Proton pump inhibitor: The dual role in gastric cancer

Proton pump inhibitor: The dual role in gastric cancer is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.3748/WJG.V25.I17.2058
P932PMC publication ID6506576
P698PubMed publication ID31114133

P2093author name stringHoon Jai Chun
Jong-Jae Park
Moon Kyung Joo
P2860cites workLong-term proton pump inhibitor (PPI) use and the development of gastric pre-malignant lesionsQ24187480
Acid suppressive drugs and gastric cancer: a meta-analysis of observational studiesQ27025101
25 Years of Proton Pump Inhibitors: A Comprehensive ReviewQ28070003
Use of Proton Pump Inhibitors and Risks of Fundic Gland Polyps and Gastric Cancer: Systematic Review and Meta-analysisQ30250237
Murine monoclonal antibody recognizing a 90-kDa cell-surface determinant selectively lost by multi-drug-resistant variants of cem cellsQ30356063
Comparison of Endoscopic Submucosal Dissection and Surgery for Differentiated Type Early Gastric Cancer within the Expanded CriteriaQ33583974
Inhibitory roles for SHP-1 and SOCS-3 following pituitary proopiomelanocortin induction by leukemia inhibitory factorQ33901975
Calcium-sensing receptor is a physiologic multimodal chemosensor regulating gastric G-cell growth and gastrin secretionQ34140416
STAT-3 correlates with lymph node metastasis and cell survival in gastric cancerQ34306802
Feedback activation of STAT3 mediates trastuzumab resistance via upregulation of MUC1 and MUC4 expressionQ34483555
The Risks and Benefits of Long-term Use of Proton Pump Inhibitors: Expert Review and Best Practice Advice From the American Gastroenterological AssociationQ34552620
Atrophic gastritis and Helicobacter pylori infection in patients with reflux esophagitis treated with omeprazole or fundoplicationQ34732772
The function of the protein tyrosine phosphatase SHP-1 in cancerQ35092309
Acquisition of resistance to trastuzumab in gastric cancer cells is associated with activation of IL-6/STAT3/Jagged-1/Notch positive feedback loopQ35741610
The IL-6-STAT3 axis mediates a reciprocal crosstalk between cancer-derived mesenchymal stem cells and neutrophils to synergistically prompt gastric cancer progressionQ36179636
Phase I Study of OPB-31121, an Oral STAT3 Inhibitor, in Patients with Advanced Solid TumorsQ36187003
Proton pump inhibitors and risk of gastric cancer: a population-based cohort studyQ37222668
Safety of Proton Pump Inhibitor ExposureQ37781495
Revisiting STAT3 signalling in cancer: new and unexpected biological functionsQ38262473
The fight against gastric cancer - the IARC Working Group reportQ38273500
Gastrin May Mediate the Carcinogenic Effect of Helicobacter pylori Infection of the StomachQ38283947
Phase I and biomarker study of OPB-51602, a novel signal transducer and activator of transcription (STAT) 3 inhibitor, in patients with refractory solid malignancies.Q38417469
Role of proton pump inhibitors in preventing hypergastrinemia-associated carcinogenesis and in antagonizing the trophic effect of gastrinQ38436701
Systematic review: the effects of long-term proton pump inhibitor use on serum gastrin levels and gastric histology.Q38547653
TNF-α-inducing protein of Helicobacter pylori induces epithelial-mesenchymal transition (EMT) in gastric cancer cells through activation of IL-6/STAT3 signaling pathwayQ38719059
Proton Pump Inhibitors Display Antitumor Effects in Barrett's Adenocarcinoma CellsQ38727019
Epigenetic regulation and anti-tumorigenic effects of SH2-containing protein tyrosine phosphatase 1 (SHP1) in human gastric cancer cellsQ38824324
Serum gastrin and cholecystokinin are associated with subsequent development of gastric cancer in a prospective cohort of Finnish smokersQ38860212
Signal transducers and activators of transcription 3-induced metastatic potential in gastric cancer cells is enhanced by glycogen synthase kinase-3β.Q38890455
Proton pump inhibitor pantoprazole abrogates adriamycin-resistant gastric cancer cell invasiveness via suppression of Akt/GSK-β/β-catenin signaling and epithelial-mesenchymal transitionQ38934990
STAT3 mediates regorafenib-induced apoptosis in hepatocellular carcinoma.Q38953983
The PAS positive material in gastric cancer cells of signet ring type is not mucinQ39019033
Proton pump inhibitor selectively suppresses proliferation and restores the chemosensitivity of gastric cancer cells by inhibiting STAT3 signaling pathwayQ39105830
STAT3 is associated with lymph node metastasis in gastric cancerQ39130872
Effect of pantoprazole on human gastric adenocarcinoma SGC7901 cells through regulation of phospho‑LRP6 expression in Wnt/β-catenin signalingQ39141497
OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cellsQ39195889
Dovitinib induces apoptosis and overcomes sorafenib resistance in hepatocellular carcinoma through SHP-1-mediated inhibition of STAT3.Q39425929
Inhibition of activated Stat3 reverses drug resistance to chemotherapeutic agents in gastric cancer cellsQ39439324
