Targeting of the AXL receptor tyrosine kinase by small molecule inhibitor leads to AXL cell surface accumulation by impairing the ubiquitin-dependent receptor degradation.

scientific article published on 6 June 2019

Targeting of the AXL receptor tyrosine kinase by small molecule inhibitor leads to AXL cell surface accumulation by impairing the ubiquitin-dependent receptor degradation. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1186/S12964-019-0377-8
P932PMC publication ID6555758
P698PubMed publication ID31171001

P50authorRobert TorkaQ74720124
P2093author name stringAnja Weber
Markus Lauter
P2860cites workPMA up-regulates the transcription of Axl by AP-1 transcription factor binding to TRE sequences via the MAPK cascade in leukaemia cellsQ39639728
Molecular analysis of alternative transcripts of equine AXL receptor tyrosine kinase geneQ41600499
Molecular mechanism of 17-allylamino-17-demethoxygeldanamycin (17-AAG)-induced AXL receptor tyrosine kinase degradationQ42155234
GAS6-expressing and self-sustaining cancer cells in 3D spheroids activate the PDK-RSK-mTOR pathway for survival and drug resistance.Q42288454
Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicityQ42408081
Therapeutic Activity of Anti-AXL Antibody against Triple-Negative Breast Cancer Patient-Derived Xenografts and MetastasisQ42502708
Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signalingQ42693450
Effects of Gas6 and hydrogen peroxide in Axl ubiquitination and downregulationQ46548747
The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case StudyQ47411655
Targeting Gas6/TAM in cancer cells and tumor microenvironmentQ47701436
The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression.Q53069540
The TAM family: phosphatidylserine sensing receptor tyrosine kinases gone awry in cancer.Q54298179
Phyllodes tumor of the breast: role of Axl and ST6GalNAcII in the development of mammary phyllodes tumors.Q55073541
Axl inhibitor R428 induces apoptosis of cancer cells by blocking lysosomal acidification and recycling independent of Axl inhibitionQ58804596
Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-siteQ24309038
Bioluminescent human breast cancer cell lines that permit rapid and sensitive in vivo detection of mammary tumors and multiple metastases in immune deficient miceQ24810598
Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming proteinQ28210330
Grb2 regulates internalization of EGF receptors through clathrin-coated pitsQ30164836
The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells.Q33357894
Writers and readers of histone acetylation: structure, mechanism, and inhibitionQ33796362
Activation of HER3 interferes with antitumor effects of Axl receptor tyrosine kinase inhibitors: suggestion of combination therapy.Q33891230
Diversification of TAM receptor tyrosine kinase functionQ34214465
Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET.Q34217927
Gas6, the ligand of Axl tyrosine kinase receptor, has mitogenic and survival activities for serum starved NIH3T3 fibroblastsQ34380670
Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivitiesQ34390266
SOMA: a single oligonucleotide mutagenesis and cloning approachQ34764129
Soluble AXL: a possible circulating biomarker for neurofibromatosis type 1 related tumor burden.Q34797452
Multicenter analysis of soluble Axl reveals diagnostic value for very early stage hepatocellular carcinoma.Q35669106
Aberrant mRNA translation in cancer pathogenesis: an old concept revisited comes finally of age.Q35750097
Targeting the degradation of AXL receptor tyrosine kinase to overcome resistance in gefitinib-resistant non-small cell lung cancerQ35832938
Identification of the receptor tyrosine kinase AXL in breast cancer as a target for the human miR-34a microRNAQ36054278
Combined inhibition of AXL, Lyn and p130Cas kinases block migration of triple negative breast cancer cellsQ36214760
Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinasesQ36493822
Differential activation of the Ras/extracellular-signal-regulated protein kinase pathway is responsible for the biological consequences induced by the Axl receptor tyrosine kinaseQ36556713
Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor ResistanceQ37380418
Specific Grb2-mediated interactions regulate clathrin-dependent endocytosis of the cMet-tyrosine kinaseQ38302515
Histone exchange, chromatin structure and the regulation of transcriptionQ38343838
AXL Inhibitors in Cancer: A Medicinal Chemistry PerspectiveQ38629669
Giving AXL the axe: targeting AXL in human malignancyQ38772267
Translation Initiation Factors: Reprogramming Protein Synthesis in CancerQ38899989
Axl glycosylation mediates tumor cell proliferation, invasion and lymphatic metastasis in murine hepatocellular carcinomaQ39256469
TAM Receptor Tyrosine Kinases in Cancer Drug ResistanceQ39319172
AXL-Driven EMT State as a Targetable Conduit in CancerQ39408053
Regulation of Axl receptor tyrosine kinase expression by miR-34a and miR-199a/b in solid cancerQ39592978
P433issue1
P304page(s)59
P577publication date2019-06-06
P1433published inCell Communication and SignalingQ1254390
P1476titleTargeting of the AXL receptor tyrosine kinase by small molecule inhibitor leads to AXL cell surface accumulation by impairing the ubiquitin-dependent receptor degradation
P478volume17

Reverse relations

cites work (P2860)
Q90148023AXL as a Target in Breast Cancer Therapy
Q92517975Soluble AXL as a marker of disease progression and survival in melanoma

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