The role of protein kinase B/Akt in insulin-induced inactivation of phosphorylase in rat hepatocytes

scientific article published on 10 December 2005

The role of protein kinase B/Akt in insulin-induced inactivation of phosphorylase in rat hepatocytes is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1035136955
P356DOI10.1007/S00125-005-0068-4
P698PubMed publication ID16341839

P50authorCatherine ArdenQ60299869
P2093author name stringL Agius
P B Iynedjian
S Aiston
L J Hampson
P2860cites workExpression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocationQ24322925
Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alphaQ24530736
The PI3K-PDK1 connection: more than just a road to PKBQ24531972
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase BQ27860731
The phosphoinositide 3-kinase pathwayQ27860738
Requirement for Akt (protein kinase B) in insulin-induced activation of glycogen synthase and phosphorylation of 4E-BP1 (PHAS-1)Q28564335
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)Q29615537
Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivoQ30454428
Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actionsQ30925087
Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcriptionQ31462537
GSK3 takes centre stage more than 20 years after its discoveryQ34374129
Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB.Q34467720
An efficient proteomics method to identify the cellular targets of protein kinase inhibitors.Q34787933
Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencingQ35146125
Unravelling the activation mechanisms of protein kinase B/AktQ35163966
A family with severe insulin resistance and diabetes due to a mutation in AKT2.Q36481707
Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent mannerQ36760948
Differing Roles of Akt and Serum- and Glucocorticoid-regulated Kinase in Glucose Metabolism, DNA Synthesis, and Oncogenic ActivityQ40649584
The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activateQ40897138
Construction and characterization of a conditionally active version of the serine/threonine kinase Akt.Q42829358
Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesisQ42831589
Phosphoinositide 3-kinase: the key switch mechanism in insulin signallingQ42991205
Regulation of sterol regulatory-element binding protein 1 gene expression in liver: role of insulin and protein kinase B/cAktQ42996869
Diverse effects of two allosteric inhibitors on the phosphorylation state of glycogen phosphorylase in hepatocytesQ43002395
Analysis of the role of protein kinase B (cAKT) in insulin-dependent induction of glucokinase and sterol regulatory element-binding protein 1 (SREBP1) mRNAs in hepatocytesQ43003345
Hepatic glycogen synthesis is highly sensitive to phosphorylase activity: evidence from metabolic control analysisQ43579828
Small increases in insulin inhibit hepatic glucose production solely caused by an effect on glycogen metabolismQ43687862
Inactivation of phosphorylase is a major component of the mechanism by which insulin stimulates hepatic glycogen synthesisQ44489227
Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B.Q44605205
Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvementQ44666331
A rapid filter paper assay for UDPglucose-glycogen glucosyltransferase, including an improved biosynthesis of UDP-14C-glucoseQ72174058
Regulation of glycogen synthase in rat hepatocytes. Evidence for multiple signaling pathwaysQ73019294
Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunctionQ74191142
Signalling pathways involved in the stimulation of glycogen synthesis by insulin in rat hepatocytesQ74303123
Leptin enhances glycogen storage in hepatocytes by inhibition of phosphorylase and exerts an additive effect with insulinQ77804873
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectpreproinsulinQ7240673
P304page(s)174-182
P577publication date2005-12-10
P1433published inDiabetologiaQ5270140
P1476titleThe role of protein kinase B/Akt in insulin-induced inactivation of phosphorylase in rat hepatocytes
P478volume49

Reverse relations

cites work (P2860)
Q35180025Defective glycogenesis contributes toward the inability to suppress hepatic glucose production in response to hyperglycemia and hyperinsulinemia in zucker diabetic fatty rats
Q35516372Impact of a glycogen phosphorylase inhibitor and metformin on basal and glucagon-stimulated hepatic glucose flux in conscious dogs
Q34805515Inhibition of hepatic glycogen synthesis by hyperhomocysteinemia mediated by TRB3
Q90685522Mechanisms of Insulin Action and Insulin Resistance
Q24614867Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function
Q37897324New insights into the signaling system and function of insulin in fish
Q26766485Pancreatic regulation of glucose homeostasis
Q80501614Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs
Q39152510The selective control of glycolysis, gluconeogenesis and glycogenesis by temporal insulin patterns.