Advances in Understanding the Immunological Pathways in Psoriasis

scientific article published on 10 February 2019

Advances in Understanding the Immunological Pathways in Psoriasis is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.3390/IJMS20030739
P953full work available at URLhttps://www.mdpi.com/1422-0067/20/3/739
P932PMC publication ID6387410
P698PubMed publication ID30744173

P50authorConstantin CaruntuQ56191507
Maria-Isabela SarbuQ61087877
Monica NeaguQ37839701
P2093author name stringCarolina Constantin
Constantin Caruntu
Clara Matei
Cristina-Iulia Mitran
Madalina-Irina Mitran
Maria-Isabela Sarbu
Mircea Tampa
Simona-Roxana Georgescu
P2860cites workTh22 cells represent a distinct human T cell subset involved in epidermal immunity and remodelingQ24647357
Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgarisQ24676186
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Regulation of interferon-gamma during innate and adaptive immune responsesQ28256001
IL-17A is essential for cell activation and inflammatory gene circuits in subjects with psoriasisQ28268370
Astilbin inhibits Th17 cell differentiation and ameliorates imiquimod-induced psoriasis-like skin lesions in BALB/c mice via Jak3/Stat3 signaling pathway.Q54221095
The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part II: The Treg role in skin diseases pathogenesis.Q54261770
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AhR modulates the IL-22-producing cell proliferation/recruitment in imiquimod-induced psoriasis mouse modelQ57194204
CD8 T Cells and IFN-γ Emerge as Critical Players for Psoriasis in a Novel Model of Mouse Psoriasiform Skin InflammationQ58235912
Secukinumab in moderate-to-severe plaque psoriasis: a multi-center, retrospective, real-life study up to 52 weeks observationQ59309381
Humanized anti–IFN-γ (HuZAF) in the treatment of psoriasisQ60683089
Phenotypic changes of lymphocyte populations in psoriasiform dermatitis animal model.Q64944673
Profiles of Foxp3+ regulatory T cells in eczematous dermatitis, psoriasis vulgaris and mycosis fungoidesQ80947270
Increased Th17 cells are accompanied by FoxP3(+) Treg cell accumulation and correlated with psoriasis disease severityQ82227244
Foxp3+ regulatory T cells and related cytokines differentially expressed in plaque vs. guttate psoriasis vulgarisQ83178735
Foxp3+ regulatory T cells of psoriasis patients easily differentiate into IL-17A-producing cells and are found in lesional skinQ84307121
TGFβ1, an epidermal controller of skin dendritic cell homeostasisQ85855950
MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiationQ88660923
Is the humoral immunity dispensable for the pathogenesis of psoriasis?Q88948467
The role of regulatory T cells and anti-inflammatory cytokines in psoriasisQ95510208
IL-10 producing Bregs are impaired in psoriatic arthritis and psoriasis and inversely correlate with IL-17- and IFNγ-producing T cells.Q50585381
Serum Levels of IL-10 and IL-22 Cytokines in Patients with Psoriasis.Q51246866
Serum vascular endothelial growth factor, transforming growth factor β1, and nitric oxide levels in patients with psoriasis vulgaris: their correlation to disease severity.Q51746554
Targeting IL-23 in psoriasis: current perspectives.Q52695350
Paeoniflorin inhibits imiquimod-induced psoriasis in mice by regulating Th17 cell response and cytokine secretion.Q52890471
Human ß-Defensin 3 and Its Mouse Ortholog Murine ß-Defensin 14 Activate Langerhans Cells and Exacerbate Psoriasis-Like Skin Inflammation in Mice.Q53137209
[Immunopathology of psoriasis: from bench to bedside].Q53138245
Human mast cells are major IL-22 producers in patients with psoriasis and atopic dermatitis.Q53576190
Novel mutations in IL-10 promoter region -377 (C>T), -150 (C>A) and their association with psoriasis in the saudi population.Q54172110
Transforming growth factor-β1 mediates psoriasis-like lesions via a Smad3-dependent mechanism in mice.Q54194408
An increased proportion of circulating Th22 and Tc22 cells in psoriasis.Q54198175
Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptideQ29619485
A New Kid on the Block: IL-10+ Regulatory B Cells and a Possible Role In PsoriasisQ33403761
Paeonol ameliorates imiquimod-induced psoriasis-like skin lesions in BALB/c mice by inhibiting the maturation and activation of dendritic cellsQ33598026
PAMs ameliorates the imiquimod-induced psoriasis-like skin disease in mice by inhibition of translocation of NF-κB and production of inflammatory cytokines.Q33626689
Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10Q33646955
Tristetraprolin expression by keratinocytes controls local and systemic inflammation.Q33752343
TWEAK mediates inflammation in experimental atopic dermatitis and psoriasis.Q33860715
Inflammation dependent mTORC1 signaling interferes with the switch from keratinocyte proliferation to differentiationQ33897776
Therapeutic targeting of the IL-12/23 pathways: generation and characterization of ustekinumabQ34199603
Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes.Q34474419
The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tumor necrosis factor-alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: a type 1 differentiatQ34505900
RORγ antagonists and inverse agonists: a patent reviewQ34540327
Pathologic patterns of interleukin 10 expression--a reviewQ34667904
Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severityQ34945351
Cathelicidin antimicrobial peptide LL-37 in psoriasis enables keratinocyte reactivity against TLR9 ligands.Q35563885
Interleukin-10 paradox: A potent immunoregulatory cytokine that has been difficult to harness for immunotherapyQ35680472
Th17 micro-milieu regulates NLRP1-dependent caspase-5 activity in skin autoinflammationQ36350856
An autoimmune "attack" on melanocytes triggers psoriasis and cellular hyperplasiaQ36398788
Update on psoriasis immunopathogenesis and targeted immunotherapy.Q36445919
Effects of Human Mesenchymal Stem Cells Transduced with Superoxide Dismutase on Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice.Q36580091
Heme oxygenase-1 induction attenuates imiquimod-induced psoriasiform inflammation by negative regulation of Stat3 signalingQ36595887
The tryptophan metabolism enzyme L-kynureninase is a novel inflammatory factor in psoriasis and other inflammatory diseasesQ36984717
Regulatory B cells suppress imiquimod-induced, psoriasis-like skin inflammationQ37176336
Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasisQ37179608
CD19+ B cell subsets in the peripheral blood and skin lesions of psoriasis patients and their correlations with disease severityQ37191197
Upregulation of ANGPTL6 in mouse keratinocytes enhances susceptibility to psoriasisQ37306962
Serum levels of selected Th17 and Th22 cytokines in psoriatic patients.Q37322356
Psoriasis patients exhibit impairment of the high potency CCR5(+) T regulatory cell subsetQ37372754
Pharmacologic modulation of RORγt translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritisQ37460263
Overexpression of Glucocorticoid-induced Leucine Zipper (GILZ) increases susceptibility to Imiquimod-induced psoriasis and involves cutaneous activation of TGF-β1.Q37488232
A role for TGFbeta signaling in the pathogenesis of psoriasisQ37587746
Prokineticin 2 Plays a Pivotal Role in PsoriasisQ37604630
Translational mini-review series on Th17 cells: development of mouse and human T helper 17 cells.Q37632469
CCN1 promotes IL-1β production in keratinocytes by activating p38 MAPK signaling in psoriasisQ37683778
Th17 and Th22 cells in psoriatic arthritis and psoriasisQ37689670
Bimodal immune activation in psoriasisQ38151778
Interleukin-22: a likely target for treatment of autoimmune diseasesQ38177958
Proteomics focusing on immune markers in psoriatic arthritis.Q38230695
Epidermal Th22 and Tc17 cells form a localized disease memory in clinically healed psoriasisQ38412949
Th17 Cell Pathway in Human Immunity: Lessons from Genetics and Therapeutic InterventionsQ38673368
The role of IL-23 and the IL-23/TH 17 immune axis in the pathogenesis and treatment of psoriasis.Q38707588
