Opening of an alternative ion permeation pathway in a nociceptor TRP channel

scientific article published on 05 January 2014

Opening of an alternative ion permeation pathway in a nociceptor TRP channel is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1022660521
P356DOI10.1038/NCHEMBIO.1428
P698PubMed publication ID24390427

P50authorRudi VennekensQ37840068
Thomas VoetsQ40270934
Joris VriensQ55692142
Balázs István TóthQ57316650
P2093author name stringBernd Nilius
Annelies Janssens
Katharina Held
Sara Kerselaers
P2860cites workAlternative splicing switches the divalent cation selectivity of TRPM3 channelsQ24299887
The capsaicin receptor: a heat-activated ion channel in the pain pathwayQ24322558
International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel familyQ24623493
Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressantQ24675998
TRP-PLIK, a bifunctional protein with kinase and ion channel activitiesQ28143098
The conduction pore of a cardiac potassium channelQ28262167
Transient receptor potential cation channels in diseaseQ28284143
In vitro susceptibilities of clinical yeast isolates to the new antifungal eberconazole compared with their susceptibilities to clotrimazole and ketoconazoleQ28343297
TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transductionQ28505709
Identification of a cold receptor reveals a general role for TRP channels in thermosensationQ28580334
Homo- and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6.Q28586678
Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearingQ28588331
TRP channels as cellular sensorsQ29615917
TRPA1 acts as a cold sensor in vitro and in vivoQ30485737
TRPM3 channel stimulated by pregnenolone sulphate in synovial fibroblasts and negatively coupled to hyaluronanQ33595202
A double-blind randomized comparative trial: eberconazole 1% cream versus clotrimazole 1% cream twice daily in Candida and dermatophyte skin infectionsQ34085890
Tamoxifen: a most unlikely pioneering medicineQ34180688
The Ca2+-activated cation channel TRPM4 is regulated by phosphatidylinositol 4,5-biphosphateQ34410954
Overview of molecular relationships in the voltage-gated ion channel superfamily.Q34480285
Novel inhibitors of the Gardos channel for the treatment of sickle cell diseaseQ34743319
Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells.Q34870762
Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate, and the ratio of insulin-like growth factor 1 to growth hormoneQ36660056
Menthol pain relief through cumulative inactivation of voltage-gated sodium channelsQ39254610
Agonist-induced changes in Ca(2+) permeation through the nociceptor cation channel TRPA1.Q39344547
Ligand stoichiometry of the cold- and menthol-activated channel TRPM8.Q39482079
TRPM3 is a nociceptor channel involved in the detection of noxious heatQ39545788
TRPV1 shows dynamic ionic selectivity during agonist stimulation.Q39994761
TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuliQ40172246
Inhibition of TRPM2 channels by the antifungal agents clotrimazole and econazole.Q40467443
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channelsQ40526282
Outer pore architecture of a Ca2+-selective TRP channelQ40596874
Molecular and functional characterization of the melastatin-related cation channel TRPM3.Q40658876
Pore dilation of neuronal P2X receptor channelsQ40960421
Gated regulation of CRAC channel ion selectivity by STIM1.Q40999366
Effect of insulin on area and Na+ channel density of apical membrane of cultured toad kidney cellsQ41411241
Dynamic changes in the TRPA1 selectivity filter lead to progressive but reversible pore dilationQ43067153
Sex- and age-related changes in epitestosterone in relation to pregnenolone sulfate and testosterone in normal subjects.Q43982468
The twisted ion-permeation pathway of a resting voltage-sensing domainQ45002461
Voltage-sensing arginines in a potassium channel permeate and occlude cation-selective poresQ45252796
A novel sustained-release clotrimazole varnish for local treatment of oral candidiasis.Q46031059
Ion permeation through a voltage- sensitive gating pore in brain sodium channels having voltage sensor mutationsQ46615032
Transient receptor potential channels in sensory neurons are targets of the antimycotic agent clotrimazoleQ46804915
Gating pore current in an inherited ion channelopathyQ48799799
Flutrimazole 1% dermal cream in the treatment of dermatomycoses: a randomized, multicentre, double‐blind, comparative clinical trial with 1% clotrimazole creamQ72021052
P433issue3
P304page(s)188-195
P577publication date2014-01-05
P1433published inNature Chemical BiologyQ904026
P1476titleOpening of an alternative ion permeation pathway in a nociceptor TRP channel
P478volume10

Reverse relations

cites work (P2860)
Q59072502A TRP channel trio mediates acute noxious heat sensing
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Q42133705CREB, AP-1, ternary complex factors and MAP kinases connect transient receptor potential melastatin-3 (TRPM3) channel stimulation with increased c-Fos expression
Q58791916Carboxamido steroids inhibit the opening properties of transient receptor potential ion channels by lipid raft modulation
Q36924610Diclofenac, a nonsteroidal anti-inflammatory drug, is an antagonist of human TRPM3 isoforms
Q58726115Functional Expression of TRP Ion Channels in Endometrial Stromal Cells of Endometriosis Patients
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Q35946504Molecular and cellular mechanisms that initiate pain and itch
Q64963359Molecular mechanisms of coupling to voltage sensors in voltage-evoked cellular signals.
Q55401194Mutations in the voltage-sensing domain affect the alternative ion permeation pathway in the TRPM3 channel.
Q90193598Noncanonical Ion Channel Behaviour in Pain
Q26999694Permeation, regulation and control of expression of TRP channels by trace metal ions
Q42403885Phosphoinositide regulation of TRPM channels - TRPM3 joins the club!
Q36945667Phosphoinositide signaling in somatosensory neurons
Q30846820Primidone inhibits TRPM3 and attenuates thermal nociception in vivo
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Q45930731TRP Channels: Pain enters through the side door.
Q35101675TRPM3 expression in mouse retina.
Q26745813TRPM3 in temperature sensing and beyond
Q39994417TRPM3 joins the ranks of PI(4,5)P2 sensitive ion channels
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Q38222961What do we really know and what do we need to know: some controversies, perspectives, and surprises

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