Exploring Structural Diversity of Microbe Secondary Metabolites Using OSMAC Strategy: A Literature Review

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Exploring Structural Diversity of Microbe Secondary Metabolites Using OSMAC Strategy: A Literature Review is …
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scholarly articleQ13442814

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P356DOI10.3389/FMICB.2019.00294
P932PMC publication ID6399155
P698PubMed publication ID30863377

P2093author name stringHong Wang
Jianwei Chen
Rui Pan
Xuelian Bai
Huawei Zhang
P2860cites workChaxapeptin, a Lasso Peptide from Extremotolerant Streptomyces leeuwenhoekii Strain C58 from the Hyperarid Atacama DesertQ27702202
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular NetworkingQ27818844
Integration of Microfractionation, qNMR and zebrafish screening for the in vivo bioassay-guided isolation and quantitative bioactivity analysis of natural productsQ28488352
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Nocardiopsis alkaliphila sp. nov., a novel alkaliphilic actinomycete isolated from desert soil in EgyptQ30890434
The DNMT1 target recognition domain resides in the N terminusQ31650618
New co-metabolites of the streptazolin pathwayQ31917281
High-throughput platform for the discovery of elicitors of silent bacterial gene clustersQ33665547
Production of induced secondary metabolites by a co-culture of sponge-associated actinomycetes, Actinokineospora sp. EG49 and Nocardiopsis sp. RV163.Q33736771
Chemical epigenetics alters the secondary metabolite composition of guttate excreted by an atlantic-forest-soil-derived Penicillium citreonigrumQ33884671
Sphaerolone and dihydrosphaerolone, two bisnaphthyl-pigments from the fungus Sphaeropsidales sp. F-24'707.Q33915596
Comazaphilones A-F, azaphilone derivatives from the marine sediment-derived fungus Penicillium commune QSD-17.Q34158556
Triazole and dihydroimidazole alkaloids from the marine sediment-derived fungus Penicillium paneum SD-44.Q34178553
Waikialoid A suppresses hyphal morphogenesis and inhibits biofilm development in pathogenic Candida albicansQ34188367
Naphthomycins L-N, ansamycin antibiotics from Streptomyces sp. CS.Q34284759
Biosynthesis of fluorinated secondary metabolites by Streptomyces cattleyaQ34304966
Cytotoxic anthranilic acid derivatives from deep sea sediment-derived fungus Penicillium paneum SD-44.Q34365696
Brocazines A-F, Cytotoxic Bisthiodiketopiperazine Derivatives from Penicillium brocae MA-231, an Endophytic Fungus Derived from the Marine Mangrove Plant Avicennia marinaQ34432959
Metabolite diversification by cultivation of the endophytic fungus Dothideomycete sp. in halogen containing media: Cultivation of terrestrial fungus in seawater.Q50936342
Bisthiodiketopiperazines and Acorane Sesquiterpenes Produced by the Marine-Derived Fungus Penicillium adametzioides AS-53 on Different Culture Media.Q51352460
Eremophilane Sesquiterpenes from a Deep Marine-Derived Fungus, Aspergillus sp. SCSIOW2, Cultivated in the Presence of Epigenetic Modifying Agents.Q51364208
Psychrophilins E-H and versicotide C, cyclic peptides from the marine-derived fungus Aspergillus versicolor ZLN-60.Q51407217
Aspewentins A-C, norditerpenes from a cryptic pathway in an algicolous strain of Aspergillus wentii.Q51471393
Secondary metabolites produced by solid fermentation of the marine-derived fungus Penicillium commune QSD-17.Q51571869
Novel open-chain cytochalsins from the marine-derived fungus Spicaria elegans.Q51687306
10-Phenyl-[12]-cytochalasins Z7, Z8, and Z9 from the marine-derived fungus Spicaria elegans.Q51725189
