Protein kinase A inhibits tumor mutator APOBEC3B through phosphorylation.

scientific article published on 5 June 2019

Protein kinase A inhibits tumor mutator APOBEC3B through phosphorylation. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-019-44407-9
P932PMC publication ID6549188
P698PubMed publication ID31165764

P50authorAnamaria Daniela SarcaQ64965356
Masayuki KobayashiQ89172211
Akifumi Takaori-KondoQ89172212
Masaru YokoyamaQ90252119
P2093author name stringHironori Sato
Kotaro Shirakawa
Hiroyuki Yamazaki
Ryo Morishita
Keisuke Shindo
Kayoko Nagata
Hiroyuki Matsui
Tadahiko Matsumoto
Yasuhiro Kazuma
Fumiko Tanabe
Hirofumi Fukuda
Wataru Maruyama
Sukenao Koyabu
P2860cites workThe cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNAQ24305266
APOBEC3A and APOBEC3B are potent inhibitors of LTR-retrotransposon function in human cellsQ24536003
The restriction factors of human immunodeficiency virusQ24605108
Improved side-chain torsion potentials for the Amber ff99SB protein force fieldQ24616749
Mutational processes molding the genomes of 21 breast cancersQ24620915
Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifsQ24671990
All APOBEC3 family proteins differentially inhibit LINE-1 retrotranspositionQ24675735
APOBEC3G targets human T-cell leukemia virus type 1.Q24811566
Gamma radiation increases endonuclease-dependent L1 retrotransposition in a cultured cell assayQ25255521
Comparison of simple potential functions for simulating liquid waterQ26778447
Assessing the Current State of Amber Force Field Modifications for DNAQ27301352
Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif proteinQ27860488
Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcriptsQ28179446
DNA deamination mediates innate immunity to retroviral infectionQ28179534
APOBEC3B and APOBEC3F inhibit L1 retrotransposition by a DNA deamination-independent mechanismQ28237264
Cytidine deamination of retroviral DNA by diverse APOBEC proteinsQ28578747
Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanesQ29397708
Signatures of mutational processes in human cancerQ29547191
Prediction of post-translational glycosylation and phosphorylation of proteins from the amino acid sequenceQ29616388
Mechanisms of specificity in protein phosphorylationQ29617541
The enzymatic activity of CEM15/Apobec-3G is essential for the regulation of the infectivity of HIV-1 virion but not a sole determinant of its antiviral activity.Q30333471
An AMBER/DYANA/MOLMOL phosphorylated amino acid library set and incorporation into NMR structure calculations.Q30351609
The AID antibody diversification enzyme is regulated by protein kinase A phosphorylationQ33226024
T cells contain an RNase-insensitive inhibitor of APOBEC3G deaminase activityQ33300132
CREB and the CRTC co-activators: sensors for hormonal and metabolic signalsQ34166530
Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancerQ34233218
PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cellsQ34249818
Evidence for APOBEC3B mutagenesis in multiple human cancersQ34357412
A cell-free protein synthesis system for high-throughput proteomicsQ34378610
Elevated APOBEC3B correlates with poor outcomes for estrogen-receptor-positive breast cancersQ34491947
Protein kinase A catalytic subunit isoform PRKACA; History, function and physiologyQ34505964
Biochemical activities of highly purified, catalytically active human APOBEC3G: correlation with antiviral effect.Q34651434
Human papillomavirus E6 triggers upregulation of the antiviral and cancer genomic DNA deaminase APOBEC3BQ34782173
A highly efficient and robust cell-free protein synthesis system prepared from wheat embryos: plants apparently contain a suicide system directed at ribosomesQ34963665
Phosphorylation directly regulates the intrinsic DNA cytidine deaminase activity of activation-induced deaminase and APOBEC3G proteinQ35128214
