The identification of small molecule inhibitors of the plant inositol phosphorylceramide synthase which demonstrate herbicidal activity.

scientific article published on 30 May 2019

The identification of small molecule inhibitors of the plant inositol phosphorylceramide synthase which demonstrate herbicidal activity. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-019-44544-1
P932PMC publication ID6542793
P698PubMed publication ID31147620

P50authorJohn G M MinaQ50948216
Michael J. StarkQ55640784
Paul W DennyQ38546115
Marc R KnightQ39065869
Patrick G SteelQ40423492
P2093author name stringStephen D Lindell
Elizabeth C Pinneh
Peter Luemmen
P2860cites workSphingosine-1-Phosphate Signaling in Immune Cells and Inflammation: Roles and Therapeutic PotentialQ26766425
A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiaeQ27860636
Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiaeQ27861085
PDR16 and PDR17, two homologous genes of Saccharomyces cerevisiae, affect lipid biosynthesis and resistance to multiple drugsQ27930853
Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 geneQ27933785
PDR3, a new yeast regulatory gene, is homologous to PDR1 and controls the multidrug resistance phenomenonQ27936636
The yeast ATP binding cassette (ABC) protein genes PDR10 and PDR15 are novel targets for the Pdr1 and Pdr3 transcriptional regulatorsQ27938648
Multiple Pdr1p/Pdr3p binding sites are essential for normal expression of the ATP binding cassette transporter protein-encoding gene PDR5.Q27939645
A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening AssaysQ28145712
Identifying inhibitors of the Leishmania inositol phosphorylceramide synthase with antiprotozoal activity using a yeast-based assay and ultra-high throughput screening platform.Q52676386
The Consequences of CO2 Stabilisation for the Impacts of Climate ChangeQ57150437
The ATP-binding cassette multidrug transporter Snq2 of Saccharomyces cerevisiae: a novel target for the transcription factors Pdr1 and Pdr3Q71662107
Solubilization and characterization of the overexpressed PDR5 multidrug resistance nucleotide triphosphatase of yeastQ72403491
Khafrefungin, a novel inhibitor of sphingolipid synthesisQ73956155
Inhibition of sphingolipid induced apoptosis by caspase inhibitors indicates that sphingosine acts in an earlier part of the apoptotic pathway than ceramideQ74440446
A plate-based assay system for analyses and screening of the Leishmania major inositol phosphorylceramide synthaseQ84438858
Methamphetamine accelerates cellular senescence through stimulation of de novo ceramide biosynthesisQ28543389
Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiaeQ29546523
The YDp plasmids: a uniform set of vectors bearing versatile gene disruption cassettes for Saccharomyces cerevisiaeQ29620826
Sphingolipids and plant defense/disease: the "death" connection and beyondQ30467364
4-Hydroxynonenal Contributes to Angiogenesis through a Redox-Dependent Sphingolipid Pathway: Prevention by Hydralazine DerivativesQ33578718
Membrane transporters and antifungal drug resistanceQ34314701
Radiation and ceramide-induced apoptosisQ35208833
Transcriptome and hormone profiling reveals Eucalyptus grandis defence responses against Chrysoporthe austroafricanaQ35519403
Sphingolipid and ceramide homeostasis: potential therapeutic targetsQ35778875
The multidrug resistance gene PDR1 from Saccharomyces cerevisiae.Q36447514
Functions and metabolism of sphingolipids in Saccharomyces cerevisiaeQ36491040
Molecular and functional characterization of the ceramide synthase from Trypanosoma cruzi.Q36551253
Yeast ATP-binding cassette transporters conferring multidrug resistanceQ38019037
Global perspective of herbicide-resistant weedsQ38168507
Transcriptional control of the yeast PDR5 gene by the PDR3 gene productQ38306711
Genome microarray analysis of transcriptional activation in multidrug resistance yeast mutantsQ38313958
Everybody needs sphingolipids, right! Mining for new drug targets in protozoan sphingolipid biosynthesisQ38668340
Sphingomyelin Synthase 1 Regulates Neuro-2a Cell Proliferation and Cell Cycle Progression Through Modulation of p27 Expression and Akt SignalingQ38969493
The AUR1 gene in Saccharomyces cerevisiae encodes dominant resistance to the antifungal agent aureobasidin A (LY295337).Q39781036
Expression of an ATP-binding cassette transporter-encoding gene (YOR1) is required for oligomycin resistance in Saccharomyces cerevisiaeQ40017844
The protozoan inositol phosphorylceramide synthase: a novel drug target that defines a new class of sphingolipid synthaseQ40252328
Ceramides modulate programmed cell death in plantsQ40266116
Rustmicin, a potent antifungal agent, inhibits sphingolipid synthesis at inositol phosphoceramide synthaseQ42541962
Sphingomyelin metabolism is involved in the differentiation of MDCK cells induced by environmental hypertonicityQ42695660
The Sphingolipid Biosynthetic Pathway Is a Potential Target for Chemotherapy against Chagas DiseaseQ42731998
Characterization of the inositol phosphorylceramide synthase activity from Trypanosoma cruzi.Q42816185
Mannosylinositol phosphorylceramide is a major sphingolipid component and is required for proper localization of plasma-membrane proteins in Schizosaccharomyces pombeQ43101001
Functional analyses of differentially expressed isoforms of the Arabidopsis inositol phosphorylceramide synthaseQ43121464
An inositolphosphorylceramide synthase is involved in regulation of plant programmed cell death associated with defense in ArabidopsisQ43700363
Complex sphingolipid synthesis in plants: characterization of inositolphosphorylceramide synthase activity in bean microsomesQ44563570
Exploring Leishmania major inositol phosphorylceramide synthase (LmjIPCS): insights into the ceramide binding domainQ45773455
Haplofungins, new inositol phosphorylceramide synthase inhibitors, from Lauriomyces bellulus SANK 26899 II. Structure elucidation.Q45915439
Identification of a sphingolipid α-glucuronosyltransferase that is essential for pollen function in ArabidopsisQ46193479
Pleofungins, novel inositol phosphorylceramide synthase inhibitors, from Phoma sp. SANK 13899. I. Taxonomy, fermentation, isolation, and biological activitiesQ48693649
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)8083
P577publication date2019-05-30
P1433published inScientific ReportsQ2261792
P1476titleThe identification of small molecule inhibitors of the plant inositol phosphorylceramide synthase which demonstrate herbicidal activity
P478volume9