Single molecule glycosylase studies with engineered 8-oxoguanine DNA damage sites show functional defects of a MUTYH polyposis variant

Single molecule glycosylase studies with engineered 8-oxoguanine DNA damage sites show functional defects of a MUTYH polyposis variant is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NAR/GKZ045
P932PMC publication ID6451117
P698PubMed publication ID30698731

P50authorSusan S WallaceQ41886664
P2093author name stringDavid M Warshaw
Shane R Nelson
April M Averill
Scott D Kathe
Andrea J Lee
Thomas S Hilzinger
P2860cites workMUTYH DNA glycosylase: the rationale for removing undamaged bases from the DNAQ21131242
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How do site-specific DNA-binding proteins find their targets?Q24563835
Base excision repair and cancerQ27025537
Structure of a trapped endonuclease III-DNA covalent intermediateQ27641607
Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylaseQ27643123
Atomic substitution reveals the structural basis for substrate adenine recognition and removal by adenine DNA glycosylaseQ27657850
Strandwise translocation of a DNA glycosylase on undamaged DNAQ27676544
The E295K Cancer Variant of Human Polymerase   Favors the Mismatch Conformational Pathway during Nucleotide SelectionQ27680388
Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: Activity, structure, and the effect of editingQ27681153
Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damageQ28114912
Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repairQ28138546
Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYHQ28212369
Hereditary and familial colon cancerQ28280647
hMYH cell cycle-dependent expression, subcellular localization and association with replication foci: evidence suggesting replication-coupled repair of adenine:8-oxoguanine mispairsQ28343394
ThunderSTORM: a comprehensive ImageJ plug-in for PALM and STORM data analysis and super-resolution imagingQ28364583
A germline polymorphism of DNA polymerase beta induces genomic instability and cellular transformationQ28485045
Complexities of the DNA base excision repair pathway for repair of oxidative DNA damageQ28597101
Enhanced activity of adenine-DNA glycosylase (Myh) by apurinic/apyrimidinic endonuclease (Ape1) in mammalian base excision repair of an A/GO mismatchQ28645615
Base-excision repair of oxidative DNA damageQ29615373
A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA.Q30477242
Single-molecule analysis reveals human UV-damaged DNA-binding protein (UV-DDB) dimerizes on DNA via multiple kinetic intermediatesQ30577983
Insights into the glycosylase search for damage from single-molecule fluorescence microscopyQ30585004
Characterization of the recombinant MutY homolog, an adenine DNA glycosylase, from yeast Schizosaccharomyces pombeQ32021272
Automatic tracking of individual fluorescence particles: application to the study of chromosome dynamics.Q33224137
Two glycosylase families diffusively scan DNA using a wedge residue to probe for and identify oxidatively damaged basesQ33665271
Purification and characterization of a mammalian homolog of Escherichia coli MutY mismatch repair protein from calf liver mitochondriaQ33786679
Nonspecifically bound proteins spin while diffusing along DNA.Q33929106
Microscopic mechanism of DNA damage searching by hOGG1Q34044395
Efficient preparation of internally modified single-molecule constructs using nicking enzymesQ34149339
Strand-specific processing of 8-oxoguanine by the human mismatch repair pathway: inefficient removal of 8-oxoguanine paired with adenine or cytosineQ40619788
Replication-associated repair of adenine:8-oxoguanine mispairs by MYH.Q40748374
MUTYH prevents OGG1 or APEX1 from inappropriately processing its substrate or reaction product with its C-terminal domainQ40969387
How do DNA repair proteins locate damaged bases in the genome?Q41509782
Structure-Activity Relationships Reveal Key Features of 8-Oxoguanine: A Mismatch Detection by the MutY GlycosylaseQ41703841
Functional analysis of MUTYH mutated proteins associated with familial adenomatous polyposisQ43086158
Inherited variants of MYH associated with somatic G:C-->T:A mutations in colorectal tumorsQ43871566
The mammalian mismatch repair pathway removes DNA 8-oxodGMP incorporated from the oxidized dNTP poolQ44025676
Identification of critical residues required for the mutation avoidance function of human MutY (hMYH) and implications in colorectal cancerQ44809395
DNA damage recognition and repair by the murine MutY homologueQ45144370
Insight into the roles of tyrosine 82 and glycine 253 in the Escherichia coli adenine glycosylase MutY.Q46771307