Potential allelopathic indole diketopiperazines produced by the plant endophytic Aspergillus fumigatus using the one strain-many compounds method.Q51774097
Modeling pH effects on microbial growth: a statistical thermodynamic approach.Q52219866
Tricycloalternarene Analogs from a Symbiotic Fungus Aspergillus sp. D and Their Antimicrobial and Cytotoxic Effects.Q52593626
A Self-Sacrificing N-Methyltransferase Is the Precursor of the Fungal Natural Product Omphalotin.Q52837051
Citrifelins A and B, Citrinin Adducts with a Tetracyclic Framework from Cocultures of Marine-Derived Isolates of Penicillium citrinum and Beauveria felina.Q53090229
Hybrid Isoprenoids from a Reeds Rhizosphere Soil Derived Actinomycete Streptomyces sp. CHQ-64Q53606309
Physiological analysis on novel coculture of Monascus sp. J101 with Saccharomyces cerevisiae.Q53762359
Concepts and Methods to Access Novel Antibiotics from Actinomycetes.Q55404741
Use and Discovery of Chemical Elicitors That Stimulate Biosynthetic Gene Clusters in Streptomyces BacteriaQ56837815
Structural Diversity of New C13-Polyketides Produced by Chaetomium mollipilium Cultivated in the Presence of a NAD+-Dependent Histone Deacetylase InhibitorQ59462430
An epigenetic modifier enhances the production of anti-diabetic and anti-inflammatory sesquiterpenoids from Aspergillus sydowii.Q42819886
Effect of C/N ratio and media optimization through response surface methodology on simultaneous productions of intra- and extracellular inulinase and invertase from Aspergillus niger ATCC 20611.Q42962059
A new 3, 4-seco-lanostane triterpenoid from a marine-derived fungus Ascotricha sp. ZJ-M-5Q43767734
Paecilomide, a new acetylcholinesterase inhibitor from Paecilomyces lilacinus.Q44851415
Optimization of carbon-nitrogen ratio for production of gibberellic acid by Pseudomonas sp.Q45102126
One strain-many compounds (OSMAC) method for production of polyketides, azaphilones, and an isochromanone using the endophytic fungus Dothideomycete sp.Q45149416
A new cyclonerol derivative from a marine-derived fungus Ascotricha sp. ZJ-M-5.Q45214334
Ophiobolins P-T, five new cytotoxic and antibacterial sesterterpenes from the endolichenic fungus Ulocladium sp.Q45397748
Sorbicillamines A-E, nitrogen-containing sorbicillinoids from the deep-sea-derived fungus Penicillium sp. F23-2.Q45742117
Nodulisporisteriods A and B, the first 3,4-seco-4-methyl-progesteroids from Nodulisporium sp.Q45836359
Induced production of emericellamides A and B from the marine-derived fungus Emericella sp. in competing co-culture.Q45973027
Isolation, structure elucidation and apoptosis-inducing activity of new compounds from the edible fungus Lentinus striguellus.Q45992990
[Effect of culture conditions on cell growth and lipid accumulation of oleaginous microorganism].Q46012908
A chemical epigenetics approach for engineering the in situ biosynthesis of a cryptic natural product from Aspergillus niger.Q46155513
Production of 5-hydroxy-7-methoxy-4-methylphthalide in a culture of Penicillium crustosum.Q46155895
Pestaloficiols A-E, bioactive cyclopropane derivatives from the plant endophytic fungus Pestalotiopsis ficiQ46603229
Enhanced production of undecylprodigiosin in Streptomyces coelicolor by co-cultivation with the corallopyronin A-producing myxobacterium, Corallococcus coralloidesQ46687018
Trichodermamide A and aspergillazine A, two cytotoxic modified dipeptides from a marine-derived fungus Spicaria elegansQ46741526
Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, induces the production of anti-inflammatory cyclodepsipeptides from Beauveria felina.Q46800017
