Adjunctive dabigatran therapy improves outcome of experimental left-sided Staphylococcus aureus endocarditis

scientific article published on 19 April 2019

Adjunctive dabigatran therapy improves outcome of experimental left-sided Staphylococcus aureus endocarditis is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PONE.0215333
P932PMC publication ID6474597
P698PubMed publication ID31002679

P50authorNiels HøibyQ12328808
Claus E MoserQ58417725
Kim ThomsenQ86199056
Christian J. LercheQ40066028
Peter Østrup JensenQ42574299
Henning BundgaardQ48005387
P2093author name stringChristian Enevold
Jens Peter Goetze
Lars J Christophersen
Pia R Nielsen
P2860cites workSelective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTESQ24304260
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Acetylsalicylic acid reduces vegetation bacterial density, hematogenous bacterial dissemination, and frequency of embolic events in experimental Staphylococcus aureus endocarditis through antiplatelet and antibacterial effectsQ77822685
Inhibition of staphylothrombin by dabigatran reduces Staphylococcus aureus virulenceQ82270679
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Dabigatran reduces thrombin-induced platelet aggregation and activation in a dose-dependent manner.Q38744436
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2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the EurQ41026009
Dabigatran Inhibits Staphylococcus aureus Coagulase ActivityQ42036878
Activated platelets enhance IL-10 secretion and reduce TNF-α secretion by monocytesQ42247181
Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases.Q42950062
Dabigatran enhances clot susceptibility to fibrinolysis by mechanisms dependent on and independent of thrombin-activatable fibrinolysis inhibitorQ43188577
Thrombin-induced platelet aggregation is mediated by a platelet plasma membrane-bound lectinQ43861672
Staphylococcus aureus endocarditis: a consequence of medical progressQ46561771
Endocarditis pathogen promotes vegetation formation by inducing intravascular neutrophil extracellular traps through activated plateletsQ46796272
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectStaphylococcus aureusQ188121
dabigatranQ419345
P304page(s)e0215333
P577publication date2019-04-19
P1433published inPLOS OneQ564954
P1476titleAdjunctive dabigatran therapy improves outcome of experimental left-sided Staphylococcus aureus endocarditis
P478volume14

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Q90042014Targeting staphylocoagulase with isoquercitrin protects mice from Staphylococcus aureus-induced pneumoniacites workP2860

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