HLA class II antibodies induce necrotic cell death in human endothelial cells via a lysosomal membrane permeabilization-mediated pathway

scientific article published on 08 March 2019

HLA class II antibodies induce necrotic cell death in human endothelial cells via a lysosomal membrane permeabilization-mediated pathway is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1112641405
P356DOI10.1038/S41419-019-1319-5
P932PMC publication ID6408495
P698PubMed publication ID30850581

P50authorAndreas LinkermannQ30225182
Stephan ImmenschuhQ47158608
Rainer BlasczykQ85026471
P2093author name stringJan Ulrich Becker
Vijith Vijayan
Constanca Figueiredo
Abid Aljabri
Christoph Nikolin
Metodi Stankov
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Sensitive detection of lysosomal membrane permeabilization by lysosomal galectin puncta assay.Q36111729
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Non-complement- and complement-activating antibodies synergize to cause rejection of cardiac allografts.Q51038604
HLA Class II-Triggered Signaling Cascades Cause Endothelial Cell Proliferation and Migration: Relevance to Antibody-Mediated Transplant Rejection.Q52373711
Rates and determinants of progression to graft failure in kidney allograft recipients with de novo donor-specific antibody.Q53459320
HLA class II-mediated death is induced via Fas/Fas ligand interactions in human splenic B lymphocytesQ73128519
De novo donor HLA-specific antibodies after heart transplantation are an independent predictor of poor patient survivalQ83159507
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HLA class I-mediated stress fiber formation requires ERK1/2 activation in the absence of an increase in intracellular Ca2+ in human aortic endothelial cellsQ36312784
Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashionQ36370419
Antibody and complement in transplant vasculopathyQ36726080
A novel pathway of chronic allograft rejection mediated by NK cells and alloantibodyQ36887068
Mitochondria and endothelial functionQ36979168
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Anti-MHC class I antibody activation of proliferation and survival signaling in murine cardiac allograftsQ37445163
A mechanism for overcoming P-glycoprotein-mediated drug resistance: novel combination therapy that releases stored doxorubicin from lysosomes via lysosomal permeabilization using Dp44mT or DpC.Q37603481
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Adenovirus type 5 rupture of lysosomes leads to cathepsin B-dependent mitochondrial stress and production of reactive oxygen species.Q38631756
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Regulated necrosis: disease relevance and therapeutic opportunitiesQ38699324
The in vivo evidence for regulated necrosisQ38809791
Cathepsin D protects colorectal cancer cells from acetate-induced apoptosis through autophagy-independent degradation of damaged mitochondriaQ38862588
Transplantation and Damage-Associated Molecular Patterns (DAMPs).Q38898214
DAMP-Induced Allograft and Tumor Rejection: The Circle Is Closing.Q38928826
Transformation-associated changes in sphingolipid metabolism sensitize cells to lysosomal cell death induced by inhibitors of acid sphingomyelinaseQ39096709
Anti-donor HLA class I antibodies: pathways to endothelial cell activation and cell-mediated allograft rejectionQ39131000
HLA class I antibodies trigger increased adherence of monocytes to endothelial cells by eliciting an increase in endothelial P-selectin and, depending on subclass, by engaging FcγRsQ39149436
Antibody-mediated rejection across solid organ transplants: manifestations, mechanisms, and therapiesQ39366396
Antibody-induced nonapoptotic cell death in human lymphoma and leukemia cells is mediated through a novel reactive oxygen species-dependent pathwayQ39392738
Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology.Q39746539
HLA Class II Antibody Activation of Endothelial Cells Promotes Th17 and Disrupts Regulatory T Lymphocyte ExpansionQ40266578
Antibodies against dengue virus nonstructural protein-1 induce heme oxygenase-1 via a redox-dependent pathway in human endothelial cellsQ40270075
Initial apoptosis is followed by increased proliferation of apoptosis-resistant endothelial cellsQ40421753
SAR650984 directly induces multiple myeloma cell death via lysosomal-associated and apoptotic pathways, which is further enhanced by pomalidomideQ40575818
Endothelial cell apoptosis induced by antibodies against dengue virus nonstructural protein 1 via production of nitric oxideQ40579380
Delineation of the HLA-DR region and the residues involved in the association with the cytoskeletonQ40587553
Value of Donor-Specific Anti-HLA Antibody Monitoring and Characterization for Risk Stratification of Kidney Allograft LossQ40634986
Signaling through HLA-DR induces PKC beta-dependent B cell death outside raftsQ40659031
Role of Sphingosine-1-Phosphate in Transplant Vasculopathy Evoked by Anti-HLA AntibodyQ40990718
Increased expression of NAPDH oxidase 4 in systemic sclerosis dermal fibroblasts: regulation by transforming growth factor β.Q43240966
Mitochondria control of cell death induced by anti-HLA-DR antibodiesQ44497849
MHC class II-mediated apoptosis in dendritic cells: a role for membrane-associated and mitochondrial signaling pathwaysQ44526947
Vascular endothelial cells evade apoptosis triggered by human leukocyte antigen-DR ligation mediated by allospecific antibodiesQ45197912
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and DiseaseQ46292537
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectimmunologyQ101929
cell deathQ2383867
P304page(s)235
P577publication date2019-03-08
P1433published inCell Death and DiseaseQ2197222
P1476titleHLA class II antibodies induce necrotic cell death in human endothelial cells via a lysosomal membrane permeabilization-mediated pathway
P478volume10

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cites work (P2860)
Q90093164Genetic Engineering of the Kidney to Permanently Silence MHC Transcripts During ex vivo Organ Perfusion
Q90532382Upregulation of Endothelial HLA Class II is a Marker of Antibody-Mediated Rejection in Heart Allograft Biopsies
Q95840792Vascular Signaling in Allogenic Solid Organ Transplantation - The Role of Endothelial Cells

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