Cocrystals Mitigate Negative Effects of High pH on Solubility and Dissolution of a Basic Drug.

scientific article published on 14 February 2018

Cocrystals Mitigate Negative Effects of High pH on Solubility and Dissolution of a Basic Drug. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1021/ACS.CGD.7B01206
P932PMC publication ID6261521
P698PubMed publication ID30505243

P2093author name stringNaír Rodríguez-Hornedo
Yitian M Chen
P2860cites workPhysiological parameters for oral delivery and in vitro testingQ27687044
A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailabilityQ28293773
Helicobacter pylori, HIV and Gastric Hypochlorhydria in the Malawian PopulationQ28547010
Solid dispersion of poorly water-soluble drugs: early promises, subsequent problems, and recent breakthroughsQ33748142
In vitro-in vivo correlations for lipophilic, poorly water-soluble drugsQ34061188
Influence of physicochemical properties on dissolution of drugs in the gastrointestinal tractQ34190317
The influence of gastric acidity on the bio-availability of ketoconazoleQ34708079
Supersaturating drug delivery systems: the answer to solubility-limited oral bioavailability?Q34976310
Impairing effect of food on ketoconazole absorptionQ35675648
Mechanistic Analysis of Cocrystal Dissolution as a Function of pH and Micellar SolubilizationQ36666790
Salt formation to improve drug solubilityQ36873893
How cocrystals of weakly basic drugs and acidic coformers might modulate solubility and stabilityQ36970866
Cocrystals to facilitate delivery of poorly soluble compounds beyond-rule-of-5Q37013110
Cocrystal Transition Points: Role of Cocrystal Solubility, Drug Solubility, and Solubilizing AgentsQ37415146
Physical stability of salts of weak bases in the solid-stateQ37849705
Pharmaceutical cocrystals and poorly soluble drugs.Q38064634
Salt disproportionation: A material science perspectiveQ39120656
Forecasting the oral absorption behavior of poorly soluble weak bases using solubility and dissolution studies in biorelevant mediaQ40648419
Characteristics and significance of the amorphous state in pharmaceutical systemsQ41323277
Alterations in gastric acidity in patients infected with human immunodeficiency virusQ45769106
pH-dependent dissolution in vitro and absorption in vivo of weakly basic drugs: development of a canine modelQ46397050
Simulation of fasting gastric conditions and its importance for the in vivo dissolution of lipophilic compoundsQ46490440
Dissolution media simulating conditions in the proximal human gastrointestinal tract: an updateQ47779125
Salt Stability - The Effect of pHmax on Salt to Free Base Conversion.Q50931533
Stability of pharmaceutical salts in solid oral dosage forms.Q50968375
pH-dependent solubility of indomethacin-saccharin and carbamazepine-saccharin cocrystals in aqueous media.Q51336621
Upper gastrointestinal (GI) pH in young, healthy men and women.Q51615125
Evaluation of various dissolution media for predicting in vivo performance of class I and II drugsQ59237519
Reaction crystallization of pharmaceutical molecular complexesQ83913212
Engineering cocrystal solubility, stability, and pH(max) by micellar solubilizationQ84936529
P433issue3
P921main subjectcocrystalQ5139913
P304page(s)1358-1366
P577publication date2018-02-14
P1433published inCrystal Growth & DesignQ3005997
P1476titleCocrystals Mitigate Negative Effects of High pH on Solubility and Dissolution of a Basic Drug.
P478volume18

Reverse relations

cites work (P2860)
Q92282236Dissolution Advantage of Nitazoxanide Cocrystals in the Presence of Cellulosic Polymers
Q57065319Mechanistic Analysis Of Co-Crystal Dissolution, Surface Ph, And Dissolution Advantage As A Guide For Rational Selection
Q47621793Understanding the Differences Between Cocrystal and Salt Aqueous Solubilities

Search more.