Uncovering biosynthetic potential of plant-associated fungi: effect of culture conditions on metabolite production by Paraphaeosphaeria quadriseptata and Chaetomium chiversiiQ46871849
Inducing secondary metabolite production by the endophytic fungus Fusarium tricinctum through coculture with Bacillus subtilis.Q46976848
Inducing Secondary Metabolite Production by Combined Culture of Talaromyces aculeatus and Penicillium variabile.Q47586996
Derivatives of Holomycin and Cyclopropaneacetic Acid from Streptomyces sp. DT-A37.Q47825068
A unique indolizinium alkaloid streptopertusacin A and bioactive bafilomycins from marine-derived Streptomyces sp. HZP-2216E.Q47965773
Chaunopyran A: Co-Cultivation of Marine Mollusk-Derived Fungi Activates a Rare Class of 2-Alkenyl-Tetrahydropyran.Q48311895
Predicting microbial growth: growth responses of salmonellae in a laboratory medium as affected by pH, sodium chloride and storage temperatureQ50198359
Chloropestolide A, an antitumor metabolite with an unprecedented spiroketal skeleton from Pestalotiopsis ficiQ50334012
Mycolic acid-containing bacteria induce natural-product biosynthesis in Streptomyces speciesQ34488008
Rhodostreptomycins, antibiotics biosynthesized following horizontal gene transfer from Streptomyces padanus to Rhodococcus fasciansQ34586795
Chlorinated polyketide obtained from a Daldinia sp. treated with the epigenetic modifier suberoylanilide hydroxamic acidQ34609464
Big effects from small changes: possible ways to explore nature's chemical diversity.Q34906532
Interspecies interactions stimulate diversification of the Streptomyces coelicolor secreted metabolomeQ34959567
Penicibrocazines A-E, five new sulfide diketopiperazines from the marine-derived endophytic fungus Penicillium brocaeQ35015338
Exploring the biologically relevant chemical space for drug discovery.Q35017407
Effects of high salt stress on secondary metabolite production in the marine-derived fungus Spicaria elegansQ35073259
Co-cultivation--a powerful emerging tool for enhancing the chemical diversity of microorganismsQ35096902
Induced Production of Halogenated Epidithiodiketopiperazines by a Marine-Derived Trichoderma cf. brevicompactum with Sodium HalidesQ35800230
Ribosome engineering and secondary metabolite productionQ35964973
Natural products from plant-associated microorganisms: distribution, structural diversity, bioactivity, and implications of their occurrenceQ35994187
Epigenetic tailoring for the production of anti-infective cytosporones from the marine fungus Leucostoma persooniiQ36006500
Epigenetics: the link between nature and nurtureQ36449017
Allelopathic Polyketides from an Endolichenic Fungus Myxotrichum SP. by Using OSMAC StrategyQ36536028
Simple histone acetylation plays a complex role in the regulation of gene expressionQ36596204
In vivo and in vitro production options for fungal secondary metabolitesQ37106391
Chemical probes for histone-modifying enzymesQ37272504
Myxococcus xanthus induces actinorhodin overproduction and aerial mycelium formation by Streptomyces coelicolorQ37283531
Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulansQ37321247
Using jasplakinolide to turn on pathways that enable the isolation of new chaetoglobosins from Phomospis asparagiQ37678104
Induction of Diverse Bioactive Secondary Metabolites from the Mangrove Endophytic Fungus Trichoderma sp. (Strain 307) by Co-Cultivation with Acinetobacter johnsonii (Strain B2).Q37678296
Production of microbial secondary metabolites: regulation by the carbon source.Q37704410
Gordonic Acid, a Polyketide Glycoside Derived from Bacterial Coculture of Streptomyces and Gordonia SpeciesQ38605991
