Synthesis, Biological Evaluation, and Molecular Modeling Studies of New Thiadiazole Derivatives as Potent P2X7 Receptor Inhibitors

scientific article published on 30 April 2019

Synthesis, Biological Evaluation, and Molecular Modeling Studies of New Thiadiazole Derivatives as Potent P2X7 Receptor Inhibitors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FCHEM.2019.00261
P932PMC publication ID6511888
P698PubMed publication ID31134177

P50authorHelena C CastroQ42532140
Nubia BoechatQ47697925
P2093author name stringLucas V B Hoelz
Carlos R Rodrigues
Murilo L Bello
Robson X Faria
Daniel T G Gonzaga
Caroline R C Reis
Felipe H Oliveira
G Q Pinho
Hellen V C M de Souza
João C M Mafra
Juliana P Salles
Luiz C S Pinheiro
N L von Ranke
Rennan P P Leme
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Pharmacology of a novel central nervous system-penetrant P2X7 antagonist JNJ-42253432.Q46109694
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1-Aryl-1H- and 2-aryl-2H-1,2,3-triazole derivatives blockade P2X7 receptor in vitro and inflammatory response in vivo.Q47876692
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A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the ratQ28264281
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Human Cancer Cell Line Based Approach of 1,3,4-thiadiazole and its Fused Ring: A Comprehensive ReviewQ38740961
Synthesis of novel pyrazole–thiadiazole hybrid as potential potent and selective cyclooxygenase-2 (COX-2) inhibitors.Q38936135
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P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectthiadiazolesQ2742440
Molecular DockingQ57976073
P304page(s)261
P577publication date2019-04-30
P1433published inFrontiers in ChemistryQ27725450
P1476titleSynthesis, Biological Evaluation, and Molecular Modeling Studies of New Thiadiazole Derivatives as Potent P2X7 Receptor Inhibitors
P478volume7

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