Clinical impact of intratumoral HER2 heterogeneity on trastuzumab efficacy in patients with HER2-positive gastric cancer.

scientific article published on 9 April 2018

Clinical impact of intratumoral HER2 heterogeneity on trastuzumab efficacy in patients with HER2-positive gastric cancer. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00535-018-1464-0
P932PMC publication ID6209002
P698PubMed publication ID29633013

P50authorNoriko Yamamoto-MitaniQ57690528
Daisuke TakahariQ87662858
Kensei YamaguchiQ87972994
Takeru WakatsukiQ88313362
Hiroki OsumiQ89122610
Mitsukuni SuenagaQ89170818
Izuma NakayamaQ91785329
Eiji ShinozakiQ96238224
Mariko OguraQ114405022
Keisho ChinQ114405023
P2093author name stringHiroshi Kawachi
Naoki Hiki
Yuichi Ishikawa
Takashi Ichimura
Takeshi Sano
Tomohiro Matsushima
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Lapatinib plus paclitaxel versus paclitaxel alone in the second-line treatment of HER2-amplified advanced gastric cancer in Asian populations: TyTAN--a randomized, phase III studyQ27853010
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Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancerQ29616112
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Poor efficacy response to trastuzumab therapy in advanced gastric cancer with homogeneous HER2 positive and non-intestinal typeQ33779412
Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: a report of the V325 Study GroupQ34572233
p185, a product of the neu proto-oncogene, is a receptorlike protein associated with tyrosine kinase activityQ36914246
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Assessment of a HER2 scoring system for gastric cancer: results from a validation studyQ37142266
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Comprehensive analyses using next-generation sequencing and immunohistochemistry enable precise treatment in advanced gastric cancerQ38951195
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HER2 heterogeneity affects trastuzumab responses and survival in patients with HER2-positive metastatic breast cancer.Q53251318
Optimal Patient Selection for Trastuzumab Treatment in HER2-Positive Advanced Gastric Cancer.Q53604901
Expression profiles of HER2, EGFR, MET and FGFR2 in a large cohort of patients with gastric adenocarcinoma.Q54218339
Intratumoral heterogeneous amplification of ERBB2 and subclonal genetic diversity in gastric cancers revealed by multiple ligation-dependent probe amplification and fluorescence in situ hybridization.Q54224717
Multicenter large-scale study of prognostic impact of HER2 expression in patients with resectable gastric cancer.Q54321983
Level of HER2 gene amplification predicts response and overall survival in HER2-positive advanced gastric cancer treated with trastuzumab.Q54402875
Impact of expression of human epidermal growth factor receptors EGFR and ERBB2 on survival in stage II/III gastric cancer.Q54483761
Clinical impact of a strategy involving endoscopic submucosal dissection for early gastric cancer: determining the optimal pathwayQ83426491
Evaluation of HER2 protein expression in gastric carcinomas: comparative analysis of 1,414 cases of whole-tissue sections and 595 cases of tissue microarraysQ83789922
A novel gene-protein assay for evaluating HER2 status in gastric cancer: simultaneous analyses of HER2 protein overexpression and gene amplification reveal intratumoral heterogeneityQ88055520
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue11
P921main subjecttrastuzumabQ412616
P304page(s)1186-1195
P577publication date2018-04-09
P1433published inJournal of GastroenterologyQ15764399
P1476titleClinical impact of intratumoral HER2 heterogeneity on trastuzumab efficacy in patients with HER2-positive gastric cancer
P478volume53

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cites work (P2860)
Q90321333Clinical and molecular prognostic markers of survival after surgery for gastric cancer: tumor-node-metastasis staging system and beyond
Q57453268Clinical significance of intratumoral HER2 heterogeneity on trastuzumab efficacy using endoscopic biopsy specimens in patients with advanced HER2 positive gastric cancer
Q91825736De novo discovery of metabolic heterogeneity with immunophenotype-guided imaging mass spectrometry
Q93175115Dissection of gastric cancer heterogeneity for precision oncology
Q89683058Emerging Targeted Therapies for HER2 Positive Gastric Cancer That Can Overcome Trastuzumab Resistance
Q89879114HER2 Heterogeneity in Personalized Therapy of Gastro-Oesophageal Malignancies: An Overview by Different Methodologies
Q89868898HER2 and BRAF mutation in colorectal cancer patients: a retrospective study in Eastern China
Q92685589HER2 heterogeneity is a poor prognosticator for HER2-positive gastric cancer
Q89795555Human Epidermal Growth Factor Receptor 2 (HER2) in Advanced Gastric Cancer: Current Knowledge and Future Perspectives
Q99712042The Role of HER2 in Self-Renewal, Invasion, and Tumorigenicity of Gastric Cancer Stem Cells