The Interactome of Palmitoyl-Protein Thioesterase 1 (PPT1) Affects Neuronal Morphology and Function

The Interactome of Palmitoyl-Protein Thioesterase 1 (PPT1) Affects Neuronal Morphology and Function is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3389/FNCEL.2019.00092
P932PMC publication ID6424868
P698PubMed publication ID30918483

P50authorMenahem SegalQ62560446
P2093author name stringPeter James
Orly Reiner
Tamar Sapir
Gayane Grigoryan
Michal Segal
Karin M Hansson
P2860cites workNeuronal ceroid lipofuscinosesQ60672673
Expression of palmitoyl protein thioesterase in neuronsQ64380898
Glycosylation, transport, and complex formation of palmitoyl protein thioesterase 1 (PPT1)--distinct characteristics in neuronsQ21284156
Palmitoyl protein thioesterase 1 protects against apoptosis mediated by Ras-Akt-caspase pathway in neuroblastoma cellsQ22253392
Palmitoyl protein thioesterase (PPT) localizes into synaptosomes and synaptic vesicles in neurons: implications for infantile neuronal ceroid lipofuscinosis (INCL)Q24290684
Lipid thioesters derived from acylated proteins accumulate in infantile neuronal ceroid lipofuscinosis: correction of the defect in lymphoblasts by recombinant palmitoyl-protein thioesteraseQ24308145
Human palmitoyl protein thioesterase: evidence for lysosomal targeting of the enzyme and disturbed cellular routing in infantile neuronal ceroid lipofuscinosisQ24316922
Ndel1 palmitoylation: a new mean to regulate cytoplasmic dynein activity.Q24318793
Mutations in the palmitoyl protein thioesterase gene causing infantile neuronal ceroid lipofuscinosisQ24322669
Palmitoyl protein thioesterase 1 is targeted to the axons in neuronsQ24337023
Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout miceQ24555093
A cross-platform toolkit for mass spectrometry and proteomicsQ24629036
Palmitoyl protein thioesterase-1 deficiency impairs synaptic vesicle recycling at nerve terminals, contributing to neuropathology in humans and miceQ24644885
Rho GTPases at the crossroad of signaling networks in mammals: impact of Rho-GTPases on microtubule organization and dynamicsQ27009021
A human interactome in three quantitative dimensions organized by stoichiometries and abundancesQ27936244
An RNA-interacting protein, SYNCRIP (heterogeneous nuclear ribonuclear protein Q1/NSAP1) is a component of mRNA granule transported with inositol 1,4,5-trisphosphate receptor type 1 mRNA in neuronal dendritesQ28584162
Mice with Ppt1Deltaex4 mutation replicate the INCL phenotype and show an inflammation-associated loss of interneuronsQ28594053
Synaptopodin regulates spine plasticity: mediation by calcium storesQ28596582
Molecular cloning and expression of palmitoyl-protein thioesteraseQ28626396
limma powers differential expression analyses for RNA-sequencing and microarray studiesQ29617988
Kinesin transports RNA: isolation and characterization of an RNA-transporting granuleQ29618417
Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometryQ29619562
Local palmitoylation cycles define activity-regulated postsynaptic subdomainsQ30541250
Syncrip/hnRNP Q influences synaptic transmission and regulates BMP signaling at the Drosophila neuromuscular synapseQ30586954
The proteios software environment: an extensible multiuser platform for management and analysis of proteomics dataQ33428180
Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranesQ33598012
The palmitoylation machinery is a spatially organizing system for peripheral membrane proteinsQ34111893
Drosophila Syncrip modulates the expression of mRNAs encoding key synaptic proteins required for morphology at the neuromuscular junctionQ34240890
Palmitoylation and depalmitoylation dynamics at a glanceQ34329570
Interplay between phosphorylation and palmitoylation mediates plasma membrane targeting and sorting of GAP43.Q34428642
The BioPlex Network: A Systematic Exploration of the Human InteractomeQ34485581
Palmitoyl-protein thioesterase-1 deficiency leads to the activation of caspase-9 and contributes to rapid neurodegeneration in INCL.Q34506674
Endoplasmic reticulum stress-induced caspase-4 activation mediates apoptosis and neurodegeneration in INCL.Q34518707
An adaptive alignment algorithm for quality-controlled label-free LC-MS.Q34544039
Architecture of the human interactome defines protein communities and disease networksQ34556869
The neuronal ceroid-lipofuscinoses: from past to presentQ34557117
Protein palmitoylation: a regulator of neuronal development and functionQ34932506
The role of attenuated astrocyte activation in infantile neuronal ceroid lipofuscinosisQ35556543
Reversible Cysteine Acylation Regulates the Activity of Human Palmitoyl-Protein Thioesterase 1 (PPT1).Q35885571
hnRNP Q regulates Cdc42-mediated neuronal morphogenesisQ36023305
Genetics of the neuronal ceroid lipofuscinoses (Batten disease).Q36053005
Modulation of neuronal protein trafficking and function by palmitoylationQ36242294
Neuronal ceroid lipofuscinosis with DNAJC5/CSPα mutation has PPT1 pathology and exhibit aberrant protein palmitoylation.Q36685260
Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylationQ37030648
Identification of PSD-95 Depalmitoylating EnzymesQ37241732
Panorama of ancient metazoan macromolecular complexesQ37283269
Dynamics of the mouse brain cortical synaptic proteome during postnatal brain development.Q37343111
Protein palmitoylation in neuronal development and synaptic plasticityQ37695052
Cell biology and function of neuronal ceroid lipofuscinosis-related proteinsQ38080980
Dendritic spines: the locus of structural and functional plasticityQ38175135
Analysis of the palmitoylation and membrane targeting domain of neuromodulin (GAP-43) by site-specific mutagenesisQ38315249
Dinosaur: A Refined Open-Source Peptide MS Feature DetectorQ38380171
SwissPalm: Protein Palmitoylation database.Q38458236
SNAP-25 palmitoylation and plasma membrane targeting require a functional secretory pathwayQ38610897
Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sortingQ38797413
Proteomic analysis of the palmitoyl protein thioesterase 1 interactome in SH-SY5Y human neuroblastoma cells.Q38888358
Batten disease: past, present, and future.Q41296624
FKBP12 binds to acylated H-ras and promotes depalmitoylationQ42724551
Proteomics insights into infantile neuronal ceroid lipofuscinosis (CLN1) point to the involvement of cilia pathology in the diseaseQ42801808
Synaptopodin regulates plasticity of dendritic spines in hippocampal neurons.Q46142239
Deficiency of the INCL protein Ppt1 results in changes in ectopic F1-ATP synthase and altered cholesterol metabolismQ46775076
ER and oxidative stresses are common mediators of apoptosis in both neurodegenerative and non-neurodegenerative lysosomal storage disorders and are alleviated by chemical chaperonesQ46910143
Synaptosomal Proteome of the Orbitofrontal Cortex from Schizophrenia Patients Using Quantitative Label-Free and iTRAQ-Based Shotgun Proteomics.Q47613341
Palmitoyl protein thioesterase 1 (Ppt1)-deficient mouse neurons show alterations in cholesterol metabolism and calcium homeostasis prior to synaptic dysfunction.Q48094283
Selective facilitation of LTP in the ventral hippocampus by calcium storesQ48695090
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that useslimmaQ112236343
P407language of work or nameEnglishQ1860
P304page(s)92
P577publication date2019-01-01
P1433published inFrontiers in Cellular NeuroscienceQ2131509
P1476titleThe Interactome of Palmitoyl-Protein Thioesterase 1 (PPT1) Affects Neuronal Morphology and Function
P478volume13