XRK3F2 Inhibition of p62-ZZ Domain Signaling Rescues Myeloma-Induced GFI1-Driven Epigenetic Repression of the Runx2 Gene in Pre-osteoblasts to Overcome Differentiation Suppression.

scientific article published on 29 June 2018

XRK3F2 Inhibition of p62-ZZ Domain Signaling Rescues Myeloma-Induced GFI1-Driven Epigenetic Repression of the Runx2 Gene in Pre-osteoblasts to Overcome Differentiation Suppression. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FENDO.2018.00344
P932PMC publication ID6033965
P698PubMed publication ID30008697

P50authorDeborah L. GalsonQ51170712
P2093author name stringDan Zhou
Silvia Marino
Xiang-Qun Xie
G David Roodman
Judith L Anderson
Quanhong Sun
Rebecca Silbermann
Juraj Adamik
P2860cites workThe interaction of p62 with RIP links the atypical PKCs to NF-kappaB activationQ22009927
Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1Q24294874
The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complexQ24301337
Ajuba functions as a histone deacetylase-dependent co-repressor for autoregulation of the growth factor-independent-1 transcription factorQ24314685
RANK is essential for osteoclast and lymph node developmentQ24598872
Regulation of gene expression in osteoblastsQ27691363
Cancer statistics, 2014Q27861018
Mechanism of Action of Bortezomib and the New Proteasome Inhibitors on Myeloma Cells and the Bone Microenvironment: Impact on Myeloma-Induced Alterations of Bone RemodelingQ28082335
Risk of progression and survival in multiple myeloma relapsing after therapy with IMiDs and bortezomib: a multicenter international myeloma working group studyQ33942495
Expression of the transcriptional repressor Gfi-1 is regulated by C/EBP{alpha} and is involved in its proliferation and colony formation-inhibitory effects in p210BCR/ABL-expressing cellsQ34203955
Osteoblast inhibition by chemokine cytokine ligand3 in myeloma-induced bone diseaseQ34720969
Distinct mechanisms for induction and tolerance regulate the immediate early genes encoding interleukin 1β and tumor necrosis factor α.Q34926054
EZH2 or HDAC1 Inhibition Reverses Multiple Myeloma-Induced Epigenetic Suppression of Osteoblast Differentiation.Q51170659
Small interfering RNA silencing of interleukin-6 in mesenchymal stromal cells inhibits multiple myeloma cell growth.Q53256917
Abnormal bone remodelling in patients with myelomatosis and normal biochemical indices of bone resorptionQ67602665
Fracture healing in metastatic bone diseaseQ71823132
Ascorbic Acid-Dependent Activation of the Osteocalcin Promoter in MC3T3-E1 Preosteoblasts: Requirement for Collagen Matrix Synthesis and the Presence of an Intact OSE2 SequenceQ73486339
Specific regulation of cytokine-dependent p38 MAP kinase activation by p62/SQSTM1Q80763828
Pathologic fractures correlate with reduced survival in patients with malignant bone diseaseQ80974012
Regulation of osteoblast differentiation by Runx2Q84966232
Gfi1 expressed in bone marrow stromal cells is a novel osteoblast suppressor in patients with multiple myeloma bone diseaseQ35631319
Pathogenesis of myeloma bone diseaseQ35683616
Paget disease of boneQ36029217
A plastic SQSTM1/p62-dependent autophagic reserve maintains proteostasis and determines proteasome inhibitor susceptibility in multiple myeloma cellsQ36111590
Blocking the ZZ domain of sequestosome1/p62 suppresses myeloma growth and osteoclast formation in vitro and induces dramatic bone formation in myeloma-bearing bones in vivo.Q36540462
Multiple myeloma bone disease: Pathophysiology of osteoblast inhibition.Q36569101
Snail/Gfi-1 (SNAG) family zinc finger proteins in transcription regulation, chromatin dynamics, cell signaling, development, and diseaseQ36579298
Signaling and transcriptional regulation in osteoblast commitment and differentiationQ36606452
Signal integration and diversification through the p62 scaffold proteinQ36686435
Mechanisms of multiple myeloma bone diseaseQ37056408
RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolismQ37108966
Increased signaling through p62 in the marrow microenvironment increases myeloma cell growth and osteoclast formationQ37201872
Sequestosome-1/p62 is the key intracellular target of innate defense regulator peptideQ37479210
Relationship between initial clinical presentation and the molecular cytogenetic classification of myeloma.Q37584754
Gfi1 and Gfi1b: key regulators of hematopoiesisQ37791430
The diagnosis and management of patients with idiopathic osteolysisQ37945260
Multiple myeloma mesenchymal stem cells: characterization, origin, and tumor-promoting effectsQ37953844
The adaptor protein p62/SQSTM1 in osteoclast signaling pathwaysQ37973113
Management of bone disease in multiple myelomaQ38179039
Myeloma cells suppress osteoblasts through sclerostin secretionQ38323256
KLF4-SQSTM1/p62-associated prosurvival autophagy contributes to carfilzomib resistance in multiple myeloma modelsQ38860336
Gfi1 expression is controlled by five distinct regulatory regions spread over 100 kilobases, with Scl/Tal1, Gata2, PU.1, Erg, Meis1, and Runx1 acting as upstream regulators in early hematopoietic cells.Q39697722
Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myelomaQ40009759
Cell-cell contact between marrow stromal cells and myeloma cells via VCAM-1 and alpha(4)beta(1)-integrin enhances production of osteoclast-stimulating activity.Q40858675
Isolation and characterization of MC3T3-E1 preosteoblast subclones with distinct in vitro and in vivo differentiation/mineralization potentialQ42472805
AMPK promotes osteogenesis and inhibits adipogenesis through AMPK-Gfi1-OPN axisQ42809876
Cancer and the microenvironment: myeloma-osteoclast interactions as a modelQ44802876
Improvement of photoaffinity SPR imaging platform and determination of the binding site of p62/SQSTM1 to p38 MAP kinaseQ44879054
GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1.Q48096449
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P304page(s)344
P577publication date2018-06-29
P1433published inFrontiers in EndocrinologyQ27723680
P1476titleXRK3F2 Inhibition of p62-ZZ Domain Signaling Rescues Myeloma-Induced GFI1-Driven Epigenetic Repression of the Runx2 Gene in Pre-osteoblasts to Overcome Differentiation Suppression.
P478volume9