Novel bioactive molecules from Lentzea violacea strain AS 08 using one strain-many compounds (OSMAC) approachQ38708034
Epigenetic Modulation of Endophytic Eupenicillium sp. LG41 by a Histone Deacetylase Inhibitor for Production of Decalin-Containing CompoundsQ38711052
Identification of spirobisnaphthalene derivatives with anti-tumor activities from the endophytic fungus Rhytidhysteron rufulum AS21B.Q38713086
OSMAC approach leads to new fusarielin metabolites from Fusarium tricinctumQ38713204
New cytotoxic furan from the marine sediment-derived fungi Aspergillus nigerQ38718828
Two new triterpenoids and a new naphthoquinone derivative isolated from a hard coral-derived fungus Scopulariopsis sp.Q38727062
Conditional changes enhanced production of bioactive metabolites of marine derived fungus Eurotium rubrum.Q38745514
Bioactive Bafilomycins and a New N-Arylpyrazinone Derivative from Marine-derived Streptomyces sp. HZP-2216E.Q38750649
Metabolites from the Fungal Endophyte Aspergillus austroafricanus in Axenic Culture and in Fungal-Bacterial Mixed CulturesQ38778910
Cytotoxic cytochalasins from marine-derived fungus Arthrinium arundinis.Q38915942
Caryophyllene sesquiterpenes from the marine-derived fungus Ascotricha sp. ZJ-M-5 by the one strain-many compounds strategyQ38990040
Triggering cryptic natural product biosynthesis in microorganismsQ61774190
Expanding the Metabolic Profile of the Fungus Chaetomium sp. through Co-culture with Autoclaved Pseudomonas aeruginosaQ62736001
Epigenetic remodeling of the fungal secondary metabolomeQ63350474
Biphenomycins A and B, novel peptide antibiotics. II. Structural elucidation of biphenomycins A and BQ69806152
Biphenomycin C, a precursor of biphenomycin A in mixed cultureQ70568294
Analysis of the morphologic changes of Monascus sp. J101 cells cocultured with Saccharomyces cerevisiaeQ73231211
A new macrolide antibiotic with antitumor activity produced by Streptomyces sp. CS, a commensal microbe of Maytenus hookeriQ73554604
RKS-1778, a new mammalian cell-cycle inhibitor and a key intermediate of the [11]cytochalasin groupQ73570103
Formation of new lipoaminopeptides, acremostatins A, B, and C, by co-cultivation of Acremonium sp. Tbp-5 and Mycogone rosea DSM 12973Q74195861
Regulation of compatible solute accumulation in bacteriaQ77163579
Spicochalasin A and New Aspochalasins from the Marine-Derived FungusSpicaria elegansQ78233080
Cathepsin B Inhibitory Tetraene Lactones from the FungusTalaromyces wortmanniiQ78234621
Novel Polyketides Isolated fromStreptomyces sp.Q78234655
Two New Cyclic Pentapeptides from the Marine-Derived Fungus Aspergillus versicolorQ78234776
Nodulisporisteroids C–L, new 4-methyl-progesteroid derivatives from Nodulisporium sp.Q78295933
Mycolic Acid Containing Bacterium Stimulates Tandem Cyclization of Polyene Macrolactam in a Lake Sediment Derived Rare ActinomyceteQ78319271
Epigenetic stimulation of polyketide production in Chaetomium cancroideum by an NAD+-dependent HDAC inhibitorQ78431511
Epigenetic modifiers alter the secondary metabolite composition of a plant endophytic fungus,Pestalotiopsis crassiusculaobtained from the leaves ofFragaria chiloensisQ78433194
Deoxy-cytochalasins from a marine-derived fungus Spicaria elegansQ78434904
Wortmannilactones A−D, 22-Membered Triene Macrolides fromTalaromyceswortmanniiQ78439878
Antifungal Metabolites from the Plant Endophytic FungusPestalotiopsis foedanQ78440575
Polycyclic Hybrid Isoprenoids from a Reed Rhizosphere Soil Derived Streptomyces sp. CHQ-64Q78441467
Isoprenylated Chromone Derivatives from the Plant Endophytic FungusPestalotiopsis ficiQ78442898
