Molecular mechanisms of cisplatin-induced nephrotoxicity: a balance on the knife edge between renoprotection and tumor toxicity

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Molecular mechanisms of cisplatin-induced nephrotoxicity: a balance on the knife edge between renoprotection and tumor toxicity is …
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review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1112739115
P356DOI10.1186/S12929-019-0518-9
P932PMC publication ID6417243
P698PubMed publication ID30866950

P50authorValentin DjonovQ87139139
Crissy FellabaumQ61136078
P2093author name stringNebojsa Arsenijevic
Vladislav Volarevic
C Randall Harrell
Marina Gazdic Jankovic
Bojana Djokovic
P2860cites workTGF-β signaling via TAK1 pathway: role in kidney fibrosisQ26824337
Mechanisms of Cisplatin nephrotoxicityQ26996320
Acute nephrotoxicity of cisplatin: molecular mechanismsQ27011912
Role of an endoplasmic reticulum Ca2+-independent phospholipase A2 in cisplatin-induced renal cell apoptosisQ28186521
The TNF and TNF receptor superfamilies: integrating mammalian biologyQ28203717
Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzymeQ28287610
Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shockQ28307404
Gamma-glutamyl transpeptidase-deficient mice are resistant to the nephrotoxic effects of cisplatinQ28363414
Attenuation of cisplatin-induced renal injury by inhibition of soluble epoxide hydrolase involves nuclear factor κB signalingQ28385015
Circulating mitochondrial DAMPs cause inflammatory responses to injuryQ29614470
Cellular processing of platinum anticancer drugsQ29617899
Monocyte recruitment during infection and inflammationQ29620067
IL233, A Novel IL-2 and IL-33 Hybrid Cytokine, Ameliorates Renal injuryQ30252348
M1 macrophage triggered by Mincle leads to a deterioration of acute kidney injuryQ30274760
Metabolism of Cisplatin to a nephrotoxin in proximal tubule cells.Q30310364
Dendritic cells in acute kidney injury: cues from the microenvironmentQ30422946
Inhibition of gamma-glutamyl transpeptidase activity by acivicin in vivo protects the kidney from cisplatin-induced toxicity.Q30465767
Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventionsQ30476563
Renal dendritic cells ameliorate nephrotoxic acute kidney injuryQ33562179
Differential expression of Toll-like receptors in murine peritoneal macrophages in vitro on treatment with cisplatinQ80186515
Endotoxin and cisplatin synergistically induce renal dysfunction and cytokine production in miceQ80310668
Tumor necrosis factor-alpha in cisplatin nephrotoxicity: a homebred foe?Q80540729
Acute renal failure: determinants and characteristics of the injury-induced hyperinflammatory responseQ83201879
Nec-1 protects against nonapoptotic cell death in cisplatin-induced kidney injuryQ83283731
Mechanistic study of BNP7787-mediated cisplatin nephroprotection: modulation of human aminopeptidase NQ84152756
Tim-1 promotes cisplatin nephrotoxicityQ84749297
Phospholipase A2 inhibits cisplatin-induced acute kidney injury by modulating regulatory T cells by the CD206 mannose receptorQ87345767
TLR2 and TLR4 play opposite role in autophagy associated with cisplatin-induced acute kidney injuryQ87942844
Changes in the mucus barrier during cisplatin-induced intestinal mucositis in ratsQ43537138
Role and regulation of activation of caspases in cisplatin-induced injury to renal tubular epithelial cellsQ43795977
Cisplatin induces acute renal failure by impairing antioxidant system in guinea pigs: effects of antioxidant supplementation on the cisplatin nephrotoxicityQ43890992
Oral erdosteine administration attenuates cisplatin-induced renal tubular damage in ratsQ44288100
Different mechanisms for gamma-glutamyltransferase-dependent resistance to carboplatin and cisplatinQ44541803
Protection of renal cells from cisplatin toxicity by cell cycle inhibitorsQ44579261
Salicylate reduces cisplatin nephrotoxicity by inhibition of tumor necrosis factor-alpha.Q44724740
Caspase-1-deficient mice are protected against cisplatin-induced apoptosis and acute tubular necrosisQ45166196
p53-dependent caspase-2 activation in mitochondrial release of apoptosis-inducing factor and its role in renal tubular epithelial cell injuryQ46570433
Inhibition of p21 modifies the response of cortical proximal tubules to cisplatin in ratsQ46935021
A pathophysiologic role for T lymphocytes in murine acute cisplatin nephrotoxicityQ46947114
Magnesium co-administration decreases cisplatin-induced nephrotoxicity in the multiple cisplatin administrationQ47257329
Function and regulation of IL-1α in inflammatory diseases and cancerQ47285901
TNF-α, IL-6 and IL-10 expressions, responsible for disparity in action of curcumin against cisplatin-induced nephrotoxicity in rats.Q47840966
MicroRNA-375 Is Induced in Cisplatin Nephrotoxicity to Repress Hepatocyte Nuclear Factor 1-β.Q47986520
