Resolution of the Holliday junction recombination intermediate by human GEN1 at the single-molecule level.

scientific article published in February 2019

Resolution of the Holliday junction recombination intermediate by human GEN1 at the single-molecule level. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NAR/GKY1280
P932PMC publication ID6393306
P698PubMed publication ID30590761

P50authorMuhammad TehseenQ59157103
Manal ZaherQ85301297
P2093author name stringMasateru Takahashi
Samir M Hamdan
Amer Bralić
Fahad Rashid
Mohamed A Sobhy
Vlad-Stefan Raducanu
P2860cites workBLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrityQ24298321
Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleasesQ24314357
A Note on the Kinetics of Enzyme ActionQ24536248
BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediatesQ24544999
Crystal structure of a DNA Holliday junctionQ27619805
Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 SuperfamilyQ27667524
Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease FamilyQ27667527
Identification of Holliday junction resolvases from humans and yeastQ27937498
MUS81 encodes a novel helix-hairpin-helix protein involved in the response to UV- and methylation-induced DNA damage in Saccharomyces cerevisiaeQ27939646
Molecular views of recombination proteins and their controlQ28207872
A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1Q59125485
The structure of the Holliday junction, and its resolutionQ67927529
Fluorescence resonance energy transfer analysis of the structure of the four-way DNA junctionQ68133215
Structure of four-way DNA junctions containing a nick in one strandQ72333494
Exploring rare conformational species and ionic effects in DNA Holliday junctions using single-molecule spectroscopyQ80407128
Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA.Q41523167
GEN1 from a thermophilic fungus is functionally closely similar to non-eukaryotic junction-resolving enzymesQ42061635
The SMX DNA Repair Tri-nucleaseQ42317231
Spatial control of the GEN1 Holliday junction resolvase ensures genome stabilityQ42911866
Aberrant chromosome morphology in human cells defective for Holliday junction resolutionQ43100849
GEN1 promotes Holliday junction resolution by a coordinated nick and counter-nick mechanism.Q43130270
Positioning the 5'-flap junction in the active site controls the rate of flap endonuclease-1-catalyzed DNA cleavageQ49806501
Biochemical and Structural Properties of Fungal Holliday Junction-Resolving Enzymes.Q49836732
Genome Instability as a Consequence of Defects in the Resolution of Recombination Intermediates.Q49953411
Missed cleavage opportunities by FEN1 lead to Okazaki fragment maturation via the long-flap pathway.Q50113616
Hidden complexity in the isomerization dynamics of Holliday junctions.Q51307505
Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I.Q52769433
Exchange between stacking conformers in a four-Way DNA junction.Q52899906
Structural dynamics of individual Holliday junctions.Q52946829
Identification of double Holliday junctions as intermediates in meiotic recombination.Q54599520
Regional conformational flexibility couples substrate specificity and scissile phosphate diester selectivity in human flap endonuclease 1.Q55368890
Human Mus81-associated endonuclease cleaves Holliday junctions in vitroQ28210371
The Bloom's syndrome helicase suppresses crossing over during homologous recombinationQ29547237
The importance of repairing stalled replication forksQ29614220
Topoisomerase IIIalpha and Bloom's helicase can resolve a mobile double Holliday junction substrate through convergent branch migrationQ33250631
Learning rates and states from biophysical time series: a Bayesian approach to model selection and single-molecule FRET dataQ33518206
The Mus81-Mms4 structure-selective endonuclease requires nicked DNA junctions to undergo conformational changes and bend its DNA substrates for cleavageQ33698561
Substrate preference of Gen endonucleases highlights the importance of branched structures as DNA damage repair intermediatesQ33701418
Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instabilityQ33851243
Observing spontaneous branch migration of Holliday junctions one step at a timeQ33936256
Mechanism of Holliday junction resolution by the human GEN1 proteinQ33998890
Versatile single-molecule multi-color excitation and detection fluorescence setup for studying biomolecular dynamicsQ34086733
Identification and characterization of the human mus81-eme1 endonucleaseQ34193657
Defining the limits of single-molecule FRET resolution in TIRF microscopyQ34250548
The junction-resolving enzymes.Q34271586
A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75.Q34510600
Holliday junction processing activity of the BLM-Topo IIIalpha-BLAP75 complexQ34668555
On the mechanism of genetic recombination: electron microscopic observation of recombination intermediatesQ35021873
Assembly of the Escherichia coli RuvABC resolvasome directs the orientation of holliday junction resolutionQ35201683
Real-time submillisecond single-molecule FRET dynamics of freely diffusing molecules with liposome tetheringQ35574911
Crossover isomer bias is the primary sequence-dependent property of immobilized Holliday junctionsQ36550054
Occurrence of crossed strand-exchange forms in yeast DNA during meiosisQ37337080
Resolution of single and double Holliday junction recombination intermediates by GEN1.Q37599023
Single-molecule FRET unveils induced-fit mechanism for substrate selectivity in flap endonuclease 1.Q37712232
Coordinated actions of SLX1-SLX4 and MUS81-EME1 for Holliday junction resolution in human cellsQ38312294
The role of Holliday junction resolvases in the repair of spontaneous and induced DNA damageQ38319089
Functional role of BLAP75 in BLM-topoisomerase IIIalpha-dependent holliday junction processingQ38868282
Ensuring productive resolution by the junction-resolving enzyme RuvC: large enhancement of the second-strand cleavage rateQ39423944
Double Holliday junctions are intermediates of DNA break repair.Q39957722
Formation, translocation and resolution of Holliday junctions during homologous genetic recombinationQ40522875
Structural basis for recruitment of human flap endonuclease 1 to PCNAQ41106952
Human Holliday junction resolvase GEN1 uses a chromodomain for efficient DNA recognition and cleavageQ41199030
P275copyright licenseCreative Commons Attribution-NonCommercial 4.0 InternationalQ34179348
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)1935-1949
P577publication date2019-02-01
P1433published inNucleic Acids ResearchQ135122
P1476titleResolution of the Holliday junction recombination intermediate by human GEN1 at the single-molecule level
P478volume47

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Q64075900Structure-Specific Endonucleases and the Resolution of Chromosome Underreplicationcites workP2860

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