Transport of Proteins into Mitochondria

scientific article published on 01 June 2019

Transport of Proteins into Mitochondria is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1112731801
P356DOI10.1007/S10930-019-09819-6
P698PubMed publication ID30868341

P50authorJohannes HerrmannQ18822221
Katja G. HansenQ64678957
P2093author name stringJohannes M. Herrmann
Katja G. Hansen
P2860cites workCrystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propellerQ24300166
Functional and mutational characterization of human MIA40 acting during import into the mitochondrial intermembrane spaceQ24336828
Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70Q24338681
Internal targeting signal of the BCS1 protein: a novel mechanism of import into mitochondriaQ24563254
An ER-mitochondria tethering complex revealed by a synthetic biology screenQ24618405
Yeast mitochondrial biogenesis: a role for the PUF RNA-binding protein Puf3p in mRNA localizationQ27301294
Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20Q27621783
Structural and Functional Requirements for Activity of the Tim9-Tim10 Complex in Mitochondrial Protein ImportQ27653002
Structural characterization of CHCHD5 and CHCHD7: two atypical human twin CX9C proteinsQ27681878
Mic10 oligomerizes to bend mitochondrial inner membranes at cristae junctionsQ27930048
OM14 is a mitochondrial receptor for cytosolic ribosomes that supports co-translational import into mitochondriaQ27930082
J protein cochaperone of the mitochondrial inner membrane required for protein import into the mitochondrial matrixQ27930249
Novel mitochondrial intermembrane space proteins as substrates of the MIA import pathwayQ27931352
Systematic analysis of the twin cx(9)c protein family.Q27931937
The GET complex mediates insertion of tail-anchored proteins into the ER membraneQ27932687
The conserved AAA-ATPase Msp1 confers organelle specificity to tail-anchored proteinsQ27933340
Mcp3 is a novel mitochondrial outer membrane protein that follows a unique IMP-dependent biogenesis pathwayQ27933659
Signal recognition initiates reorganization of the presequence translocase during protein importQ27934084
Targeting and plasticity of mitochondrial proteins revealed by proximity-specific ribosome profilingQ27934105
Mia40 is a trans-site receptor that drives protein import into the mitochondrial intermembrane space by hydrophobic substrate bindingQ27934445
The Tim21 binding domain connects the preprotein translocases of both mitochondrial membranesQ27934901
Dual role of mitofilin in mitochondrial membrane organization and protein biogenesisQ27935050
Machinery for protein sorting and assembly in the mitochondrial outer membraneQ27935206
Assembly of the mitochondrial protein import channel: role of Tom5 in two-stage interaction of Tom40 with the SAM complexQ27935538
Sorting of D-lactate dehydrogenase to the inner membrane of mitochondria. Analysis of topogenic signal and energetic requirementsQ27935676
Intermembrane space proteome of yeast mitochondriaQ27935768
The cytosolic cochaperone Sti1 is relevant for mitochondrial biogenesis and morphologyQ27935948
The role of Djp1 in import of the mitochondrial protein Mim1 demonstrates specificity between a cochaperone and its substrate proteinQ27936424
Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17.Q27936577
Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stabilityQ27937057
A disulfide relay system in the intermembrane space of mitochondria that mediates protein importQ27937691
YDJ1p facilitates polypeptide translocation across different intracellular membranes by a conserved mechanismQ27937736
Atp23 biogenesis reveals a chaperone-like folding activity of Mia40 in the IMS of mitochondriaQ27938029
Mgr2 functions as lateral gatekeeper for preprotein sorting in the mitochondrial inner membraneQ27938212
Dual function of Sdh3 in the respiratory chain and TIM22 protein translocase of the mitochondrial inner membraneQ27938244
Tim50 maintains the permeability barrier of the mitochondrial inner membraneQ27938461
Aim24 and MICOS modulate respiratory function, tafazzin-related cardiolipin modification and mitochondrial architectureQ27938907
MitoCPR—A surveillance pathway that protects mitochondria in response to protein import stressQ56950957
Cytosolic Hsp70 and Hsp40 chaperones enable the biogenesis of mitochondrial β-barrel proteinsQ57751808
Cooperation of TOM and TIM23 Complexes during Translocation of Proteins into MitochondriaQ57805247
An ER surface retrieval pathway safeguards the import of mitochondrial membrane proteins in yeastQ57820979
Vps39 Interacts with Tom40 to Establish One of Two Functionally Distinct Vacuole-Mitochondria Contact SitesQ57830526
