Role of topoisomerase II in mediating epipodophyllotoxin-induced DNA cleavage

scientific article published on 01 December 1984

Role of topoisomerase II in mediating epipodophyllotoxin-induced DNA cleavage is …
instance of (P31):
scholarly articleQ13442814

External links are
P698PubMed publication ID6094001

P2093author name stringLiu L
Ross W
Rowe T
Glisson B
Yalowich J
P433issue12 Pt 1
P407language of work or nameEnglishQ1860
P304page(s)5857-5860
P577publication date1984-12-01
P1433published inCancer ResearchQ326097
P1476titleRole of topoisomerase II in mediating epipodophyllotoxin-induced DNA cleavage
P478volume44

Reverse relations

cites work (P2860)
Q64112102A cmap-enabled gene expression signature-matching approach identifies small-molecule inducers of accelerated cell senescence
Q58769223A novel cell-based screening assay for small-molecule MYB inhibitors identifies podophyllotoxins teniposide and etoposide as inhibitors of MYB activity
Q43689095A novel topoisomerase II poison GL331 preferentially induces DNA cleavage at (C/G)T sites and can cause telomere DNA damage
Q36268156Abacavir, an anti-HIV-1 drug, targets TDP1-deficient adult T cell leukemia
Q33513762Accurate molecular classification of cancer using simple rules
Q91891315Activity of M3814, an Oral DNA-PK Inhibitor, In Combination with Topoisomerase II Inhibitors in Ovarian Cancer Models
Q34661832Acute lymphoblastic leukemia: optimizing treatment strategies in children
Q41200355Acute nonlymphocytic leukemia following chemotherapy with cisplatin and etoposide for non-small-cell carcinoma of the lung: case report
Q34183849Adipose-derived stem cells retain their regenerative potential after methotrexate treatment.
Q28487763Amitozyn impairs chromosome segregation and induces apoptosis via mitotic checkpoint activation
Q35788447Amsacrine as a topoisomerase II poison: importance of drug-DNA interactions
Q36431000Anti-tumour activities of a new benzo[c]phenanthridine agent, 2,3-(methylenedioxy)-5-methyl-7-hydroxy-8-methoxybenzo[c]phena nthridini um hydrogensulphate dihydrate (NK109), against several drug-resistant human tumour cell lines
Q37932369Antineoplastic drugs in 1990. A review (Part II).
Q36074267Antitumor agents 294. Novel E-ring-modified camptothecin-4β-anilino-4'-O-demethyl-epipodophyllotoxin conjugates as DNA topoisomerase I inhibitors and cytotoxic agents
Q72959719Antitumor agents. 125. New 4 beta-benzoylamino derivatives of 4'-O-demethyl-4-desoxypodophyllotoxin and 4 beta-benzoyl derivatives of 4'-O-demethylpodophyllotoxin as potent inhibitors of human DNA topoisomerase II
Q72962841Antitumor agents. 126. Novel 4 beta-substituted anilino derivatives of 3',4'-O,O-didemethylpodophyllotoxin as potent inhibitors of human DNA topoisomerase II
Q67914971Antitumor drug cross-resistance in vivo in a cisplatin-resistant murine P388 leukemia
Q54158839Biomodulation by hyperthermia of topoisomerase II-targeting drugs in human colorectal cancer cells.
Q34545133Cancer chemotherapy: new strategies for success
Q34379629Catalytic core of human topoisomerase IIα: insights into enzyme-DNA interactions and drug mechanism
Q36465770Characterisation of VP-16-induced DNA cleavage in oestrogen-stimulated human breast cancer cells
Q37324752Characterization and interlaboratory comparison of a gene expression signature for differentiating genotoxic mechanisms
Q28327002Characterization of DNA topoisomerase I from Candida albicans as a target for drug discovery
Q41619991Characterization of camptothecin-resistant chinese hamster lung cells
Q41134704Chromosomes with two intact axial cores are induced by G2 checkpoint override: evidence that DNA decatenation is not required to template the chromosome structure
Q72314335Chronic oral etoposide in advanced breast cancer
Q36136151Cisplatin and etoposide in oesophageal cancer: a phase II study. Rotterdam Oesophageal Tumour Study Group
