Abstract is: Aquaporins, also called water channels, are channel proteins from a larger family of major intrinsic proteins that form pores in the membrane of biological cells, mainly facilitating transport of water between cells. The cell membranes of a variety of different bacteria, fungi, animal and plant cells contain aquaporins through which water can flow more rapidly into and out of the cell than by diffusing through the phospholipid bilayer. Aquaporins have six membrane-spanning alpha helical domains with both carboxylic and amino terminals on the cytoplasmic side. Two hydrophobic loops contain conserved asparagine-proline-alanine ("NPA motif") which form a barrel surrounding a central pore-like region that contains additional protein density. Because aquaporins are usually always open and are prevalent in just about every cell type, this leads to a misconception that water readily passes through the cell membrane down its concentration gradient. Water can pass through the cell membrane through simple diffusion because it is a small molecule, and through osmosis, in cases where the concentration of water outside of the cell is greater than that of the inside. However, because water is a polar molecule this process of simple diffusion is relatively slow, and in tissues with high water permeability the majority of water passes through aquaporin. The 2003 Nobel Prize in Chemistry was awarded jointly to Peter Agre for the discovery of aquaporins and Roderick MacKinnon for his work on the structure and mechanism of potassium channels. Genetic defects involving aquaporin genes have been associated with several human diseases including nephrogenic diabetes insipidus and neuromyelitis optica.
protein family | Q417841 |
group or class of transmembrane transport proteins | Q67101749 |
major intrinsic protein | Q4338147 |
P5019 | Brockhaus Enzyklopädie online ID | aquaporine |
P8072 | CAB ID | 40220 |
P10037 | Enciclopedia della Scienza e della Tecnica ID | acquaporine |
P3219 | Encyclopædia Universalis ID | aquaporines |
P646 | Freebase ID | /m/01xnnj |
P2924 | Great Russian Encyclopedia Online ID (old version) | 1806327 |
P2926 | InterPro ID | IPR034294 |
P3827 | JSTOR topic ID (archived) | water-channels |
P8408 | KBpedia ID | Aquaporin |
P8313 | Lex ID | aquaporin |
P486 | MeSH descriptor ID | D020346 |
P672 | MeSH tree code | D12.776.157.530.400.500.040 |
D12.776.543.550.450.730.040 | ||
D12.776.543.585.400.730.040 | ||
P6366 | Microsoft Academic ID | 154280991 |
2910800694 | ||
P1245 | OmegaWiki Defined Meaning | 1423052 |
P10283 | OpenAlex ID | C154280991 |
P10376 | ScienceDirect topic ID | agricultural-and-biological-sciences/aquaporin |
agricultural-and-biological-sciences/aquaporins | ||
P7260 | Transporter Classification Database ID | 1.A.8 |
P2892 | UMLS CUI | C0599635 |
P3471 | WikiSkripta article ID | 13787 |
P10228 | facilitates flow of | water | Q283 |
P680 | molecular function | water channel activity | Q14902498 |
P910 | topic's main category | Category:Aquaporins | Q52707401 |
Q29794168 | AQuaPorin or aquaglyceroporin related CELE_C35A5.1 |
Q29791821 | AQuaPorin or aquaglyceroporin related CELE_F40F9.9 |
Q21141685 | Aquaporin 1 splice variant 2 |
Q29829607 | Aquaporin 1a (Colton blood group), tandem duplicate 1 |
Q29833351 | Aquaporin 1a (Colton blood group), tandem duplicate 2 |
Q2045854 | Aquaporin 2 |
Q14902532 | Aquaporin 2 |
Q55201551 | Aquaporin 2 |
Q28557356 | Aquaporin 2 |
Q3820749 | Aquaporin 4 |
Q14902507 | Aquaporin 4 |
Q28558532 | Aquaporin 4 |
