The inflammation-reducing compatible solute ectoine does not impair the cytotoxic effect of ionizing radiation on head and neck cancer cells

scientific article published on 29 April 2019

The inflammation-reducing compatible solute ectoine does not impair the cytotoxic effect of ionizing radiation on head and neck cancer cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-019-43040-W
P932PMC publication ID6488604
P698PubMed publication ID31036876

P50authorKai RothkammQ39034555
P2093author name stringThorsten Rieckmann
Adrian Münscher
Sabrina Christiansen
Fruzsina Gatzemeier
P2860cites workRadiation-Induced Oral MucositisQ33711362
Treatment of allergic rhinitis with ectoine containing nasal spray and eye drops in comparison with azelastine containing nasal spray and eye drops or with cromoglycic Acid containing nasal sprayQ33759064
DNA double-strand breaks induced by high NaCl occur predominantly in gene desertsQ35651286
A biological approach to mucositisQ35871694
Recovery of neutrophil apoptosis by ectoine: a new strategy against lung inflammation.Q54475068
Lack of correlation of desiccation and radiation tolerance in microorganisms from diverse extreme environments tested under anoxic conditions.Q55285388
Role of the Extremolytes Ectoine and Hydroxyectoine as Stress Protectants and Nutrients: Genetics, Phylogenomics, Biochemistry, and Structural Analysis.Q55411691
Properties of compatible solutes in aqueous solutionQ82118342
Osmolyte effects: impact on the aqueous solution around charged and neutral spheresQ86979326
Effectiveness, Tolerability, and Safety of Ectoine-Containing Mouthwash Versus Those of a Calcium Phosphate Mouthwash for the Treatment of Chemotherapy-Induced Oral Mucositis: A Prospective, Active-Controlled, Non-interventional StudyQ97675003
Supportive Management of Mucositis and Metabolic Derangements in Head and Neck Cancer PatientsQ36102873
Repopulation of cancer cells during therapy: an important cause of treatment failureQ36167592
Efficacy and tolerability of an ectoine mouth and throat spray compared with those of saline lozenges in the treatment of acute pharyngitis and/or laryngitis: a prospective, controlled, observational clinical trialQ37153374
The multifunctional role of ectoine as a natural cell protectantQ37240204
Reduction of neutrophilic lung inflammation by inhalation of the compatible solute ectoine: a randomized trial with elderly individualsQ37361474
Prevention and treatment of oral mucositis in patients receiving chemotherapyQ37605224
Influence of the Compatible Solute Ectoine on the Local Water Structure: Implications for the Binding of the Protein G5P to DNA.Q38295380
Effect of tetrahydropyrimidine derivatives on protein-nucleic acids interaction. Type II restriction endonucleases as a model systemQ38327472
DNA damage foci: Meaning and significance.Q38379038
p16INK4a impairs homologous recombination-mediated DNA repair in human papillomavirus-positive head and neck tumors.Q39029551
Tissue reactions to ionizing radiation-Oral mucosaQ39029695
HPV-positive HNSCC cell lines but not primary human fibroblasts are radiosensitized by the inhibition of Chk1.Q39112878
HNSCC cell lines positive for HPV and p16 possess higher cellular radiosensitivity due to an impaired DSB repair capacityQ39163509
Neutrons describe ectoine effects on water H-bonding and hydration around a soluble protein and a cell membraneQ39488264
Compatible Solutes and Extreme Water Stress in Eukaryotic Micro-OrganismsQ39735054
Ectoine can enhance structural changes in DNA in vitro.Q41242718
Ectoine from halophilic microorganisms induces the expression of hsp70 and hsp70B' in human keratinocytes modulating the proinflammatory responseQ42484513
Influence of osmotic stress on desiccation and irradiation tolerance of (hyper)-thermophilic microorganisms.Q43028074
Ectoine protects DNA from damage by ionizing radiation.Q45357186
Ectoine-containing cream in the treatment of mild to moderate atopic dermatitis: a randomised, comparator-controlled, intra-individual double-blind, multi-center trialQ45357875
DNA protection by ectoine from ionizing radiation: molecular mechanisms.Q47885565
Phase 1b/2a Trial of the Superoxide Dismutase Mimetic GC4419 to Reduce Chemoradiotherapy-Induced Oral Mucositis in Patients With Oral Cavity or Oropharyngeal Carcinoma.Q49647576
Phase II investigational oral drugs for the treatment of radio/chemotherapy induced oral mucositisQ50092092
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjecthead and neck cancerQ1783924
head and neck carcinomaQ18554836
neck cancerQ18966654
P304page(s)6594
P577publication date2019-04-29
P1433published inScientific ReportsQ2261792
P1476titleThe inflammation-reducing compatible solute ectoine does not impair the cytotoxic effect of ionizing radiation on head and neck cancer cells
P478volume9