squamous cell carcinoma of head and neck; association with proteasome and calpain activities
Q28363065	Immunoproteasome assembly and antigen presentation in mice lacking both PA28alpha and PA28beta.
Q35597106	Making sense of mass destruction: quantitating MHC class I antigen presentation
Q34362098	Proteasome functioning in breast cancer: connection with clinical-pathological factors
Q34700398	Protein degradation and the generation of MHC class I-presented peptides.
Q34348731	Study of antigen-processing steps reveals preferences explaining differential biological outcomes of two HLA-A2-restricted immunodominant epitopes from human immunodeficiency virus type 1.
Q39771199	The tumor suppressor ING3 is degraded by SCF(Skp2)-mediated ubiquitin-proteasome system
Q24292709	The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction
Q29617290	Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

P356	DOI	10.1074/JBC.274.31.21963
P698	PubMed publication ID	10419519