LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice

scientific article published on 26 February 2019

LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1112395364
P356DOI10.1186/S40478-019-0679-5
P2888exact matchhttps://scigraph.springernature.com/pub.10.1186/s40478-019-0679-5
P932PMC publication ID6391792
P698PubMed publication ID30808409

P50authorJohn Q. TrojanowskiQ6253636
Hannah J BrownQ89158989
P2093author name stringBin Zhang
Virginia M Y Lee
Ian McGeary
Michael X Henderson
Modupe F Olufemi
Medha Sengupta
P2860cites workParkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activityQ22254785
alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodiesQ24653247
Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologiesQ27686837
Mutation in the alpha-synuclein gene identified in families with Parkinson's diseaseQ27860459
alpha-Synuclein locus triplication causes Parkinson's diseaseQ27860533
Alpha-synuclein in Lewy bodiesQ27860680
Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPasesQ28119192
Staging of brain pathology related to sporadic Parkinson's diseaseQ28131702
The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementiaQ29547174
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's diseaseQ29547175
Alpha-synuclein locus duplication as a cause of familial Parkinson's diseaseQ29614762
Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control studyQ29614953
Kinase activity is required for the toxic effects of mutant LRRK2/dardarinQ29620478
Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic miceQ29620597
Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease.Q34330786
Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages).Q35045422
Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite-like aggregates.Q35215169
Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron deathQ35484581
Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localizationQ36780383
A novel α-synuclein missense mutation in Parkinson diseaseQ36841475
α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?Q36925651
Loss of leucine-rich repeat kinase 2 (LRRK2) in rats leads to progressive abnormal phenotypes in peripheral organsQ37308940
Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunctionQ37376010
Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cellsQ37446544
MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition.Q38832432
Ser(P)-1292 LRRK2 in urinary exosomes is elevated in idiopathic Parkinson's diseaseQ39686532
LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson's Disease Mouse ModelQ41539639
Effect of selective LRRK2 kinase inhibition on nonhuman primate lung.Q46777308
Parkinson's disease-associated mutant LRRK2 phosphorylates Rab7L1 and modifies trans-Golgi morphologyQ47338060
LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi networkQ47362838
Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylationQ48192270
Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutationsQ48252778
Lewy body diseases and multiple system atrophy as alpha-synucleinopathiesQ48326536
PFE-360-induced LRRK2 inhibition induces reversible, non-adverse renal changes in rats.Q50145319
The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human.Q55265334
LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasisQ58745072
LRRK2 activation in idiopathic Parkinson's disease.Q60143544
Causal relation between alpha-synuclein gene duplication and familial Parkinson's diseaseQ80794093
Novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathologyQ87710261
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectSynucleinQ24767155
MLI-2Q27225595
P304page(s)28
P577publication date2019-02-26
P1433published inActa Neuropathologica CommunicationsQ27724912
P1476titleLRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice
P478volume7

Reverse relations

cites work (P2860)
Q96304526"LRRK2: Autophagy and Lysosomal Activity"
Q89611946Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease
Q89484985An Assessment of LRRK2 Serine 935 Phosphorylation in Human Peripheral Blood Mononuclear Cells in Idiopathic Parkinson's Disease and G2019S LRRK2 Cohorts
Q92534986Autophagy and LRRK2 in the Aging Brain
Q89720803Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by α-synuclein
Q98177378LRRK2 and Protein Aggregation in Parkinson's Disease: Insights From Animal Models
Q92933189LRRK2 in Parkinson disease: challenges of clinical trials
Q96219413Neuron-autonomous susceptibility to induced synuclein aggregation is exacerbated by endogenous Lrrk2 mutations and ameliorated by Lrrk2 genetic knock-out
Q99716681Pathogenic LRRK2 requires secondary factors to induce cellular toxicity
Q92186851Spread of α-synuclein pathology through the brain connectome is modulated by selective vulnerability and predicted by network analysis

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