Benzophenones from an Endophytic Fungus, Graphiopsis chlorocephala, from Paeonia lactiflora Cultivated in the Presence of an NAD+-Dependent HDAC InhibitorQ78443878
Structurally Diverse Chaetophenol Productions Induced by Chemically Mediated Epigenetic Manipulation of Fungal Gene ExpressionQ78443898
Structures of Spiroindicumides A and B, Unprecedented Carbon Skeletal Spirolactones, and Determination of the Absolute Configuration by Vibrational Circular Dichroism Exciton ApproachQ78443910
Chloropupukeananin, the First Chlorinated Pupukeanane Derivative, and Its Precursors fromPestalotiopsis ficiQ78444105
A Novel Nuclear Export Inhibitor JBIR-02, a New Piericidin Discovered from Streptomyces sp. ML55Q78444620
Structure and absolute configuration of drimentine I, an alkaloid from Streptomyces sp. CHQ-64Q78445610
Tenuipyrone, a novel skeletal polyketide from the entomopathogenic fungus, Isaria tenuipes, cultivated in the presence of epigenetic modifiersQ83142346
Aromatic polyketide production in Cordyceps indigotica, an entomopathogenic fungus, induced by exposure to a histone deacetylase inhibitorQ83820118
Aromatic compounds from the halotolerant fungal strain of Wallemia sebi PXP-89 in a hypersaline mediumQ84498214
Secondary metabolite production by the basidiomycete, Lentinus strigellus, under different culture conditionsQ84592168
Induced production of mycotoxins in an endophytic fungus from the medicinal plant Datura stramonium LQ84961501
Transferring Fungi to a Deuterium-Enriched Medium Results in Assorted, Conditional Changes in Secondary Metabolite ProductionQ85348095
Marine natural productsQ86596879
Morphological change and enhanced pigment production of monascus when cocultured with saccharomyces cerevisiae or aspergillus oryzaeQ95290487
Structural Diversity of 1-O-Acyl α-L-Rhamnopyranosides by Precursor-Directed Biosynthesis withStreptomyces griseoviridisQ113960350
DIAMetAlyzer allows automated false-discovery rate-controlled analysis for data-independent acquisition in metabolomicsQ114867182
A practical strategy to discover new antitumor compounds by activating silent metabolite production in fungi by diethyl sulphate mutagenesis.Q39010289
Strategies for Fermentation Medium Optimization: An In-Depth ReviewQ39098331
Diorcinols B-E, new prenylated diphenyl ethers from the marine-derived fungus Aspergillus versicolor ZLN-60.Q39151550
Identification and Biological Evaluation of Secondary Metabolites from Marine Derived Fungi-Aspergillus sp. SCSIOW3, Cultivated in the Presence of Epigenetic Modifying AgentsQ39177111
Chloropupukeanolides C-E: cytotoxic pupukeanane chlorides with a spiroketal skeleton from Pestalotiopsis fici.Q39184084
New spiral γ-lactone enantiomers from the plant endophytic fungus Pestalotiopsis foedan.Q39189760
A new spectinabilin derivative with cytotoxic activity from ant-derived Streptomyces sp. 1H-GS5.Q39191985
Tricycloalternarenes F-H: three new mixed terpenoids produced by an endolichenic fungus Ulocladium sp. using OSMAC methodQ39211892
Novel antibiotic screening methods to awaken silent or cryptic secondary metabolic pathways in actinomycetesQ39262480
A novel tricyclic polyketide and its biosynthetic precursor azaphilone derivatives from the endophytic fungus Dothideomycete sp.Q39305409
Photipyrones A and B, new pyrone derivatives from the plant endophytic fungus Pestalotiopsis photiniaeQ39380298
Diverse metabolic profiles of a Streptomyces strain isolated from a hyper-arid environmentQ39385483
Chaxamycins A-D, bioactive ansamycins from a hyper-arid desert Streptomyces sp.Q39385490
