Hypergravity and microgravity exhibited reversal effects on the bone and muscle mass in mice

scientific article published on 29 April 2019

Hypergravity and microgravity exhibited reversal effects on the bone and muscle mass in mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-019-42829-Z
P932PMC publication ID6488638
P698PubMed publication ID31036903

P50authorYoshifumi ItohQ58809398
Tsukasa TominariQ83273178
P2093author name stringKenta Watanabe
Masaki Shirakawa
Chisato Miyaura
Masaki Inada
Michiko Hirata
Dai Shiba
Chiho Matsumoto
Ryota Ichimaru
Akane Yumoto
Keita Taniguchi
P2860cites workEffects of Hypergravity on Osteopontin Expression in OsteoblastsQ35654181
Feasibility of a Short-Arm Centrifuge for Mouse Hypergravity ExperimentsQ35722183
Ground-based assessment of JAXA mouse habitat cage unit by mouse phenotypic studies.Q36918317
Hypergravity upregulates renal inducible nitric oxide synthase expression and nitric oxide productionQ37327441
Molecular mechanisms in coupling of bone formation to resorption.Q37385000
Weight, muscle and bone loss during space flight: another perspectiveQ38063407
Molecular mechanisms of skeletal muscle development, regeneration, and osteogenic conversionQ38603476
Hindlimb unloading: rodent analog for microgravityQ38730738
Adaptation to microgravity, deconditioning, and countermeasures.Q39045178
Cessation of cyclic stretch induces atrophy of C2C12 myotubesQ39173674
Hypergravity effects on myoblast proliferation and differentiationQ39447805
Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways.Q40767544
Development of new experimental platform 'MARS'-Multiple Artificial-gravity Research System-to elucidate the impacts of micro/partial gravity on mice.Q41542605
Effects of hypergravity on proliferation and differentiation of osteoblast-like cellsQ41678156
Effect of hyper- and microgravity on collagen post-translational controls of MC3T3-E1 osteoblastsQ42796088
Hypergravity-induced enrichment of β1 integrin on the cell membranes of osteoblast-like cells via caveolae-dependent endocytosisQ42826333
Nck1 deficiency accelerates unloading-induced bone lossQ42827332
Integrin αvβ3 mediates the synergetic regulation of core-binding factor α1 transcriptional activity by gravity and insulin-like growth factor-1 through phosphoinositide 3-kinase signalingQ42835059
Hypergravity stimulates osteoblast phenotype expression: a therapeutic hint for disuse bone atrophyQ45230763
Influence of increased mechanical loading by hypergravity on the microtubule cytoskeleton and prostaglandin E2 release in primary osteoblastsQ45281009
Downstream of Akt: FoxO3 and mTOR in the regulation of autophagy in skeletal muscleQ46681308
Time-course study of macrophage infiltration and inflammation in cast immobilization-induced atrophied muscle of miceQ47189922
Impact of a simulated gravity load for atmospheric reentry, 10 g for 2 min, on conscious mice.Q47440601
Effects of hypergravity on gene levels in anti-gravity muscle and bone through the vestibular system in mice.Q48106493
Hypergravity stimulates collagen synthesis in human osteoblast-like cells: evidence for the involvement of p44/42 MAP-kinases (ERK 1/2)Q73032093
Hypergravity effects on osteoclasts activityQ73275374
Stimulative effect of high-level hypergravity on differentiated functions of osteoblast-like cellsQ77689200
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesJAXA Mouse Habitat UnitQ114813211
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectmicrogravityQ48655
P304page(s)6614
P577publication date2019-04-29
P1433published inScientific ReportsQ2261792
P1476titleHypergravity and microgravity exhibited reversal effects on the bone and muscle mass in mice
P478volume9

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cites work (P2860)
Q92288040Impact of spaceflight on the murine thymus and mitigation by exposure to artificial gravity during spaceflight
Q99234049Nrf2 contributes to the weight gain of mice during space travel
Q90471684Skeletal adaptations in young male mice after 4 weeks aboard the International Space Station
Q92460482The effects of spaceflight and fracture healing on distant skeletal sites
Q90309870Understanding vestibular-related physiological functions could provide clues on adapting to a new gravitational environment
Q89664938Validation of a New Rodent Experimental System to Investigate Consequences of Long Duration Space Habitation

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