High-throughput, genome-scale protein production method based on the wheat germ cell-free expression systemQ35561724
APOBEC family mutational signatures are associated with poor prognosis translocations in multiple myelomaQ36055752
The PKC/NF-κB signaling pathway induces APOBEC3B expression in multiple human cancersQ36244879
Crystal Structure of the DNA Deaminase APOBEC3B Catalytic DomainQ36301232
Deaminase-independent inhibition of HIV-1 reverse transcription by APOBEC3G.Q36328929
Extensive somatic L1 retrotransposition in colorectal tumorsQ36446178
Immunoglobulin class-switch DNA recombination: induction, targeting and beyondQ36534234
In silico Analysis of HIV-1 Env-gp120 Reveals Structural Bases for Viral Adaptation in Growth-Restrictive CellsQ36558933
Nuclear Magnetic Resonance Structure of the APOBEC3B Catalytic Domain: Structural Basis for Substrate Binding and DNA Deaminase ActivityQ37091342
Binding of RNA by APOBEC3G controls deamination-independent restriction of retrovirusesQ37122122
An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancersQ37211712
The DNA cytosine deaminase APOBEC3B promotes tamoxifen resistance in ER-positive breast cancer.Q37321593
APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma.Q37402303
Heterogeneity of genomic evolution and mutational profiles in multiple myelomaQ37528285
APOBEC3B is an enzymatic source of mutation in breast cancer.Q37533713
Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B.Q37629738
Molecular Dynamics Simulation of the Influenza A(H3N2) Hemagglutinin Trimer Reveals the Structural Basis for Adaptive Evolution of the Recent Epidemic Clade 3C.2a.Q37742902
Degradation of the cancer genomic DNA deaminase APOBEC3B by SIV VifQ38261732
Human Papillomavirus 16 E6 Upregulates APOBEC3B via the TEAD Transcription FactorQ38721814
Classical NF-κB pathway is responsible for APOBEC3B expression in cancer cells.Q38748945
APOBEC3B can impair genomic stability by inducing base substitutions in genomic DNA in human cells.Q39245074
The cellular antiviral protein APOBEC3G interacts with HIV-1 reverse transcriptase and inhibits its function during viral replicationQ39402465
Increased APOBEC3B Predicts Worse Outcomes in Lung Cancer: A Comprehensive Retrospective StudyQ39852184
Phosphorylation of APOBEC3G by protein kinase A regulates its interaction with HIV-1 Vif.Q39932323
A Proposal for a Structural Model of the Feline Calicivirus Protease Bound to the Substrate Peptide under Physiological ConditionsQ40089931
The intrinsic antiretroviral factor APOBEC3B contains two enzymatically active cytidine deaminase domainsQ40145723
Antiviral potency of APOBEC proteins does not correlate with cytidine deaminationQ40243154
Ubiquitination of APOBEC3 proteins by the Vif-Cullin5-ElonginB-ElonginC complex.Q40348544
Ubiquitination of APOBEC3G by an HIV-1 Vif-Cullin5-Elongin B-Elongin C complex is essential for Vif functionQ40444285
Clonal evolution of chemotherapy-resistant urothelial carcinoma.Q41315076
Dimerization regulates both deaminase-dependent and deaminase-independent HIV-1 restriction by APOBEC3G.Q41701165
Protein kinase a in cancerQ41812476
B-Myb Induces APOBEC3B Expression Leading to Somatic Mutation in Multiple CancersQ42253948
Human apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G) is incorporated into HIV-1 virions through interactions with viral and nonviral RNAs.Q44947077
Consequences of lysine 72 mutation on the phosphorylation and activation state of cAMP-dependent kinaseQ45200627
Antiviral function of APOBEC3G can be dissociated from cytidine deaminase activityQ45236572
Biological and prognostic impact of APOBEC-induced mutations in the spectrum of plasma cell dyscrasias and multiple myeloma cell lines.Q46265856
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)8307
P577publication date2019-06-05
P1433published inScientific ReportsQ2261792
P1476titleProtein kinase A inhibits tumor mutator APOBEC3B through phosphorylation
P478volume9