Involvement of the CDK2-E2F1 pathway in cisplatin cytotoxicity in vitro and in vivo.Q50469558
Autophagy guards against cisplatin-induced acute kidney injury.Q50503908
Intraperitoneal cisplatin plus intravenous cyclophosphamide versus intravenous cisplatin plus intravenous cyclophosphamide for stage III ovarian cancer.Q50512108
The leukotriene B4-leukotriene B4 receptor axis promotes cisplatin-induced acute kidney injury by modulating neutrophil recruitment.Q52781114
Induction of renal endonuclease G by cisplatin is reduced in DNase I-deficient mice.Q53536393
Nephroprotective effects of hydration with magnesium in patients with cervical cancer receiving cisplatin.Q53549841
Cisplatin-induced acute renal failure is associated with an increase in the cytokines interleukin (IL)-1beta, IL-18, IL-6, and neutrophil infiltration in the kidney.Q53562266
The role of toll-like receptor 4 in cisplatin-induced renal injury.Q53565804
Cisplatin increases TNF-alpha mRNA stability in kidney proximal tubule cells.Q53592843
Endoplasmic reticulum stress-associated caspase 12 mediates cisplatin-induced LLC-PK1 cell apoptosis.Q53675236
TNFR2-mediated apoptosis and necrosis in cisplatin-induced acute renal failure.Q53923667
Neutrophils in cisplatin AKI-mediator or marker?Q53965817
Poly(ADP-ribose) polymerase 1 activation is required for cisplatin nephrotoxicity.Q54522113
Interleukin-6 plays a protective role in development of cisplatin-induced acute renal failure through upregulation of anti-oxidative stress factors.Q54590119
Necroptosis in Acute Kidney Injury.Q54977520
Cisplatin-Induced Rodent Model of Kidney Injury: Characteristics and ChallengesQ57112108
Interleukin-10 inhibits ischemic and cisplatin-induced acute renal injuryQ58376211
Mechanisms of death induced by cisplatin in proximal tubular epithelial cells: apoptosis vs. necrosisQ71897382
Protective effects of vitamin E and C on cisplatin nephrotoxicity in developing ratsQ73862978
Cisplatin-induced apoptosis by translocation of endogenous Bax in mouse collecting duct cellsQ74613490
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancerQ77321076
Modulation of platinum-induced toxicities and therapeutic index: mechanistic insights and first- and second-generation protecting agentsQ77448244
Role of cytochrome P-450 as a source of catalytic iron in cisplatin-induced nephrotoxicityQ77650651
Cisplatin-induced nephrotoxicity is mediated by tumor necrosis factor-alpha produced by renal parenchymal cellsQ80066103
The pathological role of Bax in cisplatin nephrotoxicityQ80101271
Induction chemotherapy for head and neck cancer: recent dataQ33734261
Pathophysiology of cisplatin-induced acute kidney injuryQ34073302
Cellular Responses to Cisplatin‐Induced DNA DamageQ34089685
Cisplatin in cancer therapy: molecular mechanisms of actionQ34098163
MicroRNA-34a is induced via p53 during cisplatin nephrotoxicity and contributes to cell survivalQ34112716
Magnesium supplementation and high volume hydration reduce the renal toxicity caused by cisplatin-based chemotherapy in patients with lung cancer: a toxicity study.Q34748754
Novel role of base excision repair in mediating cisplatin cytotoxicityQ34800428
Toxicity of platinum compoundsQ35143947
Long-term complications of chemotherapy for germ cell tumoursQ35187360
Endogenous IL-10 attenuates cisplatin nephrotoxicity: role of dendritic cellsQ35205227
Dependence of cisplatin-induced cell death in vitro and in vivo on cyclin-dependent kinase 2Q35220766
Chemotherapy in advanced bladder cancer: current status and futureQ35227771
Poly(ADP-ribose) polymerase-1 is a key mediator of cisplatin-induced kidney inflammation and injuryQ35514172
Endometrial Carcinoma: A Review of Chemotherapy, Drug Resistance, and the Search for New AgentsQ35583750
Gene therapy: how to target the kidney. Promises and pitfallsQ35698689
Mast cells mediate acute kidney injury through the production of TNF.Q35758258
IL-33 exacerbates acute kidney injuryQ35758456
Application of decoy oligodeoxynucleotides-based approach to renal diseasesQ35971961
Dendritic Cell Protection from Cisplatin Nephrotoxicity Is Independent of NeutrophilsQ35996641
Prospective therapeutic applications of p53 inhibitorsQ36113115
A Systematic Review of Strategies to Prevent Cisplatin-Induced Nephrotoxicity.Q36355684
Cellular response to endoplasmic reticulum stress: a matter of life or deathQ36362409
Autophagy in proximal tubules protects against acute kidney injuryQ36377375
Hydration with magnesium and mannitol without furosemide prevents the nephrotoxicity induced by cisplatin and pemetrexed in patients with advanced non-small cell lung cancerQ36424378
Endogenous Toll-Like Receptor 9 Regulates AKI by Promoting Regulatory T Cell RecruitmentQ36624633
TLR4 signaling mediates inflammation and tissue injury in nephrotoxicityQ36662114
AP214, an analogue of alpha-melanocyte-stimulating hormone, ameliorates sepsis-induced acute kidney injury and mortalityQ36681505