Q64387165Comparison of the effect of three different topoisomerase II inhibitors combined with cisplatin in human glioblastoma cells sensitized with double strand break repair inhibitors
Q44045668Cytotoxic properties of a new synthetic demethylpodophyllotoxin derivative, BN 58705, against human tumor cell lines
Q41888583DNA damage response to the Mdm2 inhibitor nutlin-3.
Q40818137DNA topoisomerase II activity in nonreplicating, transcriptionally inactive, chicken late spermatids
Q39498218DNA topoisomerase II as a target of antineoplastic drug therapy
Q42572866DNA topoisomerase II cleaves at specific sites in the 5' flanking region of c-fos proto-oncogenes in vitro
Q36758354DNA topoisomerases from pathogenic fungi: targets for the discovery of antifungal drugs
Q39016546Design, synthesis, and biological evaluation of a novel series of bisintercalating DNA-binding piperazine-linked bisanthrapyrazole compounds as anticancer agents
Q37574005Differential and common DNA repair pathways for topoisomerase I- and II-targeted drugs in a genetic DT40 repair cell screen panel
Q42011317Differential protective effects of varying degrees of hypoxia on the cytotoxicities of etoposide and bleomycin
Q36235740Dissociation of centrosome replication events from cycles of DNA synthesis and mitotic division in hydroxyurea-arrested Chinese hamster ovary cells
Q60301633Drug discovery of anticancer drugs targeting methylenetetrahydrofolate dehydrogenase 2
Q42314511Dual effectiveness of Alternaria but not Fusarium mycotoxins against human topoisomerase II and bacterial gyrase
Q33433190Effective reinduction therapy for childhood acute nonlymphoid leukemia using simultaneous continuous infusions of teniposide and amsacrine
Q35679872Effects of Olive Metabolites on DNA Cleavage Mediated by Human Type II Topoisomerases
Q40566269Effects of VM26 (teniposide), a specific inhibitor of type II DNA topoisomerase, on SV40 DNA replication in vivo
Q37383911Effects of magnesium and related divalent metal ions in topoisomerase structure and function.
Q40391028Effects of the antitumor drug VP16 (etoposide) on the archaebacterial Halobacterium GRB 1.7 kb plasmid in vivo
Q36153748Efficacy of oral Etoposide in pretreated metastatic breast cancer: a multicenter phase 2 study
Q53606338Emetic potential of daily oral etoposide.
Q40694385Epipodophyllotoxins in the treatment of childhood cancer
Q35822033Epipodophyllotoxins, alkylating agents, and radiation and risk of secondary leukaemia after childhood cancer
Q45105697Establishment and characterization of resistant cells to etoposide (VP16) from a mouse breast cancer cell line, FM3A.
Q37601249Etoposide (VP-16-213)-induced gene alterations: potential contribution to cell death
Q37922821Etoposide and teniposide in the treatment of acute leukemia
Q39523026Etoposide and teniposide. Bioanalysis, metabolism and clinical pharmacokinetics
Q35435861Etoposide sensitizes CT26 colorectal adenocarcinoma to radiation therapy in BALB/c mice
Q41332538Etoposide-induced DNA cleavage in human leukemia cells
Q37917105Etoposide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in combination chemotherapy of cancer
Q61798290Evaluation of site-specific homologous recombination activity of BRCA1 by direct quantitation of gene editing efficiency
Q40789828Expression of drug resistance genes in VP-16 and mAMSA-selected human carcinoma cells
Q46331807Expressions of resistance and cross-resistance in teniposide-resistant L1210 cells
Q48373870Human autopsy tissue distribution of the epipodophyllotoxins etoposide and teniposide
Q37271887Identification of genomic regions contributing to etoposide-induced cytotoxicity
Q36911574In vivo localization of DNA topoisomerase II cleavage sites on Drosophila heat shock chromatin