Spotlight on ixekizumab for the treatment of moderate-to-severe plaque psoriasis: design, development, and use in therapyQ38707920
HIF-1--a big chapter in the cancer taleQ38794544
Immunopathology alters Th17 cell glucocorticoid sensitivityQ38959155
Roles of microRNAs in psoriasis: Immunological functions and potential biomarkersQ38991358
ACKR2: Nature's Decoy Receptor Lures Unsuspecting Chemokines in PsoriasisQ39051842
Update on interleukin-17: a role in the pathogenesis of inflammatory arthritis and implication for clinical practiceQ39153776
Overexpression and potential roles of NRIP1 in psoriasisQ39318754
Interleukin 17 Family Cytokines: Signaling Mechanisms, Biological Activities, and Therapeutic ImplicationsQ39376982
Spread of Psoriasiform Inflammation to Remote Tissues Is Restricted by the Atypical Chemokine Receptor ACKR2.Q39635125
Keratinocyte-Derived IL-17E Contributes to Inflammation in PsoriasisQ39666116
Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axisQ40216414
The interferon receptorsQ41518949
The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasisQ41620801
Increased IL-6 production by monocytes and keratinocytes in patients with psoriasisQ41675873
Exopolysaccharides from Cyanobacterium aponinum from the Blue Lagoon in Iceland increase IL-10 secretion by human dendritic cells and their ability to reduce the IL-17+RORγt+/IL-10+FoxP3+ ratio in CD4+ T cellsQ41700360
Elevated expression of the chemokine-scavenging receptor D6 is associated with impaired lesion development in psoriasisQ41828492
A type of human skin dendritic cell marked by CD5 is associated with the development of inflammatory skin disease.Q42042837
CD69 controls the uptake of L-tryptophan through LAT1-CD98 and AhR-dependent secretion of IL-22 in psoriasis.Q42355640
Luteolin-7-glucoside inhibits IL-22/STAT3 pathway, reducing proliferation, acanthosis, and inflammation in keratinocytes and in mouse psoriatic modelQ42369054
Up-regulation of microRNA-210 induces immune dysfunction via targeting FOXP3 in CD4(+) T cells of psoriasis vulgarisQ43812130
Polymorphisms in the TNF-α and IL-10 gene promoters and risk of psoriasis and correlation with disease severityQ44987409
Serum interferon-gamma is a psoriasis severity and prognostic markerQ46215970
Capsaicin: Friend or Foe in Skin Cancer and Other Related Malignancies?Q47162516
MicroRNA-146 and cell trauma downregulate expression of the psoriasis-associated atypical chemokine receptor ACKR2.Q47253178
Biological therapies in psoriasis - revisitedQ47601468
Serum concentrations of transforming growth factor beta 1 in patients with psoriasis vulgarisQ47795365
Scanning the Immunopathogenesis of PsoriasisQ48278167
The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part III: Polymorphisms of genes involved in Tregs' activation and function.Q49391905
Role of the IL-23/IL-17 Axis in Psoriasis and Psoriatic Arthritis: The Clinical Importance of Its Divergence in Skin and JointsQ50099588
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectimmunologyQ101929
inflammationQ101991
psoriasisQ179945
immunityQ182581
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)739
P577publication date2019-01-01
2019-02-10
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleAdvances in Understanding the Immunological Pathways in Psoriasis
P478volume20

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cites work (P2860)
Q92593942Characteristics of psoriasis vulgaris in China: a prospective cohort study protocol
Q90745225Current Developments in the Immunology of Psoriasis
Q91829705Interferon Kappa Is Up-Regulated in Psoriasis and It Up-Regulates Psoriasis-Associated Cytokines in vivo
Q96134668Pathogenesis of psoriasis in the "omic" era. Part I. Epidemiology, clinical manifestation, immunological and neuroendocrine disturbances
Q91671642Reinforcing involvement of NK cells in psoriasiform dermatitis animal model
Q93176443Salidroside inhibits MAPK, NF-κB, and STAT3 pathways in psoriasis-associated oxidative stress via SIRT1 activation

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