Acute Leukemia Induces Senescence and Impaired Osteogenic Differentiation in Mesenchymal Stem Cells Endowing Leukemic Cells with Functional Advantages

scientific article published on 01 April 2019

Acute Leukemia Induces Senescence and Impaired Osteogenic Differentiation in Mesenchymal Stem Cells Endowing Leukemic Cells with Functional Advantages is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1155/2019/3864948
P932PMC publication ID6466857
P698PubMed publication ID31065273

P50authorXimena BonillaQ91835483
Natalia-Del Pilar VanegasQ91835488
Jean Paul VernotQ91835492
P2093author name stringNatalia-Del Pilar Vanegas
Ximena Bonilla
Jean Paul Vernot
P2860cites workCellular senescence and tumor suppressor gene p16Q24629853
Multiple facets of p53 in senescence induction and maintenanceQ26738906
Senescence in Human Mesenchymal Stem Cells: Functional Changes and Implications in Stem Cell-Based TherapyQ26742060
The cytokine-mediated crosstalk between primary human acute myeloid cells and mesenchymal stem cells alters the local cytokine network and the global gene expression profile of the mesenchymal cellsQ50559586
Osteogenic differentiation of noncultured immunoisolated bone marrow-derived CD105+ cells.Q51231335
Distinct protein signatures of acute myeloid leukemia bone marrow-derived stromal cells are prognostic for patient survival.Q52653312
Transient activation of p53 in G2 phase is sufficient to induce senescence.Q53043642
Disturbed CXCR4/CXCL12 axis in paediatric precursor B-cell acute lymphoblastic leukaemia.Q53583157
K562 chronic myeloid leukemia cells modify osteogenic differentiation and gene expression of bone marrow stromal cells.Q53724137
Oxidative stress induces senescence in human mesenchymal stem cells.Q54384642
Mesenchymal stem cell abnormalities in patients with multiple myelomaQ81400579
p53-dependent ICAM-1 overexpression in senescent human cells identified in atherosclerotic lesionsQ81402289
Increased CCL2 and IL-8 in the bone marrow microenvironment in acute lymphoblastic leukemiaQ83381327
New therapeutic opportunities from dissecting the pre-B leukemia bone marrow microenvironmentQ88609395
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Senescence-associated inflammatory responses: aging and cancer perspectivesQ34043537
Evidences of early senescence in multiple myeloma bone marrow mesenchymal stromal cellsQ34652128
Human mesenchymal stem cells in contact with their environment: surface characteristics and the integrin systemQ35458958
Making sense of hematopoietic stem cell nichesQ35533593
The proinflammatory phenotype of senescent cells: the p53-mediated ICAM-1 expression.Q35832976
The bone marrow niche for haematopoietic stem cellsQ35887876
Influence of induced reactive oxygen species in p53-mediated cell fate decisions.Q37061407
Bone marrow niche-mediated survival of leukemia stem cells in acute myeloid leukemia: Yin and YangQ37094051
The leukemic stem cell niche: current concepts and therapeutic opportunitiesQ37295129
Leukemia cells induce changes in human bone marrow stromal cellsQ37441710
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Reciprocal leukemia-stroma VCAM-1/VLA-4-dependent activation of NF-κB mediates chemoresistanceQ37723478
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Leukemia stem cells and microenvironment: biology and therapeutic targetingQ37827279
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Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence?Q38182713
Regulation of hematopoietic and leukemic stem cells by the immune system.Q38225994
Inside and out: the activities of senescence in cancer.Q38230319
Senescence-associated IL-6 and IL-8 cytokines induce a self- and cross-reinforced senescence/inflammatory milieu strengthening tumorigenic capabilities in the MCF-7 breast cancer cell lineQ38704813
Phenotypic and Functional Alterations of Hematopoietic Stem and Progenitor Cells in an In Vitro Leukemia-Induced MicroenvironmentQ38715717
Loss of quiescence and self-renewal capacity of hematopoietic stem cell in an in vitro leukemic nicheQ38721767
The bone marrow microenvironment as niche retreats for hematopoietic and leukemic stem cellsQ39475895
Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cellsQ39903574
Mesenchymal Stem Cells Support Survival and Proliferation of Primary Human Acute Myeloid Leukemia Cells through Heterogeneous Molecular MechanismsQ42262053
Altered mesenchymal niche cells impede generation of normal hematopoietic progenitor cells in leukemic bone marrowQ42777252
Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML.Q49165603
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
mesenchymal stem cellQ1922379
acute leukemiaQ976388
P304page(s)3864948
P577publication date2019-04-01
P1433published inStem Cells InternationalQ26842114
P1476titleAcute Leukemia Induces Senescence and Impaired Osteogenic Differentiation in Mesenchymal Stem Cells Endowing Leukemic Cells with Functional Advantages
P478volume2019

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Q92733408ETV6/RUNX1 Fusion Gene Abrogation Decreases the Oncogenicity of Tumour Cells in a Preclinical Model of Acute Lymphoblastic Leukaemiacites workP2860

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