Q29826366 | Aquaporin 4 |
Q23513154 | Aquaporin BC4507 |
Q23455163 | Aquaporin BT_4718 |
Q56264261 | Aquaporin Z BA_4742 |
Q23522392 | Aquaporin Z BT9727_4242 |
Q23501436 | Aquaporin Z EF1192 |
Q27746998 | Aquaporin Z MSMEG_6466 |
Q56109494 | Aquaporin Z MXAN_RS24625 |
Q27475292 | Aquaporin Z SDY_2388 |
Q23548683 | Aquaporin Z-water channel protein smi_0568 |
Q23494455 | Aquaporin spr1604 |
Q23052141 | Aquaporin z, Major Intrinsic Protein (MIP) Family RSP_2782 |
Q21117937 | Aquaporin-4 |
Q27552035 | Aqy1p YPR192W |
Q27550732 | Aqy2p YLL052C |
Q29817137 | Big brain Dmel_CG4722 |
Q23569010 | Channel protein glr0003 |
Q29813187 | Drip Dmel_CG9023 |
Q29815821 | Entomoglyceroporin 1 Dmel_CG5398 |
Q29815969 | Entomoglyceroporin 3 Dmel_CG17662 |
Q23607872 | Glycerol uptake facilitator and related permease (major Intrinsic protein family)-like protein Smed_5764 |
Q23582555 | Glycerol uptake facilitator protein AMED_5085 |
Q23540307 | Glycerol uptake facilitator protein lp_3463 |
Q27742032 | Glycerol uptake facilitator, MIP channel MSMEG_2124 |
Q24101186 | Glycerol uptake transporter protein NGR_b21800 |
Q56110429 | MIP family channel protein MXAN_RS28890 |
Q30545211 | MIP family channel protein Mesci_2543 |
Q23619540 | MIP family protein CC_1504 |
Q38143053 | Major intrinsic protein (MIP)-family channel protein CCNA_01572 |
Q30520680 | Major intrinsic protein BBPR_1004 |
Q23470431 | Major intrinsic protein CT1472 |
Q21122978 | Major intrinsic protein of lens fiber |
Q21985793 | Major intrinsic protein of lens fiber |
Q55204449 | Major intrinsic protein of lens fiber |
Q29515845 | Major intrinsic protein of lens fiber |
Q29831102 | Major intrinsic protein of lens fiber a |
Q29830984 | Major intrinsic protein of lens fiber b |
Q23621629 | Membrane channel protein BL0736 |
Q23629564 | Nodulin-26 RB4879 |
Q23570416 | Pore-forming membrane protein SmpX-like protein glr1162 |
Q23589082 | Probable aquaporin Z MAB_0589 |
Q22326083 | Putative major intrinsic protein HMPREF0421_20850 |
Q24109294 | Transport transmembrane protein SMc02648 |
Q27551052 | Uncharacterized protein YLL053C |
Q56564952 | aquaporin, putative |
Q46283055 | A Review: Expression of Aquaporins in Otitis Media |
Q52686527 | Activation of AQP2 water channels without vasopressin: therapeutic strategies for congenital nephrogenic diabetes insipidus. |
Q37327581 | Aquaglyceroporins: ancient channels for metalloids |
Q27687382 | Aquaporin 1, a potential therapeutic target for migraine with aura |
Q27022405 | Aquaporin 4: a player in cerebral edema and neuroinflammation |
Q64251150 | Aquaporin Channels in the Heart-Physiology and Pathophysiology |
Q55236425 | Aquaporin Membrane Channels in Oxidative Stress, Cell Signaling, and Aging: Recent Advances and Research Trends. |
Q47108955 | Aquaporin Protein-Protein Interactions |
Q37719259 | Aquaporin expression in normal and pathological skeletal muscles: a brief review with focus on AQP4 |
Q34028930 | Aquaporin water channels in exocrine glands |
Q27021689 | Aquaporin water channels in the mammary gland: from physiology to pathophysiology and neoplasia |
Q44895851 | Aquaporin-3 in Cancer |
Q41574459 | Aquaporin-4 Functionality and Virchow-Robin Space Water Dynamics: Physiological Model for Neurovascular Coupling and Glymphatic Flow |
Q64242776 | Aquaporin-4 Water Channel in the Brain and Its Implication for Health and Disease |
Q36755429 | Aquaporin-4 and brain edema. |
Q26738432 | Aquaporin-4 in Astroglial Cells in the CNS and Supporting Cells of Sensory Organs-A Comparative Perspective |
