Premature Physiologic Aging as a Paradigm for Understanding Increased Risk of Adverse Health Across the Lifespan of Survivors of Childhood Cancer.

scientific article published on 6 June 2018

Premature Physiologic Aging as a Paradigm for Understanding Increased Risk of Adverse Health Across the Lifespan of Survivors of Childhood Cancer. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1200/JCO.2017.76.7467
P932PMC publication ID6553838
P698PubMed publication ID29874132

P50authorKirsten K NessQ59219842
P2093author name stringZhaoming Wang
Jinghui Zhang
Gregory T Armstrong
James L Kirkland
Kelly McCastlain
Mondira Kundu
Tamar Tchkonia
Maria Monica Gramatges
Saskia Martine Francesca Pluijm
Xiujie Li-Harms
P2860cites workClinical ascertainment of health outcomes among adults treated for childhood cancerQ37165621
The ageing neuromuscular system and sarcopenia: a mitochondrial perspective.Q37172598
Expression of the senescence marker p16INK4a in skin biopsies of acute lymphoblastic leukemia survivors: a pilot studyQ37308341
Frailty has a stronger association with inflammation than age in older veteransQ37349361
Senescence-messaging secretome: SMS-ing cellular stressQ37365177
Higher inflammatory marker levels in older persons: associations with 5-year change in muscle mass and muscle strengthQ37381535
Understanding how we age: insights into inflammagingQ37581232
Role of extracellular signal-regulated kinase 5 in adipocyte signalingQ37608589
Telomere content and risk of second malignant neoplasm in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study.Q37621379
Identification of Senescent Cells in the Bone MicroenvironmentQ37621816
Cellular senescence mediates fibrotic pulmonary diseaseQ37672706
Aging and risk of severe, disabling, life-threatening, and fatal events in the childhood cancer survivor studyQ37702332
A systematic review of leukocyte telomere length and age in adultsQ38075374
Mitochondrial function and mitochondrial DNA maintenance with advancing age.Q38228592
Function and information content of DNA methylationQ38319920
New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463Q38432775
Radiation-induced epigenetic DNA methylation modification of radiation-response pathwaysQ38487760
Targeting cellular senescence prevents age-related bone loss in mice.Q38616265
Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivoQ38642426
Young adult survivors of childhood acute lymphoblastic leukemia show evidence of chronic inflammation and cellular aging.Q38707197
Shortened telomere length is associated with increased risk of cancer: a meta-analysisQ21135356
DNA methylation age of human tissues and cell typesQ21183994
DNA methylation age of blood predicts all-cause mortality in later lifeQ22000595
The association between global DNA methylation and telomere length in a longitudinal study of boilermakersQ23914496
Physical exercise training interventions for children and young adults during and after treatment for childhood cancerQ24185991
Premature ageing in mice expressing defective mitochondrial DNA polymeraseQ24294365
Mitochondrial DNA mutations in human diseaseQ24676881
Mitochondrial Quality Control and Muscle Mass MaintenanceQ26770420
Exercise and inflammation-related epigenetic modifications: focus on DNA methylationQ27021305
Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stressQ27330478
Oncogene-induced senescence relayed by an interleukin-dependent inflammatory networkQ27863386
Inflammation and frailty in the elderly: A systematic review and meta-analysisQ28072928
The hallmarks of agingQ28131641
Inflamm-aging. An evolutionary perspective on immunosenescenceQ28141817
Assessment of potential bias from non-participation in a dynamic clinical cohort of long-term childhood cancer survivors: results from the St. Jude Lifetime Cohort StudyQ36542541
Mitochondrial DNA copy number variation across human cancersQ36642203
Telomeres shorten at equivalent rates in somatic tissues of adultsQ36737331
Association of shorter leukocyte telomere repeat length with dementia and mortalityQ36755832
The Risk of Cataract among Survivors of Childhood and Adolescent Cancer: A Report from the Childhood Cancer Survivor StudyQ36858502
Proinflammatory genotype is associated with the frailty phenotype in the English Longitudinal Study of AgeingQ36928076
Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue.Q36930817
Interleukin-6 and C-reactive protein, successful aging, and mortality: the PolSenior studyQ36965581
Radiation, atherosclerotic risk factors, and stroke risk in survivors of pediatric cancer: a report from the Childhood Cancer Survivor StudyQ36967228
Telomeres: hallmarks of radiosensitivity.Q37002107
Independent and combined effects of physical activity and weight loss on inflammatory biomarkers in overweight and obese older adultsQ37021995
Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activationQ37030330
Sex-specific effects of cytotoxic chemotherapy agents cyclophosphamide and mitomycin C on gene expression, oxidative DNA damage, and epigenetic alterations in the prefrontal cortex and hippocampus - an aging connectionQ37049097
Inflammatory markers and incident frailty in men and women: the English Longitudinal Study of AgeingQ37116540
Modifiable Factors Associated With Aging Phenotypes Among Adult Survivors of Childhood Acute Lymphoblastic LeukemiaQ37130223
Frailty in older adults: evidence for a phenotypeQ28205094
Aging and genome maintenance: lessons from the mouse?Q28212752
Telomere length in breast cancer patients before and after chemotherapy with or without stem cell transplantationQ28365267
Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequenceQ28385712
Age-related clonal hematopoiesis associated with adverse outcomesQ28386602
The relationship between inflammatory biomarkers and telomere length in an occupational prospective cohort studyQ28394961
Cumulative inflammatory load is associated with short leukocyte telomere length in the Health, Aging and Body Composition StudyQ28744595
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressorQ29615559
Telomere length predicts replicative capacity of human fibroblastsQ29615745
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian agingQ29616056
Epigenetics: a landscape takes shapeQ29616623
Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stressQ29619552
Feasibility and initial effectiveness of home exercise during maintenance therapy for childhood acute lymphoblastic leukemiaQ30596383
Cancer survivors' uptake and adherence in diet and exercise intervention trials: an integrative data analysisQ30844813
Tissue-specific mtDNA abundance from exome data and its correlation with mitochondrial transcription, mass and respiratory activityQ30872900
Leukocyte telomere length is related to appendicular lean mass: cross-sectional data from the Berlin Aging Study II (BASE-II).Q31032487
Interventions to prevent or reduce the level of frailty in community-dwelling older adults: a scoping review of the literature and international policiesQ33605158
Plasma protein biomarkers of the geriatric syndrome of frailtyQ33684564
Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscapeQ33742677
Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewalQ33804172
Cellular senescence drives age-dependent hepatic steatosis.Q33810220
Somatic mutations, genome mosaicism, cancer and agingQ33824102
Associations between Global DNA Methylation and Telomere Length in Healthy AdolescentsQ33830188
Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysisQ33860488
Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutationsQ33877979
Telomere length is inherited with resetting of the telomere set-point.Q33933472
The association of telomere length and cancer: a meta-analysisQ34026414
Cellular senescence and the senescent secretory phenotype: therapeutic opportunitiesQ34035882
Cellular senescence and the senescent secretory phenotype in age-related chronic diseasesQ34041042
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.Q34043405
Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factorsQ34045737
Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice.Q34046144
Directed elimination of senescent cells by inhibition of BCL-W and BCL-XLQ34046604
Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the Health ABC StudyQ34126129
Mitochondria and CancerQ38760551
Inflammatory Cytokines and Comorbidity Development in Breast Cancer Survivors Versus Noncancer Controls: Evidence for Accelerated Aging?Q38789932
Relationship of systemic cytokine concentrations to cognitive function over two years in women with early stage breast cancerQ38790290