The Presequence of Fumarase is Exposed to the Cytosol during Import into MitochondriaQ57971425
Unique features of mammalian mitochondrial translation initiation revealed by cryo-EMQ59065984
Structural Basis of Membrane Protein Chaperoning through the Mitochondrial Intermembrane SpaceQ59134794
Recruitment of Cytosolic J-Proteins by TOM Receptors Promotes Mitochondrial Protein BiogenesisQ59791039
The ribosome receptors Mrx15 and Mba1 jointly organize cotranslational insertion and protein biogenesis in mitochondriaQ63348725
The sorting route of cytochrome b2 branches from the general mitochondrial import pathway at the preprotein translocase of the inner membraneQ73890130
Mitochondrial protein import. Requirement of presequence elements and tom components for precursor binding to the TOM complexQ80508812
A presequence-binding groove in Tom70 supports import of Mdl1 into mitochondriaQ87277344
The GET pathway can increase the risk of mitochondrial outer membrane proteins to be mistargeted to the ERQ88376416
Mitochondrial protein import regulates cytosolic protein homeostasis and neuronal integrityQ89127993
Pex19 is involved in importing dually targeted tail-anchored proteins to both mitochondria and peroxisomesQ90396369
Mutations of the mitochondrial carrier translocase channel subunit TIM22 cause early-onset mitochondrial myopathyQ93211778
Msp1/ATAD1 maintains mitochondrial function by facilitating the degradation of mislocalized tail-anchored proteinsQ34343289
Dual role of the receptor Tom20 in specificity and efficiency of protein import into mitochondria.Q34471710
Hsp70 chaperones accelerate protein translocation and the unfolding of stable protein aggregates by entropic pullingQ34597309
Evidence of evolutionary constraints that influences the sequence composition and diversity of mitochondrial matrix targeting signalsQ34795171
Nanoscale distribution of mitochondrial import receptor Tom20 is adjusted to cellular conditions and exhibits an inner-cellular gradientQ35170911
In vivo protein-interaction mapping of a mitochondrial translocator protein Tom22 at workQ35216966
Mitochondrial protein import receptors in Kinetoplastids reveal convergent evolution over large phylogenetic distancesQ35311978
Role of Tim17 in coupling the import motor to the translocation channel of the mitochondrial presequence translocase.Q36271335
Intracellular protein topogenesisQ36360251
MitoCarta2.0: an updated inventory of mammalian mitochondrial proteinsQ36434534
Proteomic mapping of the human mitochondrial intermembrane space in live cells via ratiometric APEX tagging.Q36550699
Involvement of the molecular chaperone Ydj1 in the ubiquitin-dependent degradation of short-lived and abnormal proteins in Saccharomyces cerevisiaeQ36562006
Two distinct membrane potential-dependent steps drive mitochondrial matrix protein translocation.Q37576610
The intermembrane space of mitochondriaQ37724254
Protein translocation channel of mitochondrial inner membrane and matrix-exposed import motor communicate via two-domain coupling proteinQ38358839
Interaction between the human mitochondrial import receptors Tom20 and Tom70 in vitro suggests a chaperone displacement mechanismQ38421163
Membrane potential-driven protein import into mitochondria. The sorting sequence of cytochrome b(2) modulates the deltapsi-dependence of translocation of the matrix-targeting sequenceQ38490363
Mia40-dependent oxidation of cysteines in domain I of Ccs1 controls its distribution between mitochondria and the cytosolQ38697452
A molecular switch for targeting between endoplasmic reticulum (ER) and mitochondria: conversion of a mitochondria-targeting element into an ER-targeting signal in DAKAP1.Q39263155
The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPRQ39593058
Heat Shock Protein 90 kDa (Hsp90) Has a Second Functional Interaction Site with the Mitochondrial Import Receptor Tom70.Q39611443
Tim50, a novel component of the TIM23 preprotein translocase of mitochondriaQ39714672
Quantitative Profiling for Substrates of the Mitochondrial Presequence Processing Protease Reveals a Set of Nonsubstrate Proteins Increased upon Proteotoxic Stress.Q40456096
Molecular architecture of the active mitochondrial protein gateQ40503781
A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell deathQ40717951
Ergosterol content specifies targeting of tail-anchored proteins to mitochondrial outer membranesQ27939155
Lam6 Regulates the Extent of Contacts between OrganellesQ27939360
Carrier protein import into mitochondria mediated by the intermembrane proteins Tim10/Mrs11 and Tim12/Mrs5.Q27939464