Depsidones, aromatase inhibitors and radical scavenging agents from the marine-derived fungus Aspergillus unguis CRI282-03.Q39401143
Induced production of N-formyl alkaloids from Aspergillus fumigatus by co-culture with Streptomyces peucetiusQ39525651
Three new cytochalasins from the marine-derived fungus Spicaria elegans KLA03 by supplementing the cultures with L- and D-tryptophanQ39544790
Dual Induction of New Microbial Secondary Metabolites by Fungal Bacterial Co-cultivation.Q39568625
Arthpyrones A-C, pyridone alkaloids from a sponge-derived fungus Arthrinium arundinis ZSDS1-F3.Q39574019
A new naphthalene glycoside from the sponge-derived fungus Arthrinium sp. ZSDS1-F3.Q39574284
Macrolides of the bafilomycin family produced by Streptomyces sp. CSQ39658366
DNA Methyltransferase Inhibitor Induced Fungal Biosynthetic Products: Diethylene Glycol Phthalate Ester Oligomers from the Marine-Derived Fungus Cochliobolus lunatusQ39721752
Alkaloids from a deep ocean sediment-derived fungus Penicillium sp. and their antitumor activitiesQ39734934
Unique metabolites of Pestalotiopsis fici suggest a biosynthetic hypothesis involving a Diels-Alder reaction and then mechanistic diversificationQ39753351
JBIR-52, a new antimycin-like compound, from Streptomyces sp. ML55.Q39815651
Photinides A-F, cytotoxic benzofuranone-derived gamma-lactones from the plant endophytic fungus Pestalotiopsis photiniaeQ39860331
A novel antimycin-like compound, JBIR-06, from Streptomyces sp. ML55.Q39978661
Bioprospecting Chemical Diversity and Bioactivity in a Marine Derived Aspergillus terreus.Q39994498
Niizalactams A-C, Multicyclic Macrolactams Isolated from Combined Culture of Streptomyces with Mycolic Acid-Containing BacteriumQ40255055
Two new macrolides produced by Streptomyces sp. CS.Q40484456
Isolation, optimization of production and structure-activity relationship studies of monocillin I, the cytotoxic constituent of Paraphaeosphaeria quadriseptataQ40498244
New cytotoxic spectinabilin derivative from ant-associated Streptomyces sp. 1H-GS5.Q40535463
Expanding the chemical space for natural products by Aspergillus-Streptomyces co-cultivation and biotransformationQ40872092
Biphenomycin A production by a mixed cultureQ41846071
Influence of pH and carbon to nitrogen ratio on mycotoxin production by Alternaria alternata in submerged cultivationQ42147025
Cladosins F and G, two new hybrid polyketides from the deep-sea-derived Cladosporium sphaerospermum 2005-01-E3.Q42202610
Eleganketal A, a highly oxygenated dibenzospiroketal from the marine-derived fungus Spicaria elegans KLA03.Q42209849
Cladosins A-E, hybrid polyketides from a deep-sea-derived fungus, Cladosporium sphaerospermum.Q42238932
Structures and biosynthesis of 12-membered macrocyclic depsipeptides from Streptomyces sp. ML55.Q42259487
Isolation, structure elucidation and total synthesis of lajollamide A from the marine fungus Asteromyces cruciatus.Q42425305
Histone deacetylase inhibitors as a tool to up-regulate new fungal biosynthetic products: isolation of EGM-556, a cyclodepsipeptide, from Microascus sp.Q42586901
Polyketides with antimicrobial activity from the solid culture of an endolichenic fungus Ulocladium sp.Q42725152
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectsecondary metaboliteQ522244
literature reviewQ2412849
P304page(s)294
P577publication date2019-01-01
P1433published inFrontiers in MicrobiologyQ27723481
P1476titleExploring Structural Diversity of Microbe Secondary Metabolites Using OSMAC Strategy: A Literature Review
P478volume10

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cites work (P2860)
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