Targeting the functional interplay between endoplasmic reticulum oxidoreductin-1α and protein disulfide isomerase suppresses the progression of cervical cancer

scientific article published on 27 February 2019

Targeting the functional interplay between endoplasmic reticulum oxidoreductin-1α and protein disulfide isomerase suppresses the progression of cervical cancer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.EBIOM.2019.02.041
P932PMC publication ID6443025
P698PubMed publication ID30826359

P50authorXun WuQ86760994
P2093author name stringBin Lu
Tao Li
Lei Wang
Xi Wang
Xi'e Wang
Ya Cui
Lihui Zhang
Guizhi Shi
Taotao Wei
Yini Zhang
Chih-Chen Wang
Fugen Shangguan
Yongzhang Liu
P2860cites workERO1-L, a human protein that favors disulfide bond formation in the endoplasmic reticulumQ22253168
Manipulation of oxidative protein folding and PDI redox state in mammalian cellsQ24291898
Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cellsQ24299399
The human protein disulphide isomerase family: substrate interactions and functional propertiesQ24537186
Crystal structures of human Ero1α reveal the mechanisms of regulated and targeted oxidation of PDIQ27664438
Structural insights into the redox-regulated dynamic conformations of human protein disulfide isomeraseQ27679419
The unfolded protein response regulator GRP78 is a novel predictive biomarker in colorectal cancer.Q27852108
Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic diseaseQ28278638
The cellular oxygen tension regulates expression of the endoplasmic oxidoreductase ERO1‐LαQ28571513
Oxidized redox state of glutathione in the endoplasmic reticulumQ29619789
Cancer-associated oxidoreductase ERO1-α promotes immune escape through up-regulation of PD-L1 in human breast cancerQ33648621
A small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1) with selectively reversible thiol reactivityQ33966806
Peroxiredoxin 4: a multifunctional biomarker worthy of further exploration.Q34111306
Different interaction modes for protein-disulfide isomerase (PDI) as an efficient regulator and a specific substrate of endoplasmic reticulum oxidoreductin-1α (Ero1α).Q34467548
Protein disulfide isomerase: a critical evaluation of its function in disulfide bond formationQ34608269
Ero1-α and PDIs constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductasesQ34991338
Molecular mechanisms of N-acetylcysteine actionsQ35076338
ERO1-independent production of H2O2 within the endoplasmic reticulum fuels Prdx4-mediated oxidative protein foldingQ36210737
Hyperactivity of the Ero1α oxidase elicits endoplasmic reticulum stress but no broad antioxidant responseQ36408006
The endoplasmic reticulum stress marker CHOP predicts survival in malignant mesothelioma.Q36747341
Cancer-associated oxidoreductase ERO1-α drives the production of VEGF via oxidative protein folding and regulating the mRNA levelQ36964306
Ero1 and redox homeostasis in the endoplasmic reticulum.Q37055746
Hyperglycemia Promotes the Epithelial-Mesenchymal Transition of Pancreatic Cancer via Hydrogen PeroxideQ37084377
Intracellular glutathione pools are heterogeneously concentrated.Q37313912
Glutathione peroxidase 7 utilizes hydrogen peroxide generated by Ero1α to promote oxidative protein foldingQ37512947
PDIA6 promotes the proliferation of HeLa cells through activating the Wnt/β-catenin signaling pathwayQ37619742
Multiple ways to make disulfidesQ37903530
Peroxides and peroxidases in the endoplasmic reticulum: integrating redox homeostasis and oxidative foldingQ37965271
Protein disulfide isomerase: a promising target for cancer therapyQ38159179
Protein disulfide-isomerase, a folding catalyst and a redox-regulated chaperoneQ38362128
Hypoxia-inducible ERO1α promotes cancer progression through modulation of integrin-β1 modification and signalling in HCT116 colorectal cancer cellsQ38694229
Cancer-Associated Oxidase ERO1-α Regulates the Expression of MHC Class I Molecule via Oxidative FoldingQ38887670
Cancer-associated oxidoreductase ERO1-α drives the production of tumor-promoting myeloid-derived suppressor cells via oxidative protein folding.Q38919201
Role of the unfolded protein response in tumor cell characteristics and cancer outcomeQ39009190
Endoplasmic reticulum proteostasis: a key checkpoint in cancerQ39011260
Human endoplasmic reticulum oxidoreductin 1-α is a novel predictor for poor prognosis of breast cancerQ39167888
Expression of the endoplasmic reticulum oxidoreductase Ero1α in gastro-intestinal cancer reveals a link between homocysteine and oxidative protein foldingQ39200939
Endoplasmic reticulum protein ERp46 in prostate adenocarcinomaQ41811207
Molecular bases of cyclic and specific disulfide interchange between human ERO1alpha protein and protein-disulfide isomerase (PDI).Q41911143
Emerging roles of protein disulfide isomerase in cancer.Q42357758
Activation of NADPH oxidase subunit NCF4 induces ROS-mediated EMT signaling in HeLa cellsQ45272003
Reconstitution of human Ero1-Lalpha/protein-disulfide isomerase oxidative folding pathway in vitro. Position-dependent differences in role between the a and a' domains of protein-disulfide isomeraseQ46253049
C/EBP homologous protein (CHOP) contributes to hepatocyte death via the promotion of ERO1α signalling in acute liver failureQ46815639
GPx8 peroxidase prevents leakage of H2O2 from the endoplasmic reticulumQ46927941
Cancer statistics, 2018.Q47191906
EMT in cancerQ47736873
Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1α.Q54977350
Redox State of the Endoplasmic Reticulum Is Controlled by Ero1L-alpha and Intraluminal CalciumQ58424661
Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7Q58880687
The endoplasmic reticulum sulfhydryl oxidase Ero1β drives efficient oxidative protein folding with loose regulationQ82523748
Genetically encoded fluorescent indicator for intracellular hydrogen peroxideQ82918322
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P921main subjectcervix uterine cancerQ160105
endoplasmic reticulumQ79927
P304page(s)408-419
P577publication date2019-02-27
P1433published inEBioMedicineQ24912341
P1476titleTargeting the functional interplay between endoplasmic reticulum oxidoreductin-1α and protein disulfide isomerase suppresses the progression of cervical cancer
P478volume41

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cites work (P2860)
Q98159130Endoplasmic Reticulum stress-dependent expression of ERO1L promotes aerobic glycolysis in Pancreatic Cancer
Q92604176Expression of endoplasmic reticulum oxidoreductase 1-α in cholangiocarcinoma tissues and its effects on the proliferation and migration of cholangiocarcinoma cells
Q92997590ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells
Q90575718Role of the ERO1-PDI interaction in oxidative protein folding and disease
Q64903345Targeting ER stress/ER stress response in myopathies.