Q90721967 | Aquaporins Involvement in Pancreas Physiology and in Pancreatic Diseases |
Q35245970 | Aquaporins as diagnostic and therapeutic targets in cancer: how far we are? |
Q47570744 | Aquaporins during Pregnancy: Their Function and Significance |
Q39063020 | Aquaporins in Brain Edema and Neuropathological Conditions |
Q26740555 | Aquaporins in Health and Disease: An Overview Focusing on the Gut of Different Species |
Q61815142 | Aquaporins in Renal Diseases |
Q26772937 | Aquaporins in Salivary Glands: From Basic Research to Clinical Applications |
Q26744354 | Aquaporins in Urinary Extracellular Vesicles (Exosomes) |
Q24811534 | Aquaporins in development -- a review |
Q37084710 | Aquaporins in spermatozoa and testicular germ cells: identification and potential role |
Q26742044 | Aquaporins in the Colon as a New Therapeutic Target in Diarrhea and Constipation |
Q28066783 | Aquaporins in the Spinal Cord |
Q58611869 | Aquaporins in the lung |
Q26740097 | Astrocyte Aquaporin Dynamics in Health and Disease |
Q64065786 | Biomimetic Membranes with Transmembrane Proteins: State-of-the-Art in Transmembrane Protein Applications |
Q61816841 | Bursting at the Seams: Molecular Mechanisms Mediating Astrocyte Swelling |
Q64107533 | Changes in the Expression of Aquaporin-3 in the Gastrointestinal Tract Affect Drug Absorption |
Q36021354 | Comparative functional analysis of aquaporins/glyceroporins in mammals and anurans |
Q64138061 | Effects of cholecalciferol cholesterol emulsion on renal fibrosis and aquaporin 2 and 4 in mice with unilateral ureteral obstruction |
Q28077451 | Expression, Distribution and Role of Aquaporin Water Channels in Human and Animal Stomach and Intestines |
Q64329181 | Fluid Dynamics Inside the Brain Barrier: Current Concept of Interstitial Flow, Glymphatic Flow, and Cerebrospinal Fluid Circulation in the Brain |
Q64054107 | Genome-wide comparison reveals divergence of cassava and rubber aquaporin family genes after the recent whole-genome duplication |
Q26740558 | Hepatocyte and Sertoli Cell Aquaporins, Recent Advances and Research Trends |
Q47802729 | Hereditary Nephrogenic Diabetes Insipidus: Pathophysiology and Possible Treatment. An Update |
Q26740107 | Human Aquaporin-4 and Molecular Modeling: Historical Perspective and View to the Future |
Q64078656 | Identification and characterization of aquaporin genes in Arachis duranensis and Arachis ipaensis genomes, the diploid progenitors of peanut |
Q47233139 | Implications of Aquaglyceroporin 7 in Energy Metabolism |
Q64103262 | Inhibitors of Mammalian Aquaporin Water Channels |
Q64106280 | Intact leaf gas exchange provides a robust method for measuring the kinetics of stomatal conductance responses to abscisic acid and other small molecules in and grasses |
Q61797854 | Investigation of the Family in Soybean and the Promoter Activity of in Heat Stress and Hormone Responses |
Q58095625 | Involvement of Aquaporins in the Pathogenesis, Diagnosis and Treatment of Sjögren's Syndrome |
Q37681978 | Ion channels or aquaporins as novel molecular targets in gastric cancer |
Q64068918 | Laxative Effect of Spicatoside A by Cholinergic Regulation of Enteric Nerve in Loperamide-Induced Constipation: ICR Mice Model |
Q37195827 | Localization and trafficking of aquaporin 2 in the kidney. |
Q33953358 | Mechanisms of pulmonary edema clearance: from basic research to clinical implication |
Q26741610 | Neuroimmunological Implications of AQP4 in Astrocytes |
Q21245240 | Neuromyelitis optica pathogenesis and aquaporin 4 |
