Cx32 exerts anti-apoptotic and pro-tumor effects via the epidermal growth factor receptor pathway in hepatocellular carcinoma

Cx32 exerts anti-apoptotic and pro-tumor effects via the epidermal growth factor receptor pathway in hepatocellular carcinoma is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1113184522
P356DOI10.1186/S13046-019-1142-Y
P932PMC publication ID6449973
P698PubMed publication ID30947731

P2093author name stringQin Wang
Liang Tao
Xiyan Wang
Hui Ge
Yunquan Guo
Yuke Xiang
Yile Fu
P2860cites workGap junction gene and protein families: Connexins, innexins, and pannexins.Q50970758
Gap junction as an intercellular glue: Emerging roles in cancer EMT and metastasis.Q51216580
Cytoplasmic accumulation of connexin32 protein enhances motility and metastatic ability of human hepatoma cells in vitro and in vivo.Q53335533
2-aminoethoxydiphenyl borate directly inhibits channels composed of connexin26 and/or connexin32.Q53589060
Aberrant expression of connexin 26 is associated with lung metastasis of colorectal cancer.Q54548291
Implications and challenges of connexin connections to cancer.Q55052930
Renal Cell Carcinoma Is Abrogated by p53 Stabilization through Transglutaminase 2 InhibitionQ59794754
Modifications in connexin expression in liver development and cancerQ38040852
Recent progress in understanding, diagnosing, and treating hepatocellular carcinomaQ38052472
Connexin a check-point component of cell apoptosis in normal and physiopathological conditionsQ38168634
The cytoplasmic translocation of Cx32 mediates cisplatin resistance in ovarian cancer cellsQ38707550
Gap junction structure: unraveled, but not fully revealedQ39321400
Gap junctions propagate opposite effects in normal and tumor testicular cells in response to cisplatin.Q39437541
Cytoplasmic accumulation of connexin32 expands cancer stem cell population in human HuH7 hepatoma cells by enhancing its self-renewal.Q39731225
Aberrant expression and localization of connexin43 and connexin30 in a rat glioma cell line.Q40040155
Connexin32‑mediated antitumor effects of suicide gene therapy against hepatocellular carcinoma: In vitro and in vivo anticancer activityQ40875956
Non-junctional Cx32 mediates anti-apoptotic and pro-tumor effects via epidermal growth factor receptor in human cervical cancer cells.Q41082556
c-Src phosphorylates epidermal growth factor receptor on tyrosine 845.Q41281287
Connexin43 reverses the phenotype of transformed cells and alters their expression of cyclin/cyclin-dependent kinasesQ41339821
Exogenous Cx43 expression decrease cell proliferation rate in rat hepatocarcinoma cells independently of functional gap junctionQ41958034
Delayed liver regeneration and increased susceptibility to chemical hepatocarcinogenesis in transgenic mice expressing a dominant-negative mutant of connexin32 only in the liverQ44701266
Both early and late stages of hepatocarcinogenesis are enhanced in Cx32 dominant negative mutant transgenic rats with disrupted gap junctional intercellular communicationQ46917709
EGFR family and Src family kinase interactions: mechanics matters?Q47208117
Cx32 suppresses extrinsic apoptosis in human cervical cancer cells via the NF‑κB signalling pathwayQ47810107
Src phosphorylation of the epidermal growth factor receptor at novel sites mediates receptor interaction with Src and P85 alphaQ24328857
EGFR Signaling in Liver DiseasesQ26771265
Hepatocellular carcinomaQ29616359
Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitorsQ30009231
The gap junction protein connexin32 interacts with the Src homology 3/hook domain of discs large homolog 1.Q30159462
c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor functionQ30303639
Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src: implications for the etiology of multiple human cancersQ30453944
Lack of phenobarbital-mediated promotion of hepatocarcinogenesis in connexin32-null mice.Q31443692
The role of connexin43-Src interaction in astrocytomas: A molecular puzzleQ33360119
Connexin-43 can delay early recurrence and metastasis in patients with hepatitis B-related hepatocellular carcinoma and low serum alpha-fetoprotein after radical hepatectomyQ34783772
Connexin 26 correlates with Bcl-xL and Bax proteins expression in colorectal cancerQ35010472
Role of connexin32 and beta-catenin in tumor promotion in mouse liverQ35070532
Connexin32 regulates hepatoma cell metastasis and proliferation via the p53 and Akt pathwaysQ35832932
Different gap junction-propagated effects on cisplatin transfer result in opposite responses to cisplatin in normal cells versus tumor cellsQ35895396
Molecular mechanisms regulating formation, trafficking and processing of annular gap junctionsQ36031604
Gap junctions and the propagation of cell survival and cell death signalsQ36134877
Pathological significance of intracytoplasmic connexin proteins: implication in tumor progressionQ36893654
Connexin-related signaling in cell death: to live or let die?Q37386613
Gap junctions and cancer: communicating for 50 yearsQ37613777
Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer.Q37676070
Connexins: mechanisms regulating protein levels and intercellular communicationQ37707115
Gap junctions and connexins as therapeutic targets in cancerQ37743527
Non-channel functions of connexins in cell growth and cell deathQ37896241
Molecular connexin partner remodeling orchestrates connexin traffic: from physiology to pathophysiology.Q38007019
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageQuantQ112270642
P433issue1
P407language of work or nameEnglishQ1860
P921main subjecthepatocellular carcinomaQ1148337
apoptotic processQ14599311
P304page(s)145
P577publication date2019-04-04
P1433published inJournal of Experimental & Clinical Cancer ResearchQ13739415
P1476titleCx32 exerts anti-apoptotic and pro-tumor effects via the epidermal growth factor receptor pathway in hepatocellular carcinoma
P478volume38

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Q97070246GJA1-20k attenuates Ang II-induced pathological cardiac hypertrophy by regulating gap junction formation and mitochondrial functioncites workP2860

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