Microglial activation occurs late during preclinical Alzheimer's disease

scientific article published on 11 November 2018

Microglial activation occurs late during preclinical Alzheimer's disease is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/GLIA.23510
P698PubMed publication ID30417428

P50authorWolfgang J StreitQ88588846
P2093author name stringHabibeh Khoshbouei
Ingo Bechmann
Heiko Braak
Kelly Del Tredici
Wolf Müller
Christian Eisenlöffel
Judith Leyh
Julia Lier
P2860cites workMild cognitive impairment: pathology and mechanisms.Q24631255
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Brain inflammation accompanies amyloid in the majority of mild cognitive impairment cases due to Alzheimer’s diseaseQ30141537
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Mild cognitive impairment and asymptomatic Alzheimer disease subjects: equivalent β-amyloid and tau loads with divergent cognitive outcomesQ33772805
Proliferation in the Alzheimer hippocampus is due to microglia, not astroglia, and occurs at sites of amyloid depositionQ34146055
Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial functionQ34172143
Primary age-related tauopathy (PART): a common pathology associated with human agingQ34445021
Are cases with tau pathology occurring in the absence of Aβ deposits part of the AD-related pathological process?Q34445601
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Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistryQ34556945
Microglia and inflammatory mechanisms in the clearance of amyloid beta peptideQ34963822
The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's diseaseQ34992780
Neuroinflammation in Alzheimer's disease wanes with ageQ35640906
National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approachQ35706615
The microglial phagocytic role with specific plaque types in the Alzheimer disease brainQ35789675
Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray studyQ36164195
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Neuroinflammation and regeneration in the early stages of Alzheimer's disease pathology.Q36356347
Phagocytosis of amyloid-beta and inflammation: two faces of innate immunity in Alzheimer's diseaseQ36893432
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Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's diseaseQ37331433
Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer diseaseQ37332710
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Cerebral amyloid angiopathy and granulomatous angiitis: immunohistochemical study using antibodies to the Alzheimer A4 peptideQ41212490
Presence of severe neuroinflammation does not intensify neurofibrillary degeneration in human brainQ42239439
Frequency of stages of Alzheimer-related lesions in different age categoriesQ42445469
Ferritin accumulation in dystrophic microglia is an early event in the development of Huntington's diseaseQ45305307
beta-Amyloid peptides induce degeneration of cultured rat microgliaQ46885770
Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's diseaseQ48007049
Dystrophic microglia in the aging human brainQ48090856
Phagocytic activity of macrophages and microglial cells during the course of acute and chronic relapsing experimental autoimmune encephalomyelitisQ48100149
Progressive telomere shortening occurs in cultured rat microglia, but not astrocytesQ48129206
Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR.Q48219387
Evidence that aging and amyloid promote microglial cell senescenceQ48232021
Lysosome-associated membrane protein 1 (LAMP-1) in Alzheimer's disease.Q48421283
Neuroinflammation: no rose by any other nameQ48474962
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Giant cell arteritis in association with cerebral amyloid angiopathy: immunohistochemical and molecular studies.Q48577484
Microglial activation in early stages of amyloid beta protein depositionQ48612917
Inhomogeneous distribution of Iba-1 characterizes microglial pathology in Alzheimer's diseaseQ48627278
Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 yearsQ48835886
Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptorQ48933977
Rate of progression of mild cognitive impairment to dementia--meta-analysis of 41 robust inception cohort studies.Q51129033
"Preclinical" AD revisited: neuropathology of cognitively normal older adults.Q51975129
Increased senile plaques without microglia in Alzheimer's disease.Q53184055
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Role of microglia in senile plaque formation.Q53210237
A lysosomal marker for activated microglial cells involved in Alzheimer classic senile plaques.Q53210696
Slow degradation of aggregates of the Alzheimer's disease amyloid beta-protein by microglial cells.Q53220157
Microglial dystrophy in the aged and Alzheimer's disease brain is associated with ferritin immunoreactivity.Q53392859
Microglia in Alzheimer's Disease: Activated, Dysfunctional or Degenerative.Q55073016
Cell death in Alzheimer's disease evaluated by DNA fragmentation in situQ61709806
Clinico-pathologic studies in dementia: nondemented subjects with pathologically confirmed Alzheimer's diseaseQ67960261
The pathological process underlying Alzheimer's disease in individuals under thirtyQ82953907
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
Human SubjectsQ21535022
microgliaQ1622829
P304page(s)2550-2562
P577publication date2018-11-11
P1433published inGliaQ15716658
P1476titleMicroglial activation occurs late during preclinical Alzheimer's disease
P478volume66

Reverse relations

cites work (P2860)
Q90251670Chronic sleep fragmentation shares similar pathogenesis with neurodegenerative diseases: Endosome-autophagosome-lysosome pathway dysfunction and microglia-mediated neuroinflammation
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Q64265295Targeting RIPK1 for the treatment of human diseases