An Appraisal of the Influence of the Metabotropic Glutamate 5 (mGlu5) Receptor on Sociability and Anxiety

scientific article published on 19 February 2019

An Appraisal of the Influence of the Metabotropic Glutamate 5 (mGlu5) Receptor on Sociability and Anxiety is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3389/FNMOL.2019.00030
P932PMC publication ID6401637
P698PubMed publication ID30873001

P50authorFrancesco FerragutiQ42829320
P2093author name stringArnau Ramos-Prats
Maximilian Zeidler
Gabriele Schmid
Elena Paolo
Julia Kölldorfer
P2860cites workFinding and evaluating community structure in networksQ21563748
Correction of fragile X syndrome in mice.Q22251255
The pathophysiology of fragile X (and what it teaches us about synapses)Q27010675
Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out miceQ27318675
Mapping social behavior-induced brain activation at cellular resolution in the mouseQ27321325
Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autismQ27329063
Neurobiology of social behavior abnormalities in autism and Williams syndromeQ28076343
Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant miceQ28214803
Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptorsQ28362372
Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTPQ28511269
Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in miceQ29618044
Disruption of mGluR5 in parvalbumin-positive interneurons induces core features of neurodevelopmental disordersQ30402048
Metabotropic glutamate receptors: from the workbench to the bedsideQ30448778
mGluR5 ablation in cortical glutamatergic neurons increases novelty-induced locomotionQ30450936
Subpopulations of neurokinin 1 receptor-expressing neurons in the rat lateral amygdala display a differential pattern of innervation from distinct glutamatergic afferentsQ30470225
Evidence for hubs in human functional brain networksQ30557690
Neural mechanisms in Williams syndrome: a unique window to genetic influences on cognition and behaviourQ31043640
Operant sensation seeking requires metabotropic glutamate receptor 5 (mGluR5).Q33769874
Dysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with Intellectual Disability and AutismQ33877423
Optogenetic insights on the relationship between anxiety-related behaviors and social deficitsQ33906973
Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA(A) signalingQ34336029
The behavioral profile of the potent and selective mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) in rodent models of anxietyQ34340266
Automated apparatus for quantitation of social approach behaviors in mice.Q34345417
The metabotropic glutamate receptor, mGluR5, is a key determinant of good and bad spatial learning performance and hippocampal synaptic plasticityQ34392771
Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP.Q34564332
Anxiolytic-like action of MTEP expressed in the conflict drinking Vogel test in rats is serotonin dependent.Q34687749
Genetic reduction of group 1 metabotropic glutamate receptors alters select behaviors in a mouse model for fragile X syndromeQ35125117
Double Dissociation of the Roles of Metabotropic Glutamate Receptor 5 and Oxytocin Receptor in Discrete Social BehaviorsQ35960336
Bidirectional modulation of anxiety-related and social behaviors by amygdala projections to the medial prefrontal cortexQ36487978
Metabotropic glutamate receptors.Q36539070
Network analysis of brain cognitive function using metabolic and blood flow dataQ36704081
Amygdala inputs to the ventral hippocampus bidirectionally modulate social behaviorQ37410012
Negative Allosteric Modulation of mGluR5 Partially Corrects Pathophysiology in a Mouse Model of Rett Syndrome.Q37445111
Brain networks activated to form object recognition memory.Q50580601
Metabotropic glutamate receptors as targets for novel anxiolytics.Q52679411
The selective mGlu5 receptor antagonist MTEP, similar to NMDA receptor antagonists, induces social isolation in ratsQ79775681
Anxiolytic effects of buspirone and MTEP in the Porsolt Forced Swim TestQ88937489
The hippocampal CA2 region is essential for social memoryQ37724231
Group 5 metabotropic glutamate receptors: role in modulating cortical activity and relevance to cognitionQ37725302
Shifting towards a model of mGluR5 dysregulation in schizophrenia: Consequences for future schizophrenia treatment.Q38582833
Effect of the mGluR5-NAM Basimglurant on Behavior in Adolescents and Adults with Fragile X Syndrome in a Randomized, Double-Blind, Placebo-Controlled Trial: FragXis Phase 2 Results.Q38620643
Mavoglurant in fragile X syndrome: Results of two randomized, double-blind, placebo-controlled trialsQ38921198
Reduced stress-induced hyperthermia in mGluR5 knockout miceQ40569485
Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in MiceQ41634132
Contribution of mGluR5 to pathophysiology in a mouse model of human chromosome 16p11.2 microdeletionQ42059359
Cartography of complex networks: modules and universal roles.Q42861495
Modulation of neuronal microcircuit activities within the medial prefrontal cortex by mGluR5 positive allosteric modulatorQ43183421
Significant increase in anxiety during aging in mGlu5 receptor knockout miceQ43603148
Chronic administration of AFQ056/Mavoglurant restores social behaviour in Fmr1 knockout miceQ43997903
Metabotropic glutamate subtype 5 receptors modulate locomotor activity and sensorimotor gating in rodentsQ44378869
In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine).Q44523578
Effect of antipsychotic treatment on the prepulse inhibition deficit of mGluR5 knockout miceQ44654536
Interactions of the mGluR5 gene with breeding and maternal factors on startle and prepulse inhibition in miceQ44926980
Complex effects of mGluR5 antagonism on sociability and stereotypic behaviors in mice: possible implications for the pharmacotherapy of autism spectrum disordersQ44968387
Chemogenetic Interrogation of a Brain-wide Fear Memory Network in Mice.Q47326173
Insular cortex mediates approach and avoidance responses to social affective stimuli.Q47552161
Social deficits in IRSp53 mutant mice improved by NMDAR and mGluR5 suppressionQ47683497
mGlu5-dependent modulation of anxiety during early withdrawal from binge-drinking in adult and adolescent male miceQ47721022
Functional Connectivity of Multiple Brain Regions Required for the Consolidation of Social Recognition MemoryQ47776218
Pharmacological modulation of metabotropic glutamate receptor subtype 5 and 7 impairs extinction of social fear in a time-point-dependent manner.Q47920275
Brain concentrations of mGluR5 negative allosteric modulator MTEP in relation to receptor occupancy--Comparison to MPEP.Q48198045
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectMTEPQ13566097
Social BehaviorQ58310263
P304page(s)30
P577publication date2019-02-19
P1433published inFrontiers in Molecular NeuroscienceQ27721913
P1476titleAn Appraisal of the Influence of the Metabotropic Glutamate 5 (mGlu5) Receptor on Sociability and Anxiety
P478volume12

Reverse relations

Q101121234Subtype-selective mechanisms of negative allosteric modulators binding to group I metabotropic glutamate receptorscites workP2860

Search more.