HER2 and p95HER2 differentially regulate miRNA expression in MCF-7 breast cancer cells and downregulate MYB proteins through miR-221/222 and miR-503

scientific article published on 04 March 2019

HER2 and p95HER2 differentially regulate miRNA expression in MCF-7 breast cancer cells and downregulate MYB proteins through miR-221/222 and miR-503 is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/S41598-019-39733-X
P932PMC publication ID6399295
P698PubMed publication ID30833639

P50authorHelena PerssonQ55298352
Thomas LitmanQ56568931
Beatriz MoranchoQ57324555
Joaquin ArribasQ80171901
Stine PedersenQ38323001
P2093author name stringRolf Søkilde
Carlos Rovira
Andrej Gorbatenko
Ester E Sorensen
Inga Newie
P2860cites workConstitutively active ErbB2 regulates cisplatin-induced cell death in breast cancer cells via pro- and antiapoptotic mechanisms.Q50639844
Oncogenic p95HER2 regulates Na+-HCO3- cotransporter NBCn1 mRNA stability in breast cancer cells via 3'UTR-dependent processes.Q51526662
MicroRNA-503 promotes tumor progression and acts as a novel biomarker for prognosis in oesophageal cancer.Q54171415
Truncated ErbB2 receptor enhances ErbB1 signaling and induces reversible, ERK-independent loss of epithelial morphologyQ56825025
MYB oncogene amplification in hereditary BRCA1 breast cancerQ73083781
MicroRNA signatures predict oestrogen receptor, progesterone receptor and HER2/neu receptor status in breast cancerQ21195215
Comprehensive molecular portraits of human breast tumoursQ24630844
MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancerQ24645663
miR-221 overexpression contributes to liver tumorigenesisQ24646374
MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1Q24648241
The miR-200 and miR-221/222 microRNA families: opposing effects on epithelial identityQ27010233
MicroRNA biogenesis pathways in cancerQ27013841
Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogeneQ27860693
MicroRNA signatures in human cancersQ27860962
MicroRNA cluster 221-222 and estrogen receptor alpha interactions in breast cancerQ28114800
The myb gene family in cell growth, differentiation and apoptosisQ28137891
The conserved DNA binding domain mediates similar regulatory interactions for A-Myb, B-Myb, and c-Myb transcription factorsQ28205623
Tamoxifen functions as a molecular agonist inducing cell cycle-associated genes in breast cancer cellsQ28213093
Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion.Q28215016
Treatment of HCV infection by targeting microRNAQ29547712
Comparative genomic hybridization analysis of 38 breast cancer cell lines: a basis for interpreting complementary DNA microarray data.Q33180996
ISMARA: automated modeling of genomic signals as a democracy of regulatory motifsQ33564556
microRNA expression profiling identifies a four microRNA signature as a novel diagnostic and prognostic biomarker in triple negative breast cancersQ33576814
The miR-424(322)/503 cluster orchestrates remodeling of the epithelium in the involuting mammary gland.Q33588077
Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1Q34342166
B-Myb, cancer, senescence, and microRNAsQ35164933
Systemic miRNA-195 differentiates breast cancer from other malignancies and is a potential biomarker for detecting noninvasive and early stage diseaseQ35584190
Cell cycle regulation by the B-Myb transcription factor.Q35587968
Netrin-4 as a biomarker promotes cell proliferation and invasion in gastric cancer.Q35833147
Mechanism of and requirement for estrogen-regulated MYB expression in estrogen-receptor-positive breast cancer cellsQ35963023
Myb proteins: angels and demons in normal and transformed cellsQ36603616
HER2 and ESR1 mRNA expression levels and response to neoadjuvant trastuzumab plus chemotherapy in patients with primary breast cancerQ36903047
MYB function in normal and cancer cellsQ37198576
A naturally occurring HER2 carboxy-terminal fragment promotes mammary tumor growth and metastasisQ37233360
MiR-221/-222 differentiate prognostic groups in advanced breast cancers and influence cell invasion.Q37323030
p95HER2 and breast cancerQ37846003
Recurrent Fusions in MYB and MYBL1 Define a Common, Transcription Factor-Driven Oncogenic Pathway in Salivary Gland Adenoid Cystic Carcinoma.Q38275143
In vitro and in vivo analysis of B-Myb in basal-like breast cancerQ38358546
Distinct changes in gene expression induced by A-Myb, B-Myb and c-Myb proteinsQ38358724
miRNA-503 Promotes Tumor Progression and Is Associated with Early Recurrence and Poor Prognosis in Human Colorectal CancerQ38784427
MicroRNA-503 represses epithelial-mesenchymal transition and inhibits metastasis of osteosarcoma by targeting c-mybQ38803579
MiR-221/222 promote human glioma cell invasion and angiogenesis by targeting TIMP2.Q38904607
ErbB2 upregulates the Na+,HCO3(-)-cotransporter NBCn1/SLC4A7 in human breast cancer cells via Akt, ERK, Src, and Kruppel-like factor 4.Q39088649
Constitutive HER2 signaling promotes breast cancer metastasis through cellular senescence.Q39216531
A major role of p95/611-CTF, a carboxy-terminal fragment of HER2, in the down-modulation of the estrogen receptor in HER2-positive breast cancersQ39639513
Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer.Q40144433
Myb protein specificity: evidence of a context-specific transcription factor code.Q40634908
Expression of A-myb, but not c-myb and B-myb, is restricted to Burkitt's lymphoma, sIg+ B-acute lymphoblastic leukemia, and a subset of chronic lymphocytic leukemias.Q41223715
NH2-terminally truncated HER-2/neu protein: relationship with shedding of the extracellular domain and with prognostic factors in breast cancerQ41925146
A novel MAPK-microRNA signature is predictive of hormone-therapy resistance and poor outcome in ER-positive breast cancer.Q42468088
Linking Myb to the cell cycle: cyclin-dependent phosphorylation and regulation of A-Myb activityQ42796307
B-myb rescues ras-induced premature senescence, which requires its transactivation domainQ42826690
Strong association between c-myb and oestrogen-receptor expression in human breast cancer.Q43954768
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that useslimmaQ112236343
edgeRQ113334690
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)3352
P577publication date2019-03-04
P1433published inScientific ReportsQ2261792
P1476titleHER2 and p95HER2 differentially regulate miRNA expression in MCF-7 breast cancer cells and downregulate MYB proteins through miR-221/222 and miR-503
P478volume9

Reverse relations

Q92591538Role of miR-221/222 in Tumor Development and the Underlying Mechanismcites workP2860

Search more.