Q92503260 | Neuromyelitis optica spectrum disorders: still evolving and broadening |
Q55692261 | Nuclear Receptor Regulation of Aquaglyceroporins in Metabolic Organs. |
Q26740554 | Nuclear Receptor Regulation of Aquaporin-2 in the Kidney |
Q64076156 | Peroxiporins in Cancer |
Q64245619 | Phosphorylation-Dependent Regulation of Mammalian Aquaporins |
Q64262555 | Physiological and pathological impact of AQP1 knockout in mice |
Q50117395 | Plant and Mammal Aquaporins: Same but Different |
Q26783211 | Polyphenols as Modulators of Aquaporin Family in Health and Disease |
Q33881242 | Pores in the wall: claudins constitute tight junction strands containing aqueous pores |
Q26738736 | Progress in AQP Research and New Developments in Therapeutic Approaches to Ischemic and Hemorrhagic Stroke |
Q47351317 | Prostaglandin E2 in the Regulation of Water Transport in Renal Collecting Ducts |
Q47714423 | Regulation of aquaporins in plants under stress |
Q91254224 | Renal Ca2+ and Water Handling in Response to Calcium Sensing Receptor Signaling: Physiopathological Aspects and Role of CaSR-Regulated microRNAs |
Q47712531 | Role of Aquaporins in Determining Carbon and Nitrogen Status in Higher Plants |
Q26744737 | Role of Aquaporins in a Composite Model of Water Transport in the Leaf |
Q37056753 | Role of aquaporins and regulation of secretory vesicle volume in cell secretion |
Q39261031 | Structural and evolutionary divergence of aquaporins in parasites (Review). |
Q64064610 | The Deubiquitylase USP4 Interacts with the Water Channel AQP2 to Modulate Its Apical Membrane Accumulation and Cellular Abundance |
Q26739990 | The Interactions of Aquaporins and Mineral Nutrients in Higher Plants |
Q30897558 | The Molecular Mechanisms of Neural Flow Coupling: A New Concept |
Q26750778 | The Neuroprotective Effect of the Association of Aquaporin-4/Glutamate Transporter-1 against Alzheimer's Disease |
Q47303139 | The Role of Aquaporins in Ocular Lens Homeostasis |
Q21184149 | The aquaporins |
Q26771172 | Urine Aquaporin-2: A Promising Marker of Response to the Arginine Vasopressin Type-2 Antagonist, Tolvaptan in Patients with Congestive Heart Failure |
Q64232310 | Vasopressin-aquaporin-2 pathway: recent advances in understanding water balance disorders |
Q26993212 | Virchow-Robin space and aquaporin-4: new insights on an old friend |
Q56056825 | Ana Paula Martins | field of work | P101 |
Q52707401 | Category:Aquaporins | category's main topic | P301 |
uri / http://www.wikidata.org/entity/L57840-S1 | L57840-S1 | item for this sense | P5137 |
Arabic (ar / Q13955) | أكوابورين | wikipedia |
Akvaporin | wikipedia | |
Catalan (ca / Q7026) | Aquaporina | wikipedia |
Akvaporin | wikipedia | |
Aquaporin | wikipedia | |
Aquaporine | wikipedia | |
Υδατοπορίνες | wikipedia | |
Aquaporin | wikipedia | |
Acuaporina | wikipedia | |
Akvaporiin | wikipedia | |
Persian (fa / Q9168) | آکواپورین | wikipedia |
Akvaporiini | wikipedia | |
Aquaporine | wikipedia | |
gl | Acuaporina | wikipedia |
Akvaporin | wikipedia | |
Akuaporin | wikipedia | |
Acquaporine | wikipedia | |
アクアポリン | wikipedia | |
아쿠아포린 | wikipedia | |
mk | Аквапорин | wikipedia |
ml | അക്വാപോറിൻ | wikipedia |
Akuaporin | wikipedia | |
Aquaporine | wikipedia | |
Akwaporyny | wikipedia | |
Aquaporina | wikipedia | |
Aquaporină | wikipedia | |
Аквапорины | wikipedia | |
Akvaporín | wikipedia | |
Aquaporin | wikipedia | |
Аквапорини | wikipedia | |
Aquaporin | wikipedia | |
水通道蛋白 | wikipedia |
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