Temporal Trends in Treatment and Subsequent Neoplasm Risk Among 5-Year Survivors of Childhood Cancer, 1970-2015.Q38937267
Evaluation of resistance training to improve muscular strength and body composition in cancer patients undergoing neoadjuvant and adjuvant therapy: a meta-analysis.Q39067972
Cellular Senescence: A Translational PerspectiveQ39246705
A senescent cell bystander effect: senescence-induced senescenceQ39398943
Mitochondrial DNA triplication and punctual mutations in patients with mitochondrial neuromuscular disordersQ39873435
Muscle biopsies from human muscle diseases with myopathic pathology reveal common alterations in mitochondrial functionQ39888514
Telomere length inversely correlates with radiosensitivity in human carcinoma cells with the same tissue backgroundQ40031760
The cumulative burden of surviving childhood cancer: an initial report from the St Jude Lifetime Cohort Study (SJLIFE).Q40048832
Impact of sleep, fatigue, and systemic inflammation on neurocognitive and behavioral outcomes in long-term survivors of childhood acute lymphoblastic leukemiaQ40223829
Tissue-specific mutation accumulation in human adult stem cells during lifeQ40555695
Effects of a 6-Month, Group-Based, Therapeutic Exercise Program for Childhood Cancer Outpatients on Motor Performance, Level of Activity, and Quality of LifeQ40726414
Identification of HSP90 inhibitors as a novel class of senolytics.Q41606906
Cisplatin-mediated impairment of mitochondrial DNA metabolism inversely correlates with glutathione levelsQ42164278
Autophagy maintains stemness by preventing senescenceQ42487109
Cisplatin induced mitochondrial DNA damage in dorsal root ganglion neurons.Q42586741
A non-genetic, epigenetic-like mechanism of telomere length inheritance?Q42790195
Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involvedQ42827125
Influence of the polymorphism in candidate genes on late cardiac damage in patients treated due to acute leukemia in childhoodQ43253475
Peripheral blood leukocyte telomere length and mortality among 64,637 individuals from the general populationQ44430361
Telomere length shortening in non-Hodgkin's lymphoma patients undergoing chemotherapyQ44544281
The effect of chemotherapy on telomere dynamics: clinical results and possible mechanisms.Q44800699
PGC-1α overexpression via local transfection attenuates mitophagy pathway in muscle disuse atrophyQ46613292
Effects of Resistance Training and Protein Supplementation in Breast Cancer SurvivorsQ46702419
Carcinogenesis Young Investigator Award. Telomere epigenetics: a higher-order control of telomere length in mammalian cellsQ47637566
Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: cross-sectional findings from the Newcastle 85+ Study.Q47666819
Higher levels of fatigue are associated with higher CRP levels in disease-free breast cancer survivorsQ48288216
Clonal haematopoiesis is not prevalent in survivors of childhood cancer.Q48335516
DNA methylation of a novel PAK4 locus influences ototoxicity susceptibility following cisplatin and radiation therapy for pediatric embryonal tumorsQ48659411
Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice.Q49121379
Cellular senescence biomarker p16INK4a+ cell burden in thigh adipose is associated with poor physical function in older women.Q50556209
Clinical and biological markers of premature aging after autologous SCT in childhood cancer.Q51205666
Mitochondrial DNA mutations in primary leukemia cells after chemotherapy: clinical significance and therapeutic implications.Q51661489
Cardiorespiratory Capacity and Leukocyte Telomere Length Among Adults in the United States.Q53435913
Effect of exercise on the mitochondrial DNA content of peripheral blood in healthy women.Q54037089
Insulin Resistance and Inflammation as Precursors of FrailtyQ59442589
Inflammatory Markers and Loss of Muscle Mass (Sarcopenia) and StrengthQ60298077
A deletion of mitochondrial DNA in murine doxorubicin-induced cardiotoxicityQ72926826
Cross-sectional and prospective relationships of interleukin-6 and C-reactive protein with physical performance in elderly persons: MacArthur studies of successful agingQ73326181
High innate production capacity of tumor necrosis factor-alpha and decline of handgrip strength in old ageQ80832901
A crucial role for adipose tissue p53 in the regulation of insulin resistanceQ84491291
