Diabetes Mellitus as a Risk Factor for Parkinson's Disease: a Molecular Point of View

scientific article published on 28 March 2018

Diabetes Mellitus as a Risk Factor for Parkinson's Disease: a Molecular Point of View is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S12035-018-1025-9
P698PubMed publication ID29594935

P50authorLuigi BubaccoQ38543824
Marco BisagliaQ60973461
Tiago Fleming OuteiroQ79139390
P2093author name stringAlice Biosa
P2860cites workParkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine, and lysine residuesQ24306921
Human DJ-1 and its homologs are novel glyoxalasesQ24316421
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonismQ24321359
Dopamine covalently modifies and functionally inactivates parkinQ24338423
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activityQ24595845
Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson diseaseQ24632904
Diabetes Mellitus Induces Alzheimer's Disease Pathology: Histopathological Evidence from Animal ModelsQ26750648
Dicarbonyl stress in cell and tissue dysfunction contributing to ageing and diseaseQ26824465
Site-specific AGE modifications in the extracellular matrix: a role for glyoxal in protein damage in diabetesQ26865565
AMP-activated protein kinase: an energy sensor that regulates all aspects of cell functionQ26865723
Parkinson's disease and immune system: is the culprit LRRKing in the periphery?Q27687171
Mutation in the alpha-synuclein gene identified in families with Parkinson's diseaseQ27860459
Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritanceQ28077356
Type 1 diabetesQ28301396
Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's diseaseQ28391762
Metformin Prevents Nigrostriatal Dopamine Degeneration Independent of AMPK Activation in Dopamine NeuronsQ28553200
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteinsQ28574891
Global and societal implications of the diabetes epidemicQ29614551
Methylglyoxal, A Metabolite Increased in Diabetes is Associated with Insulin Resistance, Vascular Dysfunction and Neuropathies.Q30385523
Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adductQ31029246
Aggregation of alpha-synuclein by DOPAL, the monoamine oxidase metabolite of dopamineQ33344779
Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation.Q33355903
Dopamine-induced conformational changes in alpha-synucleinQ33500157
Divalent metal ions enhance DOPAL-induced oligomerization of alpha-synuclein.Q33771253
Benomyl, aldehyde dehydrogenase, DOPAL, and the catecholaldehyde hypothesis for the pathogenesis of Parkinson's diseaseQ34065897
Neurodegeneration and motor dysfunction in mice lacking cytosolic and mitochondrial aldehyde dehydrogenases: implications for Parkinson's diseaseQ34181738
Advanced glycation endproducts: what is their relevance to diabetic complications?Q34613062
Diabetes and risk of Parkinson's diseaseQ34718429
Diabetes and the risk of developing Parkinson's disease in Denmark.Q35043736
Metformin inhibition of glycation processesQ35539971
Risk of Parkinson disease onset in patients with diabetes: a 9-year population-based cohort study with age and sex stratifications.Q35898211
Dopamine-derived quinones affect the structure of the redox sensor DJ-1 through modifications at Cys-106 and Cys-53Q36002833
Oligomerization and Membrane-binding Properties of Covalent Adducts Formed by the Interaction of α-Synuclein with the Toxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde (DOPAL).Q36282886
Risk of dementia in diabetes mellitus: a systematic reviewQ36345254
Risk of Parkinson Disease in Diabetes Mellitus: An Updated Meta-Analysis of Population-Based Cohort StudiesQ36891855
Dicarbonyls and glyoxalase in disease mechanisms and clinical therapeuticsQ37156152
Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neuronsQ37180671
Metformin Prevents Dopaminergic Neuron Death in MPTP/P-Induced Mouse Model of Parkinson's Disease via Autophagy and Mitochondrial ROS ClearanceQ37299382
Structural insights on physiological functions and pathological effects of alpha-synuclein.Q37307280
Mitochondrial biology and oxidative stress in Parkinson disease pathogenesisQ37315448
Diabetes, oxidative stress, nitric oxide and mitochondria function.Q37481730
DOPAL derived alpha-synuclein oligomers impair synaptic vesicles physiological function.Q37584540
Increased risk of Parkinson disease with diabetes mellitus in a population-based studyQ37613409
Methylglyoxal, glyoxalase 1 and the dicarbonyl proteomeQ37801856
Shared dysregulated pathways lead to Parkinson's disease and diabetesQ38078667
Dysfunction of dopamine homeostasis: clues in the hunt for novel Parkinson's disease therapies.Q38086812
Neuronal vulnerability, pathogenesis, and Parkinson's diseaseQ38099288