Mitochondria as a critical target of the chemotheraputic agent cisplatin in head and neck cancer.Q36743607
Tumor necrosis factor-α: regulation of renal function and blood pressureQ36836229
Proximal tubule-targeted heme oxygenase-1 in cisplatin-induced acute kidney injuryQ36904744
Cisplatin nephrotoxicity: a reviewQ36910929
Cisplatin nephrotoxicity: mechanisms and renoprotective strategiesQ37084089
The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicityQ37138812
Phase II study of low-dose paclitaxel and cisplatin as a second-line therapy after 5-fluorouracil/platinum chemotherapy in gastric cancerQ37222473
Regulation and pathological role of p53 in cisplatin nephrotoxicityQ37235870
Gender difference in Cisplatin-induced nephrotoxicity in a rat model: greater intensity of damage in male than femaleQ37316465
Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicityQ37353430
Chemotherapy-induced bone marrow nerve injury impairs hematopoietic regeneration.Q37660869
Mediators of inflammation in acute kidney injuryQ37698228
Cisplatin rescue therapy: experience with sodium thiosulfate, WR2721, and diethyldithiocarbamateQ37903232
Cisplatin-induced nephrotoxicity and targets of nephroprotection: an updateQ37989844
Onco-nephrology: renal toxicities of chemotherapeutic agentsQ38033523
Treatment of non-small cell lung cancer (NSCLC).Q38150348
Chemotherapy advances in small-cell lung cancerQ38155856
Membrane transporters as mediators of cisplatin side-effectsQ38176883
Immune cells in experimental acute kidney injuryQ38261586
Controversial role of gamma-glutamyl transferase activity in cisplatin nephrotoxicityQ39012156
Xenobiotic transporters and kidney injuryQ39098252
Cisplatin nephrotoxicity: a review of the literatureQ39223600
Protecting cisplatin-induced nephrotoxicity with cimetidine does not affect antitumor activityQ39636023
Disruption of multidrug and toxin extrusion MATE1 potentiates cisplatin-induced nephrotoxicityQ39660260
TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicityQ39738416
Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cellsQ39977465
Autophagy is associated with apoptosis in cisplatin injury to renal tubular epithelial cellsQ40015691
Transcriptional activation of caspase-6 and -7 genes by cisplatin-induced p53 and its functional significance in cisplatin nephrotoxicityQ40038493
Characterization of mitochondria in cisplatin-resistant human ovarian carcinoma cellsQ40224571
Regulation of PUMA-alpha by p53 in cisplatin-induced renal cell apoptosis.Q40313668
Regulation of TauT by cisplatin in LLC-PK1 renal cellsQ40412436
Identification of the functional domain of p21(WAF1/CIP1) that protects cells from cisplatin cytotoxicityQ40433093
Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): a multicentre, randomised, controlled, open-label, phase 3 trialQ40443233
p38 MAP kinase inhibition ameliorates cisplatin nephrotoxicity in mice.Q40460320
gamma-Glutamyl transpeptidase catalyses the extracellular detoxification of cisplatin in a human cell line derived from the proximal convoluted tubule of the kidneyQ40653504
Amifostine pretreatment for protection against cyclophosphamide-induced and cisplatin-induced toxicities: results of a randomized control trial in patients with advanced ovarian cancerQ40666961
Roles of toll-like receptors in C-C chemokine production by renal tubular epithelial cellsQ40712456
Manganese superoxide dismutase attenuates Cisplatin-induced renal injury: importance of superoxide.Q40765619
A chemical inhibitor of p53 that protects mice from the side effects of cancer therapyQ40929887
Protection from toxicant-mediated renal injury in the rat with anti-CD54 antibodyQ41687992
AMP-activated protein kinase regulates autophagic protection against cisplatin-induced tissue injury in the kidneyQ41916518
Role of IL-1α in cisplatin-induced acute renal failure in miceQ42025525
CD4+CD25+ regulatory T cells attenuate cisplatin-induced nephrotoxicity in miceQ42171670
Innate IL-17A-producing leukocytes promote acute kidney injury via inflammasome and Toll-like receptor activationQ42223932
Urinary parameters predictive of cisplatin-induced acute renal injury in dogsQ42960046
Esophageal cancer chemotherapy: recent advances.Q43194164
Mast cell-derived tumour necrosis factor-alpha mediates macrophage inflammatory protein-2-induced recruitment of neutrophils in miceQ43261409
Mechanistic study of BNP7787-mediated cisplatin nephroprotection: modulation of gamma-glutamyl transpeptidaseQ43284420
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectinflammationQ101991
signal transductionQ828130
kidneyQ9377
P304page(s)25
P577publication date2019-03-13
P1433published inJournal of Biomedical ScienceQ15759332
P1476titleMolecular mechanisms of cisplatin-induced nephrotoxicity: a balance on the knife edge between renoprotection and tumor toxicity
P478volume26