Sequential duplications of an ancient member of the DnaJ-family expanded the functional chaperone network in the eukaryotic cytosol.Q27939634
Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stabilityQ28116190
TIM29 is a subunit of the human carrier translocase required for protein transportQ28118577
The Ca(2+)-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca(2+) UptakeQ28118964
Predicting subcellular localization of proteins based on their N-terminal amino acid sequenceQ28140578
MINOS is plus: a Mitofilin complex for mitochondrial membrane contactsQ28250904
The three modules of ADP/ATP carrier cooperate in receptor recruitment and translocation into mitochondriaQ28354447
Computational method to predict mitochondrially imported proteins and their targeting sequencesQ29547581
Importing mitochondrial proteins: machineries and mechanismsQ29616477
Translocation of proteins into mitochondriaQ29616478
Separating mitochondrial protein assembly and endoplasmic reticulum tethering by selective coupling of Mdm10Q30152716
Characterization of the targeting signal in mitochondrial β-barrel proteinsQ30152766
Presequence recognition by the tom40 channel contributes to precursor translocation into the mitochondrial matrixQ30153367
Mdm10 is an ancient eukaryotic porin co-occurring with the ERMES complexQ30153494
The C-terminal domain of Fcj1 is required for formation of crista junctions and interacts with the TOB/SAM complex in mitochondriaQ30155339
Eukaryote-wide sequence analysis of mitochondrial β-barrel outer membrane proteinsQ30155876
Roles of the Mdm10, Tom7, Mdm12, and Mmm1 proteins in the assembly of mitochondrial outer membrane proteins in Neurospora crassaQ30156923
Signal-anchored proteins follow a unique insertion pathway into the outer membrane of mitochondriaQ30160816
Regulated membrane remodeling by Mic60 controls formation of mitochondrial crista junctionsQ30313136
A novel intermembrane space-targeting signal docks cysteines onto Mia40 during mitochondrial oxidative foldingQ30435762
Polyglutamine toxicity in yeast induces metabolic alterations and mitochondrial defectsQ30663550
The SND proteins constitute an alternative targeting route to the endoplasmic reticulumQ33364351
Roles of Tom70 in import of presequence-containing mitochondrial proteinsQ33505156
Tom20 mediates localization of mRNAs to mitochondria in a translation-dependent mannerQ33558151
Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocationQ33574368
Proteomic mapping of cytosol-facing outer mitochondrial and ER membranes in living human cells by proximity biotinylationQ33603020
Dual interaction of scaffold protein Tim44 of mitochondrial import motor with channel-forming translocase subunit Tim23Q33649453
Predicting the targeting of tail-anchored proteins to subcellular compartments in mammalian cells.Q33743186
Interaction of mitochondrial targeting signals with acidic receptor domains along the protein import pathway: evidence for the 'acid chain' hypothesisQ33889115
The ATP synthase is involved in generating mitochondrial cristae morphologyQ34085619
A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptidesQ34172156
Central role of Mic10 in the mitochondrial contact site and cristae organizing systemQ40960585
Definition of a High-Confidence Mitochondrial Proteome at Quantitative ScaleQ40981642
The principle of antagonism ensures protein targeting specificity at the endoplasmic reticulumQ41094661
GxxxG motifs hold the TIM23 complex togetherQ41235258
Sengers Syndrome-Associated Mitochondrial Acylglycerol Kinase Is a Subunit of the Human TIM22 Protein Import Complex.Q41412885
Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria.Q41413036
Landscape of submitochondrial protein distribution.Q41448038
Cristae architecture is determined by an interplay of the MICOS complex and the F1FO ATP synthase via Mic27 and Mic10.Q41499085
Organization of the mitochondrial translation machinery studied in situ by cryoelectron tomographyQ41546831
Visualization of cytosolic ribosomes on the surface of mitochondria by electron cryo-tomography.Q41596754
Cryo-electron microscopy structure of a yeast mitochondrial preprotein translocaseQ41622352
A disulfide bond in the TIM23 complex is crucial for voltage gating and mitochondrial protein importQ41737012
Protein import and oxidative folding in the mitochondrial intermembrane space of intact mammalian cells.Q41783546
Identification of the signal directing Tim9 and Tim10 into the intermembrane space of mitochondriaQ41838204
Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation.Q41953002
Conservation of Transit Peptide-Independent Protein Import into the Mitochondrial and Hydrogenosomal Matrix.Q41983944
