NOD-like receptors: major players (and targets) in the interface between innate immunity and cancer

scientific article published on 09 April 2019

NOD-like receptors: major players (and targets) in the interface between innate immunity and cancer is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1042/BSR20181709
P932PMC publication ID6454022
P698PubMed publication ID30837326

P50authorMari C SogayarQ59068799
Ricardo G CorreaQ59555225
Valesca AnschauQ86490039
Fernando J. VellosoQ47167810
P2093author name stringMarina Trombetta-Lima
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NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signalingQ28505592
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestineQ28506198
Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injuryQ28506653
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Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxinQ28586508
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Pro-inflammatory programmed cell deathQ29300293
Autophagy is activated for cell survival after endoplasmic reticulum stressQ29614485
Epidemiology and molecular pathology of gliomaQ36577353
NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer.Q36580437
Cdx2 Expression and Intestinal Metaplasia Induced by H. pylori Infection of Gastric Cells Is Regulated by NOD1-Mediated Innate Immune Responses.Q36705808
Increased Expression of the NOD-like Receptor Family, Pyrin Domain Containing 3 Inflammasome in Dermatomyositis and Polymyositis is a Potential Contributor to Their PathogenesisQ36856554
NOD1 and NOD2 signalling links ER stress with inflammation.Q36908738
NLRC5/MHC class I transactivator is a target for immune evasion in cancerQ36957315
Nod1 Limits Colitis-Associated Tumorigenesis by Regulating IFN-γ ProductionQ36971453
Intracellular NOD-like receptors in host defense and diseaseQ36984454
The inflammasome: a danger sensing complex triggering innate immunityQ36989115
NLRP7 and related inflammasome activating pattern recognition receptors and their function in host defense and diseaseQ37042805
Nod-like proteins in inflammation and disease.Q37045747
AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC.Q37090120
Therapeutic applications of TRAIL receptor agonists in cancer and beyondQ37114025
The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis.Q37144338
Neuronal apoptosis inhibitory protein is overexpressed in patients with unfavorable prognostic factors in breast cancerQ37222549
Functions of NOD-Like Receptors in Human DiseasesQ37231612
Obesity-associated NLRC4 inflammasome activation drives breast cancer progressionQ37330542
pH-dependent internalization of muramyl peptides from early endosomes enables Nod1 and Nod2 signalingQ37358204
Telomerase reverse transcriptase promotes cancer cell proliferation by augmenting tRNA expressionQ37395716
Activation of mutant TERT promoter by RAS-ERK signaling is a key step in malignant progression of BRAF-mutant human melanomasQ37514988
NLRP1 is an inflammasome sensor for Toxoplasma gondiiQ37548192
Neuronal apoptosis inhibitory protein (NAIP) localizes to the cytokinetic machinery during cell divisionQ37563497
Influence of obesity on breast cancer receptor status and prognosisQ37577918
The impact of the immune system on tumor: angiogenesis and vascular remodelingQ37702536
NF-κB, inflammation, and metabolic disease.Q37825008
Insight into the mechanisms regulating immune homeostasis in health and disease.Q37874228
Role of NOD1/CARD4 and NOD2/CARD15 gene polymorphisms in cancer etiologyQ37899978
Cancer and inflammation: an old intuition with rapidly evolving new conceptsQ37973768
Inflammasomes in liver diseasesQ38013465
Relationship between the proteasomal system and autophagyQ38103557
Dissecting Major Signaling Pathways throughout the Development of Prostate CancerQ38112122
The complexity of NF-κB signaling in inflammation and cancerQ38126565
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NOD-like receptors: versatile cytosolic sentinels.Q38300466
Zebrafish IkappaB kinase 1 negatively regulates NF-kappaB activity.Q38323063
The pattern-recognition molecule Nod1 is localized at the plasma membrane at sites of bacterial interaction.Q52583128
Class II transactivator knockdown limits major histocompatibility complex II expression, diminishes immune rejection, and improves survival of allogeneic bone marrow stem cells in the infarcted heart.Q52867523
Skin Cancer.Q52900112
Small molecule GL-V9 protects against colitis-associated colorectal cancer by limiting NLRP3 inflammasome through autophagy.Q53179313
NOD2 Suppresses Colorectal Tumorigenesis via Downregulation of the TLR Pathways.Q53184998
NOD1 and NOD2: Molecular targets in prevention and treatment of infectious diseasesQ47365157
Expression of IAP family proteins in colon cancers from patients with different age groupsQ47617044
Neuronal apoptosis inhibitory protein, NAIP, is an inhibitor of procaspase-9.Q47838100
Inflammasome polymorphisms confer susceptibility to sporadic malignant melanomaQ47869519
Investigation of single and synergic effects of NLRC5 and PD-L1 variants on the risk of colorectal cancerQ48097366
Evaluation of Colorectal Cancer Incidence Trends in the United States (2000-2014).Q48132277