Sorafenib overcomes TRAIL resistance of hepatocellular carcinoma cells through the inhibition of STAT3.Q39649432
pH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidityQ39781678
Effects and mechanisms of proton pump inhibitors as a novel chemosensitizer on human gastric adenocarcinoma (SGC7901) cellsQ39841916
PAI-1 deficiency increases the trophic effects of hypergastrinemia in the gastric corpus mucosa.Q39869088
Gastrectomy plus chemotherapy versus chemotherapy alone for advanced gastric cancer with a single non-curable factor (REGATTA): a phase 3, randomised controlled trialQ40046733
Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphomaQ40258085
Activated proliferation of B-cell lymphomas/leukemias with the SHP1 gene silencing by aberrant CpG methylationQ40604741
Regulation of CD44v6 expression in gastric carcinoma by the IL-6/STAT3 signaling pathway and its clinical significanceQ41233768
Tumor microenvironment interruption: a novel anti-cancer mechanism of Proton-pump inhibitor in gastric cancer by suppressing the release of microRNA-carrying exosomesQ41769227
Targeted molecular ablation of cancer stem cells for curing gastrointestinal cancers.Q41912339
Proton-pump inhibitors: understanding the complications and risksQ41996131
Gastric acid suppression and risk of oesophageal and gastric adenocarcinoma: a nested case control study in the UKQ42836024
Effects of 6-12 months of esomeprazole treatment on the gastric mucosaQ44485391
Selective induction of apoptosis with proton pump inhibitor in gastric cancer cellsQ45205129
Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use.Q46270157
Association between use of acid-suppressive drugs and risk of gastric cancer. A nested case-control studyQ46476447
Proton pump inhibitors may reduce tumour resistanceQ46548498
Helicobacter pylori infection and development of gastric cancer in Korea: long-term follow-upQ46698299
Changes of gastric mucosal architecture during long-term omeprazole therapy: results of a randomized clinical trialQ46946129
Maintenance therapy with proton pump inhibitors and risk of gastric cancer: a nationwide population-based cohort study in SwedenQ47095023
Neuroendocrine differentiation in human gastric carcinomaQ47741319
High salt diets dose-dependently promote gastric chemical carcinogenesis in Helicobacter pylori-infected Mongolian gerbils associated with a shift in mucin production from glandular to surface mucous cellsQ48090212
Proton-pump inhibitors and increased gastric cancer risk: time-related biases.Q48314505
Helicobacter pylori eradication failure may have confounded the recent large-scale health database study that showed proton pump inhibitors increase gastric cancer riskQ49790378
Risk factors for gastric cancer: is it time to discard PPIs?Q50053998
Targeting BMI1+ Cancer Stem Cells Overcomes Chemoresistance and Inhibits Metastases in Squamous Cell Carcinoma.Q50962433
Bidirectional regulation between TMEFF2 and STAT3 may contribute to Helicobacter pylori-associated gastric carcinogenesis.Q53234855
STAT3 activation regulates growth, inflammation, and vascularization in a mouse model of gastric tumorigenesis.Q53594652
Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study.Q54325125
Helicobacter pyloriInfectionQ56157319
S1PR1 predicts patient survival and promotes chemotherapy drug resistance in gastric cancer cells through STAT3 constitutive activationQ57477986
Effects of proton pump inhibitors on reversing multidrug resistance via downregulating V-ATPases/PI3K/Akt/mTOR/HIF-1α signaling pathway through TSC1/2 complex and Rheb in human gastric adenocarcinoma cells in vitro and in vivoQ57816333
Inhibition of STAT3 in gastric cancer: role of pantoprazole as SHP-1 inducerQ58761778
A comparison of five maintenance therapies for reflux esophagitisQ71758935
Heterogeneity of intracellular pH and of mechanisms that regulate intracellular pH in populations of cultured cellsQ74530718
Lack of effect of acid suppression therapy on gastric atrophy. Nordic Gerd Study GroupQ78039842
Signet ring cells in gastric carcinomas are derived from neuroendocrine cellsQ81606632
Targeting STAT3 in cancer: how successful are we?Q82824786
STAT3 expression in gastric cancer indicates a poor prognosisQ83254865
TMEFF2 deregulation contributes to gastric carcinogenesis and indicates poor survival outcomeQ88202058
Proton pump inhibitors (PPIs) may cause gastric cancer - clinical consequencesQ88935714
P275copyright licenseCreative Commons Attribution-NonCommercial 4.0 InternationalQ34179348
P433issue17
P407language of work or nameEnglishQ1860
P921main subjectgastroenterologyQ120569
drug resistanceQ12147416
antineoplastic resistanceQ13416904
proton-pump inhibitorQ421704
stomach neoplasmQ4335552
Helicobacter infectionQ65666252
P304page(s)2058-2070
P577publication date2019-05-07
P1433published inWorld Journal of GastroenterologyQ15708885
P1476titleProton pump inhibitor: The dual role in gastric cancer
P478volume25

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