Compound K Induces Endoplasmic Reticulum Stress and Apoptosis in Human Liver Cancer Cells by Regulating STAT3.

scientific article published on 19 June 2018

Compound K Induces Endoplasmic Reticulum Stress and Apoptosis in Human Liver Cancer Cells by Regulating STAT3. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3390/MOLECULES23061482
P932PMC publication ID6099685
P698PubMed publication ID29921768

P2093author name stringYan Yan
Xuan Zhang
Xuewu Zhang
Silin Zhang
Wenjun Jiao
Qitong Sun
P2860cites workRoles of CHOP/GADD153 in endoplasmic reticulum stressQ24302185
Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell deathQ24338605
Ginseng pharmacology: multiple constituents and multiple actionsQ28138460
Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solutionQ28291780
The STATs of cancer--new molecular targets come of ageQ29614601
Endoplasmic Reticulum Stress and Unfolded Protein Response in Cartilage Pathophysiology; Contributing Factors to Apoptosis and OsteoarthritisQ30235128
Protodioscin Induces Apoptosis Through ROS-Mediated Endoplasmic Reticulum Stress via the JNK/p38 Activation Pathways in Human Cervical Cancer Cells.Q51415673
A novel herbal formula, SGE, induces endoplasmic reticulum stress-mediated cancer cell death and alleviates cachexia symptoms induced by colon-26 adenocarcinoma.Q52584343
Pharmacokinetics and dopamine/acetylcholine releasing effects of ginsenoside Re in hippocampus and mPFC of freely moving ratsQ33572429
Fasudil protects the heart against ischemia-reperfusion injury by attenuating endoplasmic reticulum stress and modulating SERCA activity: the differential role for PI3K/Akt and JAK2/STAT3 signaling pathwaysQ34464791
Antitumor activity of a novel ginseng saponin metabolite in human pulmonary adenocarcinoma cells resistant to cisplatinQ34505173
NF-κB and STAT3 - key players in liver inflammation and cancerQ35347976
Panax ginseng.Q35574823
Ginsenosides as Anticancer Agents: In vitro and in vivo Activities, Structure-Activity Relationships, and Molecular Mechanisms of ActionQ35787329
Altered p-STAT3 (tyr705) expression is associated with histological grading and intratumour microvessel density in hepatocellular carcinomaQ35954415
Cryptotanshinone enhances the effect of Arsenic trioxide in treating liver cancer cell by inducing apoptosis through downregulating phosphorylated- STAT3 in vitro and in vivoQ36277354
Constitutive activation of STAT3 in breast cancer cells: A reviewQ36711689
Potential role of signal transducer and activator of transcription (STAT)3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinomaQ38056018
Cell death induced by endoplasmic reticulum stress.Q38639996
Norcantharidin inhibits IL-6-induced epithelial‑mesenchymal transition via the JAK2/STAT3/TWIST signaling pathway in hepatocellular carcinoma cellsQ38693318
Quercetin induces endoplasmic reticulum stress to enhance cDDP cytotoxicity in ovarian cancer: involvement of STAT3 signaling.Q38917585
Knockdown of glucose-regulated protein 78 enhances poly(ADP-ribose) polymerase cleavage in human pancreatic cancer cells exposed to endoplasmic reticulum stressQ38946261
Elatoside C protects against hypoxia/reoxygenation-induced apoptosis in H9c2 cardiomyocytes through the reduction of endoplasmic reticulum stress partially depending on STAT3 activationQ38946896
STAT3 mediates regorafenib-induced apoptosis in hepatocellular carcinoma.Q38953983
Compound K-induced apoptosis of human hepatocellular carcinoma MHCC97-H cells in vitroQ38997563
Curcumin ameliorates streptozotocin-induced liver damage through modulation of endoplasmic reticulum stress-mediated apoptosis in diabetic ratsQ39390726
Inhibition of JAK1/STAT3 signaling mediates compound K-induced apoptosis in human multiple myeloma U266 cellsQ39573576
Caspase-4 directly activates caspase-9 in endoplasmic reticulum stress-induced apoptosis in SH-SY5Y cells.Q39599805
Intestinal metabolite compound K of ginseng saponin potently attenuates metastatic growth of hepatocellular carcinoma by augmenting apoptosis via a Bid-mediated mitochondrial pathwayQ39625311
Compound K, intestinal metabolite of ginsenoside, attenuates hepatic lipid accumulation via AMPK activation in human hepatoma cellsQ39889054
A novel synthetic Asiatic acid derivative induces apoptosis and inhibits proliferation and mobility of gastric cancer cells by suppressing STAT3 signaling pathwayQ39984598
Antiallergic Activity of Ginsenoside Rh2Q40619483
Endothelial cells, endoplasmic reticulum stress and oxysterolsQ41271798
The Role of Endoplasmic Reticulum Stress in Cardiovascular Disease and Exercise.Q41508828
Apoptosis, autophagy and ER stress in mevalonate cascade inhibition-induced cell death of human atrial fibroblastsQ41959819
A kindling model of pharmacoresistant temporal lobe epilepsy in Sprague-Dawley rats induced by Coriaria lactone and its possible mechanismQ44393921
Hepatoprotective effect of ginsenoside Rb1 and compound K on tert-butyl hydroperoxide-induced liver injuryQ46702722
Activated epidermal growth factor receptor-Stat-3 signaling promotes tumor survival in vivo in non-small cell lung cancerQ46831080
Protective effects of a G. lucidum proteoglycan on INS-1 cells against IAPP-induced apoptosis via attenuating endoplasmic reticulum stress and modulating CHOP/JNK pathwaysQ47687951
Artesunate acts as fuel to fire in sensitizing HepG2 cells towards TRAIL mediated apoptosis via STAT3 inhibition and DR4 augmentationQ47694351
A Bacterial Metabolite, Compound K, Induces Programmed Necrosis in MCF-7 Cells via GSK3β.Q50271268
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageQuantQ112270642
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectendoplasmic reticulumQ79927
liver cancerQ623031
P577publication date2018-06-19
P1433published inMoleculesQ151332
P1476titleCompound K Induces Endoplasmic Reticulum Stress and Apoptosis in Human Liver Cancer Cells by Regulating STAT3.
P478volume23

Reverse relations

cites work (P2860)
Q918074917-epi-Clusianone, a Multi-Targeting Natural Product with Potential Chemotherapeutic, Immune-Modulating, and Anti-Angiogenic Properties
Q92782319Genome-scale CRISPR screening for potential targets of ginsenoside compound K
Q91906850Ginsenosides: the need to move forward from bench to clinical trials
Q64266062Harnessing the potential of gene editing technology using CRISPR in inflammatory bowel disease
Q59796205Synthesis and Anticancer Activity Evaluation of Hydrolyzed Derivatives of Saponins

Search more.