NLRC3 regulates cellular proliferation and apoptosis to attenuate the development of colorectal cancerQ48300450
LRP6 targeting suppresses gastric tumorigenesis via P14ARF-Mdm2-P53-dependent cellular senescence.Q49206184
Cancer preventive effect of recombinant TRAIL by ablation of oncogenic inflammation in colitis-associated cancer rather than anticancer effectQ49567330
Gastric cancer: epidemiology, prevention, classification, and treatmentQ49702243
MiR-22 sustains NLRP3 expression and attenuates H. pylori-induced gastric carcinogenesisQ50068790
Long-Range Chromatin Interactions Drive Mutant TERT Promoter Activation.Q51481805
Inhibition of NF-kappaB activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis.Q52188586
Tumour compartment transcriptomics demonstrates the activation of inflammatory and odontogenic programmes in human adamantinomatous craniopharyngioma and identifies the MAPK/ERK pathway as a novel therapeutic target.Q52354928
NLRP3/cryopyrin is necessary for interleukin-1beta (IL-1beta) release in response to hyaluronan, an endogenous trigger of inflammation in response to injuryQ38356203
The NLRP1 inflammasomesQ38423366
Helicobacter pylori and gastric cancer: a state of the art reviewQ38546560
ER Stress and AutophagyQ38590612
Interleukin-1-induced changes in the glioblastoma secretome suggest its role in tumor progressionQ38637324
Dietary cholesterol promotes AOM-induced colorectal cancer through activating the NLRP3 inflammasomeQ38790585
Genomic Alterations in CIITA Are Frequent in Primary Mediastinal Large B Cell Lymphoma and Are Associated with Diminished MHC Class II ExpressionQ38820967
The NF-κB family: Key players during embryonic development and HSC emergenceQ38822130
The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summaryQ38829244
Quantitative assessment of telomerase components in cancer cell linesQ38902476
The immune receptor NOD1 and kinase RIP2 interact with bacterial peptidoglycan on early endosomes to promote autophagy and inflammatory signalingQ39002980
Thymoquinone suppresses metastasis of melanoma cells by inhibition of NLRP3 inflammasomeQ39166983
Glioblastoma-associated microglia and macrophages: targets for therapies to improve prognosis.Q39196377
Cancers of the brain and CNS: global patterns and trends in incidenceQ39443492
Limiting inflammation-the negative regulation of NF-κB and the NLRP3 inflammasomeQ39443989
Global Incidence and Mortality for Prostate Cancer: Analysis of Temporal Patterns and Trends in 36 Countries.Q39601302
Immunomodulatory IL-18 binding protein is produced by prostate cancer cells and its levels in urine and serum correlate with tumor status.Q39650148
Uptake of Helicobacter pylori outer membrane vesicles by gastric epithelial cells.Q39650801
Clathrin- and dynamin-dependent endocytic pathway regulates muramyl dipeptide internalization and NOD2 activationQ39870668
Hexamethylene bisacetamide (HMBA) simultaneously targets AKT and MAPK pathway and represses NF kappaB activity: implications for cancer therapy.Q39912768
NOD1 and NOD2: Beyond Peptidoglycan Sensing.Q40077398
Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation.Q40111903
Modulation of Nod2-dependent NF-kappaB signaling by the actin cytoskeletonQ40159814
Regulation of Nod1-mediated signaling pathwaysQ40191060
SLC46 Family Transporters Facilitate Cytosolic Innate Immune Recognition of Monomeric PeptidoglycansQ40200523
Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival.Q40202994
Innate Immune ReceptorsQ40661175
Role of inflammasome genetics in susceptibility to HPV infection and cervical cancer development.Q40766665
Inflammasomes are important mediators of prostatic inflammation associated with BPH.Q40822366
Bacterial vaginosis and inflammatory response showed association with severity of cervical neoplasia in HPV-positive womenQ40880011
NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing apoptosis in metastatic melanoma.Q40961149
Severe liver degeneration in mice lacking the IkappaB kinase 2 geneQ40962152
Innate immune recognition of mtDNA--an undercover signal?Q41697263
The class II transactivator (CIITA) is regulated by post-translational modification cross-talk between ERK1/2 phosphorylation, mono-ubiquitination and Lys63 ubiquitinationQ41880378
Endosomes are specialized platforms for bacterial sensing and NOD2 signallingQ42152351
The immune system in cancer metastasis: friend or foe?Q42656251
Modulation of inflammasome activity for the treatment of auto-inflammatory disordersQ42735930
Chronic baseline prostate inflammation is associated with lower tumor volume in men with prostate cancer on repeat biopsy: Results from the REDUCE studyQ44130971
Cutting edge: CATERPILLER: a large family of mammalian genes containing CARD, pyrin, nucleotide-binding, and leucine-rich repeat domainsQ44172193
Discovery of quinazolines as a novel structural class of potent inhibitors of NF-kappa B activationQ44271884
A nucleotide binding site in caspase-9 regulates apoptosome activation.Q45988890
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defenceQ46064734
International Patterns and Trends in Endometrial Cancer Incidence, 1978-2013.Q46324858
The crossroads of breast cancer progression: insights into the modulation of major signaling pathwaysQ47167746
Tumor-infiltrating immune cells and prognosis: the potential link between conventional cancer therapy and immunityQ35588434
