Protease-activated receptor 2 protects against VEGF inhibitor-induced glomerular endothelial and podocyte injury

Protease-activated receptor 2 protects against VEGF inhibitor-induced glomerular endothelial and podocyte injury is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-019-39914-8
P932PMC publication ID6393426
P698PubMed publication ID30814628

P50authorSadayoshi ItōQ30932255
P2093author name stringHiroshi Sato
Emiko Sato
Nobuyuki Takahashi
Junichi Sugawara
Kiyomi Kisu
Yuji Oe
Akiyo Sekimoto
Tomofumi Fushima
P2860cites workVEGF inhibition and renal thrombotic microangiopathyQ24632792
Crosstalk in glomerular injury and repairQ28085092
Endothelial NO synthase genotype and risk of preeclampsia: a multicenter case-control studyQ28281936
Importance of CXC chemokine receptor 2 in the homing of human peripheral blood endothelial progenitor cells to sites of arterial injuryQ28286412
Proangiogenic effects of protease-activated receptor 2 are tumor necrosis factor-alpha and consecutively Tie2 dependentQ28567109
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsiaQ29615916
Chemokines as mediators of neovascularizationQ30438032
CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis.Q30596736
Activation of protease-activated receptor 2 induces VEGF independently of HIF-1.Q31103929
Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.Q33230191
Expression patterns of RelA and c-mip are associated with different glomerular diseases following anti-VEGF therapyQ33410553
Clinicopathological spectrum of kidney diseases in cancer patients treated with vascular endothelial growth factor inhibitors: a report of 5 cases and review of literatureQ33416857
Role of tissue factor in a mouse model of thrombotic microangiopathy induced by antiphospholipid antibodiesQ34080920
The role of VEGF-A in glomerular development and functionQ34314360
TLR2 and TLR4 mediate differential responses to limb ischemia through MyD88-dependent and independent pathwaysQ34500561
The Detection of Urinary Podocytes from Drug-Induced Glomerular Thrombotic Microangiopathy in Advanced Cancer Patients.Q50909982
PAR2-SMAD3 in microvascular endothelial cells is indispensable for vascular stability via tissue factor signaling.Q53247182
Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy.Q53579565
Expression of vascular endothelial growth factor in human umbilical vein endothelial cells stimulated with interleukin-1alpha--an autocrine regulation of angiogenesis and inflammatory reactionsQ74006140
Nitric oxide and angiogenesisQ78057257
Tandem mass spectrometry measurements of creatinine in mouse plasma and urine for determining glomerular filtration rateQ79408625
Blockade of vascular endothelial growth factor signaling ameliorates diabetic albuminuria in miceQ80305250
Increased urinary excretion of nephrin, podocalyxin, and βig-h3 in women with preeclampsiaQ83388487
High-mobility group box-1 mediates toll-like receptor 4-dependent angiogenesisQ83524736
Roles of coagulation pathway and factor Xa in the progression of diabetic nephropathy in db/db miceQ84236710
Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesisQ85302060
Angiogenesis mediated by toll-like receptor 4 in ischemic neural tissueQ85653931
Urinary podocyte excretion and proteinuria in patients treated with antivascular endothelial growth factor therapy for solid tumor malignanciesQ88026834
Glomerular endothelial cell injury and damage precedes that of podocytes in adriamycin-induced nephropathyQ34566167
Protease-activated receptor (PAR)2, but not PAR1, is involved in collateral formation and anti-inflammatory monocyte polarization in a mouse hind limb ischemia model.Q34700750
Vascular endothelial growth factor receptor 2 direct interaction with nephrin links VEGF-A signals to actin in kidney podocytesQ35562791
eNOS deficiency acts through endothelin to aggravate sFlt-1-induced pre-eclampsia-like phenotypeQ35853296
Protease-activated receptor-2 augments experimental crescentic glomerulonephritisQ35963188
Neutrophil activation by the tissue factor/Factor VIIa/PAR2 axis mediates fetal death in a mouse model of antiphospholipid syndromeQ36890849
Abnormal angiogenesis in diabetic nephropathy.Q37236268
Obesity promotes breast cancer by CCL2-mediated macrophage recruitment and angiogenesisQ37298848
Nicotinamide benefits both mothers and pups in two contrasting mouse models of preeclampsiaQ37451322
Permanent cell line expressing human factor VIII-related antigen established by hybridizationQ37615209
Pre-eclampsia: relationship between coagulation, fibrinolysis and inflammationQ37796300
Protease-activated receptor 2 signaling in inflammationQ37942473
High-mobility group box-1 and its role in angiogenesisQ38181042
Inhibition of the VEGF signalling pathway and glomerular disorders.Q38284055
Endothelial mitochondrial oxidative stress determines podocyte depletion in segmental glomerulosclerosisQ38592152
Exosomes from high glucose-treated glomerular endothelial cells trigger the epithelial-mesenchymal transition and dysfunction of podocytesQ38609396
Coagulation Factor Xa and Protease-Activated Receptor 2 as Novel Therapeutic Targets for Diabetic Nephropathy.Q38765383
Protease-activated receptor 2 exacerbates adenine-induced renal tubulointerstitial injury in mice.Q39063513
Protein kinase C alpha promotes angiogenic activity of human endothelial cells via induction of vascular endothelial growth factor.Q40040832
Role of protease activated receptor 1 and 2 signaling in hypoxia-induced angiogenesisQ40158269
Cathepsin S Cleavage of Protease-Activated Receptor-2 on Endothelial Cells Promotes Microvascular Diabetes Complications.Q40322521
Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progressionQ40868885
Production of vascular endothelial growth factor by murine macrophages: regulation by hypoxia, lactate, and the inducible nitric oxide synthase pathwayQ41015545
Glomerular structure and function require paracrine, not autocrine, VEGF-VEGFR-2 signaling.Q41575948
Elevated tissue factor expression contributes to exacerbated diabetic nephropathy in mice lacking eNOS fed a high fat dietQ42971825
Depletion of CXCR2 inhibits tumor growth and angiogenesis in a murine model of lung cancerQ46374116
In vitro procoagulant activity induced in endothelial cells by chemotherapy and antiangiogenic drug combinations: modulation by lower-dose chemotherapyQ46549052
Hepatic dysfunction and thrombocytopenia induced by excess sFlt1 in mice lacking endothelial nitric oxide synthaseQ49751930
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)2986
P577publication date2019-02-27
P1433published inScientific ReportsQ2261792
P1476titleProtease-activated receptor 2 protects against VEGF inhibitor-induced glomerular endothelial and podocyte injury
P478volume9

Reverse relations

Q90571160Dual blockade of protease-activated receptor 1 and 2 additively ameliorates diabetic kidney diseasecites workP2860

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