Frailty and quality of life in adult survivors of childhood cancerQ87940071
Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice.Q34128617
Fat tissue, aging, and cellular senescenceQ34130783
Lifestyle and metabolic syndrome in adult survivors of childhood cancer: a report from the St. Jude Lifetime Cohort StudyQ34193699
Exercise training in childhood cancer survivors with subclinical cardiomyopathy who were treated with anthracyclinesQ34205317
Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesisQ34301317
Telomere dysfunction induced by chemotherapeutic agents and radiation in normal human cells.Q34315672
The effects of physical activity on serum C-reactive protein and inflammatory markers: a systematic reviewQ34418795
Telomere length in blood, buccal cells, and fibroblasts from patients with inherited bone marrow failure syndromesQ34424931
Clinical strategies and animal models for developing senolytic agentsQ34450706
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age.Q34502049
Targeting senescent cells enhances adipogenesis and metabolic function in old ageQ34505890
Human telomere biology: A contributory and interactive factor in aging, disease risks, and protectionQ34509804
Time-Dependent and Tissue-Specific Accumulation of mtDNA and Respiratory Chain Defects in Chronic Doxorubicin CardiomyopathyQ34542655
Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.Q34724924
Modifiable risk factors and major cardiac events among adult survivors of childhood cancerQ34977801
Neurocognitive functioning and health-related behaviours in adult survivors of childhood cancer: a report from the Childhood Cancer Survivor StudyQ35012032
Physiologic frailty as a sign of accelerated aging among adult survivors of childhood cancer: a report from the St Jude Lifetime cohort studyQ35046223
Association between telomere length and type 2 diabetes mellitus: a meta-analysisQ35053395
Systemic inflammation predicts all-cause mortality: a glasgow inflammation outcome study.Q35136980
Frailty in childhood cancer survivorsQ35582195
Effects of physical activity in telomere length: Systematic review and meta-analysis.Q35625594
Blood-borne biomarkers of mortality risk: systematic review of cohort studiesQ35651148
Telomere length is associated with decline in grip strength in older persons aged 65 years and overQ35678653
Transcripts of agingQ35774486
Association of proinflammatory cytokines and chemotherapy-associated cognitive impairment in breast cancer patients: a multi-centered, prospective, cohort studyQ35775258
Benefits of Regular Exercise on Inflammatory and Cardiovascular Risk Markers in Normal Weight, Overweight and Obese AdultsQ35810477
Mechanisms linking mtDNA damage and aging.Q35868104
Inflammation and frailty measures in older peopleQ35893237
Effects of a caloric restriction weight loss diet and exercise on inflammatory biomarkers in overweight/obese postmenopausal women: a randomized controlled trialQ35930163
Anthracycline-related cardiomyopathy after childhood cancer: role of polymorphisms in carbonyl reductase genes--a report from the Children's Oncology Group.Q36058273
Endocrine Abnormalities in Aging Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor StudyQ36068659
Pathways connecting telomeres and p53 in senescence, apoptosis, and cancerQ36113169
Leukocyte telomere length and mortality in the National Health and Nutrition Examination Survey, 1999-2002Q36371781
Epigenetic regulation of ageing: linking environmental inputs to genomic stabilityQ36531421
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectlifetimeQ22675021
P304page(s)2206-2215
P577publication date2018-06-06
P1433published inJournal of Clinical OncologyQ400292
P1476titlePremature Physiologic Aging as a Paradigm for Understanding Increased Risk of Adverse Health Across the Lifespan of Survivors of Childhood Cancer.
P478volume36

Reverse relations

cites work (P2860)
Q98647331Accelerated aging among childhood, adolescent, and young adult cancer survivors is evidenced by increased expression of p16INK4a and frailty
Q89951322Discovery, development, and future application of senolytics: theories and predictions
Q92558151Prediction of Low and Very Low Bone Mineral Density Among Adult Survivors of Childhood Cancer
Q64286784Senolytics and senostatics as adjuvant tumour therapy