New insights into the targeting of a subset of tail-anchored proteins to the outer mitochondrial membraneQ41995686
The MICOS component Mic60 displays a conserved membrane-bending activity that is necessary for normal cristae morphologyQ42094974
Mas37p, a novel receptor subunit for protein import into mitochondria.Q42138104
The Yin & Yang of Mitochondrial Architecture - Interplay of MICOS and F1Fo-ATP synthase in cristae formation.Q42349153
Localization of mRNAs coding for mitochondrial proteins in the yeast Saccharomyces cerevisiaeQ42861994
A cooperative action of the ATP-dependent import motor complex and the inner membrane potential drives mitochondrial preprotein importQ42951875
Principles of ER cotranslational translocation revealed by proximity-specific ribosome profilingQ43093001
Protein folding causes an arrest of preprotein translocation into mitochondria in vivoQ43108111
Integration of tail-anchored proteins into the mitochondrial outer membrane does not require any known import componentsQ44066667
Folding of fumarase during mitochondrial import determines its dual targeting in yeastQ44576332
The yeast mitochondrial proteome, a study of fermentative and respiratory growthQ44642026
Adaptation of a Genetic Screen Reveals an Inhibitor for Mitochondrial Protein Import Component Tim44.Q45976544
Refining the definition of plant mitochondrial presequences through analysis of sorting signals, N-terminal modifications, and cleavage motifs.Q45993903
Mia40 and MINOS act in parallel with Ccs1 in the biogenesis of mitochondrial Sod1.Q46099834
Erv1 of Arabidopsis thaliana can directly oxidize mitochondrial intermembrane space proteins in the absence of redox-active Mia40.Q46177582
Structural and functional roles of the conserved cysteine residues of the redox-regulated import receptor Mia40 in the intermembrane space of mitochondriaQ46244988
ER-mitochondria tethering by PDZD8 regulates Ca2+ dynamics in mammalian neuronsQ47035955
Live-cell mapping of organelle-associated RNAs via proximity biotinylation combined with protein-RNA crosslinking.Q47104479
Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging.Q47137613
Protein Translocation into the Intermembrane Space and Matrix of Mitochondria: Mechanisms and Driving ForcesQ47138504
Structure-function insights into direct lipid transfer between membranes by Mmm1-Mdm12 of ERMES.Q47253239
Targeting and translocation of proteins to the endoplasmic reticulum at a glanceQ47287563
Crystal structures of Mmm1 and Mdm12-Mmm1 reveal mechanistic insight into phospholipid trafficking at ER-mitochondria contact sitesQ47594185
Tom70 enhances mitochondrial preprotein import efficiency by binding to internal targeting sequences.Q47802996
Vps13-Mcp1 interact at vacuole-mitochondria interfaces and bypass ER-mitochondria contact sites.Q47867992
Cryo-EM Structure of the TOM Core Complex from Neurospora crassaQ47961381
Defining the physiological role of SRP in protein-targeting efficiency and specificity.Q48216182
Membrane protein insertion through a mitochondrial β-barrel gateQ48216620
αβ'-NAC cooperates with Sam37 to mediate early stages of mitochondrial protein import.Q51176211
An Essential Role for COPI in mRNA Localization to Mitochondria and Mitochondrial Function.Q51533254
Mitochondria. Cell cycle-dependent regulation of mitochondrial preprotein translocase.Q51685479
Molecular and structural architecture of polyQ aggregates in yeast.Q51731331
Translation-coupled translocation of yeast fumarase into mitochondria in vivo.Q52580834
Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol.Q53394237
Regulation of mitochondrial protein import by cytosolic kinases.Q54621528
Convergent Evolution of Receptors for Protein Import into MitochondriaQ55113469
P433issue3
P921main subjectbioengineeringQ580689
mitochondrionQ39572
P304page(s)330-342
P577publication date2019-06-01
P1433published inThe Protein JournalQ15760422
P1476titleTransport of Proteins into Mitochondria
P478volume38

Reverse relations

cites work (P2860)
Q92593245Characterization of Factors Involved in Localized Translation Near Mitochondria by Ribosome-Proximity Labeling
Q99634809Differential Evolution of α-Glucan Water Dikinase (GWD) in Plants
Q89914662Homologue replacement in the import motor of the mitochondrial inner membrane of trypanosomes
Q100946558Quality control of the mitochondrial proteome
Q90621982Ribosome pausing, a dangerous necessity for co-translational events
Q93081208S. cerevisiae Strain Lacking Mitochondrial IF3 Shows Increased Levels of Tma19p during Adaptation to Respiratory Growth
Q90311460STAT3 and STAT5 Activation in Solid Cancers

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