PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy

scientific article published on 07 March 2019

PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI.INSIGHT.97903
P932PMC publication ID6483522
P698PubMed publication ID30843886

P50authorShigeki NishimoriQ92188487
P2093author name stringTso-Pang Yao
Tatsuya Kobayashi
Andrew B Lassar
Elena Kozhemyakina
Henry M Kronenberg
Forest Lai
Mieno Shiraishi
P2860cites workThe parathyroid hormone (PTH)/PTH-related peptide receptor mediates actions of both ligands in murine boneQ22008500
Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localizationQ22254367
Absence of functional receptors for parathyroid hormone and parathyroid hormone-related peptide in Blomstrand chondrodysplasiaQ24564439
The many roles of histone deacetylases in development and physiology: implications for disease and therapyQ24628821
Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibersQ24673210
Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone developmentQ28119185
Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophyQ28219383
A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasiaQ28299144
Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesisQ28505748
MEF2C transcription factor controls chondrocyte hypertrophy and bone developmentQ28505927
PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growthQ28506149
SIK3 is essential for chondrocyte hypertrophy during skeletal development in miceQ28507197
Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10Q28509194
Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehogQ28586013
The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogrammingQ28590118
Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide geneQ28590408
Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart developmentQ28592216
A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expressionQ28645691
Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblastsQ29547605
Developmental regulation of the growth plateQ29618969
Twenty-five years of PTHrP progress: from cancer hormone to multifunctional cytokineQ30416231
Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels.Q30531794
Deletion and point mutations of PTHLH cause brachydactyly type E.Q33708563
Vasculature-associated cells expressing nestin in developing bones encompass early cells in the osteoblast and endothelial lineageQ33852558
Haploinsufficiency of HDAC4 causes brachydactyly mental retardation syndrome, with brachydactyly type E, developmental delays, and behavioral problemsQ34050919
A subset of chondrogenic cells provides early mesenchymal progenitors in growing bonesQ34602826
Sonic hedgehog promotes somitic chondrogenesis by altering the cellular response to BMP signalingQ35187097
Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone developmentQ36010744
Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formationQ37332979
Brachydactyly E: isolated or as a feature of a syndromeQ37359454
Dlx5 and mef2 regulate a novel runx2 enhancer for osteoblast-specific expressionQ39009198
The tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylasesQ39197659
Parathyroid hormone-related peptide represses chondrocyte hypertrophy through a protein phosphatase 2A/histone deacetylase 4/MEF2 pathwayQ42250004
Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors.Q50722204
PTHrP and Indian hedgehog control differentiation of growth plate chondrocytes at multiple steps.Q52118956
Col2a1-directed expression of Cre recombinase in differentiating chondrocytes in transgenic mice.Q52169988
The parathyroid hormone-like peptide associated with humoral hypercalcemia of malignancy and parathyroid hormone bind to the same receptor on the plasma membrane of ROS 17/2.8 cellsQ69829079
P433issue5
P407language of work or nameEnglishQ1860
P577publication date2019-03-07
P1433published inJCI insightQ27727187
P1476titlePTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy
P478volume4

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cites work (P2860)
Q94471881Conditional deletion of HDAC4 from collagen type 2α1-expressing cells increases angiogenesis in vivo
Q91787941Interplay between genetics and epigenetics in osteoarthritis
Q92726613Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodeling

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