Downregulation of PDK4 Increases Lipogenesis and Associates with Poor Prognosis in Hepatocellular Carcinoma

Downregulation of PDK4 Increases Lipogenesis and Associates with Poor Prognosis in Hepatocellular Carcinoma is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.7150/JCA.27226
P932PMC publication ID6400816
P698PubMed publication ID30854098

P2093author name stringHui Wang
Jia He
Chen Yang
Ming Yao
Wenxin Qin
Yuanyuan Lv
Siying Wang
Dishui Gu
Guangzhi Jin
Haojie Jin
Haoyu Ruan
Chengtao Yu
Zhuoan Cheng
Botai Li
Qiaozhu Zuo
P2860cites workHallmarks of Cancer: The Next GenerationQ22252312
Cloning and characterization of PDK4 on 7q21.3 encoding a fourth pyruvate dehydrogenase kinase isoenzyme in humanQ24321423
Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferationQ24323390
Global cancer statistics, 2012Q27860501
PDK4 protein promotes tumorigenesis through activation of cAMP-response element-binding protein (CREB)-Ras homolog enriched in brain (RHEB)-mTORC1 signaling cascadeQ28246822
Cancer cell metabolism: Warburg and beyondQ28293198
Inhibition of cancer cell proliferation by PPARγ is mediated by a metabolic switch that increases reactive oxygen species levelsQ34315365
Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancerQ34575904
Hepatocellular carcinoma: clinical frontiers and perspectivesQ35112053
Prognostic significance of kynurenine 3-monooxygenase and effects on proliferation, migration, and invasion of human hepatocellular carcinomaQ35775787
Advances in measuring cellular bioenergetics using extracellular fluxQ37110791
Downregulation of ACSM3 promotes metastasis and predicts poor prognosis in hepatocellular carcinomaQ37743514
Evidence-Based Diagnosis, Staging, and Treatment of Patients With Hepatocellular Carcinoma.Q38706131
Inhibition of FASN suppresses migration, invasion and growth in hepatoma carcinoma cells by deregulating the HIF-1α/IGFBP1 pathwayQ38716451
Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6.Q38718555
Loss of the novel mitochondrial protein FAM210B promotes metastasis via PDK4-dependent metabolic reprogramming.Q38736595
The Burden of Primary Liver Cancer and Underlying Etiologies From 1990 to 2015 at the Global, Regional, and National Level: Results From the Global Burden of Disease Study 2015.Q41923187
Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivationQ42009070
Mitogenic Sonic hedgehog signaling drives E2F1-dependent lipogenesis in progenitor cells and medulloblastomaQ42167075
Metabolic and transcriptional profiling reveals pyruvate dehydrogenase kinase 4 as a mediator of epithelial-mesenchymal transition and drug resistance in tumor cells.Q42977115
Up-regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) protein expression in oxidative skeletal muscle does not require the obligatory participation of peroxisome-proliferator-activated receptor alpha (PPARalpha).Q43002185
Coordinate expression of the PDK4 gene: a means of regulating fuel selection in a hibernating mammalQ43884371
Genes with aberrant expression in murine preneoplastic intestine show epigenetic and expression changes in normal mucosa of colon cancer patientsQ45734518
The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesisQ46488114
Pyruvate Dehydrogenase Kinase 4 Deficiency Results in Expedited Cellular Proliferation through E2F1-Mediated Increase of CyclinsQ48008302
Gene expression profiles in prostate cancer: identification of candidate non-invasive diagnostic markers.Q50483702
Regulator of Calcineurin 1 Gene Isoform 4, Down-regulated in Hepatocellular Carcinoma, Prevents Proliferation, Migration, and Invasive Activity of Cancer Cells and Metastasis of Orthotopic Tumors by Inhibiting Nuclear Translocation of NFAT1.Q50600121
Increased Serotonin Signaling Contributes to the Warburg Effect in Pancreatic Tumor Cells Under Metabolic Stress and Promotes Growth of Pancreatic Tumors in Mice.Q50791502
Oncogenic role of PDK4 in human colon cancer cells.Q51135000
Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis.Q52715864
P433issue4
P407language of work or nameEnglishQ1860
P921main subjecthepatocellular carcinomaQ1148337
lipid biosynthetic processQ21096257
ProliferationQ25096177
P304page(s)918-926
P577publication date2019-01-01
P1433published inJournal of CancerQ6294901
P1476titleDownregulation of PDK4 Increases Lipogenesis and Associates with Poor Prognosis in Hepatocellular Carcinoma
P478volume10

Reverse relations

cites work (P2860)
Q93174238STAT3-dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer
Q103804672microRNA-9-5p regulates the mitochondrial function of hepatocellular carcinoma cells through suppressing PDK4

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