Generation of reporter plasmids containing defined base modifications in the DNA strand of choice.Q50501056
Structural Basis for the Lesion-scanning Mechanism of the MutY DNA Glycosylase.Q50927527
Diffusion-driven mechanisms of protein translocation on nucleic acids. 1. Models and theory.Q52732418
Mechanism of action of Micrococcus luteus .gamma.-endonucleaseQ62061132
Efficient recognition of substrates and substrate analogs by the adenine glycosylase MutY requires the C-terminal domainQ34249739
Escherichia coli mutY gene encodes an adenine glycosylase active on G-A mispairsQ34319463
Molecular mechanism of PCNA-dependent base excision repairQ34367191
Multiple DNA glycosylases for repair of 8-oxoguanine and their potential in vivo functionsQ34367211
Base excision repair.Q34374847
MUTYH Associated Polyposis (MAP).Q34608633
Biological consequences of free radical-damaged DNA bases.Q34710048
The fidelity of the human leading and lagging strand DNA replication apparatus with 8-oxodeoxyguanosine triphosphateQ35004473
Single Qdot-labeled glycosylase molecules use a wedge amino acid to probe for lesions while scanning along DNAQ35224383
Structural Basis for Avoidance of Promutagenic DNA Repair by MutY Adenine DNA GlycosylaseQ35837084
Human POLB gene is mutated in high percentage of colorectal tumorsQ36078847
Colon cancer-associated DNA polymerase β variant induces genomic instability and cellular transformationQ36078852
The DNA trackwalkers: principles of lesion search and recognition by DNA glycosylasesQ36153889
MutYH (MYH) and colorectal cancerQ36206408
MUTYH-associated polyposis--from defect in base excision repair to clinical genetic testingQ36680267
The human gastric cancer-associated DNA polymerase β variant D160N is a mutator that induces cellular transformationQ36761129
Germ-line variant of human NTH1 DNA glycosylase induces genomic instability and cellular transformationQ37143498
Escherichia coli MutY protein has both N-glycosylase and apurinic/apyrimidinic endonuclease activities on A.C and A.G mispairsQ37209405
Characterization of mutant MUTYH proteins associated with familial colorectal cancer.Q37386808
Distinct functional consequences of MUTYH variants associated with colorectal cancer: Damaged DNA affinity, glycosylase activity and interaction with PCNA and Hus1.Q37397651
Adenine removal activity and bacterial complementation with the human MutY homologue (MUTYH) and Y165C, G382D, P391L and Q324R variants associated with colorectal cancerQ37464076
Real-time studies of conformational dynamics of the repair enzyme E. coli formamidopyrimidine-DNA glycosylase and its DNA complexes during catalytic cycleQ37596621
DNA polymerases and oxidative damage: friends or foes?Q37659080
Detection of damaged DNA bases by DNA glycosylase enzymesQ37752315
DNA determinants and substrate specificities of Escherichia coli MutY.Q38290583
Structure of a DNA glycosylase searching for lesionsQ38315509
Cells with pathogenic biallelic mutations in the human MUTYH gene are defective in DNA damage binding and repairQ38324266
Insight into the functional consequences of hMYH variants associated with colorectal cancer: distinct differences in the adenine glycosylase activity and the response to AP endonucleases of Y150C and G365D murine MYH.Q38331638
Single-turnover and pre-steady-state kinetics of the reaction of the adenine glycosylase MutY with mismatch-containing DNA substratesQ38332366
Specific recognition of A/G and A/7,8-dihydro-8-oxoguanine (8-oxoG) mismatches by Escherichia coli MutY: removal of the C-terminal domain preferentially affects A/8-oxoG recognitionQ38350336
Insight into the functional consequences of inherited variants of the hMYH adenine glycosylase associated with colorectal cancer: complementation assays with hMYH variants and pre-steady-state kinetics of the corresponding mutated E.coli enzymesQ38356866
MUTYH mutations associated with familial adenomatous polyposis: functional characterization by a mammalian cell-based assay.Q39768428
P275copyright licenseCreative Commons Attribution-NonCommercial 4.0 InternationalQ34179348
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectpolyposisQ2103081
P304page(s)3058-3071
P577publication date2019-04-08
P1433published inNucleic Acids ResearchQ135122
P1476titleSingle molecule glycosylase studies with engineered 8-oxoguanine DNA damage sites show functional defects of a MUTYH polyposis variant
P478volume47

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Q91286795Additive manufacturing of laminar flow cells for single-molecule experimentscites workP2860

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