The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell defectsQ35716042
The Nlrp3 Inflammasome Suppresses Colorectal Cancer Metastatic Growth in the Liver by Promoting Natural Killer Cell Tumoricidal ActivityQ35780700
HPV infection and cervical neoplasia: associated risk factorsQ35914231
Chronic inflammation in cancer development.Q35928265
Characterization of tumor infiltrating natural killer cell subsetQ35955463
Nuclear DNA damage-triggered NLRP3 inflammasome activation promotes UVB-induced inflammatory responses in human keratinocytesQ36061625
A dual role for receptor-interacting protein kinase 2 (RIP2) kinase activity in nucleotide-binding oligomerization domain 2 (NOD2)-dependent autophagyQ36126998
NOD proteins: an intracellular pathogen-recognition system or signal transduction modifiers?Q36159955
Induction of neuronal apoptosis inhibitory protein expression in response to androgen deprivation in prostate cancerQ36207331
TAK1 is a central mediator of NOD2 signaling in epidermal cellsQ36528456
Expression profile of innate immune receptors, NLRs and AIM2, in human colorectal cancer: correlation with cancer stages and inflammasome componentsQ36545181
Pyroptosis: host cell death and inflammationQ29615594
NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentationQ29615617
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entryQ29615618
Activation and regulation of the inflammasomesQ29615664
The inflammasome NLRs in immunity, inflammation, and associated diseasesQ29616025
NF-kappaB: a key role in inflammatory diseasesQ29617726
Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycanQ29618544
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosisQ29619852
An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acidQ29620015
The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune responseQ29620414
Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome ActivationQ30090220
Identification of a negative regulatory cis-element in the enhancer core region of the prostate-specific antigen promoter: implications for intersection of androgen receptor and nuclear factor-kappaB signalling in prostate cancer cellsQ30312189
CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2005-2009.Q30447832
Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein responseQ33264844
Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cellsQ33510340
Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1betaQ33673719
The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling.Q33688960
Expression of interleukin-1 (IL-1) ligands system in the most common endometriosis-associated ovarian cancer subtypesQ33706144
The NOD-like receptor signalling pathway in Helicobacter pylori infection and related gastric cancer: a case-control study and gene expression analysesQ33717170
Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasomeQ33733606
CD200Fc reduces LPS-induced IL-1β activation in human cervical cancer cells by modulating TLR4-NF-κB and NLRP3 inflammasome pathwayQ33779417
Pancreatic cancer, inflammation, and microbiomeQ33956107
NALP1 in vitiligo-associated multiple autoimmune diseaseQ34003106
Characterization of NF-kappa B/I kappa B proteins in zebra fish and their involvement in notochord development.Q34346048
Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4.Q34411406
NOD-LRR proteins: role in host-microbial interactions and inflammatory diseaseQ34426050
Nod1-dependent control of tumor growthQ34478644
Colorectal Cancer Epidemiology: Incidence, Mortality, Survival, and Risk FactorsQ34624887
Transcriptional analysis of the three Nlrp1 paralogs in miceQ34626353
NOD1 and NOD2: signaling, host defense, and inflammatory diseaseQ34745603
The Nlrp3 inflammasome: contributions to intestinal homeostasisQ34762033
Primary mediastinal B-cell lymphoma and mediastinal gray zone lymphoma: do they require a unique therapeutic approach?Q34802443
Aging-related gene signature regulated by Nlrp3 predicts glioma progressionQ34991231
IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formationQ35013368
NOD2 polymorphisms associated with cancer risk: a meta-analysisQ35107083
Epithelial NAIPs protect against colonic tumorigenesisQ35161488
Modification of Helicobacter pylori Peptidoglycan Enhances NOD1 Activation and Promotes Cancer of the StomachQ35463860
NOD1 and NOD2 Genetic Variants in Association with Risk of Gastric Cancer and Its Precursors in a Chinese Population.Q35560812
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectbiophysicsQ7100
neoplasmQ1216998
intracellular signaling peptides and proteinsQ67575047
P304page(s)BSR20181709
P577publication date2019-04-09
2019-04-30
P1433published inBioscience ReportsQ2790714
P1476titleNOD-like receptors: major players (and targets) in the interface between innate immunity and cancer
P478volume39

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cites work (P2860)
Q89539247HPV-mediated down-regulation of NOD1 inhibits apoptosis in cervical cancer
Q96167094Surgical trauma-induced immunosuppression in cancer: Recent advances and the potential therapies
Q104495212Systems biology drug screening identifies statins as enhancers of current therapies in chronic lymphocytic leukemia

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