scholarly article | Q13442814 |
P50 | author | Helena C Castro | Q42532140 |
Nubia Boechat | Q47697925 | ||
P2093 | author name string | Lucas V B Hoelz | |
Carlos R Rodrigues | |||
Murilo L Bello | |||
Robson X Faria | |||
Daniel T G Gonzaga | |||
Caroline R C Reis | |||
Felipe H Oliveira | |||
G Q Pinho | |||
Hellen V C M de Souza | |||
João C M Mafra | |||
Juliana P Salles | |||
Luiz C S Pinheiro | |||
N L von Ranke | |||
Rennan P P Leme | |||
P2860 | cites work | Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation. | Q51306717 |
Synthesis of Some Novel Thiadiazole Derivative Compounds and Screening Their Antidepressant-Like Activities. | Q53429385 | ||
Generalized correlation for biomolecular dynamics | Q81628609 | ||
P2RX7 Purinoceptor as a Therapeutic Target-The Second Coming? | Q90016514 | ||
8-Hydroxy-2-(1H-1,2,3-triazol-1-yl)-1,4-naphtoquinone derivatives inhibited P2X7 Receptor-Induced dye uptake into murine Macrophages | Q90350802 | ||
Expression of P2X purinoceptors in PC12 phaeochromocytoma cells | Q40059431 | ||
Synthesis and antiviral evaluation of novel 1,3,4-oxadiazole/thiadiazole-chalcone conjugates | Q40071498 | ||
Are second messengers crucial for opening the pore associated with P2X7 receptor? | Q40506943 | ||
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The P2X7 Receptor Contributes to the Development of the Exacerbated Inflammatory Response Associated with Sepsis. | Q41444442 | ||
Design, synthesis and anti-P. falciparum activity of pyrazolopyridine-sulfonamide derivatives. | Q41914498 | ||
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A phase I clinical trial demonstrates that nfP2X7 -targeted antibodies provide a novel, safe and tolerable topical therapy for basal cell carcinoma | Q42505092 | ||
Efficacy and safety of CE-224,535, an antagonist of P2X7 receptor, in treatment of patients with rheumatoid arthritis inadequately controlled by methotrexate | Q42720832 | ||
Discovery, synthesis and SAR of azinyl- and azolylbenzamides antagonists of the P2X₇ receptor. | Q42730208 | ||
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Pharmacology of a novel central nervous system-penetrant P2X7 antagonist JNJ-42253432. | Q46109694 | ||
Identification of (R)-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor | Q46129724 | ||
Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents | Q46391026 | ||
1,4-Naphthoquinones potently inhibiting P2X7 receptor activity. | Q47407925 | ||
1-Aryl-1H- and 2-aryl-2H-1,2,3-triazole derivatives blockade P2X7 receptor in vitro and inflammatory response in vivo. | Q47876692 | ||
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The P2X7 purinergic receptor: An emerging therapeutic target in cardiovascular diseases. | Q49793266 | ||
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Molecular physiology of P2X receptors | Q28203477 | ||
RM1: a reparameterization of AM1 for H, C, N, O, P, S, F, Cl, Br, and I | Q28239815 | ||
A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat | Q28264281 | ||
Receptors for purines and pyrimidines | Q28283941 | ||
OPM database and PPM web server: resources for positioning of proteins in membranes | Q28740946 | ||
Novel Series of Dihydropyridinone P2X7 Receptor Antagonists | Q30010551 | ||
R.E.D. Server: a web service for deriving RESP and ESP charges and building force field libraries for new molecules and molecular fragments | Q31014950 | ||
1,3,4-Thiadiazole: synthesis, reactions, and applications in medicinal, agricultural, and materials chemistry | Q34414456 | ||
MolDock: a new technique for high-accuracy molecular docking | Q34530159 | ||
A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases | Q35044923 | ||
Medicinal chemistry of adenosine, P2Y and P2X receptors | Q35873582 | ||
Synthesis and biological activities of novel 1,3,4-thiadiazole-containing pyrazole oxime derivatives | Q36057339 | ||
CHARMM-GUI PDB manipulator for advanced modeling and simulations of proteins containing nonstandard residues. | Q36539936 | ||
Optimization of the additive CHARMM all-atom protein force field targeting improved sampling of the backbone φ, ψ and side-chain χ(1) and χ(2) dihedral angles | Q36546184 | ||
Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567. | Q37219098 | ||
Structural basis for subtype-specific inhibition of the P2X7 receptor. | Q37524867 | ||
The P2X7 purinergic receptor: from physiology to neurological disorders. | Q37610687 | ||
P2X receptors as drug targets | Q38068620 | ||
Physiological roles and potential therapeutic applications of the P2X7 receptor in inflammation and pain | Q38135247 | ||
Recent advances in bioactive pyrazoles | Q38306223 | ||
1,3,4-Thiadiazoles of pharmacological interest: Recent trends in their synthesis via tandem 1,3-dipolar cycloaddition: Review | Q38356909 | ||
P2X7 antagonists for CNS indications: recent patent disclosures | Q38714381 | ||
Human Cancer Cell Line Based Approach of 1,3,4-thiadiazole and its Fused Ring: A Comprehensive Review | Q38740961 | ||
Synthesis of novel pyrazole–thiadiazole hybrid as potential potent and selective cyclooxygenase-2 (COX-2) inhibitors. | Q38936135 | ||
The Role of Interleukin-1 in Inflammatory and Malignant Human Skin Diseases and the Rationale for Targeting Interleukin-1 Alpha | Q38948602 | ||
P2X7 receptor antagonists: a patent review (2010-2015). | Q38977163 | ||
Synthesis of some new pyrazole-based 1,3-thiazoles and 1,3,4-thiadiazoles as anticancer agents | Q39063170 | ||
Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors | Q39832611 | ||
P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
P6216 | copyright status | copyrighted | Q50423863 |
P407 | language of work or name | English | Q1860 |
P921 | main subject | thiadiazoles | Q2742440 |
Molecular Docking | Q57976073 | ||
P304 | page(s) | 261 | |
P577 | publication date | 2019-04-30 | |
P1433 | published in | Frontiers in Chemistry | Q27725450 |
P1476 | title | Synthesis, Biological Evaluation, and Molecular Modeling Studies of New Thiadiazole Derivatives as Potent P2X7 Receptor Inhibitors | |
P478 | volume | 7 |
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