Q39870942Induction of calf thymus topoisomerase II-mediated DNA breakage by the antibacterial isothiazoloquinolones A-65281 and A-65282
Q34909651Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavage
Q36379849Interlinked DNA nano-circles for measuring topoisomerase II activity at the level of single decatenation events
Q40757795Modification of the 8 drugs in 1 day regimen: feasibility of substitution of other agents.
Q42407872Modulation of therapy-induced senescence by reactive lipid aldehydes
Q34051008Mutational analysis of a type II topoisomerase cleavage site: distinct requirements for enzyme and inhibitors
Q41571202Novel selection and genetic characterisation of an etoposide-resistant human leukaemic CCRF-CEM cell line
Q34572663Novobiocin enhances alkylating agent cytotoxicity and DNA interstrand crosslinks in a murine model
Q99711909Oxygen-Free Regioselective Biocatalytic Demethylation of Methyl-phenyl Ethers via Methyltransfer Employing Veratrol-O-demethylase
Q33919425Periodicity of DNA folding in higher order chromatin structures
Q39768346Pharmacokinetics of anticancer drugs in children
Q54303722Pharmacokinetics of continuous-infusion amsacrine and teniposide for the treatment of relapsed childhood acute nonlymphocytic leukemia.
Q37658182Phytochemicals as Anticancer and Chemopreventive Topoisomerase II Poisons
Q56334908Polyamine-containing etoposide derivatives as poisons of human type II topoisomerases: Differential effects on topoisomerase IIα and IIβ
Q41650634Potentiation of etoposide-induced cytotoxicity and DNA damage in CCRF-CEM cells by pretreatment with non-cytotoxic concentrations of arabinosyl cytosine
Q39378487Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response
Q48326443Quantification of Etoposide Hypersensitivity: A Sensitive, Functional Method for Assessing Pluripotent Stem Cell Quality.
Q64902788Recent developments in topoisomerase-targeted cancer chemotherapy.
Q27005726Recent progress on C-4-modified podophyllotoxin analogs as potent antitumor agents
Q37394291Role for topoisomerases in the release of DNA into the detergent-soluble fraction of eukaryotic cells
Q41873946Role of the semi-quinone free radical of the anti-tumour agent etoposide (VP-16-213) in the inactivation of single- and double-stranded phi X174 DNA.
Q33929257Sequence specificity of DNA topoisomerase I in the presence and absence of camptothecin
Q41500551Structure-activity relationships of VP-16 analogues
Q35706214Structure-based design, synthesis and biological testing of piperazine-linked bis-epipodophyllotoxin etoposide analogs
Q46371632Studies on DNA topoisomerase activity during in vitro chromatin assembly
Q37332317Substituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity.
Q36934032Suramin is an inhibitor of DNA topoisomerase II in vitro and in Chinese hamster fibrosarcoma cells
Q40694338Teniposide: overview of its therapeutic potential in adult cancers
Q36685541The ascidian natural product eusynstyelamide B is a novel topoisomerase II poison that induces DNA damage and growth arrest in prostate and breast cancer cells
Q39658304The clinical pharmacology of etoposide and teniposide
Q36839637The geometry of DNA supercoils modulates topoisomerase-mediated DNA cleavage and enzyme response to anticancer drugs
Q33922870Topoisomerase II - drug interaction domains: identification of substituents on etoposide that interact with the enzyme.
Q36782421Topoisomerase II cleavage of herpes simplex virus type 1 DNA in vivo is replication dependent
Q40535267Topoisomerase II in multiple drug resistance
Q36920787Topoisomerase-specific drug sensitivity in relation to cell cycle progression
Q90643414Topoisomerases and cancer chemotherapy: recent advances and unanswered questions
Q37877829Topoisomerases, new targets in cancer chemotherapy
Q79685121Two cases of secondary acute myeloid leukemia accompanying adult T-cell leukemia/lymphoma