Are dopamine derivatives implicated in the pathogenesis of Parkinson's disease?Q38175706
Biophysical groundwork as a hinge to unravel the biology of α-synuclein aggregation and toxicityQ38180144
Dementia and cognitive decline in type 2 diabetes and prediabetic stages: towards targeted interventions.Q38195478
Metformin: from mechanisms of action to therapiesQ38279824
The role of type 2 diabetes in neurodegenerationQ38450518
Lysines, Achilles' heel in alpha-synuclein conversion to a deadly neuronal endotoxinQ38675441
Improved Glycemic Control and Vascular Function in Overweight and Obese Subjects by Glyoxalase 1 Inducer Formulation.Q38769539
Is Alzheimer's disease a Type 3 Diabetes? A critical appraisalQ38938961
Measurement of methylglyoxal by stable isotopic dilution analysis LC-MS/MS with corroborative prediction in physiological samplesQ38972136
DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's diseaseQ38972171
Selective neuronal vulnerability in Parkinson diseaseQ39095738
Risk of dementia among persons with diabetes mellitus: a population-based cohort studyQ39441115
Cellular oligomerization of alpha-synuclein is determined by the interaction of oxidized catechols with a C-terminal sequenceQ40085533
Structural and functional changes in human insulin induced by methylglyoxalQ40275723
Methylglyoxal toxicity in mammalsQ40678654
Guanine glycation repair by DJ-1/Park7 and its bacterial homologsQ41412797
Protein reactivity of 3,4-dihydroxyphenylacetaldehyde, a toxic dopamine metabolite, is dependent on both the aldehyde and the catecholQ41786059
Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycationQ42499319
Accumulation of endogenous methylglyoxal impaired insulin signaling in adipose tissue of fructose-fed ratsQ42826171
Molecular characterization of dopamine-derived quinones reactivity toward NADH and glutathione: implications for mitochondrial dysfunction in Parkinson diseaseQ42987474
Dopamine quinones interact with alpha-synuclein to form unstructured adducts.Q43131429
Glycation and glycoxidation of low-density lipoproteins by glucose and low-molecular mass aldehydes. Formation of modified and oxidized particlesQ44550064
Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations.Q46427562
Prevalence of diabetes and impaired fasting glucose in adults in the U.S. population: National Health And Nutrition Examination Survey 1999-2002.Q46443909
Dopamine promotes alpha-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathwayQ46537593
Evidence of oxidative stress in the neocortex in incidental Lewy body diseaseQ46686665
Type 2 diabetes mellitus in the pathophysiology of Alzheimer's diseaseQ47096119
Gestational diabetes from A to Z.Q47155722
Impaired peripheral glucose homeostasis and Alzheimer's diseaseQ47422317
Metformin lowers α-synuclein phosphorylation and upregulates neurotrophic factor in the MPTP mouse model of Parkinson's diseaseQ47954089
Connecting Alzheimer's disease to diabetes: Underlying mechanisms and potential therapeutic targetsQ47973063
Neuroprotective effect of metformin in MPTP-induced Parkinson's disease in miceQ48613553
Glycoxidation and oxidative stress in Parkinson disease and diffuse Lewy body diseaseQ48888308
Association of diabetes mellitus and dementia: the Rotterdam Study.Q50989914
Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies.Q51063701
Increased plasma methylglyoxal level, inflammation, and vascular endothelial dysfunction in diabetic nephropathy.Q51385393
Type 2 diabetes and the risk of Parkinson's disease.Q53016612
Metformin-inclusive sulfonylurea therapy reduces the risk of Parkinson's disease occurring with Type 2 diabetes in a Taiwanese population cohort.Q53098272
Diabetes mellitus and the risk of dementia: The Rotterdam Study.Q53231897
Kinetic and structural analysis of the early oxidation products of dopamine: analysis of the interactions with alpha-synuclein.Q53285842
The Critical Role of Methylglyoxal and Glyoxalase 1 in Diabetic NephropathyQ60786520
Glyoxalase System in Clinical Diabetes Mellitus and Correlation with Diabetic ComplicationsQ60786679
Binding and modification of proteins by methylglyoxal under physiological conditions. A kinetic and mechanistic study with N alpha-acetylarginine, N alpha-acetylcysteine, and N alpha-acetyllysine, and bovine serum albuminQ72352188
Reaction of metformin with dicarbonyl compounds. Possible implication in the inhibition of advanced glycation end product formationQ73203933
Metformin reduces systemic methylglyoxal levels in type 2 diabetesQ77804967
Type 2 diabetesQ89258111
P433issue11
P921main subjectParkinson's diseaseQ11085
P304page(s)8754-8763
P577publication date2018-03-28
P1433published inMolecular NeurobiologyQ15716645
P1476titleDiabetes Mellitus as a Risk Factor for Parkinson's Disease: a Molecular Point of View
P478volume55