SERPINs-From Trap to Treatment

scientific article published on 12 February 2019

SERPINs-From Trap to Treatment is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FMED.2019.00025
P932PMC publication ID6379291
P698PubMed publication ID30809526

P50authorCoen MaasQ52872286
P2093author name stringSteven de Maat
Wariya Sanrattana
P2860cites workStructure of a serpin-protease complex shows inhibition by deformationQ24290459
Serpin reactive center loop mobility is required for inhibitor function but not for enzyme recognition.Q38302674
Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturationQ40763807
Antithrombin Pittsburgh: an alpha1-antitrypsin variant causing hemorrhagic diseaseQ41346980
Antithrombin III Utilization in a Large Teaching HospitalQ42771225
The serpin inhibitory mechanism is critically dependent on the length of the reactive center loopQ43590670
Inhibition of HIV-1 gp160-dependent membrane fusion by a furin-directed alpha 1-antitrypsin variantQ43912898
C1-inhibitor in patients with severe sepsis and septic shock: beneficial effect on renal dysfunctionQ44090857
Inhibition of activated protein C by recombinant alpha 1-antitrypsin variants with substitution of arginine or leucine for methionine358.Q44465337
The serpins: nature's molecular mousetrapsQ45303721
The MEROPS database of proteolytic enzymes, their substrates and inhibitors in 2017 and a comparison with peptidases in the PANTHER database.Q45995268
Physiologic inhibition of human activated protein C by alpha 1-antitrypsinQ46689022
Manipulation of thrombin exosite I, by ligand-directed covalent modificationQ46990394
Familial thrombosis due to antithrombin 3 deficiencyQ47894264
Pathophysiology of Alpha-1 Antitrypsin Deficiency Liver DiseaseQ48018051
N- and O-glycosylation analysis of human C1-inhibitor reveals extensive mucin-type O-glycosylationQ49886884
A Phase I/II, Double-Blind, Placebo-Controlled Study Assessing Safety and Efficacy of C1 Esterase Inhibitor for Prevention of Delayed Graft Function in Deceased Donor Kidney Transplant Recipients.Q52594635
UniProt: the universal protein knowledgebaseQ52697061
Kinetics of association of serine proteinases with native and oxidized alpha-1-proteinase inhibitor and alpha-1-antichymotrypsin.Q52761499
Hereditary angioedema: the plasma contact system out of controlQ56673357
Dominant negative SERPING1 variants cause intracellular retention of C1-inhibitor in hereditary angioedemaQ58607420
Overview of Serpins and Their Roles in Biological SystemsQ59353093
Heparin modulation of human plasma kallikrein on different substrates and inhibitorsQ62065130
Reactivity of alpha 1-antitrypsin mutants against proteolytic enzymes of the kallikrein-kinin, complement, and fibrinolytic systemsQ68518085
Effect of heparin on the inactivation rate of human activated factor XII by antithrombin IIIQ69869393
Serpin-protease complexes are trapped as stable acyl-enzyme intermediatesQ71823584
Mechanism of protein C deficiency in a patient with arginine 358 alpha 1-antitrypsin (Pittsburgh mutation): role in the maintenance of hemostatic balanceQ72133584
C1 esterase inhibitor concentrate for capillary leakage syndrome following bone marrow transplantationQ73877807
Role of the P6-P3' region of the serpin reactive loop in the formation and breakdown of the inhibitory complexQ73940199
Recombinant antitrypsin Pittsburgh undergoes proteolytic cleavage during E. coli sepsis and fails to prevent the associated coagulopathy in a primate modelQ77647776
Effects of C1 inhibitor on tissue damage in a porcine model of controlled hemorrhageQ84344626
[Inter[retation of 2019 Global Strategy for the Diagnosis, Management and Prevention of chronic Obstructive Pulmonary Disease]Q91164841
The effect of a single nucleotide polymorphism on human alpha 2-antiplasmin activityQ24298078
Canonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinasesQ24308401
An overview of the serpin superfamilyQ24684030
Topography of a 2.0 Å structure of α1-antitrypsin reveals targets for rational drug design to prevent conformational diseaseQ27626230
The S variant of human alpha 1-antitrypsin, structure and implications for function and metabolismQ27728485
On the size of the active site in proteases. I. PapainQ27860826
Serpin structure, mechanism, and functionQ28217095
Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigenQ28610305
Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombinQ30836220
C1 esterase inhibitor reduces lower extremity ischemia/reperfusion injury and associated lung damageQ31132259
Partitioning of serpin-proteinase reactions between stable inhibition and substrate cleavage is regulated by the rate of serpin reactive center loop insertion into beta-sheet A.Q33179776
Phylogeny of the serpin superfamily: implications of patterns of amino acid conservation for structure and function.Q33928073
Serpin structure, function and dysfunctionQ34202797
The kinetics of hemostatic enzyme-antithrombin interactions in the presence of low molecular weight heparinQ34260789
Emerging principles in protease-based drug discoveryQ34282102
Effects of mutations in the hinge region of serpinsQ34352355
Recombinant alpha 1-antitrypsin Pittsburgh (Met 358----Arg) is a potent inhibitor of plasma kallikrein and activated factor XII fragmentQ34522312
Inherited antithrombin deficiency: a reviewQ34920789
Protection by recombinant alpha 1-antitrypsin Ala357 Arg358 against arterial hypotension induced by factor XII fragmentQ35577711
Recombinant alpha 1-antitrypsin Pittsburgh attenuates experimental gram-negative septicemiaQ35818183
Design and characterization of an APC-specific serpin for the treatment of hemophilia.Q36176667
alpha(1)-Proteinase inhibitor mutants with specificity for plasma kallikrein and C1s but not C1Q36639349
Serpins in thrombosis, hemostasis and fibrinolysisQ36884340
Contribution of Plasma Protease Inhibitors to the Inactivation of Kallikrein in PlasmaQ37007907
Cinryze, a human plasma-derived c1 esterase inhibitor for prophylaxis of hereditary angioedemaQ37231222
Kinetic intermediates en route to the final serpin-protease complex: studies of complexes of α1-protease inhibitor with trypsinQ37272213
Exosite determinants of serpin specificityQ37343928
Mechanisms of emphysema in alpha1-antitrypsin deficiency: molecular and cellular insightsQ37569437
The plasma bradykinin-forming pathways and its interrelationships with complementQ37767845
Molecular mechanisms of antithrombin-heparin regulation of blood clotting proteinases. A paradigm for understanding proteinase regulation by serpin family protein proteinase inhibitors.Q37777806
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)25
P577publication date2019-02-12
P1433published inFrontiers in MedicineQ27726181
P1476titleSERPINs-From Trap to Treatment
P478volume6

Reverse relations

cites work (P2860)
Q93081751Brown Spider (Loxosceles) Venom Toxins as Potential Biotools for the Development of Novel Therapeutics
Q90151818Serine protease inhibitors and human wellbeing interplay: new insights for old friends
Q99638653Using serpins cysteine protease cross-specificity to possibly trap SARS-CoV-2 Mpro with reactive center loop chimera

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