Novel orally active iron chelators (3-hydroxypyridin-4-ones) enhance the biliary excretion of plasma non-transferrin-bound iron in rats

scientific article published on 01 July 1997

Novel orally active iron chelators (3-hydroxypyridin-4-ones) enhance the biliary excretion of plasma non-transferrin-bound iron in rats is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0168-8278(97)80299-1
P698PubMed publication ID9252093

P50authorDominique GuyaderQ43035112
Bertrand CossonQ56508868
Roberto VernaQ59207477
P2093author name stringS Singh
J Arnaud
O Loréal
P Brissot
G Lescoat
R C Hider
G Zanninelli
R Choudury
P2860cites workLong-term trial with the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one (L1). II. Clinical observationsQ33392285
Biliary excretion of iron from hepatocyte lysosomes in the rat. A major excretory pathway in experimental iron overloadQ34518111
Efficient clearance of non-transferrin-bound iron by rat liver. Implications for hepatic iron loading in iron overload statesQ34559341
Tissue distribution and clearance kinetics of non-transferrin-bound iron in the hypotransferrinemic mouse: a rodent model for hemochromatosisQ34625175
Clinically useful chelators of tripositive elements.Q34774041
The pathology of hepatic iron overload: a free radical--mediated process?Q37870467
Long-term therapy with deferiproneQ40972034
Design of orally active iron chelatorsQ40972044
Hepatic lipid peroxidation in vivo in rats with chronic iron overloadQ40983697
Non-specific serum iron in thalassaemia: an abnormal serum iron fraction of potential toxicityQ42024944
Low-molecular-weight iron complexes and oxygen radical reactions in idiopathic haemochromatosisQ47226630
Clinical consequences of acquired transfusional iron overload in adultsQ71524888
Iron-chelation therapy with oral deferiprone in patients with thalassemia majorQ72596367
Synthesis, physicochemical properties, and biological evaluation of N-substituted 2-alkyl-3-hydroxy-4(1H)-pyridinones: orally active iron chelators with clinical potentialQ72889098
Measurement of liver-iron concentration in needle-biopsy specimensQ93695357
P433issue1
P304page(s)176-184
P577publication date1997-07-01
P1433published inJournal of HepatologyQ15724402
P1476titleNovel orally active iron chelators (3-hydroxypyridin-4-ones) enhance the biliary excretion of plasma non-transferrin-bound iron in rats
P478volume27

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cites work (P2860)
Q35097652Beta-thalassaemia: emergence of new and improved iron chelators for treatment.
Q58580509Gastrointestinal iron excretion and reversal of iron excess in a mouse model of inherited iron excess
Q78099562Gradient ion-pair high-performance liquid chromatographic method for analysis of 3-hydroxypyridin-4-one iron chelators
Q73509138Liquid extraction and ion-pair HPLC for determination of hydrophilic 3-hydroxypyridin-4-one iron chelators
Q34094832The design and properties of 3-hydroxypyridin-4-one iron chelators with high pFe(3+) values
Q77530290The labile iron pool of hepatocytes in chronic and acute iron overload and chelator-induced iron deprivation