Use of Cannabidiol in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials

Use of Cannabidiol in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.3390/MOLECULES24081459
P932PMC publication ID6514832
P698PubMed publication ID31013866

P50authorEmanuela MazzonQ56849438
Placido BramantiQ59692852
P2093author name stringEugenio Cavalli
Santa Mammana
Serena Silvestro
P2860cites workMutations of SCN1A, encoding a neuronal sodium channel, in two families with GEFS+2Q22253421
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Long-Term Safety, Tolerability, and Efficacy of Cannabidiol in Children with Refractory Epilepsy: Results from an Expanded Access Program in the USQ93259363
Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis.Q50484928
Cannabidiol as a new treatment for drug-resistant epilepsy in tuberous sclerosis complex.Q51438384
Protective effect of cannabidiol on hydrogen peroxide‑induced apoptosis, inflammation and oxidative stress in nucleus pulposus cells.Q51633723
Effects of Levetiracetam, Carbamazepine, Phenytoin, Valproate, Lamotrigine, Oxcarbazepine, Topiramate, Vinpocetine and Sertraline on Presynaptic Hippocampal Na(+) and Ca(2+) Channels Permeability.Q52147101
Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome.Q52655447
The neuroprotection of cannabidiol against MPP⁺-induced toxicity in PC12 cells involves trkA receptors, upregulation of axonal and synaptic proteins, neuritogenesis, and might be relevant to Parkinson's disease.Q53281783
Drug-drug interaction between clobazam and cannabidiol in children with refractory epilepsy.Q53835626
Anti-inflammatory and antioxidant effects of a combination of cannabidiol and moringin in LPS-stimulated macrophages.Q54154383
Letter: Cannabidiol and Cannabis sativa extract protect mice and rats against convulsive agents.Q54347871
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Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Δ⁹-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive-compulsivQ56768080
Long‐term cannabidiol treatment in patients with Dravet syndrome: An open‐label extension trialQ62867962
Long-term safety and treatment effects of cannabidiol in children and adults with treatment-resistant epilepsies: Expanded access program resultsQ62868096
Open-label use of highly purified CBD (Epidiolex®) in patients with CDKL5 deficiency disorder and Aicardi, Dup15q, and Doose syndromesQ62868102
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Serotonin 1A receptors, depression, and memory in temporal lobe epilepsy.Q35659141
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CDKL5 mutations cause infantile spasms, early onset seizures, and severe mental retardation in female patients.Q36930153
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Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvementQ40313822
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Evaluation of the role of the cannabidiol system in an animal model of ischemia/reperfusion kidney injuryQ42547658
The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB(2) and adenosine receptors.Q43245497
Perceived efficacy of cannabidiol-enriched cannabis extracts for treatment of pediatric epilepsy: A potential role for infantile spasms and Lennox-Gastaut syndromeQ44297058
Reduction of voltage-operated potassium currents by levetiracetam: a novel antiepileptic mechanism of action?Q44563679
Controlled clinical trial of cannabidiol in Huntington's diseaseQ45293556
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Effects of cannabidiol interactions with Wnt/β-catenin pathway and PPARγ on oxidative stress and neuroinflammation in Alzheimer's diseaseQ46293996
Mechanisms of action of cannabidiol in adoptively transferred experimental autoimmune encephalomyelitis.Q46312650
Forty Years of Sodium Channels: Structure, Function, Pharmacology, and EpilepsyQ47288120
Effects of the benzodiazepine GABAA α1-preferring antagonist 3-isopropoxy-β-carboline hydrochloride (3-ISOPBC) on alcohol seeking and self-administration in baboonsQ47383106
Quality of Life in Childhood Epilepsy in pediatric patients enrolled in a prospective, open-label clinical study with cannabidiolQ47558300
Cannabidiol attenuates seizures and social deficits in a mouse model of Dravet syndromeQ47668118
Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: role of 5-HT1A receptorsQ47889899
Effects of cannabidiol in the treatment of patients with Parkinson's disease: an exploratory double-blind trialQ48065074
Anticonvulsant effect of cannabidiol in the pentylenetetrazole model: Pharmacological mechanisms, electroencephalographic profile, and brain cytokine levels.Q48149242
Reduced hippocampal 5HT1A PET receptor binding and depression in temporal lobe epilepsyQ48198805
Interactions between cannabidiol and commonly used antiepileptic drugs.Q48283873
Effects of felbamate on veratridine- and K(+)-stimulated release of glutamate from mouse cortexQ48859348
Efficacy of artisanal preparations of cannabidiol for the treatment of epilepsy: Practical experiences in a tertiary medical centerQ50074904
Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trialQ50109024
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectanxiolyticQ62903
antipsychoticsQ208144
anticonvulsant agentQ576618
seizureQ6279182
P304page(s)1459
P577publication date2019-04-12
P1433published inMoleculesQ151332
P1476titleUse of Cannabidiol in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials
P478volume24

Reverse relations

cites work (P2860)
Q90248051Cannabidiol Drugs Clinical Trial Outcomes and Adverse Effects
Q90919200Cannabidiol prevents LPS-induced microglial inflammation by inhibiting ROS/NF-κB-dependent signaling and glucose consumption
Q90479312Phytocannabinoids: Useful Drugs for the Treatment of Obesity? Special Focus on Cannabidiol
Q90333815Preliminary Study: Comparison of Antioxidant Activity of Cannabidiol (CBD) and α-Tocopherol Added to Refined Olive and Sunflower Oils

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